PE20071116A1 - Compuestos de heteroarilo biciclicos como inhibidores de pde10 - Google Patents
Compuestos de heteroarilo biciclicos como inhibidores de pde10Info
- Publication number
- PE20071116A1 PE20071116A1 PE2007000001A PE2007000001A PE20071116A1 PE 20071116 A1 PE20071116 A1 PE 20071116A1 PE 2007000001 A PE2007000001 A PE 2007000001A PE 2007000001 A PE2007000001 A PE 2007000001A PE 20071116 A1 PE20071116 A1 PE 20071116A1
- Authority
- PE
- Peru
- Prior art keywords
- alkyl
- bicycle
- heteroaryl
- benzoimidazole
- pyridin
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/06—Peri-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Addiction (AREA)
- Hospice & Palliative Care (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
REFERIDA A UN COMPUESTO HETEROARILO BICICLICO DE FORMULA (I), DONDE HET1 SE SELECCIONA DE HETEROARILO MONOCICLICO Y UN HETEROARILO BICICLICO, DONDE DICHO HET1 ESTA OPCIONALMENTE SUSTITUIDO CON POR LO MENOS UN R4; HET2 ES UN HETEROARILO MONOCICLICO OPCIONALMENTE SUSTITUIDO CON R5; HET3 ES UN HETEROARILO BICICLICO DE 8 O 9 MIEMBROS OPCIONALMENTE SUSTITUIDO CON R6; R1 ES HALOGENO, OH, CIANO, ALQUILO C1-C8, ENTRE OTROS; B1 Y B2 SON CARBONO O NITROGENO; B3 ES CARBONO; B4 ES NITROGENO; X Y X1 SON OXIGENO, AZUFRE O C(R2)2; R4 ES H, ALQUILO C1-C8, CIANO, OH, ENTRE OTROS; R5 ES HALOGENO, OH, ALQUENILO C2-C8, ENTRE OTROS; R6 ES ALQUILO C1-C8, ALQUENILO C2-C8, OH, ENTRE OTROS; R2 ES ALQUILO C1-C8, H, ALQUENILO C2-C8, ENTRE OTROS; p ES 0, 1 O 2. SON COMPUESTOS PREFERIDOS: 1-METIL-2-[4-(4-PIRIDIN-4-IL-1H-PIRAZOL-3-IL)-FENOXIMETIL]-1H-BENZOIMIDAZOL, 2-[4-(1-ETIL-4-PIRIDIN-4-IL-1H-PIRAZOL-3-IL)-FENOXIMETIL]-1-METIL-1H-BENZOIMIDAZOL, 1-{3-[4-(1-METIL-1H-BENZOIMIDAZOL-2-IL-METOXI)-FENIL]-4-PIRIDIN-4-IL-PIRAZOL-1-IL}-PROPAN-2-OL, ENTRE OTROS. TAMBIEN ESTA REFERIDA A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON INHIBIDORES DE LA FOSFODIESTERASA (PDE), PREFERIBLEMENTE PDE-10 Y SON UTILES EN EL TRATAMIENTO DE TRASTORNOS DEL SISTEMA NERVIOSO CENTRAL, TRASTORNOS NEURODEGENERATIVOS, PSIQUIATRICOS, ENTRE OTROS
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US75645006P | 2006-01-05 | 2006-01-05 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20071116A1 true PE20071116A1 (es) | 2007-11-17 |
Family
ID=38131538
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2007000001A PE20071116A1 (es) | 2006-01-05 | 2007-01-03 | Compuestos de heteroarilo biciclicos como inhibidores de pde10 |
Country Status (10)
Country | Link |
---|---|
US (1) | US20070155779A1 (es) |
EP (1) | EP1979343A2 (es) |
JP (1) | JP2009522346A (es) |
AR (1) | AR058919A1 (es) |
CA (1) | CA2636264A1 (es) |
NL (1) | NL2000397C2 (es) |
PE (1) | PE20071116A1 (es) |
TW (1) | TW200736246A (es) |
UY (1) | UY30080A1 (es) |
WO (1) | WO2007077490A2 (es) |
Families Citing this family (44)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2650976A1 (en) * | 2006-05-02 | 2007-11-15 | Pfizer Products Inc. | Bicyclic heteroaryl compounds as pde10 inhibitors |
PE20091953A1 (es) * | 2008-05-08 | 2010-01-09 | Du Pont | Azoles sustituidos como fungicidas |
US8133897B2 (en) | 2008-06-20 | 2012-03-13 | H. Lundbeck A/S | Phenylimidazole derivatives as PDE10A enzyme inhibitors |
TWI501965B (zh) * | 2008-06-20 | 2015-10-01 | Lundbeck & Co As H | 作為pde10a酵素抑制劑之新穎苯基咪唑衍生物 |
MX2011000175A (es) | 2008-06-25 | 2011-06-27 | Envivo Pharmaceuticals Inc | Compuestos heterociclicos 1,2-di-substituidos. |
