RS51317B - Postupci pravljenja 3-0 zaštićenih morfinona i 3-0 zaštićenih morfinon dienol karboksilata - Google Patents

Postupci pravljenja 3-0 zaštićenih morfinona i 3-0 zaštićenih morfinon dienol karboksilata

Info

Publication number
RS51317B
RS51317B RSP-2010/0064A RSP20100064A RS51317B RS 51317 B RS51317 B RS 51317B RS P20100064 A RSP20100064 A RS P20100064A RS 51317 B RS51317 B RS 51317B
Authority
RS
Serbia
Prior art keywords
protected
formula
making
methods
compound
Prior art date
Application number
RSP-2010/0064A
Other languages
English (en)
Inventor
Andreas Stumpf
Original Assignee
Euro-Celtique S.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34860329&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=RS51317(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Euro-Celtique S.A. filed Critical Euro-Celtique S.A.
Publication of RS51317B publication Critical patent/RS51317B/sr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Catalysts (AREA)
  • Saccharide Compounds (AREA)
  • Steroid Compounds (AREA)

Abstract

Postupak za dobijanje jedinjenja formule (III):koji se sastoji od:(a) reagovanja jedinjenja formule (I):pod pogodnim uslovima, u prisustvu smeše jedinjenja formule R1SR2 i trihloroizocijanurinske kiseline, tako da se dobije jedinjenje formule (II):ib) reagovanja jedinjenja formule (II) pod povoljnim uslovima sa prvom bazom i agensom za acilovanje, formule R4(C(O)OC(O)R4 ili R4C(O)X, tako da se dobije jedinjenje formule (III), u kome su:R1 i R2 svaki nezavisno, -(C1-C20)alkil, -(C3-C8)cikloalkil ili -fenil;R3 je neka zaštitna grupa;R4 je –(C1-C10)alkil; iX je –Cl, Br ili –I.Prijava sadrži još 22 patentna zahteva.
RSP-2010/0064A 2004-02-06 2005-02-04 Postupci pravljenja 3-0 zaštićenih morfinona i 3-0 zaštićenih morfinon dienol karboksilata RS51317B (sr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US54271104P 2004-02-06 2004-02-06

Publications (1)

Publication Number Publication Date
RS51317B true RS51317B (sr) 2010-12-31

Family

ID=34860329

Family Applications (2)

Application Number Title Priority Date Filing Date
RSP-2008/0553A RS50663B (sr) 2004-02-06 2005-02-04 Postupci za dobijanje 3-o-zaštićenih morfinona i 3-o-zaštićenih morfinon dienol karboksilata
RSP-2010/0064A RS51317B (sr) 2004-02-06 2005-02-04 Postupci pravljenja 3-0 zaštićenih morfinona i 3-0 zaštićenih morfinon dienol karboksilata

Family Applications Before (1)

Application Number Title Priority Date Filing Date
RSP-2008/0553A RS50663B (sr) 2004-02-06 2005-02-04 Postupci za dobijanje 3-o-zaštićenih morfinona i 3-o-zaštićenih morfinon dienol karboksilata

Country Status (34)

