PE20091194A1 - Derivados de heterociclicos como moduladores del receptor m1 - Google Patents
Derivados de heterociclicos como moduladores del receptor m1Info
- Publication number
- PE20091194A1 PE20091194A1 PE2008001632A PE2008001632A PE20091194A1 PE 20091194 A1 PE20091194 A1 PE 20091194A1 PE 2008001632 A PE2008001632 A PE 2008001632A PE 2008001632 A PE2008001632 A PE 2008001632A PE 20091194 A1 PE20091194 A1 PE 20091194A1
- Authority
- PE
- Peru
- Prior art keywords
- methyl
- alkyl
- benzoxazole
- piperidinyl
- cyclohexyl
- Prior art date
Links
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- 208000024827 Alzheimer disease Diseases 0.000 abstract 1
- 208000028698 Cognitive impairment Diseases 0.000 abstract 1
- 208000010877 cognitive disease Diseases 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- QUPDWYMUPZLYJZ-UHFFFAOYSA-N ethyl Chemical compound C[CH2] QUPDWYMUPZLYJZ-UHFFFAOYSA-N 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- -1 {[2- (METHYLOXY) ETHYL] OXY} CYCLOHEXYL Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
SE REFIERE A UN COMPUESTO DE FORMULA (I), DONDE R4, R5 Y R6 SON CADA UNO H, HALOGENO, ALQUILO(C1-C6), ENTRE OTROS; EL ANILLO A ES BENCENO O UN ANILLO HETEROCICLICO DE 6 MIEMBROS; R ES CICLOALQUIL(C3-C6)-AQUILO(C1-C4), AQLUILOXI(C1-C6).ALQUILO(C1-C6), CICLOALQUILOXI(C3-C6)-ALQUILO(C1-C6), ENTRE OTROS; Q ES H Y ALQUILO (C1-C6); Y ES O, S, CF2, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: 3-[1-TRANS-1-METIL-4{[2-(METILOXI)ETIL]OXI}CICLOHEXIL)-4-PIPERIDINIL]-2-OXO-2,3-DIHIDRO-1,3-BENZOXAZOL-5-CARBONITRILO, 5-METIL-3-[1-(TRANS-1-METIL-4{[2-(METOXI)ETIL]OXI}CICLOHEXIL)-4-PIPERIDINIL]-2-OXO-2,3-DIHIDRO-1,3-BENZOXAZOL-6-CARBONITRILO, 6-FLUORO-5-METIL-3-[1-(TRANS-1-METIL-4-{[2-(METILOXI)ETIL]OXI}CICLOHEXIL)-4-PIPERIDINIL]-1,3-BENZOXAZOL-2(3H)-ONA, ENTRE OTROS. SE REFIERE TAMBIEN A UN METODO DE PREPARACION Y A UNA COMPOSICION FARMACEUTICA QUE LOS COMPRENDE. LOS COMPUESTOS DE LA PRESENTE INVENCION SON MODULADORES DE LA ACTIVIDAD M1, POR LO QUE SON UTILES EN EL TRATMIENTO DEL DETERIORO COGNITIVO, TAL COMO LA ENFERMEDAD DE ALZHEIMER
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB0718419A GB0718419D0 (en) | 2007-09-20 | 2007-09-20 | Compounds |
GB0814902A GB0814902D0 (en) | 2008-08-14 | 2008-08-14 | Compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20091194A1 true PE20091194A1 (es) | 2009-09-05 |
Family
ID=40029139
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2008001632A PE20091194A1 (es) | 2007-09-20 | 2008-09-18 | Derivados de heterociclicos como moduladores del receptor m1 |
Country Status (9)
Country | Link |
---|---|
US (1) | US8299257B2 (es) |
EP (1) | EP2194983A1 (es) |
JP (1) | JP2010539218A (es) |
AR (1) | AR068480A1 (es) |
CL (1) | CL2008002808A1 (es) |
PE (1) | PE20091194A1 (es) |
TW (1) | TW200930367A (es) |
UY (1) | UY31346A1 (es) |
WO (1) | WO2009037296A1 (es) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JO2769B1 (en) * | 2005-10-26 | 2014-03-15 | جانسين فارماسوتيكا ان. في | Rapid decomposition of physiologically antagonistic agents of the 2-dopamine receptor |
