CO6150145A2 - Derivados de aril/heterociclo/cicloalquil/cicloalquil fenil substituidos utiles como agentes inmunosupresores - Google Patents
Derivados de aril/heterociclo/cicloalquil/cicloalquil fenil substituidos utiles como agentes inmunosupresoresInfo
- Publication number
- CO6150145A2 CO6150145A2 CO09008880A CO09008880A CO6150145A2 CO 6150145 A2 CO6150145 A2 CO 6150145A2 CO 09008880 A CO09008880 A CO 09008880A CO 09008880 A CO09008880 A CO 09008880A CO 6150145 A2 CO6150145 A2 CO 6150145A2
- Authority
- CO
- Colombia
- Prior art keywords
- alkylene
- alkyl
- co2alkyl
- cicloalquil
- co2h
- Prior art date
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- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D277/28—Radicals substituted by nitrogen atoms
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- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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- C07F9/65395—Five-membered rings containing two nitrogen atoms having the two nitrogen atoms in positions 1 and 2
Abstract
1.- Un compuesto de la fórmula I:o una sal farmacéuticamente aceptable del mismo, en donde: R1 es hidrógeno, halógeno, ciano, alquilo, arilo, heteroarilo, cicloalquilo, heterocicloalquilo, aralquilo, heteroalquilo, -O-alquilo, -O-arilo, -O-heteroarilo, -S-alquilo, alquileno-O-alquilo, alquileno-CO2H, alquileno-CO2alquilo, alquiloSO2, alquilensulfonilo, alquileno-CO-amino, alquileno-CO-alquilamino, alquileno-CO-dialquilamino, alquileno-NH- CO2H, alquileno-NH-CO2alquilo-CO2alquilo, -OH, -C(O)-alquilo, -C(O)O-alquilo, -CONH2, -CO-alquilamino, -CO-dialquilamino, amino, alquilamino o dialquilamino, cualquiera de los cuales puede ser opcionalmente sustituido en carbono con 1, 2 ó 3 grupos seleccionados de halógeno, alquilo, halogenoalquilo, -CF3, arilo, -CN, -OH, o -O-alquilo; A es alquileno(C1-C20), alquenileno(C2-C20), o alquinileno(C2-C20), cada uno de los cuales puede ser opcionalmente sustituido en carbono con 1, 2 ó 3 grupos seleccionados de OH, CO2H, CO2alquilo, halógeno, amino, alquilamino, dialquilamino, -O-alquilo, alquileno-O-alquilo, alquileno-OH, o alquileno-CO2H; X1 es un enlace o es CH2, O, -CH2O-, S, -S(O), -S(O)2, -C(O)-C(O)O-, o NRx, en donde Rx es H o alquilo (C1-C6); R' y R" son cada uno independientemente hidrógeno, halógeno, alquilo opcionalmente sustituido en carbono con halógeno, alquilo, o tomados junto al carbono al cual están unidos forman C=O o un anillo de 3, 4, 5 ó 6 miembros, que contiene opcionalmente 1 ó 2 heteroátomos seleccionados de O NH, N-alquilo, SO o SO2, cualquiera de los cuales puede ser opcionalmente sustituido en carbono con alquilo o halógeno; R2 es ciano, alquilo, arilo, heteroarilo, cicloalquilo, heterocicloalquilo, aralquilo, heteroalquilo, -O-alquilo, -O-arilo, -O-heteroarilo, aralcoxi, heteroaralcoxi, -S-alquilo, alquileno-O-alquilo, alquileno-CO2H, alquileno-CO2alquilo, alquiloSO2, alquilensulfonilo, alquileno-CO-amino, alquileno-CO-alquilamino, alquileno-CO-dialquilamino, alquileno-NH-CO2H, alquileno-NH-CO2alquilo -CO2alquilo, -OH, -C(O)-alquilo, -C(O)O-alquilo, ...