Country Link
US (6) US8003793B2 (sr)
EP (3) EP2194059A3 (sr)
JP (1) JP4963968B2 (sr)
KR (4) KR100921695B1 (sr)
CN (1) CN1918168B (sr)
AP (1) AP2006003716A0 (sr)
AT (2) ATE451374T1 (sr)
AU (1) AU2005212258B2 (sr)
BR (1) BRPI0506607B8 (sr)
CA (2) CA2808199C (sr)
CR (1) CR8590A (sr)
CY (2) CY1108506T1 (sr)
DE (2) DE602005009321D1 (sr)
DK (2) DK1864987T3 (sr)
EA (2) EA012905B1 (sr)
EC (1) ECSP066824A (sr)
ES (2) ES2338054T3 (sr)
GE (1) GEP20084454B (sr)
HK (2) HK1103071A1 (sr)
HR (2) HRP20080618T3 (sr)
IL (2) IL177281A (sr)
MA (1) MA28346A1 (sr)
MX (1) MXPA06008931A (sr)
NO (2) NO20063989L (sr)
NZ (2) NZ548786A (sr)
PL (2) PL1864987T3 (sr)
PT (2) PT1864987E (sr)
RS (2) RS50663B (sr)
SG (1) SG150500A1 (sr)
SI (2) SI1711502T1 (sr)
TN (1) TNSN06248A1 (sr)
UA (2) UA88646C2 (sr)
WO (1) WO2005077957A2 (sr)
ZA (1) ZA200606252B (sr)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2338054T3 (es) 2004-02-06 2010-05-03 Euro-Celtique S.A. Metodos para producir morfinonas 3-o-protegidas y carboxilatos de morfinona dienol 3-o-protegidos.
WO2008036172A1 (en) * 2006-09-20 2008-03-27 Mallinckrodt Inc. Preparation of substituted morphinan-6-ones and salts and intermediates thereof
PL2147920T3 (pl) * 2007-03-06 2017-02-28 Mallinckrodt Llc Sposób wytwarzania czwartorzędowych N-alkilowych soli alkaloidu morfinanowego
US9040726B2 (en) 2007-03-06 2015-05-26 Mallinckrodt Llc Process for the preparation of quaternary N-alkyl morphinan alkaloid salts
CA2726220C (en) * 2008-05-27 2017-03-28 Mallinckrodt Inc. Processes and compounds for the preparation of normorphinans
US9458109B2 (en) 2008-09-03 2016-10-04 Mallinckrodt Llc Substituted berbines and processes for their synthesis
US9901540B2 (en) 2010-05-10 2018-02-27 Euro-Celtique S.A. Combination of active loaded granules with additional actives
GB2492037A (en) 2010-05-10 2012-12-19 Euro Celtique Sa Pharmaceutical compositions comprising hydromorphone and naloxone
US9993433B2 (en) 2010-05-10 2018-06-12 Euro-Celtique S.A. Manufacturing of active-free granules and tablets comprising the same
AU2014350135B2 (en) 2013-11-13 2017-08-31 Euro-Celtique S.A. Hydromorphone and naloxone for treatment of pain and opioid bowel dysfunction syndrome
US10351512B2 (en) 2015-09-30 2019-07-16 Fujifilm Wako Pure Chemical Corporation Method of producing organic compound

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2654756A (en) 1949-10-20 1953-10-06 Mallinckrodt Chemical Works Process of preparing codeinone, dihydrocodeinone, and dihydromorphinone
DE902257C (de) 1951-07-17 1954-01-21 Knoll Ag Verfahren zur Herstellung von Acylderivaten der Enolform des Codeinons
GB1495271A (en) * 1974-04-10 1977-12-14 Macfarlan Smith Ltd Dehydrohalogenation of codeinone derivatives
US4472253A (en) * 1981-08-17 1984-09-18 The Florida Board Of Regents On Behalf Of The Florida State University Process for the preparation of an N-substituted 3-O-alkyl-14-hydroxynormorphinone derivative
US5112975A (en) * 1984-03-27 1992-05-12 Mallinckrodt Specialty Chemicals Company Preparation of noroxymorphone from morphine
SE9003665D0 (sv) * 1990-11-16 1990-11-16 Kabivitrum Ab Morphine prodrugs
GB9116909D0 (en) * 1991-08-06 1991-09-18 Salford Ultrafine Chem & Res Morphine derivatives
US5821374A (en) * 1995-11-21 1998-10-13 Hoffmann-La Roche Inc. Process for the oxidation of alcohols
US5869669A (en) * 1996-07-26 1999-02-09 Penick Corporation Preparation of 14-hydroxynormorphinones from normorphinone dienol acylates
GB9713703D0 (en) * 1997-06-30 1997-09-03 Johnson Matthey Plc Preparation of opiates
US6177567B1 (en) 1999-10-15 2001-01-23 Boehringer Ingelheim Chemicals, Inc. Method for preparing oxycodone
US6596877B2 (en) * 2001-10-17 2003-07-22 Novartis Ag Accelerated process for preparing O-methyl phenols, N-methyl heteroaromatic compounds, and methylated aminophenols
ES2338054T3 (es) 2004-02-06 2010-05-03 Euro-Celtique S.A. Metodos para producir morfinonas 3-o-protegidas y carboxilatos de morfinona dienol 3-o-protegidos.

