SI1864987T1 - Postopki za izdelavo 3-O-zašŽŤitenih morfinonov in 3-0-zašŽŤitenih morfinondienol karboksilatov - Google Patents

Postopki za izdelavo 3-O-zašŽŤitenih morfinonov in 3-0-zašŽŤitenih morfinondienol karboksilatov

Info

Publication number
SI1864987T1
SI1864987T1 SI200530925T SI200530925T SI1864987T1 SI 1864987 T1 SI1864987 T1 SI 1864987T1 SI 200530925 T SI200530925 T SI 200530925T SI 200530925 T SI200530925 T SI 200530925T SI 1864987 T1 SI1864987 T1 SI 1864987T1
Authority
SI
Slovenia
Prior art keywords
protected
making
methods
morphinones
morphinone dienol
Prior art date
Application number
SI200530925T
Other languages
English (en)
Inventor
Andreas Stumpf
Original Assignee
Euro Celtique Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34860329&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SI1864987(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Euro Celtique Sa filed Critical Euro Celtique Sa
Publication of SI1864987T1 publication Critical patent/SI1864987T1/sl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic System
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
SI200530925T 2004-02-06 2005-02-04 Postopki za izdelavo 3-O-zašŽŤitenih morfinonov in 3-0-zašŽŤitenih morfinondienol karboksilatov SI1864987T1 (sl)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US54271104P 2004-02-06 2004-02-06
EP07014411A EP1864987B1 (en) 2004-02-06 2005-02-04 Methods for making 3-O protected morphinones and 3-O-protected morphinone dienol carboxylates

Publications (1)

Publication Number Publication Date
SI1864987T1 true SI1864987T1 (sl) 2010-04-30

Family

ID=34860329

Family Applications (2)

Application Number Title Priority Date Filing Date
SI200530468T SI1711502T1 (sl) 2004-02-06 2005-02-04 Postopki za izdelavo 3-O-zaščitenih morfinonov in 3-O-zaščitenih morfinondienol karboksilatov
SI200530925T SI1864987T1 (sl) 2004-02-06 2005-02-04 Postopki za izdelavo 3-O-zašŽŤitenih morfinonov in 3-0-zašŽŤitenih morfinondienol karboksilatov

Family Applications Before (1)

Application Number Title Priority Date Filing Date
SI200530468T SI1711502T1 (sl) 2004-02-06 2005-02-04 Postopki za izdelavo 3-O-zaščitenih morfinonov in 3-O-zaščitenih morfinondienol karboksilatov

Country Status (34)

