RS51317B - Postupci pravljenja 3-0 zaštićenih morfinona i 3-0 zaštićenih morfinon dienol karboksilata - Google Patents
Postupci pravljenja 3-0 zaštićenih morfinona i 3-0 zaštićenih morfinon dienol karboksilataInfo
- Publication number
- RS51317B RS51317B RSP-2010/0064A RSP20100064A RS51317B RS 51317 B RS51317 B RS 51317B RS P20100064 A RSP20100064 A RS P20100064A RS 51317 B RS51317 B RS 51317B
- Authority
- RS
- Serbia
- Prior art keywords
- protected
- formula
- making
- methods
- compound
- Prior art date
Links
- -1 morphinone dienol carboxylates Chemical class 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 6
- 125000000008 (C1-C10) alkyl group Chemical group 0.000 abstract 1
- YRIZYWQGELRKNT-UHFFFAOYSA-N 1,3,5-trichloro-1,3,5-triazinane-2,4,6-trione Chemical compound ClN1C(=O)N(Cl)C(=O)N(Cl)C1=O YRIZYWQGELRKNT-UHFFFAOYSA-N 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 230000002349 favourable effect Effects 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 125000006239 protecting group Chemical group 0.000 abstract 1
- 229950009390 symclosene Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
- C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Neurosurgery (AREA)
- Life Sciences & Earth Sciences (AREA)
- Neurology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pain & Pain Management (AREA)
- Pharmacology & Pharmacy (AREA)
- Biomedical Technology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Catalysts (AREA)
- Steroid Compounds (AREA)
- Saccharide Compounds (AREA)
Abstract
Postupak za dobijanje jedinjenja formule (III):koji se sastoji od:(a) reagovanja jedinjenja formule (I):pod pogodnim uslovima, u prisustvu smeše jedinjenja formule R1SR2 i trihloroizocijanurinske kiseline, tako da se dobije jedinjenje formule (II):ib) reagovanja jedinjenja formule (II) pod povoljnim uslovima sa prvom bazom i agensom za acilovanje, formule R4(C(O)OC(O)R4 ili R4C(O)X, tako da se dobije jedinjenje formule (III), u kome su:R1 i R2 svaki nezavisno, -(C1-C20)alkil, -(C3-C8)cikloalkil ili -fenil;R3 je neka zaštitna grupa;R4 je –(C1-C10)alkil; iX je –Cl, Br ili –I.Prijava sadrži još 22 patentna zahteva.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US54271104P | 2004-02-06 | 2004-02-06 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RS51317B true RS51317B (sr) | 2010-12-31 |
Family
ID=34860329
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RSP-2008/0553A RS50663B (sr) | 2004-02-06 | 2005-02-04 | Postupci za dobijanje 3-o-zaštićenih morfinona i 3-o-zaštićenih morfinon dienol karboksilata |
| RSP-2010/0064A RS51317B (sr) | 2004-02-06 | 2005-02-04 | Postupci pravljenja 3-0 zaštićenih morfinona i 3-0 zaštićenih morfinon dienol karboksilata |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RSP-2008/0553A RS50663B (sr) | 2004-02-06 | 2005-02-04 | Postupci za dobijanje 3-o-zaštićenih morfinona i 3-o-zaštićenih morfinon dienol karboksilata |
Country Status (34)
| Country | Link |
|---|---|
| US (6) | US8003793B2 (sr) |
| EP (3) | EP2194059A3 (sr) |
| JP (1) | JP4963968B2 (sr) |
| KR (4) | KR20070108956A (sr) |
| CN (1) | CN1918168B (sr) |
| AP (1) | AP2006003716A0 (sr) |
| AT (2) | ATE406372T1 (sr) |
| AU (1) | AU2005212258B2 (sr) |
| BR (1) | BRPI0506607B8 (sr) |
| CA (2) | CA2555215C (sr) |
| CR (1) | CR8590A (sr) |
| CY (2) | CY1108506T1 (sr) |
| DE (2) | DE602005018265D1 (sr) |
| DK (2) | DK1864987T3 (sr) |
| EA (2) | EA012905B1 (sr) |
| EC (1) | ECSP066824A (sr) |
| ES (2) | ES2313299T3 (sr) |
| GE (1) | GEP20084454B (sr) |
| HK (2) | HK1103071A1 (sr) |
| HR (2) | HRP20080618T3 (sr) |
| IL (2) | IL177281A (sr) |
| MA (1) | MA28346A1 (sr) |
| MX (1) | MXPA06008931A (sr) |
| NO (2) | NO20063989L (sr) |
| NZ (2) | NZ565355A (sr) |
| PL (2) | PL1711502T3 (sr) |
| PT (2) | PT1711502E (sr) |
| RS (2) | RS50663B (sr) |
| SG (1) | SG150500A1 (sr) |