RU2506260C2 (ru) * | 2008-06-25 | 2014-02-10 | Энвиво Фармасьютикалз, Инк. | 1,2-дизамещенные гетероциклические соединения |
WO2010019861A1 (en) * | 2008-08-15 | 2010-02-18 | University Of Louisville Research Foundation, Inc. | Compounds, their syntheses, and their uses |
TW201030001A (en) * | 2008-11-14 | 2010-08-16 | Amgen Inc | Pyridine and pyrimidine derivatives as phosphodiesterase 10 inhibitors |
US8637500B2 (en) | 2008-12-17 | 2014-01-28 | Amgen Inc. | Aminopyridine and carboxypyridine compounds as phosphodiesterase 10 inhibitors |
KR101662699B1 (ko) * | 2009-05-07 | 2016-10-05 | 포럼 파마슈티칼즈 인크. | 페녹시메틸 헤테로고리 화합물 |
CA2763900A1 (en) | 2009-06-05 | 2010-12-09 | Cephalon, Inc. | Preparation and uses of 1,2,4-triazolo [1,5a] pyridine derivatives |
US8349830B2 (en) | 2009-10-30 | 2013-01-08 | Merck Sharp & Dohme | Aryl aminopyridine PDE10 inhibitors |
JP5778164B2 (ja) * | 2009-10-30 | 2015-09-16 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプJanssen Pharmaceutica Naamloze Vennootschap | 放射標識pde10リガンド |
TWI485151B (zh) * | 2009-12-17 | 2015-05-21 | Lundbeck & Co As H | 作為pde10a酵素抑制劑之雜芳香族苯基咪唑衍生物 |
TWI487705B (zh) * | 2009-12-17 | 2015-06-11 | Lundbeck & Co As H | 作為pde10a酵素抑制劑之雜芳香族芳基三唑衍生物 |
AR081810A1 (es) | 2010-04-07 | 2012-10-24 | Bayer Cropscience Ag | Piridinilpirazoles biciclicos |
MX351368B (es) | 2010-05-26 | 2017-10-12 | Sunovion Pharmaceuticals Inc | Compuestos heteroarilo y metodos para utilizarlos. |
TW201215607A (en) | 2010-07-02 | 2012-04-16 | Lundbeck & Co As H | Aryl-and heteroarylamid derivatives as PDE10A enzyme inhibitor |
JP5973990B2 (ja) * | 2011-03-16 | 2016-08-23 | 武田薬品工業株式会社 | 縮合複素環化合物 |
JP2014122161A (ja) * | 2011-03-31 | 2014-07-03 | Astellas Pharma Inc | ピラゾール化合物 |
WO2012162213A1 (en) * | 2011-05-24 | 2012-11-29 | Merck Sharp & Dohme Corp. | Aryloxymethyl cyclopropane derivatives as pde10 inhibitors |
US9938269B2 (en) | 2011-06-30 | 2018-04-10 | Abbvie Inc. | Inhibitor compounds of phosphodiesterase type 10A |
ES2572527T3 (es) * | 2011-08-25 | 2016-06-01 | Merck Sharp & Dohme Corp. | Inhibidores de PDE10 de pirimidina |
SG11201400759RA (en) * | 2011-09-19 | 2014-07-30 | Hoffmann La Roche | Triazolopyridine compounds as pde10a inhibitors |
US20130116241A1 (en) | 2011-11-09 | 2013-05-09 | Abbvie Inc. | Novel inhibitor compounds of phosphodiesterase type 10a |
MX2014005705A (es) | 2011-11-09 | 2014-09-04 | Abbvie Deutschland | Carboxamidas heterociclicas utiles como inhibidores de fosfodiesterasa del tipo 10a. |
US9138494B2 (en) * | 2011-12-23 | 2015-09-22 | Abbvie Inc. | Radiolabeled PDE10A ligands |
US9309232B2 (en) * | 2012-04-24 | 2016-04-12 | Board Of Trustees Of Northern Illinois University | Synthesis of novel inhibitors of isoprenoid biosynthesis |
EA201491967A1 (ru) | 2012-04-26 | 2015-03-31 | Бристол-Майерс Сквибб Компани | Производные имидазотиадиазола в качестве ингибиторов активируемых протеазой рецепторов 4 (par4) для лечения агрегации тромбоцитов |
KR20150003766A (ko) | 2012-04-26 | 2015-01-09 | 브리스톨-마이어스 스큅 컴퍼니 | 혈소판 응집을 치료하기 위한 프로테아제 활성화 수용체 4 (par4) 억제제로서의 이미다조티아디아졸 및 이미다조피리다진 유도체 |
DK3243826T3 (da) | 2012-04-26 | 2020-02-03 | Bristol Myers Squibb Co | Imidazothiadiazol-og imidazopyrazinderivater som proteaseaktiverede receptor 4- (par4) hæmmere til behandling af blodpladeaggregation |
US9464085B2 (en) | 2012-08-17 | 2016-10-11 | AbbVie Deutschland GmbH & Co. KG | Inhibitor compounds of phosphodiesterase type 10A |
