ATE451374T1 - Verfahren zur herstellung 3-o-geschützter morphinone und 3-o-geschützter morphinon-dienol- carboxylate - Google Patents
Verfahren zur herstellung 3-o-geschützter morphinone und 3-o-geschützter morphinon-dienol- carboxylateInfo
- Publication number
- ATE451374T1 ATE451374T1 AT07014411T AT07014411T ATE451374T1 AT E451374 T1 ATE451374 T1 AT E451374T1 AT 07014411 T AT07014411 T AT 07014411T AT 07014411 T AT07014411 T AT 07014411T AT E451374 T1 ATE451374 T1 AT E451374T1
- Authority
- AT
- Austria
- Prior art keywords
- protected
- producing
- morphinones
- morphinone
- dienol carboxylates
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
- C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pain & Pain Management (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Catalysts (AREA)
- Saccharide Compounds (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US54271104P | 2004-02-06 | 2004-02-06 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE451374T1 true ATE451374T1 (de) | 2009-12-15 |
Family
ID=34860329
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT05712726T ATE406372T1 (de) | 2004-02-06 | 2005-02-04 | Verfahren zur herstellung von 3-o-geschützten morphinonen und 3-o-geschützten morphinondienolcarboxylaten |
| AT07014411T ATE451374T1 (de) | 2004-02-06 | 2005-02-04 | Verfahren zur herstellung 3-o-geschützter morphinone und 3-o-geschützter morphinon-dienol- carboxylate |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT05712726T ATE406372T1 (de) | 2004-02-06 | 2005-02-04 | Verfahren zur herstellung von 3-o-geschützten morphinonen und 3-o-geschützten morphinondienolcarboxylaten |
Country Status (34)
| Country | Link |
|---|---|
| US (6) | US8003793B2 (de) |
| EP (3) | EP1864987B1 (de) |
| JP (1) | JP4963968B2 (de) |
| KR (4) | KR100921695B1 (de) |
| CN (1) | CN1918168B (de) |
| AP (1) | AP2006003716A0 (de) |
| AT (2) | ATE406372T1 (de) |
| AU (1) | AU2005212258B2 (de) |
| BR (1) | BRPI0506607B8 (de) |
| CA (2) | CA2555215C (de) |
| CR (1) | CR8590A (de) |
| CY (2) | CY1108506T1 (de) |
| DE (2) | DE602005018265D1 (de) |
| DK (2) | DK1711502T3 (de) |
| EA (2) | EA012905B1 (de) |
| EC (1) | ECSP066824A (de) |
| ES (2) | ES2338054T3 (de) |
| GE (1) | GEP20084454B (de) |
| HK (2) | HK1103071A1 (de) |
| HR (2) | HRP20080618T3 (de) |
| IL (2) | IL177281A (de) |
| MA (1) | MA28346A1 (de) |
| MX (1) | MXPA06008931A (de) |
| NO (2) | NO20063989L (de) |
| NZ (2) | NZ548786A (de) |
| PL (2) | PL1864987T3 (de) |
| PT (2) | PT1711502E (de) |
| RS (2) | RS50663B (de) |
| SG (1) | SG150500A1 (de) |
| SI (2) | SI1711502T1 (de) |
| TN (1) | TNSN06248A1 (de) |
| UA (2) | UA88646C2 (de) |
| WO (1) | WO2005077957A2 (de) |
| ZA (1) | ZA200606252B (de) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2338054T3 (es) | 2004-02-06 | 2010-05-03 | Euro-Celtique S.A. | Metodos para producir morfinonas 3-o-protegidas y carboxilatos de morfinona dienol 3-o-protegidos. |
| RU2009112685A (ru) * | 2006-09-20 | 2010-10-27 | Маллинкродт Инк. (Us) | Получение замещенных морфинан-6-онов и их солей и промежуточных соединений |
| ES2598140T3 (es) * | 2007-03-06 | 2017-01-25 | Mallinckrodt Llc | Procedimiento para la preparación de sales cuaternarias de alcaloides de N-alquil morfinano |
| US9040726B2 (en) * | 2007-03-06 | 2015-05-26 | Mallinckrodt Llc | Process for the preparation of quaternary N-alkyl morphinan alkaloid salts |
| CA2726220C (en) * | 2008-05-27 | 2017-03-28 | Mallinckrodt Inc. | Processes and compounds for the preparation of normorphinans |
| US9458109B2 (en) * | 2008-09-03 | 2016-10-04 | Mallinckrodt Llc | Substituted berbines and processes for their synthesis |
