ZA982818B - Prevention of breast cancer using selective estrogen receptor modulators. - Google Patents

Prevention of breast cancer using selective estrogen receptor modulators.

Info

Publication number
ZA982818B
ZA982818B ZA9802818A ZA982818A ZA982818B ZA 982818 B ZA982818 B ZA 982818B ZA 9802818 A ZA9802818 A ZA 9802818A ZA 982818 A ZA982818 A ZA 982818A ZA 982818 B ZA982818 B ZA 982818B
Authority
ZA
South Africa
Prior art keywords
prevention
breast cancer
estrogen receptor
receptor modulators
selective estrogen
Prior art date
Application number
ZA9802818A
Inventor
Andrew Lawrence Glasebrook
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of ZA982818B publication Critical patent/ZA982818B/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D333/00Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/62Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/64Oxygen atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/38Heterocyclic compounds having sulfur as a ring hetero atom
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445Non condensed piperidines, e.g. piperocaine
    • A61K31/4523Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4535Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom, e.g. pizotifen
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
ZA9802818A 1997-04-09 1998-04-02 Prevention of breast cancer using selective estrogen receptor modulators. ZA982818B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US4311897P 1997-04-09 1997-04-09

Publications (1)

Publication Number Publication Date
ZA982818B true ZA982818B (en) 1999-10-04

Family

ID=21925594

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA9802818A ZA982818B (en) 1997-04-09 1998-04-02 Prevention of breast cancer using selective estrogen receptor modulators.

Country Status (15)

Country Link
EP (1) EP0975628A4 (en)
JP (1) JP2001518897A (en)
KR (1) KR20010006215A (en)
CN (1) CN1259945A (en)
AU (1) AU6957398A (en)
CA (1) CA2286207A1 (en)
EA (1) EA199900910A1 (en)
HU (1) HUP0001845A2 (en)
ID (1) ID23653A (en)
IL (1) IL132279A0 (en)
NO (1) NO994902L (en)
PL (1) PL336206A1 (en)
TR (1) TR199903244T2 (en)
WO (1) WO1998045286A1 (en)
ZA (1) ZA982818B (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6610706B1 (en) 1999-07-29 2003-08-26 Eli Lilly And Company Crystalline form of 6-hydroxy-3-(4-[2-(piperidin-1-yl)ethoxy]phenoxy)-2-(4-methoxyphenyl)benzo[b]thiophene hydrochloride
US6653479B1 (en) 1999-07-29 2003-11-25 Eli Lilly And Company Crystalline form of 6-hydroxy-3-(4-[2-(piperidin-1-yl)ethoxy]phenoxy)-2-(4-methoxyphenyl)benzo[b] thiophene hydrochloride
JP5558358B2 (en) 2007-10-16 2014-07-23 レプロス セラピューティクス インコーポレイティド TRANS-clomiphene for metabolic syndrome
CA2865234A1 (en) 2012-02-29 2013-09-06 Repros Therapeutics Inc. Combination therapy for treating androgen deficiency
EP3360870A1 (en) 2013-02-19 2018-08-15 Novartis AG Benzothiophene derivatives and compositions thereof as selective estrogen receptor degraders
GB201311888D0 (en) * 2013-07-03 2013-08-14 Glaxosmithkline Ip Dev Ltd Novel compounds
AU2016352592B2 (en) 2015-11-10 2023-04-27 Paracrine Therapeutics Ab Treatment of ER-negative breast cancer with an PDGF-CC inhibitor and an anti estrogen

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5510357A (en) * 1995-02-28 1996-04-23 Eli Lilly And Company Benzothiophene compounds as anti-estrogenic agents
PE44597A1 (en) * 1995-02-28 1997-10-13 Lilly Co Eli BENZOTIOFEN COMPOUNDS, INTERMEDIATE PRODUCTS, COMPOSITIONS AND PROCEDURES
US5731342A (en) * 1996-02-22 1998-03-24 Eli Lilly And Company Benzothiophenes, formulations containing same, and methods

Also Published As

Publication number Publication date
TR199903244T2 (en) 2000-05-22
NO994902L (en) 1999-12-07
ID23653A (en) 2000-05-11
IL132279A0 (en) 2001-03-19
KR20010006215A (en) 2001-01-26
EP0975628A4 (en) 2001-03-21
JP2001518897A (en) 2001-10-16
EP0975628A1 (en) 2000-02-02
AU6957398A (en) 1998-10-30
CN1259945A (en) 2000-07-12
EA199900910A1 (en) 2000-04-24
WO1998045286A1 (en) 1998-10-15
CA2286207A1 (en) 1998-10-15
PL336206A1 (en) 2000-06-05
HUP0001845A2 (en) 2001-06-28
NO994902D0 (en) 1999-10-08

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