| SI (2) | SI1711502T1 (sr) |
| TN (1) | TNSN06248A1 (sr) |
| UA (2) | UA88646C2 (sr) |
| WO (1) | WO2005077957A2 (sr) |
| ZA (1) | ZA200606252B (sr) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2194059A3 (en) | 2004-02-06 | 2010-09-22 | Euro-Celtique S.A. | Methods for making 3-O-protected morphinones and 3-O-protected morphinone dienol carboxylates |
| CA2663909A1 (en) * | 2006-09-20 | 2008-03-27 | Mallinckrodt Inc. | Preparation of substituted morphinan-6-ones and salts and intermediates thereof |
| US9040726B2 (en) * | 2007-03-06 | 2015-05-26 | Mallinckrodt Llc | Process for the preparation of quaternary N-alkyl morphinan alkaloid salts |
| CA2707757C (en) * | 2007-03-06 | 2017-01-03 | Peter X. Wang | Process for the preparation of quaternary n-alkyl morphinan alkaloid salts |
| AU2009251427B2 (en) | 2008-05-27 | 2014-05-22 | SpecGx LLC | Processes and compounds for the preparation of normorphinans |
| WO2010028004A2 (en) | 2008-09-03 | 2010-03-11 | Mallinckrodt Inc. | Substituted berbines and processes for their synthesis |
| BR112012028656A2 (pt) | 2010-05-10 | 2016-08-09 | Euro Celtique Sa | combinação de grânulos carregados ativos com ativos adicionais |
| CA2798884C (en) | 2010-05-10 | 2016-09-13 | Euro-Celtique S.A. | Manufacturing of active-free granules and tablets comprising the same |
| AR083150A1 (es) | 2010-05-10 | 2013-02-06 | Euro Celtique Sa | Composiciones farmaceuticas que comprenden hidromorfona y naloxona |
| DE112014005175T5 (de) | 2013-11-13 | 2016-07-21 | Euro-Celtique S.A. | Hydromorphon und Naloxon für die Behandlung von Schmerzen und Opioid-Darm-Dysfunktions-Syndrom |
| MX2018001968A (es) * | 2015-09-30 | 2018-11-09 | Fujifilm Finechemicals Co Ltd | Metodo de produccion de compuestos organicos. |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2654756A (en) * | 1949-10-20 | 1953-10-06 | Mallinckrodt Chemical Works | Process of preparing codeinone, dihydrocodeinone, and dihydromorphinone |
| DE902257C (de) | 1951-07-17 | 1954-01-21 | Knoll Ag | Verfahren zur Herstellung von Acylderivaten der Enolform des Codeinons |
| GB1495271A (en) * | 1974-04-10 | 1977-12-14 | Macfarlan Smith Ltd | Dehydrohalogenation of codeinone derivatives |
| US4472253A (en) * | 1981-08-17 | 1984-09-18 | The Florida Board Of Regents On Behalf Of The Florida State University | Process for the preparation of an N-substituted 3-O-alkyl-14-hydroxynormorphinone derivative |
| US5112975A (en) * | 1984-03-27 | 1992-05-12 | Mallinckrodt Specialty Chemicals Company | Preparation of noroxymorphone from morphine |
| SE9003665D0 (sv) * | 1990-11-16 | 1990-11-16 | Kabivitrum Ab | Morphine prodrugs |
| GB9116909D0 (en) * | 1991-08-06 | 1991-09-18 | Salford Ultrafine Chem & Res | Morphine derivatives |
| US5821374A (en) * | 1995-11-21 | 1998-10-13 | Hoffmann-La Roche Inc. | Process for the oxidation of alcohols |
| US5869669A (en) * | 1996-07-26 | 1999-02-09 | Penick Corporation | Preparation of 14-hydroxynormorphinones from normorphinone dienol acylates |
| GB9713703D0 (en) * | 1997-06-30 | 1997-09-03 | Johnson Matthey Plc | Preparation of opiates |
| US6177567B1 (en) * | 1999-10-15 | 2001-01-23 | Boehringer Ingelheim Chemicals, Inc. | Method for preparing oxycodone |
| US6596877B2 (en) * | 2001-10-17 | 2003-07-22 | Novartis Ag | Accelerated process for preparing O-methyl phenols, N-methyl heteroaromatic compounds, and methylated aminophenols |
| EP2194059A3 (en) | 2004-02-06 | 2010-09-22 | Euro-Celtique S.A. | Methods for making 3-O-protected morphinones and 3-O-protected morphinone dienol carboxylates |
-
2005
- 2005-02-04 EP EP09015220A patent/EP2194059A3/en not_active Withdrawn
- 2005-02-04 WO PCT/US2005/003390 patent/WO2005077957A2/en active Application Filing
- 2005-02-04 DE DE602005018265T patent/DE602005018265D1/de active Active
