DE60315615D1 - Tricyclische verbindungen auf thiophengrundlage und pharmazeutische zusammensetzungen, die diese enthalten - Google Patents

Tricyclische verbindungen auf thiophengrundlage und pharmazeutische zusammensetzungen, die diese enthalten

Info

Publication number
DE60315615D1
DE60315615D1 DE60315615T DE60315615T DE60315615D1 DE 60315615 D1 DE60315615 D1 DE 60315615D1 DE 60315615 T DE60315615 T DE 60315615T DE 60315615 T DE60315615 T DE 60315615T DE 60315615 D1 DE60315615 D1 DE 60315615D1
Authority
DE
Germany
Prior art keywords
sub
thyophical
pharmaceutical compositions
compositions containing
tricyclic compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60315615T
Other languages
English (en)
Other versions
DE60315615T2 (de
Inventor
Makonen Belema
Amy Bunker
Van Nguyen
Francis Beaulieu
Carl Ouellet
Anne Marinier
Stephan Roy
Xuejie Yang
Yuping Qiu
Yunhui Zhang
Alain Martel
Christopher Zusi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Squibb Co
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Application granted granted Critical
Publication of DE60315615D1 publication Critical patent/DE60315615D1/de
Publication of DE60315615T2 publication Critical patent/DE60315615T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D495/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pulmonology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DE60315615T 2002-04-03 2003-03-27 Tricyclische verbindungen basierend auf thiophen und arzneimittel, die diese umfassen Expired - Lifetime DE60315615T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US36969802P 2002-04-03 2002-04-03
US369698P 2002-04-03
PCT/US2003/009549 WO2003084959A1 (en) 2002-04-03 2003-03-27 Thiopene-based tricyclic compounds and pharmaceutical compositions comprising same

Publications (2)

Publication Number Publication Date
DE60315615D1 true DE60315615D1 (de) 2007-09-27
DE60315615T2 DE60315615T2 (de) 2008-10-02

Family

ID=28791986

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60315615T Expired - Lifetime DE60315615T2 (de) 2002-04-03 2003-03-27 Tricyclische verbindungen basierend auf thiophen und arzneimittel, die diese umfassen

Country Status (7)