Country Link
US (6) US8003793B2 (sl)
EP (3) EP1711502B1 (sl)
JP (1) JP4963968B2 (sl)
KR (4) KR100921695B1 (sl)
CN (1) CN1918168B (sl)
AP (1) AP2006003716A0 (sl)
AT (2) ATE451374T1 (sl)
AU (1) AU2005212258B2 (sl)
BR (1) BRPI0506607B8 (sl)
CA (2) CA2555215C (sl)
CR (1) CR8590A (sl)
CY (2) CY1108506T1 (sl)
DE (2) DE602005009321D1 (sl)
DK (2) DK1864987T3 (sl)
EA (2) EA016062B1 (sl)
EC (1) ECSP066824A (sl)
ES (2) ES2338054T3 (sl)
GE (1) GEP20084454B (sl)
HK (2) HK1103071A1 (sl)
HR (2) HRP20080618T3 (sl)
IL (2) IL177281A (sl)
MA (1) MA28346A1 (sl)
MX (1) MXPA06008931A (sl)
NO (2) NO20063989L (sl)
NZ (2) NZ548786A (sl)
PL (2) PL1711502T3 (sl)
PT (2) PT1864987E (sl)
RS (2) RS51317B (sl)
SG (1) SG150500A1 (sl)
SI (2) SI1711502T1 (sl)
TN (1) TNSN06248A1 (sl)
UA (2) UA88646C2 (sl)
WO (1) WO2005077957A2 (sl)
ZA (1) ZA200606252B (sl)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA88646C2 (uk) 2004-02-06 2009-11-10 Евро-Селтик С.А. Способи одержання 3-о-захищених морфінонів і 3-о-захищених морфінондієнолкарбоксилатів, а також композиція для окислення спирту до кетону
CA2663909A1 (en) * 2006-09-20 2008-03-27 Mallinckrodt Inc. Preparation of substituted morphinan-6-ones and salts and intermediates thereof
US9040726B2 (en) * 2007-03-06 2015-05-26 Mallinckrodt Llc Process for the preparation of quaternary N-alkyl morphinan alkaloid salts
ES2540534T3 (es) * 2007-03-06 2015-07-10 Mallinckrodt Llc Procedimiento para la preparación de sales cuaternarias de alcaloides de N-alquil morfinano
WO2009146288A1 (en) * 2008-05-27 2009-12-03 Mallinckrodt Inc. Processes and compounds for the preparation of normorphinans
WO2010028004A2 (en) 2008-09-03 2010-03-11 Mallinckrodt Inc. Substituted berbines and processes for their synthesis
NZ603170A (en) 2010-05-10 2015-04-24 Euro Celtique Sa Combination of active loaded granules with additional actives
JP5838199B2 (ja) 2010-05-10 2016-01-06 ユーロ−セルティーク エス．エイ． 活性剤を含まない顆粒およびその顆粒を含む錠剤の製造
ES2408343B2 (es) 2010-05-10 2014-07-17 Euro-Celtique, Sa Composiciones farmacéuticas que comprenden hidromorfona y naloxona
MX2016006279A (es) 2013-11-13 2016-09-07 Euro Celtique Sa Hidromorfona y naloxona para el tratamiento del dolor y el sindrome de disfuncion intestinal opiacea.
JP6888550B2 (ja) 2015-09-30 2021-06-16 富士フイルム和光純薬株式会社 有機化合物の製造方法

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2654756A (en) 1949-10-20 1953-10-06 Mallinckrodt Chemical Works Process of preparing codeinone, dihydrocodeinone, and dihydromorphinone
DE902257C (de) 1951-07-17 1954-01-21 Knoll Ag Verfahren zur Herstellung von Acylderivaten der Enolform des Codeinons
GB1495271A (en) * 1974-04-10 1977-12-14 Macfarlan Smith Ltd Dehydrohalogenation of codeinone derivatives
US4472253A (en) 1981-08-17 1984-09-18 The Florida Board Of Regents On Behalf Of The Florida State University Process for the preparation of an N-substituted 3-O-alkyl-14-hydroxynormorphinone derivative
US5112975A (en) 1984-03-27 1992-05-12 Mallinckrodt Specialty Chemicals Company Preparation of noroxymorphone from morphine
SE9003665D0 (sv) 1990-11-16 1990-11-16 Kabivitrum Ab Morphine prodrugs
GB9116909D0 (en) 1991-08-06 1991-09-18 Salford Ultrafine Chem & Res Morphine derivatives
US5821374A (en) 1995-11-21 1998-10-13 Hoffmann-La Roche Inc. Process for the oxidation of alcohols
US5869669A (en) 1996-07-26 1999-02-09 Penick Corporation Preparation of 14-hydroxynormorphinones from normorphinone dienol acylates
GB9713703D0 (en) * 1997-06-30 1997-09-03 Johnson Matthey Plc Preparation of opiates
US6177567B1 (en) 1999-10-15 2001-01-23 Boehringer Ingelheim Chemicals, Inc. Method for preparing oxycodone
US6596877B2 (en) 2001-10-17 2003-07-22 Novartis Ag Accelerated process for preparing O-methyl phenols, N-methyl heteroaromatic compounds, and methylated aminophenols
UA88646C2 (uk) 2004-02-06 2009-11-10 Евро-Селтик С.А. Способи одержання 3-о-захищених морфінонів і 3-о-захищених морфінондієнолкарбоксилатів, а також композиція для окислення спирту до кетону