| SE1251371A1 (sv) | 2010-05-10 | 2012-12-27 | Euro Celtique Sa | Farmaceutiska kompositioner innefattande hydromorfon och naloxon |
| CA2798884C (en) | 2010-05-10 | 2016-09-13 | Euro-Celtique S.A. | Manufacturing of active-free granules and tablets comprising the same |
| US9901540B2 (en) | 2010-05-10 | 2018-02-27 | Euro-Celtique S.A. | Combination of active loaded granules with additional actives |
| BR112016009749A8 (pt) | 2013-11-13 | 2018-01-30 | Euro Celtique Sa | hidromorfona e naloxona para tratamento de dor e síndrome de disfunção intestinal opioide |
| JP6888550B2 (ja) | 2015-09-30 | 2021-06-16 | 富士フイルム和光純薬株式会社 | 有機化合物の製造方法 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2654756A (en) | 1949-10-20 | 1953-10-06 | Mallinckrodt Chemical Works | Process of preparing codeinone, dihydrocodeinone, and dihydromorphinone |
| DE902257C (de) | 1951-07-17 | 1954-01-21 | Knoll Ag | Verfahren zur Herstellung von Acylderivaten der Enolform des Codeinons |
| GB1495271A (en) * | 1974-04-10 | 1977-12-14 | Macfarlan Smith Ltd | Dehydrohalogenation of codeinone derivatives |
| US4472253A (en) | 1981-08-17 | 1984-09-18 | The Florida Board Of Regents On Behalf Of The Florida State University | Process for the preparation of an N-substituted 3-O-alkyl-14-hydroxynormorphinone derivative |
| US5112975A (en) | 1984-03-27 | 1992-05-12 | Mallinckrodt Specialty Chemicals Company | Preparation of noroxymorphone from morphine |
| SE9003665D0 (sv) | 1990-11-16 | 1990-11-16 | Kabivitrum Ab | Morphine prodrugs |
| GB9116909D0 (en) | 1991-08-06 | 1991-09-18 | Salford Ultrafine Chem & Res | Morphine derivatives |
| US5821374A (en) | 1995-11-21 | 1998-10-13 | Hoffmann-La Roche Inc. | Process for the oxidation of alcohols |
| US5869669A (en) | 1996-07-26 | 1999-02-09 | Penick Corporation | Preparation of 14-hydroxynormorphinones from normorphinone dienol acylates |
| GB9713703D0 (en) * | 1997-06-30 | 1997-09-03 | Johnson Matthey Plc | Preparation of opiates |
| US6177567B1 (en) * | 1999-10-15 | 2001-01-23 | Boehringer Ingelheim Chemicals, Inc. | Method for preparing oxycodone |
| US6596877B2 (en) | 2001-10-17 | 2003-07-22 | Novartis Ag | Accelerated process for preparing O-methyl phenols, N-methyl heteroaromatic compounds, and methylated aminophenols |
| ES2338054T3 (es) | 2004-02-06 | 2010-05-03 | Euro-Celtique S.A. | Metodos para producir morfinonas 3-o-protegidas y carboxilatos de morfinona dienol 3-o-protegidos. |
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2005
- 2005-02-04 ES ES07014411T patent/ES2338054T3/es active Active
- 2005-02-04 AP AP2006003716A patent/AP2006003716A0/xx unknown
- 2005-02-04 DK DK05712726T patent/DK1711502T3/da active
- 2005-02-04 SI SI200530468T patent/SI1711502T1/sl unknown
- 2005-02-04 DK DK07014411.8T patent/DK1864987T3/da active
- 2005-02-04 PL PL07014411T patent/PL1864987T3/pl unknown
- 2005-02-04 NZ NZ548786A patent/NZ548786A/en unknown
- 2005-02-04 US US10/588,637 patent/US8003793B2/en active Active
- 2005-02-04 NZ NZ565355A patent/NZ565355A/en unknown
- 2005-02-04 EP EP07014411A patent/EP1864987B1/de active Active
- 2005-02-04 EA EA200601394A patent/EA012905B1/ru not_active IP Right Cessation
- 2005-02-04 RS RSP-2008/0553A patent/RS50663B/sr unknown
- 2005-02-04 KR KR1020077025206A patent/KR100921695B1/ko active IP Right Grant
- 2005-02-04 EA EA200801811A patent/EA016062B1/ru not_active IP Right Cessation
- 2005-02-04 MX MXPA06008931A patent/MXPA06008931A/es active IP Right Grant
- 2005-02-04 UA UAA200704105A patent/UA88646C2/uk unknown