RU2015114331A (ru) | 2012-09-17 | 2016-11-10 | Эббви Дойчланд Гмбх Унд Ко. Кг | Новые соединения в качестве ингибиторов фосфодиэстеразы типа 10а |
US10154988B2 (en) | 2012-11-14 | 2018-12-18 | The Johns Hopkins University | Methods and compositions for treating schizophrenia |
US9790203B2 (en) * | 2012-11-26 | 2017-10-17 | Abbvie Inc. | Inhibitor compounds of phosphodiesterase type 10A |
US9200005B2 (en) | 2013-03-13 | 2015-12-01 | AbbVie Deutschland GmbH & Co. KG | Inhibitor compounds of phosphodiesterase type 10A |
BR112015021701A2 (pt) | 2013-03-14 | 2017-07-18 | Abbvie Deutschland | novos compostos inibidores da fosfoestearase tipo 10a |
US9464076B2 (en) | 2013-03-15 | 2016-10-11 | Daiichi Sankyo Company, Limited | Benzothiophene derivative |
SI3055315T1 (sl) * | 2013-10-11 | 2018-11-30 | F. Hoffmann-La Roche Ag | Tiazolopirimidinoni kot modulatorji aktivnosti receptorjev NMDA |
CN107531696B (zh) | 2015-04-15 | 2021-03-16 | 豪夫迈·罗氏有限公司 | 作为nmda受体调节剂的吡啶并嘧啶酮类及它们的用途 |
US20210379061A1 (en) | 2018-09-28 | 2021-12-09 | Takeda Pharmaceutical Company Limited | Balipodect for treating or preventing autism spectrum disorders |
GB202002926D0 (en) | 2020-02-28 | 2020-04-15 | Benevolentai Tech Limited | Compositions and uses thereof |
WO2021190616A1 (en) * | 2020-03-27 | 2021-09-30 | Gritscience Biopharmaceuticals Co., Ltd. | Methods for inhibiting casein kinases |
GB202110990D0 (en) * | 2021-07-30 | 2021-09-15 | Benevolentai Cambridge Ltd | Organic compound and their uses |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4876346A (en) * | 1985-05-02 | 1989-10-24 | American Home Products Corporation | Quinoline compounds |
US4681940A (en) * | 1985-11-19 | 1987-07-21 | American Home Products Corporation | 5-[3-[[2-quinolyl]methoxy]phenyl]-1,3-oxazoles |
US5843958A (en) * | 1996-11-27 | 1998-12-01 | Ortho Pharmaceutical Corporation | Arylpyrazoles as leukotriene inhibitors |
MXPA06014236A (es) * | 2004-06-07 | 2007-02-14 | Pfizer Prod Inc | Inhibicion de la fosfodiesterasa 10 como tratamiento para las afecciones relacionadas con el sindrome metabolico y con la obesidad. |
SI1841757T1 (sl) * | 2005-01-07 | 2010-09-30 | Pfizer Prod Inc | Heteroaromatske kinolinske spojine in njihova uporaba kot zaviralci PDE |
-
2006
- 2006-12-21 NL NL2000397A patent/NL2000397C2/nl not_active IP Right Cessation
- 2006-12-27 JP JP2008549069A patent/JP2009522346A/ja not_active Withdrawn
- 2006-12-27 EP EP06831852A patent/EP1979343A2/en not_active Withdrawn
- 2006-12-27 WO PCT/IB2006/003875 patent/WO2007077490A2/en active Application Filing
- 2006-12-27 CA CA002636264A patent/CA2636264A1/en not_active Abandoned
-
2007
- 2007-01-03 US US11/619,218 patent/US20070155779A1/en not_active Abandoned
- 2007-01-03 UY UY30080A patent/UY30080A1/es not_active Application Discontinuation
- 2007-01-03 PE PE2007000001A patent/PE20071116A1/es not_active Application Discontinuation
- 2007-01-04 AR ARP070100041A patent/AR058919A1/es unknown
- 2007-01-04 TW TW096100305A patent/TW200736246A/zh unknown
Also Published As
Publication number | Publication date |
---|---|
WO2007077490A2 (en) | 2007-07-12 |
TW200736246A (en) | 2007-10-01 |
US20070155779A1 (en) | 2007-07-05 |
CA2636264A1 (en) | 2007-07-12 |
EP1979343A2 (en) | 2008-10-15 |
WO2007077490A3 (en) | 2007-10-04 |
UY30080A1 (es) | 2007-08-31 |
AR058919A1 (es) | 2008-03-05 |
NL2000397A1 (nl) | 2007-07-06 |
NL2000397C2 (nl) | 2007-10-30 |
JP2009522346A (ja) | 2009-06-11 |
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