Also Published As

Publication number Publication date
KR20070108956A (ko) 2007-11-13
DE602005018265D1 (de) 2010-01-21
EA200801811A1 (ru) 2008-12-30
ECSP066824A (es) 2006-12-29
IL205596A (en) 2011-11-30
US8003793B2 (en) 2011-08-23
GEP20084454B (en) 2008-08-10
US20140171643A1 (en) 2014-06-19
DK1864987T3 (da) 2010-04-12
PT1864987E (pt) 2010-03-09
HK1119160A1 (en) 2009-02-27
CA2555215C (en) 2013-05-21
KR100921696B1 (ko) 2009-10-15
KR20070026401A (ko) 2007-03-08
EA016062B1 (ru) 2012-01-30
IL177281A (en) 2012-02-29
KR20070117701A (ko) 2007-12-12
ES2338054T3 (es) 2010-05-03
DK1711502T3 (da) 2008-12-01
EP2194059A3 (en) 2010-09-22
KR100921695B1 (ko) 2009-10-15
CA2808199C (en) 2015-10-27
US8198444B2 (en) 2012-06-12
CA2808199A1 (en) 2005-08-25
US20170233400A1 (en) 2017-08-17
MA28346A1 (fr) 2006-12-01
US8975257B2 (en) 2015-03-10
PL1711502T3 (pl) 2009-02-27
US9670218B2 (en) 2017-06-06
US20120022259A1 (en) 2012-01-26
KR101011460B1 (ko) 2011-01-28
EP1864987A3 (en) 2008-02-20
CN1918168B (zh) 2011-04-27
SG150500A1 (en) 2009-03-30
JP2007520563A (ja) 2007-07-26
PL1864987T3 (pl) 2010-05-31
NO339083B1 (no) 2016-11-14
NZ565355A (en) 2008-09-26
KR20090089486A (ko) 2009-08-21
US20150239898A1 (en) 2015-08-27
US20120225902A1 (en) 2012-09-06
UA88646C2 (uk) 2009-11-10
TNSN06248A1 (fr) 2007-12-03
NZ548786A (en) 2008-08-29
BRPI0506607B8 (pt) 2021-05-25
RS51317B (sr) 2010-12-31
BRPI0506607B1 (pt) 2018-01-16
EP1711502A2 (en) 2006-10-18
JP4963968B2 (ja) 2012-06-27
CA2555215A1 (en) 2005-08-25
DE602005009321D1 (de) 2008-10-09
CN1918168A (zh) 2007-02-21
AU2005212258B2 (en) 2008-05-22
AP2006003716A0 (en) 2006-08-31
EP1711502B1 (en) 2008-08-27
CR8590A (es) 2007-07-19
ATE406372T1 (de) 2008-09-15
WO2005077957A2 (en) 2005-08-25
IL177281A0 (en) 2006-12-10
WO2005077957A3 (en) 2006-05-04
NO20150276L (no) 2006-10-31
CY1108506T1 (el) 2014-04-09
US8685996B2 (en) 2014-04-01
US20080146804A1 (en) 2008-06-19
SI1711502T1 (sl) 2009-02-28
HRP20080618T3 (en) 2009-01-31
ZA200606252B (en) 2007-11-28
EP2194059A2 (en) 2010-06-09
MXPA06008931A (es) 2007-01-26
EA012905B1 (ru) 2010-02-26
RS50663B (sr) 2010-06-30
EP1864987A2 (en) 2007-12-12
HRP20100123T1 (hr) 2010-04-30
HK1103071A1 (en) 2007-12-14
UA87833C2 (uk) 2009-08-25
BRPI0506607A (pt) 2007-05-02
AU2005212258A1 (en) 2005-08-25
CY1109838T1 (el) 2014-09-10
ES2313299T3 (es) 2009-03-01
ATE451374T1 (de) 2009-12-15
NO20063989L (no) 2006-10-31
EA200601394A1 (ru) 2006-12-29
EP1864987B1 (en) 2009-12-09
PT1711502E (pt) 2008-11-20

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