CO6241170A2 - Administracion de oligonucleotidos antisentido complementarios a la apolipoproteina b humana - Google Patents

Administracion de oligonucleotidos antisentido complementarios a la apolipoproteina b humana

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Publication number
CO6241170A2
CO6241170A2 CO09118478A CO09118478A CO6241170A2 CO 6241170 A2 CO6241170 A2 CO 6241170A2 CO 09118478 A CO09118478 A CO 09118478A CO 09118478 A CO09118478 A CO 09118478A CO 6241170 A2 CO6241170 A2 CO 6241170A2
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dose
administered
phase
week
induction
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CO09118478A
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English (en)
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Richard Geray
Shengrong Yu
Mark Wedel
Diane Tribble
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Genzyme Corp
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Publication of CO6241170A2 publication Critical patent/CO6241170A2/es

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Abstract

1.- Un método que comprende administrar a un sujetouna composición farmacéutica que comprende unoligonucleótido antisentido complementario a un ácidonucléico que coditica apolipoproteína humana B-100, endonde la administración comprende una fase de inducción,en donde una dosis del oligonucleótido antisentido quevaria entre 100-300 mg es administrada una vez porsemana durante al menos 13 semanas, seguida por unafase de mantenimiento, en donde una dosis deloligonucleótido antisentido que varía entre 80-200 mg esadministrada una vez por semana o una vez cada dossemanas durante el tiempo que se requiera, sea efectivay/o tolerada.2.- El método de la reivindicación 1, en donde la dosisadministrada en la fase de inducción es una dosis de 100mg y la dosis administrada en la fase de mantenimiento esuna dosis de 200 mg administrada una vez por semana.3.- El método de la reivindicación 1, en donde la dosisadministrada en la fase de inducción es una dosis de 100mg y la dosis administrada en la fase de mantenimiento esuna dosis de 200 mg administrada una vez por semana, yen donde la tolerabilidad o la efectividad delolilgonucleótido antisentido se evalúan durante o al final delperiodo de inducción, o una porción del mismo una vez porsemana durante la fase de mantenimiento.4.- El método de la reivindicación 1, en donde la dosisadministrada en la fase de inducción es una dosis de 100mg y la dosis administrada en la fase de mantenimiento esuna dosis de 100 mg administrada una vez cada dossemanas, y en donde la tolerabilidad o la efectividad deloligonucleótido antisentido se evalúan durante o al final delperiodo de inducción, o una porción del mismo.5.- El método de la reivindicación 1, en donde la dosisadministrada en la fase de inducción es una dosis de 200mg y la dosis administrada en la fase de mantenimiento esuna dosis de 200 mg administrada una vez cada dossemanas, y en donde la tolerabilidad o la efectividad deloligonucleótido antisentido se evalúan durante o al final delperiodo de inducción, o una porción del mismo.6.- El método de la reivindicación 1, en donde la dosisadministrada en la fase de inducción es una dosis de 100mg a 200 mg y la dosis administrada en la fase demantenimiento es una dosis de 200 mg a 300 mg y esadministrada una vez por semana.7.- El método de la reivindicación 1, en donde dichaadministración parenteral comprende administraciónsubcutánea.
CO09118478A 2007-03-24 2009-10-22 Administracion de oligonucleotidos antisentido complementarios a la apolipoproteina b humana CO6241170A2 (es)

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US89691407P 2007-03-24 2007-03-24

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US (2) US9347061B2 (es)
EP (1) EP2137311A1 (es)
JP (3) JP2010522245A (es)
KR (2) KR20150090284A (es)
CN (2) CN103480002A (es)
AU (1) AU2008230886B9 (es)
BR (1) BRPI0809320A2 (es)
CA (1) CA2682082A1 (es)
CO (1) CO6241170A2 (es)
IL (1) IL201183A0 (es)
MX (1) MX2009010196A (es)
RU (2) RU2015127794A (es)
WO (1) WO2008118883A1 (es)
ZA (1) ZA200906772B (es)

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CA2682082A1 (en) 2008-10-02
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US20170096662A1 (en) 2017-04-06
WO2008118883A1 (en) 2008-10-02
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RU2559536C2 (ru) 2015-08-10
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