Country Link
US (1) US6933294B2 (de)
EP (1) EP1490371B1 (de)
AT (1) ATE370145T1 (de)
AU (1) AU2003222106A1 (de)
DE (1) DE60315615T2 (de)
ES (1) ES2291628T3 (de)
WO (1) WO2003084959A1 (de)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2006512313A (ja) 2002-10-31 2006-04-13 アムジェン インコーポレイテッド 抗炎症剤
ITMI20032069A1 (it) * 2003-10-23 2005-04-24 Dinamite Dipharma S P A In Forma A Bbreviata Diph Procedimento per la preparazione di derivati benzilmidazolici.
PE20060373A1 (es) 2004-06-24 2006-04-29 Smithkline Beecham Corp Derivados 3-piperidinil-7-carboxamida-indazol como inhibidores de la actividad cinasa de ikk2
PE20060748A1 (es) 2004-09-21 2006-10-01 Smithkline Beecham Corp Derivados de indolcarboxamida como inhibidores de quinasa ikk2
EP1833836B1 (de) * 2004-11-12 2011-12-21 Bristol-Myers Squibb Company Imidazokondensierte tricyclische verbindungen auf thiazolo[4,5-b]pyridin-basis und pharmazeutische zusammensetzungen damit
US7557211B2 (en) * 2004-11-12 2009-07-07 Bristol-Myers Squibb Company 8H-imidazo[4,5-D]thiazolo[4,5-B]pyridine based tricyclic compounds and pharmaceutical compositions comprising same
AU2005310979A1 (en) * 2004-11-16 2006-06-08 Bellus Health (International) Limited Compounds for the treatment of CNS and amyloid associated diseases
US7683171B2 (en) * 2005-02-04 2010-03-23 Bristol-Myers Squibb Company 1H-imidazo[4,5-d]thieno[3,2-b]pyridine based tricyclic compounds and pharmaceutical compositions comprising same
US7737279B2 (en) * 2005-05-10 2010-06-15 Bristol-Myers Squibb Company 1,6-dihydro-1,3,5,6-tetraaza-as-indacene based tricyclic compounds and pharmaceutical compositions comprising same
UA99699C2 (ru) 2005-06-30 2012-09-25 Смитклайн Бичам Корпорейшн Производные индолкарбоксамида и фармацевтическая композиция, которая их содержит
US8063071B2 (en) 2007-10-31 2011-11-22 GlaxoSmithKline, LLC Chemical compounds
US20090175852A1 (en) 2006-06-06 2009-07-09 Schering Corporation Imidazopyrazines as protein kinase inhibitors
PE20081889A1 (es) 2007-03-23 2009-03-05 Smithkline Beecham Corp Indol carboxamidas como inhibidores de ikk2
TWI490214B (zh) 2008-05-30 2015-07-01 艾德克 上野股份有限公司 苯或噻吩衍生物及該等作為ｖａｐ－１抑制劑之用途
JP2012520257A (ja) 2009-03-10 2012-09-06 グラクソ グループ リミテッド Ｉｋｋ２阻害剤としてのインドール誘導体
ME01838B (me) 2009-06-29 2014-12-20 Lncyte Holdings Corp Pirimidinoni kao inhibitori pi3k
WO2011075643A1 (en) * 2009-12-18 2011-06-23 Incyte Corporation Substituted heteroaryl fused derivatives as pi3k inhibitors
WO2011075630A1 (en) * 2009-12-18 2011-06-23 Incyte Corporation Substituted fused aryl and heteroaryl derivatives as pi3k inhibitors
AR081823A1 (es) 2010-04-14 2012-10-24 Incyte Corp DERIVADOS FUSIONADOS COMO INHIBIDORES DE PI3Kd
US9062055B2 (en) 2010-06-21 2015-06-23 Incyte Corporation Fused pyrrole derivatives as PI3K inhibitors
FR2962438B1 (fr) 2010-07-06 2012-08-17 Sanofi Aventis Derives d'indolizines, procedes de preparation et application en therapeutique
AR084366A1 (es) 2010-12-20 2013-05-08 Incyte Corp N-(1-(fenil sustituido)etil)-9h-purin-6-aminas como inhibidores de pi3k
US9108984B2 (en) 2011-03-14 2015-08-18 Incyte Corporation Substituted diamino-pyrimidine and diamino-pyridine derivatives as PI3K inhibitors
US9126948B2 (en) 2011-03-25 2015-09-08 Incyte Holdings Corporation Pyrimidine-4,6-diamine derivatives as PI3K inhibitors
EA033646B1 (ru) 2011-09-02 2019-11-13 Incyte Holdings Corp Гетероциклиламины как ингибиторы pi3k
AR090548A1 (es) 2012-04-02 2014-11-19 Incyte Corp Azaheterociclobencilaminas biciclicas como inhibidores de pi3k
WO2015191677A1 (en) 2014-06-11 2015-12-17 Incyte Corporation Bicyclic heteroarylaminoalkyl phenyl derivatives as pi3k inhibitors
CN104163788A (zh) * 2014-07-07 2014-11-26 湖南华腾制药有限公司 一种吡啶衍生物的制备方法
WO2016138363A1 (en) 2015-02-27 2016-09-01 Incyte Corporation Salts of pi3k inhibitor and processes for their preparation
US9732097B2 (en) 2015-05-11 2017-08-15 Incyte Corporation Process for the synthesis of a phosphoinositide 3-kinase inhibitor
US9988401B2 (en) 2015-05-11 2018-06-05 Incyte Corporation Crystalline forms of a PI3K inhibitor
WO2023203254A2 (en) * 2022-04-22 2023-10-26 Fundamental Pharma Gmbh Effective means to modulate nmda receptor-mediated toxicity

