PE20070586A1 - Compuestos de (4-piperidinil)-1,3-dihidro-2h-bencimidazol-2-ona sustituidos como agonistas del receptor muscarinico m1 - Google Patents

Compuestos de (4-piperidinil)-1,3-dihidro-2h-bencimidazol-2-ona sustituidos como agonistas del receptor muscarinico m1

Info

Publication number
PE20070586A1
PE20070586A1 PE2006001184A PE2006001184A PE20070586A1 PE 20070586 A1 PE20070586 A1 PE 20070586A1 PE 2006001184 A PE2006001184 A PE 2006001184A PE 2006001184 A PE2006001184 A PE 2006001184A PE 20070586 A1 PE20070586 A1 PE 20070586A1
Authority
PE
Peru
Prior art keywords
piperidinyl
dihydro
ona
benzymidazole
agonists
Prior art date
Application number
PE2006001184A
Other languages
English (en)
Inventor
Brian Budzik
David Gwyn Cooper
Vincenzo Garzya
Dongchuan Shi
Graham Walker
Paul William Smith
Jian Jin
Ian Thomson Forbes
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB0519949.2A external-priority patent/GB0519949D0/en
Priority claimed from GB0602856A external-priority patent/GB0602856D0/en
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of PE20070586A1 publication Critical patent/PE20070586A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/34—Tobacco-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Addiction (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Hospice & Palliative Care (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

SE REFIERE A COMPUESTOS DE (4-PIPERIDINIL)-1,3-DIHIDRO-2H-BENCIMIDAZOL-2-ONA, DE FORMULA (I) DONDE R5 ES HALOGENO, ALQUILO(C1-C6) O ALCOXI(C1-C6) OPCIONALMENTE SUSTITUIDOS CON FLUOR O CN; R6 ES HALOGENO, ALQUILO(C1-C6), CICLOALQUILO(C3-C6), ALCOXI(C1-C6), OPCIONALMENTE SUSTITUIDOS CON FLUOR O CN; Q ES H O ALQUILO(C1-C6). SON PREFERIDOS: 6-CLORO-5-FLUORO-1-[1-(TETRAHIDRO-2H-PIRAN-4-IL)-4-PIPERIDINIL]-1,3-DIHIDRO-2H-BENCIMIDAZOL-2-ONA, 6-CLORO-5-METIL-1-[1-(TETRAHIDRO-2H-PIRAN-4-IL)-4-PIPERIDINIL]-1,3-DIHIDRO-2H-BENCIMIDAZOL-2-ONA, 6-CLORO-1-[1-(TETRAHIDRO-2H-PIRAN-4-IL)-4-PIPERIDINIL]-5-(TRIFLUOROMETIL)-1,3-DIHIDRO-2H-BENCIMIDAZOL-2-ONA, ENTRE OTROS. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA Y UN PROCEDIMIENTO DE PREPARACION. ESTOS COMPUESTOS SON AGONISTAS DEL RECEPTOR MUSCARINICO M1 SIENDO UTILES EN EL TRATAMIENTO DE ESQUIZOFRENIA, TRASTORNO BIPOLAR, DEPRESION, ESTADOS SICOTICOS ASOCIADOS CON DETERIORO COGNITIVO
PE2006001184A 2005-09-30 2006-09-28 Compuestos de (4-piperidinil)-1,3-dihidro-2h-bencimidazol-2-ona sustituidos como agonistas del receptor muscarinico m1 PE20070586A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0519949.2A GB0519949D0 (en) 2005-09-30 2005-09-30 Compounds
GB0602856A GB0602856D0 (en) 2006-02-13 2006-02-13 Compounds

Publications (1)

Publication Number Publication Date
PE20070586A1 true PE20070586A1 (es) 2007-06-16

Family

ID=37635729

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2006001184A PE20070586A1 (es) 2005-09-30 2006-09-28 Compuestos de (4-piperidinil)-1,3-dihidro-2h-bencimidazol-2-ona sustituidos como agonistas del receptor muscarinico m1

Country Status (8)

Country Link
US (1) US8288412B2 (es)
EP (1) EP1960389B1 (es)
JP (1) JP5209481B2 (es)
AR (1) AR055667A1 (es)
ES (1) ES2391107T3 (es)
PE (1) PE20070586A1 (es)
TW (1) TW200804355A (es)
WO (1) WO2007036718A2 (es)

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GB0605784D0 (en) * 2006-03-22 2006-05-03 Glaxo Group Ltd Compounds
GB0706174D0 (en) * 2007-03-29 2007-05-09 Glaxo Group Ltd Compounds
GB0706164D0 (en) * 2007-03-29 2007-05-09 Glaxo Group Ltd Compounds
GB0706170D0 (en) * 2007-03-29 2007-05-09 Glaxo Group Ltd Compounds
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GB0817982D0 (en) 2008-10-01 2008-11-05 Glaxo Group Ltd Compounds
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Also Published As

Publication number Publication date
WO2007036718A3 (en) 2007-05-31
AR055667A1 (es) 2007-08-29
US8288412B2 (en) 2012-10-16
WO2007036718A2 (en) 2007-04-05
JP2009510041A (ja) 2009-03-12
US20080293770A1 (en) 2008-11-27
TW200804355A (en) 2008-01-16
ES2391107T3 (es) 2012-11-21
EP1960389B1 (en) 2012-08-15
EP1960389A2 (en) 2008-08-27
JP5209481B2 (ja) 2013-06-12

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