- 2005-02-04 SI SI200530925T patent/SI1864987T1/sl unknown
- 2005-02-04 WO PCT/US2005/003390 patent/WO2005077957A2/en active Application Filing
- 2005-02-04 BR BRPI0506607A patent/BRPI0506607B8/pt active IP Right Grant
- 2005-02-04 EP EP05712726A patent/EP1711502B1/de active Active
- 2005-02-04 JP JP2006552236A patent/JP4963968B2/ja active Active
- 2005-02-04 CN CN2005800040830A patent/CN1918168B/zh active Active
- 2005-02-04 SG SG200900838-4A patent/SG150500A1/en unknown
- 2005-02-04 ES ES05712726T patent/ES2313299T3/es active Active
- 2005-02-04 KR KR1020097016500A patent/KR101011460B1/ko active IP Right Grant
- 2005-02-04 CA CA2555215A patent/CA2555215C/en active Active
- 2005-02-04 CA CA2808199A patent/CA2808199C/en active Active
- 2005-02-04 EP EP09015220A patent/EP2194059A3/de not_active Withdrawn
- 2005-02-04 GE GEAP20059608A patent/GEP20084454B/en unknown
- 2005-02-04 AU AU2005212258A patent/AU2005212258B2/en active Active
- 2005-02-04 AT AT05712726T patent/ATE406372T1/de active
- 2005-02-04 RS RSP-2010/0064A patent/RS51317B/sr unknown
- 2005-02-04 KR KR1020077025207A patent/KR20070108956A/ko not_active Application Discontinuation
- 2005-02-04 PL PL05712726T patent/PL1711502T3/pl unknown
- 2005-02-04 DE DE602005018265T patent/DE602005018265D1/de active Active
- 2005-02-04 DE DE602005009321T patent/DE602005009321D1/de active Active
- 2005-02-04 AT AT07014411T patent/ATE451374T1/de active
- 2005-02-04 PT PT05712726T patent/PT1711502E/pt unknown
- 2005-02-04 PT PT07014411T patent/PT1864987E/pt unknown
- 2005-04-02 UA UAA200609622A patent/UA87833C2/uk unknown
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2006
- 2006-07-28 ZA ZA200606252A patent/ZA200606252B/en unknown
- 2006-08-03 IL IL177281A patent/IL177281A/en active IP Right Grant
- 2006-08-04 TN TNP2006000248A patent/TNSN06248A1/fr unknown
- 2006-08-04 MA MA29240A patent/MA28346A1/fr unknown
- 2006-09-01 CR CR8590A patent/CR8590A/es unknown
- 2006-09-05 EC EC2006006824A patent/ECSP066824A/es unknown
- 2006-09-05 KR KR1020067018113A patent/KR100921696B1/ko active IP Right Grant
- 2006-09-06 NO NO20063989A patent/NO20063989L/no not_active Application Discontinuation
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2007
- 2007-04-18 HK HK07104100.2A patent/HK1103071A1/xx unknown
- 2007-04-18 HK HK08106459.3A patent/HK1119160A1/xx unknown
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2008
- 2008-11-12 CY CY20081101295T patent/CY1108506T1/el unknown
- 2008-11-26 HR HR20080618T patent/HRP20080618T3/xx unknown
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2010
- 2010-02-25 CY CY20101100178T patent/CY1109838T1/el unknown
- 2010-03-05 HR HR20100123T patent/HRP20100123T1/hr unknown
- 2010-05-06 IL IL205596A patent/IL205596A/en active IP Right Grant
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2011
- 2011-07-22 US US13/189,228 patent/US8198444B2/en active Active
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2012
- 2012-05-15 US US13/472,227 patent/US8685996B2/en active Active
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2014
- 2014-02-24 US US14/188,430 patent/US8975257B2/en active Active
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2015
- 2015-03-02 NO NO20150276A patent/NO339083B1/no unknown
- 2015-03-03 US US14/637,129 patent/US9670218B2/en not_active Expired - Fee Related
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2017
- 2017-05-04 US US15/587,118 patent/US20170233400A1/en not_active Abandoned
Also Published As
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
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