Applications Claiming Priority (4)
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US82110106P | 2006-08-01 | 2006-08-01 | |
US82791906P | 2006-10-03 | 2006-10-03 | |
US89643107P | 2007-03-22 | 2007-03-22 | |
US95929107P | 2007-07-12 | 2007-07-12 |
Publications (1)
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CO6150145A2 true CO6150145A2 (es) | 2010-04-20 |
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CO09008880A CO6150145A2 (es) | 2006-08-01 | 2009-01-30 | Derivados de aril/heterociclo/cicloalquil/cicloalquil fenil substituidos utiles como agentes inmunosupresores |
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US (2) | US20100009936A1 (es) |
EP (1) | EP2046746A2 (es) |
JP (1) | JP2009545599A (es) |
KR (1) | KR20090033912A (es) |
AR (1) | AR062156A1 (es) |
AU (1) | AU2007281491A1 (es) |
BR (1) | BRPI0714512A2 (es) |
CA (1) | CA2659473A1 (es) |
CO (1) | CO6150145A2 (es) |
CR (1) | CR10628A (es) |
EA (1) | EA200970173A1 (es) |
IL (1) | IL196595A0 (es) |
MA (1) | MA30639B1 (es) |
MX (1) | MX2009001188A (es) |
NO (1) | NO20090739L (es) |
PE (1) | PE20080730A1 (es) |
TW (1) | TW200823182A (es) |
WO (1) | WO2008016692A2 (es) |
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KR20220084423A (ko) | 2008-07-23 | 2022-06-21 | 아레나 파마슈티칼스, 인크. | 자가면역성 및 염증성의 장애의 치료에 유용한 치환된 1,2,3,4-테트라히드로시클로펜타[b]인돌-3-일)아세트산 유도체 |
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US20100016260A1 (en) * | 2006-08-01 | 2010-01-21 | Praecis Pharmaceuticals Incorporated | Agonists of sphingosine-1 phosphate receptor (slp) |
TW200823182A (en) * | 2006-08-01 | 2008-06-01 | Praecis Pharm Inc | Chemical compounds |
EP2099768A2 (en) * | 2006-08-04 | 2009-09-16 | Praecis Pharmaceuticals Incorporated | Agonists of the sphingosine-1-phosphate receptor |
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2007
- 2007-07-31 TW TW096127869A patent/TW200823182A/zh unknown
- 2007-07-31 AR ARP070103371A patent/AR062156A1/es not_active Application Discontinuation
- 2007-08-01 JP JP2009522874A patent/JP2009545599A/ja active Pending
- 2007-08-01 EP EP07836442A patent/EP2046746A2/en not_active Withdrawn
- 2007-08-01 WO PCT/US2007/017282 patent/WO2008016692A2/en active Application Filing
- 2007-08-01 EA EA200970173A patent/EA200970173A1/ru unknown
- 2007-08-01 BR BRPI0714512-8A patent/BRPI0714512A2/pt not_active IP Right Cessation
- 2007-08-01 US US12/375,682 patent/US20100009936A1/en not_active Abandoned
- 2007-08-01 AU AU2007281491A patent/AU2007281491A1/en not_active Abandoned
- 2007-08-01 KR KR1020097004192A patent/KR20090033912A/ko not_active Application Discontinuation
- 2007-08-01 CA CA002659473A patent/CA2659473A1/en not_active Abandoned
- 2007-08-01 US US11/888,909 patent/US7759370B2/en not_active Expired - Fee Related
- 2007-08-01 PE PE2007001000A patent/PE20080730A1/es not_active Application Discontinuation
- 2007-08-01 MX MX2009001188A patent/MX2009001188A/es unknown
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2009
- 2009-01-19 IL IL196595A patent/IL196595A0/en unknown
- 2009-01-30 CO CO09008880A patent/CO6150145A2/es unknown
- 2009-02-11 MA MA31631A patent/MA30639B1/fr unknown
- 2009-02-16 NO NO20090739A patent/NO20090739L/no not_active Application Discontinuation
- 2009-02-20 CR CR10628A patent/CR10628A/es not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
MA30639B1 (fr) | 2009-08-03 |
KR20090033912A (ko) | 2009-04-06 |
NO20090739L (no) | 2009-04-24 |
AU2007281491A1 (en) | 2008-02-07 |
CR10628A (es) | 2009-04-28 |
MX2009001188A (es) | 2009-02-13 |
CA2659473A1 (en) | 2008-02-07 |
PE20080730A1 (es) | 2008-06-12 |
US20080096938A1 (en) | 2008-04-24 |
JP2009545599A (ja) | 2009-12-24 |
TW200823182A (en) | 2008-06-01 |
EA200970173A1 (ru) | 2009-10-30 |
AR062156A1 (es) | 2008-10-22 |
US20100009936A1 (en) | 2010-01-14 |
US7759370B2 (en) | 2010-07-20 |
WO2008016692A3 (en) | 2008-03-20 |
WO2008016692A2 (en) | 2008-02-07 |
EP2046746A2 (en) | 2009-04-15 |
BRPI0714512A2 (pt) | 2015-06-16 |
IL196595A0 (en) | 2009-11-18 |
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