ECSP066824A - Métodos para elaborar morfinonas 3-o protegidas y carboxilatos de dienol morfinona 3-o protegidos - Google Patents

Métodos para elaborar morfinonas 3-o protegidas y carboxilatos de dienol morfinona 3-o protegidos

Info

Publication number
ECSP066824A
ECSP066824A EC2006006824A ECSP066824A ECSP066824A EC SP066824 A ECSP066824 A EC SP066824A EC 2006006824 A EC2006006824 A EC 2006006824A EC SP066824 A ECSP066824 A EC SP066824A EC SP066824 A ECSP066824 A EC SP066824A
Authority
EC
Ecuador
Prior art keywords
protected
methods
compound
carboxylates
formula
Prior art date
Application number
EC2006006824A
Other languages
English (en)
Inventor
Andreas Stumpf
Original Assignee
Euro Celtique Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34860329&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ECSP066824(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Euro Celtique Sa filed Critical Euro Celtique Sa
Publication of ECSP066824A publication Critical patent/ECSP066824A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Catalysts (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Steroid Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

Se describen métodos para elaborar aldehídos y cetonas que comprenden permitir que el alcohol primario o secundario correspondiente reaccione en presencia de un ácido tricloroisocianúrico, un compuesto de Fórmula R1SR2 y una base. En una formulación, el alcohol es un compuesto de Fórmula (I) donde R3 es un grupo protector. También se describen métodos para elaborar carboxilatos de dienol morfinona 3-O protegidos, que comprenden permitir que un compuesto de Fórmula (I) se oxide en presencia de un compuesto que contiene cloro y un compuesto de Fórmula R1SR2; y permitir que el producto del paso de oxidación reaccione con un agente acilante.
EC2006006824A 2004-02-06 2006-09-05 Métodos para elaborar morfinonas 3-o protegidas y carboxilatos de dienol morfinona 3-o protegidos ECSP066824A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US54271104P 2004-02-06 2004-02-06

Publications (1)

Publication Number Publication Date
ECSP066824A true ECSP066824A (es) 2006-12-29

Family

ID=34860329

Family Applications (1)

Application Number Title Priority Date Filing Date
EC2006006824A ECSP066824A (es) 2004-02-06 2006-09-05 Métodos para elaborar morfinonas 3-o protegidas y carboxilatos de dienol morfinona 3-o protegidos

Country Status (34)

