CO6270215A2 - Trans-clomifeno para el sindrome metabolico - Google Patents
Trans-clomifeno para el sindrome metabolicoInfo
- Publication number
- CO6270215A2 CO6270215A2 CO10040524A CO10040524A CO6270215A2 CO 6270215 A2 CO6270215 A2 CO 6270215A2 CO 10040524 A CO10040524 A CO 10040524A CO 10040524 A CO10040524 A CO 10040524A CO 6270215 A2 CO6270215 A2 CO 6270215A2
- Authority
- CO
- Colombia
- Prior art keywords
- clomiphene
- trans
- composition
- metabolic syndrome
- antiestrogen
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/138—Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/32—Antioestrogens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Diabetes (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Endocrinology (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- Reproductive Health (AREA)
- Pain & Pain Management (AREA)
- Child & Adolescent Psychology (AREA)
- Rheumatology (AREA)
- Gynecology & Obstetrics (AREA)
- Pregnancy & Childbirth (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
Abstract
Administracion de composiciones que comprenden un antiestrogeno, preferentemente trans-clomifeno, para el tratamiento del sindrome metabolico en un sujeto. La invencion también se refiere a métodos para reducir los niveles de glucosa en ayunas en un sujeto mediante la administracion de una composicion que comprende un antiestrogeno, preferentemente trans-clomifeno. 1.- Un método de tratamiento de un sintoma del sindrome metabolico, CARACTERIZADO PORQUE comprende administrarle a un sujeto que lo necesita una cantidad eficaz de una composicion que comprende un antiestrogeno. 2.- El método de la reivindicacion 1, CARACTERIZADO PORQUE la composicion comprende entre 0% y 29% p/p aproximadamente de cis-clomifeno y entre aproximadamente 100% y aproximadamente 71% de trans-clomifeno o analogos de los mismos. 3.- El método de la reivindicacion 2, CARACTERIZADO PORQUE la composicion consiste esencialmente de trans-clomifeno o un analogo del mismo.4.- El método de la reivindicacion 3, CARACTERIZADO PORQUE el sintoma se selecciona del grupo formado por niveles de glucosa elevados, niveles de triglicéridos elevados, niveles de colesterol elevados, resistencia a insulina, presion sanguinea alta, obesidad abdominal, estado protrombotico o estado proinflamatorio. 5.- El método de la reivindicacion 4, CARACTERIZADO PORQUE la dosificacion de trans-clomifeno comprende entre aproximadamente 12,5 y aproximadamente 50 mg.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US98033407P | 2007-10-16 | 2007-10-16 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO6270215A2 true CO6270215A2 (es) | 2011-04-20 |
Family
ID=40023452
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CO10040524A CO6270215A2 (es) | 2007-10-16 | 2010-04-08 | Trans-clomifeno para el sindrome metabolico |
Country Status (25)
| Country | Link |
|---|---|
| US (2) | US8372887B2 (es) |
| EP (2) | EP2211848A1 (es) |
| JP (4) | JP5558358B2 (es) |
| KR (1) | KR101493472B1 (es) |
| CN (2) | CN101896174B (es) |
| AR (1) | AR069541A1 (es) |
| BR (1) | BRPI0818637A2 (es) |
| CA (3) | CA2702710C (es) |
| CL (1) | CL2008002999A1 (es) |
| CO (1) | CO6270215A2 (es) |
| CR (1) | CR11418A (es) |
| EA (2) | EA022760B1 (es) |
| EC (1) | ECSP10010106A (es) |
| ES (1) | ES2718912T3 (es) |
| HK (1) | HK1150023A1 (es) |
| IL (1) | IL205053A (es) |
| ME (1) | ME00996B (es) |
| MX (1) | MX2010004195A (es) |
| MY (1) | MY150082A (es) |
| NI (1) | NI201000053A (es) |
| NZ (2) | NZ585389A (es) |
| SG (1) | SG185311A1 (es) |
| TW (1) | TW200918093A (es) |
| UA (1) | UA96076C2 (es) |
| WO (1) | WO2009051908A1 (es) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2453337C (en) | 2001-07-09 | 2012-08-28 | Zonagen, Inc. | Methods and materials for the treatment of testosterone deficiency in men |
| US7737185B2 (en) | 2001-07-09 | 2010-06-15 | Repros Therapeutics Inc. | Methods and compositions with trans-clomiphene |
| CA2597700A1 (en) | 2005-03-22 | 2006-09-28 | Repros Therapeutics Inc. | Dosing regimes for trans-clomiphene |
| JP5558358B2 (ja) | 2007-10-16 | 2014-07-23 | レプロス セラピューティクス インコーポレイティド | メタボリック症候群用のｔｒａｎｓ−クロミフェン |
| TWI458478B (zh) * | 2008-11-07 | 2014-11-01 | Repros Therapeutics Inc | 用於代謝症候群與第２型糖尿病的反式氯米芬 |
| ES2784497T3 (es) | 2010-09-16 | 2020-09-28 | Shimoda Biotech Pty Ltd | Composiciones de fulvestrant y métodos de uso |
| UA113291C2 (xx) | 2011-08-04 | 2017-01-10 | Метаболіти транскломіфену і їх застосування | |
| CA2865234A1 (en) * | 2012-02-29 | 2013-09-06 | Repros Therapeutics Inc. | Combination therapy for treating androgen deficiency |
| BR112015002288A2 (pt) | 2012-08-21 | 2017-07-04 | Repros Therapeutics Inc | formulações de trans-clomifeno e usos das mesmas |
| AU2013338311A1 (en) | 2012-11-02 | 2015-05-14 | Repros Therapeutics Inc. | Trans-clomiphene for use in cancer therapy |
| US20160051495A1 (en) * | 2014-08-20 | 2016-02-25 | Professional Compounding Centers Of America | Oral Transmucosal Compositions including C-SERMs for Low Testosterone Levels in Men |
| US20160051565A1 (en) * | 2014-08-20 | 2016-02-25 | Professional Compounding Centers Of America (Pcca) | Transdermal Pharmaceutical Compositions Including Testosterone and an Aromatase Inhibitor |
| WO2016089904A1 (en) * | 2014-12-02 | 2016-06-09 | Repros Therapeutics Inc. | Trans-clomiphene and its analogues as agents for treating or preventing filovirus diseases |
| EP3167869A1 (en) | 2015-11-16 | 2017-05-17 | Capsugel Belgium NV | Tamperproof oral dosage form |
| EP3167870B1 (en) | 2015-11-16 | 2024-01-03 | Capsugel Belgium NV | Tamperproof oral dosage form |
| RU2611936C1 (ru) * | 2016-02-16 | 2017-03-01 | Федеральное государственное бюджетное научное учреждение "Научно-исследовательский институт фармакологии и регенеративной медицины имени Е.Д. Гольдберга" | Способ моделирования гипогонадизма, вызванного метаболическими нарушениями |
| JP2019506425A (ja) * | 2016-02-25 | 2019-03-07 | アスペン パーク ファーマシューティカルズ，インコーポレイティド | クロミフェン異性体の経口剤形および続発性性腺機能低下症を治療するために経口剤形を使用する方法 |
| EP3493794A4 (en) * | 2016-08-04 | 2020-05-06 | University of Iowa Research Foundation | USE OF SWELL1 INHIBITORS AND MODULATORS FOR TREATING TYPE 2 DIABETES AND ADIPOSITAS |
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