Also Published As

Publication number Publication date
KR20070026401A (ko) 2007-03-08
CA2808199C (en) 2015-10-27
US8975257B2 (en) 2015-03-10
US20170233400A1 (en) 2017-08-17
UA88646C2 (uk) 2009-11-10
KR20070108956A (ko) 2007-11-13
NZ565355A (en) 2008-09-26
DK1864987T3 (da) 2010-04-12
WO2005077957A2 (en) 2005-08-25
ATE406372T1 (de) 2008-09-15
SI1864987T1 (sl) 2010-04-30
PT1711502E (pt) 2008-11-20
EP1864987A3 (en) 2008-02-20
HK1103071A1 (en) 2007-12-14
CN1918168B (zh) 2011-04-27
TNSN06248A1 (fr) 2007-12-03
ZA200606252B (en) 2007-11-28
US9670218B2 (en) 2017-06-06
EP2194059A3 (en) 2010-09-22
RS50663B (sr) 2010-06-30
NO339083B1 (no) 2016-11-14
EP2194059A2 (en) 2010-06-09
IL205596A (en) 2011-11-30
BRPI0506607B1 (pt) 2018-01-16
IL177281A0 (en) 2006-12-10
CA2555215A1 (en) 2005-08-25
US20120022259A1 (en) 2012-01-26
EA016062B1 (ru) 2012-01-30
EA200601394A1 (ru) 2006-12-29
HRP20100123T1 (hr) 2010-04-30
EP1864987B1 (en) 2009-12-09
NO20150276L (no) 2006-10-31
MA28346A1 (fr) 2006-12-01
CY1108506T1 (el) 2014-04-09
EA012905B1 (ru) 2010-02-26
EP1711502B1 (en) 2008-08-27
BRPI0506607B8 (pt) 2021-05-25
US8198444B2 (en) 2012-06-12
HK1119160A1 (en) 2009-02-27
NO20063989L (no) 2006-10-31
US20140171643A1 (en) 2014-06-19
PT1864987E (pt) 2010-03-09
ATE451374T1 (de) 2009-12-15
DK1711502T3 (da) 2008-12-01
PL1864987T3 (pl) 2010-05-31
DE602005009321D1 (de) 2008-10-09
IL177281A (en) 2012-02-29
BRPI0506607A (pt) 2007-05-02
CY1109838T1 (el) 2014-09-10
US8003793B2 (en) 2011-08-23
EP1711502A2 (en) 2006-10-18
ES2313299T3 (es) 2009-03-01
KR101011460B1 (ko) 2011-01-28
AP2006003716A0 (en) 2006-08-31
US20080146804A1 (en) 2008-06-19
NZ548786A (en) 2008-08-29
AU2005212258B2 (en) 2008-05-22
JP2007520563A (ja) 2007-07-26
EP1864987A2 (en) 2007-12-12
JP4963968B2 (ja) 2012-06-27
CA2555215C (en) 2013-05-21
KR100921696B1 (ko) 2009-10-15
WO2005077957A3 (en) 2006-05-04
GEP20084454B (en) 2008-08-10
DE602005018265D1 (de) 2010-01-21
ES2338054T3 (es) 2010-05-03
SG150500A1 (en) 2009-03-30
CA2808199A1 (en) 2005-08-25
PL1711502T3 (pl) 2009-02-27
MXPA06008931A (es) 2007-01-26
KR20090089486A (ko) 2009-08-21
US8685996B2 (en) 2014-04-01
CR8590A (es) 2007-07-19
US20120225902A1 (en) 2012-09-06
EA200801811A1 (ru) 2008-12-30
ECSP066824A (es) 2006-12-29
AU2005212258A1 (en) 2005-08-25
SI1711502T1 (sl) 2009-02-28
HRP20080618T3 (en) 2009-01-31
KR100921695B1 (ko) 2009-10-15
UA87833C2 (uk) 2009-08-25
CN1918168A (zh) 2007-02-21
KR20070117701A (ko) 2007-12-12
US20150239898A1 (en) 2015-08-27

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