FR2909090B1 (fr) * | 2006-11-23 | 2009-01-09 | Sanofi Aventis Sa | Derives de 2,5-dihydro-3h-pyrazolo[4,3-c]pyridazin-3-one substitues,leur preparation et leur application en therapeutique. |
JO2849B1 (en) * | 2007-02-13 | 2015-03-15 | جانسين فارماسوتيكا ان. في | Dopamine 2 receptor antagonists are rapidly hydrolyzed |
KR20100016620A (ko) * | 2007-04-23 | 2010-02-12 | 얀센 파마슈티카 엔.브이. | 속해리성 도파민 2 수용체 길항제로서의 4-알콕시피리다진 유도체 |
US20100137368A1 (en) * | 2007-04-23 | 2010-06-03 | Janssen Pharmaceutica N.V. | Pyridine derivatives as fast dissociating dopamine 2 receptor antagonists |
MX2009011416A (es) * | 2007-04-23 | 2009-11-05 | Janssen Pharmaceutica Nv | Tia(di)azoles como antagonistas del receptor de dopamina 2 de disociacion rapida. |
US8278328B2 (en) * | 2007-09-20 | 2012-10-02 | Glaxo Group Limited | Compounds which have activity at M1 receptor and their uses in medicine |
RU2502734C2 (ru) * | 2008-07-03 | 2013-12-27 | Янссен Фармацевтика Нв | Замещенные 6-(1-пиперазинил)-пиридазины в качестве антагонистов 5-нт6 рецептора |
CN102171189B (zh) * | 2008-07-31 | 2013-11-20 | 詹森药业有限公司 | 作为快速解离多巴胺2受体拮抗剂的哌嗪-1-基-三氟甲基取代的吡啶 |
JP7473484B2 (ja) | 2019-01-24 | 2024-04-23 | 第一三共株式会社 | 置換基を有するウレア化合物 |
CN112812782B (zh) * | 2021-01-21 | 2023-09-29 | 西安瑞联新材料股份有限公司 | 一种环己烷类苯并噁唑液晶化合物、制备方法及其应用 |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2002515008A (ja) * | 1994-10-27 | 2002-05-21 | メルク エンド カンパニー インコーポレーテッド | ムスカリン・アンタゴニスト |
AU7478396A (en) * | 1995-10-31 | 1997-05-22 | Merck & Co., Inc. | Muscarine agonists |
AU2307999A (en) * | 1997-12-23 | 1999-07-12 | Alcon Laboratories, Inc. | Muscarinic agents and use thereof to treat glaucoma, myopia and various other conditions |
MXPA04003103A (es) * | 2001-10-02 | 2004-07-27 | Acadia Pharm Inc | Derivados de bencimidazolidinona como agentes muscarinicos. |
WO2004089942A2 (en) * | 2001-10-02 | 2004-10-21 | Acadia Pharmaceuticals Inc. | Benzimidazolidinone derivatives as muscarinic agents |
EP1937670A1 (en) | 2005-09-30 | 2008-07-02 | Glaxo Group Limited | Benzimidazolones which have activity at m1 receptor |
GB0605786D0 (en) * | 2006-03-22 | 2006-05-03 | Glaxo Group Ltd | Compounds |
US8278328B2 (en) * | 2007-09-20 | 2012-10-02 | Glaxo Group Limited | Compounds which have activity at M1 receptor and their uses in medicine |
-
2008
- 2008-09-18 EP EP08804347A patent/EP2194983A1/en not_active Withdrawn
- 2008-09-18 PE PE2008001632A patent/PE20091194A1/es not_active Application Discontinuation
- 2008-09-18 WO PCT/EP2008/062403 patent/WO2009037296A1/en active Application Filing
- 2008-09-18 US US12/678,353 patent/US8299257B2/en not_active Expired - Fee Related
- 2008-09-18 TW TW097135729A patent/TW200930367A/zh unknown
- 2008-09-18 JP JP2010525340A patent/JP2010539218A/ja active Pending
- 2008-09-18 AR ARP080104059A patent/AR068480A1/es not_active Application Discontinuation
- 2008-09-18 UY UY31346A patent/UY31346A1/es unknown
- 2008-09-22 CL CL2008002808A patent/CL2008002808A1/es unknown
Also Published As
Publication number | Publication date |