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5182386A (en) * 1991-08-27 1993-01-26 Neurogen Corporation Certain imidazoquinoxalinones; a new class of gaba brain receptor ligands
US5243012A (en) 1992-06-10 1993-09-07 Miles Inc. Polyurea coating compositions having improved pot lives
US5306819A (en) 1992-08-27 1994-04-26 Neurogen Corporation Certain aryl a cycloalkyl fused imidazopyrazinols; and new class of GABA brain receptor ligands
FR2707645B1 (fr) * 1993-07-16 1995-08-11 Rhone Poulenc Rorer Sa Dérivés d'imidazo[1,2-a]pirazine-4-one, leur préparation et les médicaments les contenant.
FR2722789B1 (fr) * 1994-07-20 1996-08-23 Rhone Poulenc Rorer Sa Derives d'acide imidazo (1,2-a)indeno(1,2-e) pyrazine-2-carboxylique, leur preparation et les medicaments les contenant
JP2000119271A (ja) * 1998-08-12 2000-04-25 Hokuriku Seiyaku Co Ltd １ｈ―イミダゾピリジン誘導体

Also Published As

Publication number Publication date
US6933294B2 (en) 2005-08-23
EP1490371B1 (de) 2007-08-15
ES2291628T3 (es) 2008-03-01
EP1490371A1 (de) 2004-12-29
EP1490371A4 (de) 2006-03-22
AU2003222106A1 (en) 2003-10-20
DE60315615T2 (de) 2008-10-02
WO2003084959A1 (en) 2003-10-16
ATE370145T1 (de) 2007-09-15
US20040058930A1 (en) 2004-03-25

Similar Documents

Publication Publication Date Title
DE60315615D1 (de) Tricyclische verbindungen auf thiophengrundlage und pharmazeutische zusammensetzungen, die diese enthalten
DE602004008098D1 (de) Substituierte 2h-ä1,2,4ütriazoloä4,3-aüpyrazine als gsk-3-inhibitoren
BRPI0610312B8 (pt) dispositivo de assistência à caminhada
YU11997A (sh) Laktamski derivati i njihove farmaceutske kompozicije
ME00411B (me) Nova jedinjenja koja imaju inhibitorno dejstvo na transporter glukoze zavistan od natrijuma
ATE503746T1 (de) Neue imidazolidinderivate
AP1902A (en) N-aryl-2-oxazolidinone-5-carboxamides and their derivatives and their use as antibacterials
NO20060219L (no) Forbindelser
NO20004091L (no) Bisykliske pyrrolderivater som MCP-1 inhibitorer
EA200401613A1 (ru) Лекарственное средство для лечения рака
HRP20050213A2 (en) 2,4-substituted indoles and their use as 5-ht6 modulators
ATE280763T1 (de) Matrix-metalloproteinase-hemmer
HRP20050390A2 (en) Substituted benzoxazinones and uses thereof
NO20054787D0 (no) Indenderivater som farmasotiske midler
DE60118225D1 (de) Chinolin- und chinazolinderivate und deren verwendung als farnesyl transferase inhibitoren
HUP0201953A2 (hu) Benzolszármazékok, eljárás a vegyületek előállítására és a vegyületeket tartalmazó gyógyászati készítmények
HRP20070286T3 (en) Substituted diketopiperazines and their use as oxytocyn antagonists
ATE525366T1 (de) Benzoxazolderivate und pharmazeutische zubereitungen die diese enthalten
DE602004020730D1 (de) Pharmazeutisches verfahren und damit hergestellte verbindungen
WO2005097100A3 (en) Antibacterial agents
ATE399755T1 (de) Aminoalkoholderivate, pharmazeutische zusammensetzungen, die diese enthalten, und verwendung davon
NO20051028L (no) Substituerte tiaziner som materialbeskyttelsesmidler
AR027035A1 (es) Pirroles sustituidos
ATE374751T1 (de) 3,4-dihydro-1h-chinolin-2-onderivate als norepinephrin-wiederaufnahme-hemmern
MXPA06004299A (es) Derivados de arilespirofuropiridina.

Legal Events

Date Code Title Description
8332 No legal effect for de
8370 Indication related to discontinuation of the patent is to be deleted
8364 No opposition during term of opposition