Country Link
US (6) US8003793B2 (es)
EP (3) EP1864987B1 (es)
JP (1) JP4963968B2 (es)
KR (4) KR101011460B1 (es)
CN (1) CN1918168B (es)
AP (1) AP2006003716A0 (es)
AT (2) ATE451374T1 (es)
AU (1) AU2005212258B2 (es)
BR (1) BRPI0506607B8 (es)
CA (2) CA2808199C (es)
CR (1) CR8590A (es)
CY (2) CY1108506T1 (es)
DE (2) DE602005018265D1 (es)
DK (2) DK1711502T3 (es)
EA (2) EA012905B1 (es)
EC (1) ECSP066824A (es)
ES (2) ES2338054T3 (es)
GE (1) GEP20084454B (es)
HK (2) HK1119160A1 (es)
HR (2) HRP20080618T3 (es)
IL (2) IL177281A (es)
MA (1) MA28346A1 (es)
MX (1) MXPA06008931A (es)
NO (2) NO20063989L (es)
NZ (2) NZ548786A (es)
PL (2) PL1864987T3 (es)
PT (2) PT1864987E (es)
RS (2) RS50663B (es)
SG (1) SG150500A1 (es)
SI (2) SI1711502T1 (es)
TN (1) TNSN06248A1 (es)
UA (2) UA88646C2 (es)
WO (1) WO2005077957A2 (es)
ZA (1) ZA200606252B (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE451374T1 (de) 2004-02-06 2009-12-15 Euro Celtique Sa Verfahren zur herstellung 3-o-geschützter morphinone und 3-o-geschützter morphinon-dienol- carboxylate
RU2009112685A (ru) * 2006-09-20 2010-10-27 Маллинкродт Инк. (Us) Получение замещенных морфинан-6-онов и их солей и промежуточных соединений
US9040726B2 (en) * 2007-03-06 2015-05-26 Mallinckrodt Llc Process for the preparation of quaternary N-alkyl morphinan alkaloid salts
US8669366B2 (en) * 2007-03-06 2014-03-11 Mallinckrodt Llc Process for the preparation of quaternary N-alkyl morphinan alkaloid salts
WO2009146288A1 (en) * 2008-05-27 2009-12-03 Mallinckrodt Inc. Processes and compounds for the preparation of normorphinans
US9458109B2 (en) * 2008-09-03 2016-10-04 Mallinckrodt Llc Substituted berbines and processes for their synthesis
SG184523A1 (en) 2010-05-10 2012-11-29 Euro Celtique Sa Pharmaceutical compositions comprising hydromorphone and naloxone
WO2011141490A1 (en) 2010-05-10 2011-11-17 Euro-Celtique S.A. Combination of active loaded granules with additional actives
CA2798884C (en) 2010-05-10 2016-09-13 Euro-Celtique S.A. Manufacturing of active-free granules and tablets comprising the same
JP6232135B2 (ja) 2013-11-13 2017-11-15 ユーロ−セルティーク エス．エイ． 疼痛およびオピオイドによる腸機能障害症候群の治療のためのヒドロモルホンおよびナロキソン
US10351512B2 (en) 2015-09-30 2019-07-16 Fujifilm Wako Pure Chemical Corporation Method of producing organic compound

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2654756A (en) * 1949-10-20 1953-10-06 Mallinckrodt Chemical Works Process of preparing codeinone, dihydrocodeinone, and dihydromorphinone
DE902257C (de) 1951-07-17 1954-01-21 Knoll Ag Verfahren zur Herstellung von Acylderivaten der Enolform des Codeinons
GB1495271A (en) * 1974-04-10 1977-12-14 Macfarlan Smith Ltd Dehydrohalogenation of codeinone derivatives
US4472253A (en) * 1981-08-17 1984-09-18 The Florida Board Of Regents On Behalf Of The Florida State University Process for the preparation of an N-substituted 3-O-alkyl-14-hydroxynormorphinone derivative
US5112975A (en) * 1984-03-27 1992-05-12 Mallinckrodt Specialty Chemicals Company Preparation of noroxymorphone from morphine
SE9003665D0 (sv) * 1990-11-16 1990-11-16 Kabivitrum Ab Morphine prodrugs
GB9116909D0 (en) * 1991-08-06 1991-09-18 Salford Ultrafine Chem & Res Morphine derivatives
US5821374A (en) * 1995-11-21 1998-10-13 Hoffmann-La Roche Inc. Process for the oxidation of alcohols
US5869669A (en) * 1996-07-26 1999-02-09 Penick Corporation Preparation of 14-hydroxynormorphinones from normorphinone dienol acylates
GB9713703D0 (en) * 1997-06-30 1997-09-03 Johnson Matthey Plc Preparation of opiates
US6177567B1 (en) * 1999-10-15 2001-01-23 Boehringer Ingelheim Chemicals, Inc. Method for preparing oxycodone
US6596877B2 (en) * 2001-10-17 2003-07-22 Novartis Ag Accelerated process for preparing O-methyl phenols, N-methyl heteroaromatic compounds, and methylated aminophenols
ATE451374T1 (de) 2004-02-06 2009-12-15 Euro Celtique Sa Verfahren zur herstellung 3-o-geschützter morphinone und 3-o-geschützter morphinon-dienol- carboxylate

