CO6260070A2 - Entidades quimicas de imidazopiridina paea el tratamiento de infecciones con hepatitis c - Google Patents

Entidades quimicas de imidazopiridina paea el tratamiento de infecciones con hepatitis c

Info

Publication number
CO6260070A2
CO6260070A2 CO10015824A CO10015824A CO6260070A2 CO 6260070 A2 CO6260070 A2 CO 6260070A2 CO 10015824 A CO10015824 A CO 10015824A CO 10015824 A CO10015824 A CO 10015824A CO 6260070 A2 CO6260070 A2 CO 6260070A2
Authority
CO
Colombia
Prior art keywords
optionally substituted
nr10r11
nr11c
imidazopiridine
pains
Prior art date
Application number
CO10015824A
Other languages
English (en)
Inventor
Franz Ulrich Schmitz
Vincent W-F Tai
Roopa Rai
Christopher R Roberts
Ali Dehghani Abadi
Subramanian Baskaran
Irina Slobodov
Jack Maung
Martin Leon Nietzel
Original Assignee
Glaxosmithkline Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxosmithkline Llc filed Critical Glaxosmithkline Llc
Publication of CO6260070A2 publication Critical patent/CO6260070A2/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

1.- Al menos una entidad química seleccionada a partir de los compuestos de la fórmula 1:y las sales farmacéuticamente aceptables de los mismos, en donde: W1 se selecciona a partir de CR1 y NR1' W3 se selecciona a partir de CR3 y NR3 W4 se selecciona a partir de CR4 y N; W6 se selecciona a partir de CR6 y N; W8 se selecciona a partir de C y N; W9 se selecciona a partir de C y N; R1 está ausente o se selecciona a partir de hidrógeno, halógeno, alquilo opcionalmente sustituido, alquenilo opcionalmente sustituido, alquinilo opcionalmente sustituido, cicloalquilo opcionalmente sustituido, amino opcionalmente sustituido, hetero-cicloalquilo opcionalmente sustituido, arilo opcionalmente sustituido, heteroarilo opcionalmente sustituido, -OR15, -SR15, -S(O)R16, -S(O)2R16, -S(O)2NR10R11, -NR10R11, -NR11C(O)NR10R11, -NR11C(S)NR10R11, -NR11S(O)2R14, -NR11C(O)OR13, -NR11C(O)R12, -C(NR11)NR10R11, -C(O)NR10R11, -C(O)OR13, -CN, -NO2, y -C(O)R12; R2 se selecciona a partir de halógeno, alquilo opcionalmente sustituido, alquenilo opcionalmente sustituido, alquinilo opcionalmente sustituido, cicloalquilo opcionalmente sustituido, amino opcionalmente sustituido, hetero-cicloalquilo opcionalmente sustituido, arilo opcionalmente sustituido, heteroarilo opcionalmente sustituido, -OR15, -SR15, -S(O)R16, -S(O)2R16, -S(O)2NR10R11, -NR10R11, -NR11C(O)NR10R11, -NR11C(S)NR10R11, -NR11S(O)2R14, -NR11C(O)OR13, -NR11C(O)R12, -C(NR11)NR10R11, -C(O)NR10R11, -C(O)OR13, -CN, -NO2, y -C(O)R12; R3 está ausente o se selecciona a partir de hidrógeno, halógeno, alquilo opcionalmente sustituido, alquenilo opcionalmente sustituido, alquinilo opcionalmente sustituido, cicloalquilo opcionalmente sustituido, amino opcionalmente sustituido, hetero-cicloalquilo opcionalmente sustituido, arilo opcionalmente sustituido, heteroarilo opcionalmente sustituido, -OR15, -SR15, -S(O)R16, -S(O)2R15, -S(O)2NR10R11, -NR10R11, -NR11C(O)NR10R11, ...
CO10015824A 2007-08-10 2010-02-12 Entidades quimicas de imidazopiridina paea el tratamiento de infecciones con hepatitis c CO6260070A2 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US96422307P 2007-08-10 2007-08-10
US4108408P 2008-03-31 2008-03-31

Publications (1)

Publication Number Publication Date
CO6260070A2 true CO6260070A2 (es) 2011-03-22

Family

ID=39884633

Family Applications (1)

Application Number Title Priority Date Filing Date
CO10015824A CO6260070A2 (es) 2007-08-10 2010-02-12 Entidades quimicas de imidazopiridina paea el tratamiento de infecciones con hepatitis c

Country Status (15)

Country Link
US (2) US20120121540A1 (es)
EP (1) EP2187883A2 (es)
JP (1) JP2010535773A (es)
KR (1) KR20100053647A (es)
CN (1) CN101842098A (es)
AU (1) AU2008287421A1 (es)
BR (1) BRPI0814939A2 (es)
CA (1) CA2695989A1 (es)
CO (1) CO6260070A2 (es)
DO (1) DOP2010000052A (es)
EA (1) EA201000201A1 (es)
MX (1) MX2010001650A (es)
TW (1) TW200922569A (es)
WO (1) WO2009023179A2 (es)
ZA (1) ZA201001523B (es)

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