CL2011000722A1 - Composicion farmaceutica en forma de unguento estable al almacenamiento, que comprende: a) un compuesto de vitamina d, b) un corticosteroide y c) un compuesto alquilamino sustituido, en un vehiculo de petrolato que opcionalmente contiene aceite mineral, tocoferol o una combinacion de ellos; uso en tratamiento de la psoriasis. - Google Patents

Composicion farmaceutica en forma de unguento estable al almacenamiento, que comprende: a) un compuesto de vitamina d, b) un corticosteroide y c) un compuesto alquilamino sustituido, en un vehiculo de petrolato que opcionalmente contiene aceite mineral, tocoferol o una combinacion de ellos; uso en tratamiento de la psoriasis.

Info

Publication number
CL2011000722A1
CL2011000722A1 CL2011000722A CL2011000722A CL2011000722A1 CL 2011000722 A1 CL2011000722 A1 CL 2011000722A1 CL 2011000722 A CL2011000722 A CL 2011000722A CL 2011000722 A CL2011000722 A CL 2011000722A CL 2011000722 A1 CL2011000722 A1 CL 2011000722A1
Authority
CL
Chile
Prior art keywords
compound
corticosteroid
tocopherol
psoriasis
vitamin
Prior art date
Application number
CL2011000722A
Other languages
English (en)
Inventor
William Shifeng Wei
Yiping Wang
Jianzhen Pan
Sung Hi Jo
Original Assignee
Nexmed Holdings Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nexmed Holdings Inc filed Critical Nexmed Holdings Inc
Publication of CL2011000722A1 publication Critical patent/CL2011000722A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/221—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin with compounds having an amino group, e.g. acetylcholine, acetylcarnitine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
    • A61K31/355—Tocopherols, e.g. vitamin E
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Dermatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Emergency Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Composición farmacéutica, en forma de ungüento estable al almacenamiento, que comprende: a) Un compuesto de vitamina d, b) Un corticosteroide y c) Un compuesto alquilamino sustituido, en un vehículo de petrolato que opcionalmente contiene aceite mineral, tocoferol o una combinación de ellos; y su uso en el tratamiento de la psoriasis.
CL2011000722A 2008-10-03 2011-04-01 Composicion farmaceutica en forma de unguento estable al almacenamiento, que comprende: a) un compuesto de vitamina d, b) un corticosteroide y c) un compuesto alquilamino sustituido, en un vehiculo de petrolato que opcionalmente contiene aceite mineral, tocoferol o una combinacion de ellos; uso en tratamiento de la psoriasis. CL2011000722A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US19512608P 2008-10-03 2008-10-03

Publications (1)

Publication Number Publication Date
CL2011000722A1 true CL2011000722A1 (es) 2012-01-20

Family

ID=42073781

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2011000722A CL2011000722A1 (es) 2008-10-03 2011-04-01 Composicion farmaceutica en forma de unguento estable al almacenamiento, que comprende: a) un compuesto de vitamina d, b) un corticosteroide y c) un compuesto alquilamino sustituido, en un vehiculo de petrolato que opcionalmente contiene aceite mineral, tocoferol o una combinacion de ellos; uso en tratamiento de la psoriasis.

Country Status (18)

Country Link
US (2) US9220701B2 (es)
EP (1) EP2343978A4 (es)
JP (1) JP5667060B2 (es)
KR (1) KR20110067145A (es)
CN (1) CN102202509A (es)
AU (1) AU2009300331A1 (es)
BR (1) BRPI0920728A2 (es)
CA (1) CA2739376A1 (es)
CL (1) CL2011000722A1 (es)
CR (1) CR20110225A (es)
EC (1) ECSP11011022A (es)
IL (1) IL212062A0 (es)
MX (1) MX2011003568A (es)
NZ (1) NZ592300A (es)
PE (1) PE20110849A1 (es)
RU (1) RU2526162C2 (es)
WO (1) WO2010039251A1 (es)
ZA (1) ZA201103061B (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ592300A (en) * 2008-10-03 2013-01-25 Nexmed Holdings Inc Stabilized composition for treating psoriasis
US8809307B2 (en) 2010-11-22 2014-08-19 Dow Pharmaceutical Sciences, Inc. Pharmaceutical formulations containing corticosteroids for topical administration
US11957753B2 (en) 2010-11-22 2024-04-16 Bausch Health Ireland Limited Pharmaceutical formulations containing corticosteroids for topical administration
WO2014028780A2 (en) * 2012-08-15 2014-02-20 Nexmed Holdings, Inc. Antifungal compounds and methods of use
CN105784902A (zh) * 2016-03-11 2016-07-20 重庆华邦制药有限公司 低浓度丁酸氯倍他松的检测方法
EP3456314A1 (en) 2017-09-14 2019-03-20 Tiofarma B.V. Topical formulation comprising 17-ketolic corticosteroid
WO2020044223A1 (en) * 2018-08-28 2020-03-05 Glenmark Pharmaceuticals Limited Container system and pharmaceutical foam composition comprising betamethasone

