CO6251288A2 - Novedosas fenilpirrolidinas disustuidas como moduladores de la neurotransmision catecolaminergica cortical - Google Patents
Novedosas fenilpirrolidinas disustuidas como moduladores de la neurotransmision catecolaminergica corticalInfo
- Publication number
- CO6251288A2 CO6251288A2 CO09145364A CO09145364A CO6251288A2 CO 6251288 A2 CO6251288 A2 CO 6251288A2 CO 09145364 A CO09145364 A CO 09145364A CO 09145364 A CO09145364 A CO 09145364A CO 6251288 A2 CO6251288 A2 CO 6251288A2
- Authority
- CO
- Colombia
- Prior art keywords
- phenylpirrolidins
- novedosa
- disenuted
- catecolaminergic
- neurotransmission
- Prior art date
Links
- 230000001054 cortical effect Effects 0.000 title 1
- 230000005062 synaptic transmission Effects 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 abstract 1
- 150000001204 N-oxides Chemical class 0.000 abstract 1
- 125000004186 cyclopropylmethyl group Chemical group [H]C([H])(*)C1([H])C([H])([H])C1([H])[H] 0.000 abstract 1
- 125000002541 furyl group Chemical group 0.000 abstract 1
- 125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 abstract 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 125000004108 n-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 abstract 1
- 125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 abstract 1
- 125000000246 pyrimidin-2-yl group Chemical group [H]C1=NC(*)=NC([H])=C1[H] 0.000 abstract 1
- 125000002914 sec-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 abstract 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 abstract 1
- 125000000335 thiazolyl group Chemical group 0.000 abstract 1
- 125000001544 thienyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/12—Oxygen or sulfur atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Neurology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Anesthesiology (AREA)
- Hospice & Palliative Care (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US94199407P | 2007-06-05 | 2007-06-05 | |
| SE0701387 | 2007-06-05 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO6251288A2 true CO6251288A2 (es) | 2011-02-21 |
Family
ID=39743744
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CO09145364A CO6251288A2 (es) | 2007-06-05 | 2009-12-18 | Novedosas fenilpirrolidinas disustuidas como moduladores de la neurotransmision catecolaminergica cortical |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US8188301B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP2155671B8 (cg-RX-API-DMAC7.html) |
| JP (1) | JP5444535B2 (cg-RX-API-DMAC7.html) |
| KR (1) | KR20100038295A (cg-RX-API-DMAC7.html) |
| CN (1) | CN101808987A (cg-RX-API-DMAC7.html) |
| AU (1) | AU2008258599B2 (cg-RX-API-DMAC7.html) |
| BR (1) | BRPI0812740A2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2690091A1 (cg-RX-API-DMAC7.html) |
| CO (1) | CO6251288A2 (cg-RX-API-DMAC7.html) |
| IL (1) | IL202045A0 (cg-RX-API-DMAC7.html) |
| MX (1) | MX2009012787A (cg-RX-API-DMAC7.html) |
| NZ (1) | NZ581364A (cg-RX-API-DMAC7.html) |
| RU (1) | RU2471781C2 (cg-RX-API-DMAC7.html) |
| UA (1) | UA98783C2 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2008148801A2 (cg-RX-API-DMAC7.html) |
| ZA (1) | ZA200908592B (cg-RX-API-DMAC7.html) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20100038295A (ko) | 2007-06-05 | 2010-04-14 | 엔에스아베 필리알 아프 뉴로서치 스웨덴 아베 스베리게 | 피질 카테콜아민성 신경 전달의 조정자로서의 이치환된 페닐피롤리딘 |
| US20110257148A1 (en) * | 2008-11-24 | 2011-10-20 | Nsab, Filial Af Neurosearch Sweden Ab, Sverige | Novel 1-alkyl-3-hydroxy-3-phenylazetidine derivatives useful as modulators of cortical catecholaminergic neurotransmission |
| CN102224135A (zh) | 2008-11-24 | 2011-10-19 | Nsab神经研究瑞典公司分公司 | 用作皮质儿茶酚胺能神经传递调节剂的新3-苯基-氮杂环丁烷衍生物 |
| EP2367788A1 (en) | 2008-11-24 | 2011-09-28 | NSAB, Filial af NeuroSearch Sweden AB, Sverige | 3-phenyl-3-methoxypyrrolidine derivatives as modulators of cortical catecholaminergic neurotransmission |