- 2005-02-04 EP EP05712726A patent/EP1711502B1/en active Active
- 2005-02-04 EA EA200601394A patent/EA012905B1/ru not_active IP Right Cessation
- 2005-02-04 AP AP2006003716A patent/AP2006003716A0/xx unknown
- 2005-02-04 AT AT05712726T patent/ATE406372T1/de active
- 2005-02-04 KR KR1020077025207A patent/KR20070108956A/ko not_active Application Discontinuation
- 2005-02-04 SI SI200530468T patent/SI1711502T1/sl unknown
- 2005-02-04 NZ NZ565355A patent/NZ565355A/en unknown
- 2005-02-04 CN CN2005800040830A patent/CN1918168B/zh active Active
- 2005-02-04 EA EA200801811A patent/EA016062B1/ru not_active IP Right Cessation
- 2005-02-04 NZ NZ548786A patent/NZ548786A/en unknown
- 2005-02-04 GE GEAP20059608A patent/GEP20084454B/en unknown
- 2005-02-04 MX MXPA06008931A patent/MXPA06008931A/es active IP Right Grant
- 2005-02-04 EP EP07014411A patent/EP1864987B1/en active Active
- 2005-02-04 SG SG200900838-4A patent/SG150500A1/en unknown
- 2005-02-04 KR KR1020097016500A patent/KR101011460B1/ko active IP Right Grant
- 2005-02-04 JP JP2006552236A patent/JP4963968B2/ja active Active
- 2005-02-04 KR KR1020077025206A patent/KR100921695B1/ko active IP Right Grant
- 2005-02-04 DE DE602005009321T patent/DE602005009321D1/de active Active
- 2005-02-04 US US10/588,637 patent/US8003793B2/en active Active
- 2005-02-04 CA CA2555215A patent/CA2555215C/en active Active
- 2005-02-04 PL PL05712726T patent/PL1711502T3/pl unknown
- 2005-02-04 AU AU2005212258A patent/AU2005212258B2/en active Active
- 2005-02-04 PT PT05712726T patent/PT1711502E/pt unknown
- 2005-02-04 ES ES05712726T patent/ES2313299T3/es active Active
- 2005-02-04 UA UAA200704105A patent/UA88646C2/uk unknown
- 2005-02-04 RS RSP-2008/0553A patent/RS50663B/sr unknown
- 2005-02-04 BR BRPI0506607A patent/BRPI0506607B8/pt active IP Right Grant
- 2005-02-04 CA CA2808199A patent/CA2808199C/en active Active
- 2005-02-04 SI SI200530925T patent/SI1864987T1/sl unknown
- 2005-02-04 DK DK07014411.8T patent/DK1864987T3/da active
- 2005-02-04 RS RSP-2010/0064A patent/RS51317B/sr unknown
- 2005-02-04 PT PT07014411T patent/PT1864987E/pt unknown
- 2005-02-04 AT AT07014411T patent/ATE451374T1/de active
- 2005-02-04 DK DK05712726T patent/DK1711502T3/da active
- 2005-02-04 ES ES07014411T patent/ES2338054T3/es active Active
- 2005-02-04 PL PL07014411T patent/PL1864987T3/pl unknown
- 2005-04-02 UA UAA200609622A patent/UA87833C2/uk unknown
-
2006
- 2006-07-28 ZA ZA200606252A patent/ZA200606252B/en unknown
- 2006-08-03 IL IL177281A patent/IL177281A/en active IP Right Grant
- 2006-08-04 MA MA29240A patent/MA28346A1/fr unknown
- 2006-08-04 TN TNP2006000248A patent/TNSN06248A1/fr unknown
- 2006-09-01 CR CR8590A patent/CR8590A/es unknown
- 2006-09-05 KR KR1020067018113A patent/KR100921696B1/ko active IP Right Grant
- 2006-09-05 EC EC2006006824A patent/ECSP066824A/es unknown
- 2006-09-06 NO NO20063989A patent/NO20063989L/no not_active Application Discontinuation
-
2007
- 2007-04-18 HK HK07104100.2A patent/HK1103071A1/xx unknown
- 2007-04-18 HK HK08106459.3A patent/HK1119160A1/xx unknown
-
2008
- 2008-11-12 CY CY20081101295T patent/CY1108506T1/el unknown
- 2008-11-26 HR HR20080618T patent/HRP20080618T3/xx unknown
-
2010
- 2010-02-25 CY CY20101100178T patent/CY1109838T1/el unknown
- 2010-03-05 HR HR20100123T patent/HRP20100123T1/hr unknown
- 2010-05-06 IL IL205596A patent/IL205596A/en active IP Right Grant
-
2011
- 2011-07-22 US US13/189,228 patent/US8198444B2/en active Active
-
2012
- 2012-05-15 US US13/472,227 patent/US8685996B2/en active Active
-
2014
- 2014-02-24 US US14/188,430 patent/US8975257B2/en active Active
-
2015
- 2015-03-02 NO NO20150276A patent/NO339083B1/no unknown
- 2015-03-03 US US14/637,129 patent/US9670218B2/en not_active Expired - Fee Related
-
2017
- 2017-05-04 US US15/587,118 patent/US20170233400A1/en not_active Abandoned
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