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4980378A (en) * 1988-06-01 1990-12-25 Odontex, Inc. Biodegradable absorption enhancers
US6046244A (en) * 1997-11-05 2000-04-04 Nexmed Holdings, Inc. Topical compositions for prostaglandin E1 delivery
US6414028B1 (en) 1997-11-05 2002-07-02 Nexmed Holdings, Inc. Topical compositions containing prostaglandin E1
US8263580B2 (en) * 1998-09-11 2012-09-11 Stiefel Research Australia Pty Ltd Vitamin formulation
RU2207844C2 (ru) 1998-12-23 2003-07-10 Идеа Аг. УСОВЕРШЕНСТВОВАННЫЙ ПРЕПАРАТ ДЛЯ МЕСТНОГО НЕИНВАЗИВНОГО ПРИМЕНЕНИЯ in vivo
ES2432691T3 (es) 1999-04-23 2013-12-04 Leo Pharma A/S Composición farmacéutica para uso dérmico que comprende calcipotril y betametasona para el tratamiento de la psoriasis
MXPA05003805A (es) 2002-12-17 2005-06-08 Galderma Sa Composiciones farmaceuticas que comprenden una combinacion de calcitriol y propionato de clobetasol.
DK1635770T3 (da) * 2003-03-21 2009-08-03 Nexmed Holdings Inc Antifungal neglelak og anvendelsesmetode
US20080069779A1 (en) * 2003-08-04 2008-03-20 Foamix Ltd. Foamable vehicle and vitamin and flavonoid pharmaceutical compositions thereof
FR2871696B1 (fr) * 2004-06-17 2006-11-10 Galderma Sa Composition topique pour le traitement du psoriasis
US20060057075A1 (en) * 2004-08-02 2006-03-16 Moshe Arkin Pharmaceutical and cosmeceutical wash-off mousse shampoo compositions, processes for preparing the same and uses thereof
JP2009519940A (ja) * 2005-12-14 2009-05-21 ザーズ， インコーポレイテッド 皮膚科学的状態を処置するための組成物および方法
US7560489B2 (en) * 2006-10-11 2009-07-14 Nexmed Holdings, Inc. Stabilized prostaglandin E composition
NZ592300A (en) * 2008-10-03 2013-01-25 Nexmed Holdings Inc Stabilized composition for treating psoriasis

Also Published As

Publication number Publication date
CR20110225A (es) 2011-07-18
US20110237558A1 (en) 2011-09-29
RU2011117230A (ru) 2012-11-10
MX2011003568A (es) 2011-06-09
US20160067266A1 (en) 2016-03-10
WO2010039251A1 (en) 2010-04-08
JP2012504607A (ja) 2012-02-23
NZ592300A (en) 2013-01-25
ECSP11011022A (es) 2011-06-30
PE20110849A1 (es) 2011-12-02
EP2343978A1 (en) 2011-07-20
RU2526162C2 (ru) 2014-08-20
KR20110067145A (ko) 2011-06-21
EP2343978A4 (en) 2013-11-27
AU2009300331A1 (en) 2010-04-08
CA2739376A1 (en) 2010-04-08
ZA201103061B (en) 2012-04-25
CN102202509A (zh) 2011-09-28
IL212062A0 (en) 2011-06-30
JP5667060B2 (ja) 2015-02-12
BRPI0920728A2 (pt) 2015-08-18
US9220701B2 (en) 2015-12-29

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