NO994902L - Breast cancer prevention by selective estrogen receptor modulators - Google Patents

Breast cancer prevention by selective estrogen receptor modulators

Info

Publication number
NO994902L
NO994902L NO994902A NO994902A NO994902L NO 994902 L NO994902 L NO 994902L NO 994902 A NO994902 A NO 994902A NO 994902 A NO994902 A NO 994902A NO 994902 L NO994902 L NO 994902L
Authority
NO
Norway
Prior art keywords
breast cancer
estrogen receptor
receptor modulators
selective estrogen
cancer prevention
Prior art date
Application number
NO994902A
Other languages
Norwegian (no)
Other versions
NO994902D0 (en
Inventor
Andrew Lawrence Glasebrook
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of NO994902D0 publication Critical patent/NO994902D0/en
Publication of NO994902L publication Critical patent/NO994902L/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/64—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4535—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom, e.g. pizotifen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)

Abstract

Den foreliggende oppfinnelsen tilveiebringer en fremgangsmåte for forebygging av brystkarsinom eller kreft hos en pasient som innbefatter administrering av en terapeutisk effektiv mengde av en forbindelse som har strukturen (I) (O hvori R1 og R2 er uavhengig hydroksy eller alkoksy med en til fire karbonatomer; og R3 og R4 er uavhengig metyl eller etyl eller R3 og R4 sammen med nitrogenatomet som de er bundet til danner en pyrrolidino, metylpyrrolidino, dimetylpyrrolidino, piperidino, morfolino eller heksametylenimino ring.The present invention provides a method for preventing breast carcinoma or cancer in a patient which includes administering a therapeutically effective amount of a compound having structure (I) (O wherein R 1 and R 2 are independently hydroxy or alkoxy having one to four carbon atoms; and R3 and R4 are independently methyl or ethyl or R3 and R4 together with the nitrogen atom to which they are attached form a pyrrolidino, methylpyrrolidino, dimethylpyrrolidino, piperidino, morpholino or hexamethyleneimino ring.

NO994902A 1997-04-09 1999-10-08 Breast cancer prevention by selective estrogen receptor modulators NO994902L (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US4311897P 1997-04-09 1997-04-09
PCT/US1998/006989 WO1998045286A1 (en) 1997-04-09 1998-04-07 Prevention of breast cancer with selective estrogen receptor modulators

Publications (2)

Publication Number Publication Date
NO994902D0 NO994902D0 (en) 1999-10-08
NO994902L true NO994902L (en) 1999-12-07

Family

ID=21925594

Family Applications (1)

Application Number Title Priority Date Filing Date
NO994902A NO994902L (en) 1997-04-09 1999-10-08 Breast cancer prevention by selective estrogen receptor modulators

Country Status (15)

Country Link
EP (1) EP0975628A4 (en)
JP (1) JP2001518897A (en)
KR (1) KR20010006215A (en)
CN (1) CN1259945A (en)
AU (1) AU6957398A (en)
CA (1) CA2286207A1 (en)
EA (1) EA199900910A1 (en)
HU (1) HUP0001845A2 (en)
ID (1) ID23653A (en)
IL (1) IL132279A0 (en)
NO (1) NO994902L (en)
PL (1) PL336206A1 (en)
TR (1) TR199903244T2 (en)
WO (1) WO1998045286A1 (en)
ZA (1) ZA982818B (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6610706B1 (en) 1999-07-29 2003-08-26 Eli Lilly And Company Crystalline form of 6-hydroxy-3-(4-[2-(piperidin-1-yl)ethoxy]phenoxy)-2-(4-methoxyphenyl)benzo[b]thiophene hydrochloride
US6653479B1 (en) 1999-07-29 2003-11-25 Eli Lilly And Company Crystalline form of 6-hydroxy-3-(4-[2-(piperidin-1-yl)ethoxy]phenoxy)-2-(4-methoxyphenyl)benzo[b] thiophene hydrochloride
ME00996B (en) 2007-10-16 2012-10-20 Repros Therapeutics Inc Trans-clomiphene for metabolic syndrome
US20150031656A1 (en) 2012-02-29 2015-01-29 Repros Therapeutics Inc. Combination therapy for treating androgen deficiency
SG11201505697VA (en) 2013-02-19 2015-09-29 Novartis Ag Benzothiophene derivatives and compositions thereof as selective estrogen receptor degraders
GB201311888D0 (en) * 2013-07-03 2013-08-14 Glaxosmithkline Ip Dev Ltd Novel compounds
US11633382B2 (en) 2015-11-10 2023-04-25 Paracrine Therapeutics Ab Treatment of ER-negative breast cancer with an PDGF-CC inhibitor and anti-estrogen

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL182493B1 (en) * 1995-02-28 2002-01-31 Lilly Co Eli Novel derivatives of bezothiophene, method of obtaining them, novel intermediate compounds and pharmaceutical agent
US5510357A (en) * 1995-02-28 1996-04-23 Eli Lilly And Company Benzothiophene compounds as anti-estrogenic agents
US5731342A (en) * 1996-02-22 1998-03-24 Eli Lilly And Company Benzothiophenes, formulations containing same, and methods

Also Published As

Publication number Publication date
ID23653A (en) 2000-05-11
JP2001518897A (en) 2001-10-16
NO994902D0 (en) 1999-10-08
EP0975628A4 (en) 2001-03-21
TR199903244T2 (en) 2000-05-22
CA2286207A1 (en) 1998-10-15
WO1998045286A1 (en) 1998-10-15
AU6957398A (en) 1998-10-30
HUP0001845A2 (en) 2001-06-28
EA199900910A1 (en) 2000-04-24
KR20010006215A (en) 2001-01-26
CN1259945A (en) 2000-07-12
EP0975628A1 (en) 2000-02-02
IL132279A0 (en) 2001-03-19
PL336206A1 (en) 2000-06-05
ZA982818B (en) 1999-10-04

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Legal Events

Date Code Title Description
FC2A Withdrawal, rejection or dismissal of laid open patent application