---|---|
US8299257B2 (en) | 2012-10-30 |
TW200930367A (en) | 2009-07-16 |
EP2194983A1 (en) | 2010-06-16 |
JP2010539218A (ja) | 2010-12-16 |
WO2009037296A1 (en) | 2009-03-26 |
CL2008002808A1 (es) | 2010-01-15 |
AR068480A1 (es) | 2009-11-18 |
UY31346A1 (es) | 2009-04-30 |
US20100210687A1 (en) | 2010-08-19 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
PE20091194A1 (es) | Derivados de heterociclicos como moduladores del receptor m1 | |
AR066509A1 (es) | Derivados de tiazol, medicamentos que los contienen, proceso de preparacion y usos como moduladores de beta amiloide. | |
PE20080730A1 (es) | Derivados de fenilo como moduladores del receptor s1p | |
PE20120031A1 (es) | Compuestos aril metil benzoquinazolinona como moduladores alostericos positivos del receptor m1 | |
ECSP099728A (es) | Compuestos amino-heterocíclicos | |
PE20090729A1 (es) | Moduladores de gamma-secretasa | |
UY29412A1 (es) | Compuestos de n-sulfonilaminofeniletil-2-fenoxiacetamida sustituidos. | |
PE20070790A1 (es) | Derivados de 2-aminopirimidina como moduladores de la actividad del receptor de histamina h-4 | |
PE20070586A1 (es) | Compuestos de (4-piperidinil)-1,3-dihidro-2h-bencimidazol-2-ona sustituidos como agonistas del receptor muscarinico m1 | |
AR077935A1 (es) | Derivados de 3-amino-5 fenil-5,6-dihidro-2h-(1,4)oxazina | |
ECSP088863A (es) | Compuestos que son agonistas de receptores muscarínicos y que pueden ser eficaces en el tratamiento del dolor, la enfermedad de alzheimer y/o la esquizofrenia | |
PE20060691A1 (es) | Serinamidas sustituidas por benzoilo | |
PE20141281A1 (es) | Compuestos de tetrahidropirido-piridina y tetrahidropirido-pirimidina y su uso como moduladores de receptores de c5a | |
AR060604A1 (es) | Nuevos arilamino n- heteroarilos como inhibidores de mek | |
PE20091689A1 (es) | DERIVADOS DE 4-AMINOCICLOHEXANO SUSTITUIDO CON ACTIVIDAD SOBRE RECEPTORES µ Y ORL-1 | |
PE20081228A1 (es) | Compuesto heteromonociclico | |
PA8614301A1 (es) | Derivados de tropano | |
PE20090651A1 (es) | Derivados de isoquinolinilo e isoindolinilo como antagonistas de histamina-3 | |
PE20081753A1 (es) | Compuestos y composiciones como inhibidores de la proteasa activadora de canal | |
PE20090363A1 (es) | Moduladores de la gamma secretasa | |
AR061580A1 (es) | Profarmacos de 5- amino-3-(3'- desoxi- beta-d - ribofuronosil)-tiazolo [4 ,5- d] pirimidin-2,7- diona | |
ECSP088967A (es) | Agonistas del receptor muscarínico que son efectivos en el tratamiento del dolor, la enfermedad de alzheimer y la esquizofrenia | |
AR071245A1 (es) | Derivados de piperidina como antagonistas de receptores muscarinicos, procesos de obtencion y composiciones farmaceuticas | |
CO6382118A2 (es) | Nuevas octahidrociclopenta(c)ciprol-4aminas sustituidas como bloqueantes de los canales de calcio | |
ECSP088966A (es) | Agonistas del receptor muscarínico que son efectivos en el tratamiento del dolor, la enfermedad de alzheimer y la esquizofrenia |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG | Grant, registration | ||
FD | Application declared void or lapsed |