| CN102282155B (zh) | 2008-12-02 | 2017-06-09 | 日本波涛生命科学公司 | 磷原子修饰的核酸的合成方法 |
| AR074755A1 (es) * | 2008-12-16 | 2011-02-09 | Astrazeneca Ab | Derivados cuaternarios de piperidina y sus usos |
| BR112012000828A8 (pt) | 2009-07-06 | 2017-10-10 | Ontorii Inc | Novas pró-drogas de ácido nucleico e métodos de uso das mesmas |
| EP2620428B1 (en) | 2010-09-24 | 2019-05-22 | Wave Life Sciences Ltd. | Asymmetric auxiliary group |
| ES2626488T3 (es) | 2011-07-19 | 2017-07-25 | Wave Life Sciences Pte. Ltd. | Procedimientos para la síntesis de ácidos nucleicos funcionalizados |
| ES2862073T3 (es) | 2012-07-13 | 2021-10-06 | Wave Life Sciences Ltd | Grupo auxiliar asimétrico |
| BR112015000723A2 (pt) | 2012-07-13 | 2017-06-27 | Shin Nippon Biomedical Laboratories Ltd | adjuvante de ácido nucléico quiral |
| ES2940887T3 (es) | 2012-07-13 | 2023-05-12 | Wave Life Sciences Ltd | Método de preparación de oligonucleótidos quirales |
| JPWO2015108048A1 (ja) | 2014-01-15 | 2017-03-23 | 株式会社新日本科学 | 抗腫瘍作用を有するキラル核酸アジュバンド及び抗腫瘍剤 |
| WO2015108047A1 (ja) | 2014-01-15 | 2015-07-23 | 株式会社新日本科学 | 免疫誘導活性を有するキラル核酸アジュバンド及び免疫誘導活性剤 |
| US10322173B2 (en) | 2014-01-15 | 2019-06-18 | Shin Nippon Biomedical Laboratories, Ltd. | Chiral nucleic acid adjuvant having anti-allergic activity, and anti-allergic agent |
| CN113278617A (zh) | 2014-01-16 | 2021-08-20 | 波涛生命科学有限公司 | 手性设计 |
| EP3297987B1 (en) | 2015-05-20 | 2019-05-15 | Integrative Research Laboratories Sweden AB | Novel azetidine derivatives useful as modulators of cortical cathecolaminergic neurotransmission |
| EP3415499B1 (en) | 2016-02-10 | 2020-05-13 | Sumitomo Chemical Company, Limited | Method for producing 1-methylpyrrolidin-3-ol |
| ES2943252T3 (es) * | 2017-05-19 | 2023-06-12 | Integrative Res Laboratories Sweden Ab | Fumarato de (+)-3-(2,3-difluorofenil)-3-metoxipirrolidina, un proceso para su preparación y sus usos |
Family Cites Families (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2878264A (en) | 1959-03-17 | Substituted amino alcohols | ||
| DE1144279B (de) | 1957-09-26 | 1963-02-28 | Robins Co Inc A H | Verfahren zur Herstellung von 3-Aryl-3-hydroxypyrrolidinen und deren Salzen |
| US3118907A (en) * | 1961-08-14 | 1964-01-21 | Mead Johnson & Co | 3-substituted-3-pyrrolidinols |
| BE704683A (cg-RX-API-DMAC7.html) | 1966-11-07 | 1968-02-15 | ||
| US3635982A (en) | 1969-04-08 | 1972-01-18 | American Home Prod | Amino-substituted-quinoxalinyloxazolidines and -oxazines |
| US5128362A (en) | 1988-01-15 | 1992-07-07 | Abbott Laboratories | 1-aminomethyl-1,2,3,4-tetrahydronaphthalenes |
| DE3802175A1 (de) | 1988-01-26 | 1989-08-03 | Hoechst Ag | N-phenylbenzamide und n-phenylbenzamidoxime, verfahren zu ihrer herstellung, sie enthaltende mittel und ihre verwendung als schaedlingsbekaempfungsmittel |
| DE3835291A1 (de) * | 1988-04-19 | 1989-11-02 | Bayer Ag | 1,3-disubstituierte pyrrolidine |
| US5444083A (en) * | 1989-02-03 | 1995-08-22 | Eisai Co., Ltd. | Pyrrolidine compound and pharmaceutical use |
| ES2157204T3 (es) * | 1991-04-17 | 2001-08-16 | Upjohn Co | Derivados de (s)-3-fenilpiperidina sustituidos, su preparacion y uso como antagonistas de autorreceptores de dopamina. |
| EP0586229A1 (en) * | 1992-09-01 | 1994-03-09 | Zeneca Limited | 3-Hydroxy-3-(subst-akyl)-pyrrolidines as 5-lipoxygenase inhibitors |
| US5665754A (en) * | 1993-09-20 | 1997-09-09 | Glaxo Wellcome Inc. | Substituted pyrrolidines |
| WO1997024325A1 (en) | 1995-12-28 | 1997-07-10 | Takeda Chemical Industries, Ltd. | DIPHENYLMETHANE DERIVATIVES AS MIP-1α/RANTES RECEPTOR ANTAGONISTS |
| HUP0102622A3 (en) | 1998-07-20 | 2002-12-28 | Merck Patent Gmbh | Biphenyl derivatives, process for producing them and pharmaceutical compositions containing them |
| US20020169155A1 (en) | 1998-09-04 | 2002-11-14 | Millennium Pharmaceuticals, Inc. | Chemokine receptor anagonists and methods of use therefor |
