PE20080730A1 - Derivados de fenilo como moduladores del receptor s1p - Google Patents

Derivados de fenilo como moduladores del receptor s1p

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Publication number
PE20080730A1
PE20080730A1 PE2007001000A PE2007001000A PE20080730A1 PE 20080730 A1 PE20080730 A1 PE 20080730A1 PE 2007001000 A PE2007001000 A PE 2007001000A PE 2007001000 A PE2007001000 A PE 2007001000A PE 20080730 A1 PE20080730 A1 PE 20080730A1
Authority
PE
Peru
Prior art keywords
alkyl
phenyl
cyane
alkylene
aryl
Prior art date
Application number
PE2007001000A
Other languages
English (en)
Inventor
Ghotas Evindar
Hongfeng Deng
Sylvie Bernier
Gang Yao
Aaron Coffin
Hongfang Yang
Original Assignee
Praecis Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Praecis Pharm Inc filed Critical Praecis Pharm Inc
Publication of PE20080730A1 publication Critical patent/PE20080730A1/es

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    • C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • C07F9/65395—Five-membered rings containing two nitrogen atoms having the two nitrogen atoms in positions 1 and 2

Abstract

REFERIDA A UN COMPUESTO DE FORMULA (I), DONDE R1 ES H, HALOGENO, CIANO, ENTRE OTROS; A ES ALQUILENO C1-C20, ALQUENILENO C2-C20, ALQUINILENO C2-C20, ENTRE OTROS; X1 ES UN ENLACE, CH2, O, CH2-O, ENTRE OTROS; R' y R'' SON H, HALOGENO, ALQUILO C1-C12, ENTRE OTROS; R2 ES CIANO, ALQUILO C1-C12, ARIL C1-C5, ENTRE OTROS; R3 ES H, HALOGENO, CIANO, ENTRE OTROS; EL ANILLO A ES FENIL O PIRIDIL; EL ANILLO B ES ARIL C1-C5, HETEROARIL, CICLOALQUIL, ENTRE OTROS; R4 ES H, CIANO, ALQUILO C1-C12, ARILO C1-C5, ENTRE OTROS; R5 Y R6 SON H, ALQUILO C1-C12, ARILO C1-C5, ENTRE OTROS; R7 ES OH, -O-ALQUIL, CO2H, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: (S)-2-AMINO-2-(5-(4-(OCTILOXI)-3-(TRIFLUOROMETIL)FENIL)TIAZOL-2-IL)PROPANO-1-OL, (S)-2-AMINO-2-(5-(4-(OCTILOXI)-3-(TRIFLUOROMETIL)FENIL)TIAZOL-2-IL)PROPANO-1,3-DIOL, (S)-2-AMINO-2-(5-(4-(OCTILOXI)-3-(TRIFLUOROMETIL)FENIL)-1,3,4-TIADIAZOL-2-IL)PROPANO-1-OL, ENTRE OTROS. TAMBIEN ESTA REFERIDA A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS TIENEN ACTIVIDAD SOBRE EL RECEPTOR S1P, PARTICULARMENTE SOBRE S1P-1 Y SON UTILES EN EL TRATAMIENTO DE DESORDENES RELACIONADOS CON LA AUTO-INMUNIDAD, CON EL RECHAZO AL TRANSPLANTE DE ORGANOS, DESORDENES MODULADOS POR LA LINFOPENIA, ENTRE OTROS
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