Also Published As

Publication number Publication date
WO2005077957A3 (en) 2006-05-04
EP1711502B1 (en) 2008-08-27
TNSN06248A1 (fr) 2007-12-03
NZ548786A (en) 2008-08-29
ATE451374T1 (de) 2009-12-15
NO339083B1 (no) 2016-11-14
UA87833C2 (uk) 2009-08-25
ZA200606252B (en) 2007-11-28
HRP20100123T1 (hr) 2010-04-30
BRPI0506607B8 (pt) 2021-05-25
HK1119160A1 (en) 2009-02-27
EP1864987A2 (en) 2007-12-12
CY1108506T1 (el) 2014-04-09
PL1711502T3 (pl) 2009-02-27
AP2006003716A0 (en) 2006-08-31
US9670218B2 (en) 2017-06-06
ES2338054T3 (es) 2010-05-03
EP1864987B1 (en) 2009-12-09
RS51317B (sr) 2010-12-31
BRPI0506607B1 (pt) 2018-01-16
SI1864987T1 (sl) 2010-04-30
SI1711502T1 (sl) 2009-02-28
DE602005009321D1 (de) 2008-10-09
CN1918168B (zh) 2011-04-27
BRPI0506607A (pt) 2007-05-02
EA012905B1 (ru) 2010-02-26
NZ565355A (en) 2008-09-26
EA016062B1 (ru) 2012-01-30
IL205596A (en) 2011-11-30
WO2005077957A2 (en) 2005-08-25
AU2005212258A1 (en) 2005-08-25
KR20070117701A (ko) 2007-12-12
CA2808199C (en) 2015-10-27
HK1103071A1 (en) 2007-12-14
SG150500A1 (en) 2009-03-30
KR100921695B1 (ko) 2009-10-15
PL1864987T3 (pl) 2010-05-31
CR8590A (es) 2007-07-19
US20170233400A1 (en) 2017-08-17
CA2808199A1 (en) 2005-08-25
NO20150276L (no) 2006-10-31
EA200801811A1 (ru) 2008-12-30
JP4963968B2 (ja) 2012-06-27
US20140171643A1 (en) 2014-06-19
ATE406372T1 (de) 2008-09-15
KR20090089486A (ko) 2009-08-21
DK1711502T3 (da) 2008-12-01
ES2313299T3 (es) 2009-03-01
MA28346A1 (fr) 2006-12-01
EP1711502A2 (en) 2006-10-18
RS50663B (sr) 2010-06-30
JP2007520563A (ja) 2007-07-26
US8003793B2 (en) 2011-08-23
AU2005212258B2 (en) 2008-05-22
GEP20084454B (en) 2008-08-10
KR100921696B1 (ko) 2009-10-15
EP1864987A3 (en) 2008-02-20
IL177281A0 (en) 2006-12-10
HRP20080618T3 (en) 2009-01-31
CY1109838T1 (el) 2014-09-10
NO20063989L (no) 2006-10-31
EP2194059A3 (en) 2010-09-22
US20120022259A1 (en) 2012-01-26
EA200601394A1 (ru) 2006-12-29
US8198444B2 (en) 2012-06-12
DE602005018265D1 (de) 2010-01-21
CN1918168A (zh) 2007-02-21
DK1864987T3 (da) 2010-04-12
KR20070108956A (ko) 2007-11-13
CA2555215A1 (en) 2005-08-25
UA88646C2 (uk) 2009-11-10
KR101011460B1 (ko) 2011-01-28
PT1864987E (pt) 2010-03-09
US20080146804A1 (en) 2008-06-19
CA2555215C (en) 2013-05-21
IL177281A (en) 2012-02-29
US20150239898A1 (en) 2015-08-27
US8685996B2 (en) 2014-04-01
US20120225902A1 (en) 2012-09-06
US8975257B2 (en) 2015-03-10
KR20070026401A (ko) 2007-03-08
EP2194059A2 (en) 2010-06-09
MXPA06008931A (es) 2007-01-26
PT1711502E (pt) 2008-11-20

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