| US7271176B2 (en) | 1998-09-04 | 2007-09-18 | Millennium Pharmaceuticals, Inc. | Chemokine receptor antagonists and methods of use thereof |
| DE19840611A1 (de) * | 1998-09-05 | 2000-03-09 | Klaus Wanner | GABA-uptake-Inhibitoren mit Pyrrolidinstruktur |
| WO2000070417A1 (en) | 1999-05-17 | 2000-11-23 | The Foxboro Company | Process control configuration system with parameterized objects |
| ECSP003637A (es) | 1999-08-31 | 2002-03-25 | Agouron Pharma | Inhibidores triciclicos de poli (adp-ribosa) polimerasas |
| SE9904723D0 (sv) | 1999-12-22 | 1999-12-22 | Carlsson A Research Ab | New modulators of dopamine neurotransmission II |
| US7547693B2 (en) | 2003-09-22 | 2009-06-16 | Banyu Pharmaceutical Co. Ltd. | Piperidine derivative |
| SE0401465D0 (sv) | 2004-06-08 | 2004-06-08 | Carlsson A Research Ab | New substituted piperdines as modulators of dopamine neurotransmission |
| US7700587B2 (en) | 2004-09-07 | 2010-04-20 | Florida A&M University | Haloperidol analogs |
| US7598279B2 (en) | 2005-04-22 | 2009-10-06 | Sk Holdings Co., Ltd. | Neurotherapeutic azole compounds |
| JP2008540395A (ja) | 2005-05-03 | 2008-11-20 | ファイザー・インク | アミドレソルシノール化合物 |
| WO2007053145A1 (en) | 2005-11-04 | 2007-05-10 | Florida A & M University | Haloperidol analogs |
| EP1966164B1 (en) | 2005-12-21 | 2013-03-06 | Janssen Pharmaceutica N.V. | Novel substituted pyrazinone derivatives for use in mch-1 mediated diseases |
| KR20100038295A (ko) | 2007-06-05 | 2010-04-14 | 엔에스아베 필리알 아프 뉴로서치 스웨덴 아베 스베리게 | 피질 카테콜아민성 신경 전달의 조정자로서의 이치환된 페닐피롤리딘 |
| US20100197760A1 (en) | 2007-06-05 | 2010-08-05 | Nsab, Filial Af Neurosearch Sweden Ab, Sverige | Disubstituted phenylpyrrolidines as modulators of cortical catecholaminergic neurotransmission |
-
2008
- 2008-06-04 KR KR1020097025393A patent/KR20100038295A/ko not_active Withdrawn
- 2008-06-04 CN CN200880018820A patent/CN101808987A/zh active Pending
- 2008-06-04 CA CA2690091A patent/CA2690091A1/en not_active Abandoned
- 2008-06-04 WO PCT/EP2008/056915 patent/WO2008148801A2/en not_active Ceased
- 2008-06-04 NZ NZ581364A patent/NZ581364A/en not_active IP Right Cessation
- 2008-06-04 MX MX2009012787A patent/MX2009012787A/es active IP Right Grant
- 2008-06-04 UA UAA200911475A patent/UA98783C2/ru unknown
- 2008-06-04 RU RU2009143104/04A patent/RU2471781C2/ru not_active IP Right Cessation
- 2008-06-04 AU AU2008258599A patent/AU2008258599B2/en not_active Expired - Fee Related
- 2008-06-04 EP EP08760496.3A patent/EP2155671B8/en not_active Not-in-force
- 2008-06-04 BR BRPI0812740A patent/BRPI0812740A2/pt not_active IP Right Cessation
- 2008-06-04 JP JP2010510783A patent/JP5444535B2/ja not_active Expired - Fee Related
- 2008-06-04 US US12/663,223 patent/US8188301B2/en not_active Expired - Fee Related
-
2009
- 2009-11-11 IL IL202045A patent/IL202045A0/en unknown
- 2009-12-03 ZA ZA2009/08592A patent/ZA200908592B/en unknown
- 2009-12-18 CO CO09145364A patent/CO6251288A2/es not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| RU2009143104A (ru) | 2011-07-20 |
| EP2155671A2 (en) | 2010-02-24 |
| JP2010529081A (ja) | 2010-08-26 |
| JP5444535B2 (ja) | 2014-03-19 |
| US8188301B2 (en) | 2012-05-29 |
| AU2008258599A1 (en) | 2008-12-11 |
| EP2155671B1 (en) | 2017-12-20 |
| CA2690091A1 (en) | 2008-12-11 |
| US20100179211A1 (en) | 2010-07-15 |
| AU2008258599B2 (en) | 2013-06-13 |
| KR20100038295A (ko) | 2010-04-14 |
| WO2008148801A3 (en) | 2009-01-29 |
| NZ581364A (en) | 2011-10-28 |
| UA98783C2 (en) | 2012-06-25 |
| RU2471781C2 (ru) | 2013-01-10 |
| CN101808987A (zh) | 2010-08-18 |
| EP2155671B8 (en) | 2018-02-21 |
| IL202045A0 (en) | 2010-06-16 |
| WO2008148801A2 (en) | 2008-12-11 |
| BRPI0812740A2 (pt) | 2016-07-19 |
| WO2008148801A8 (en) | 2009-12-10 |
| MX2009012787A (es) | 2009-12-15 |
| ZA200908592B (en) | 2011-02-23 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC | Application refused |