AU2008258599B2 - Disubstituted phenylpyrrolidines as modulators of cortical catecholaminergic neurotransmission - Google Patents

Disubstituted phenylpyrrolidines as modulators of cortical catecholaminergic neurotransmission Download PDF

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Publication number
AU2008258599B2
AU2008258599B2 AU2008258599A AU2008258599A AU2008258599B2 AU 2008258599 B2 AU2008258599 B2 AU 2008258599B2 AU 2008258599 A AU2008258599 A AU 2008258599A AU 2008258599 A AU2008258599 A AU 2008258599A AU 2008258599 B2 AU2008258599 B2 AU 2008258599B2
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AU
Australia
Prior art keywords
difluorophenyl
pyrrolidin
fluorophenyl
mmol
chloro
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Expired - Fee Related
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AU2008258599A
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English (en)
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AU2008258599A1 (en
Inventor
Fredrik Pettersson
Clas Sonesson
Lars Swanson
Nicholas Waters
Susanna Waters
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NSAB Filial af Neurosearch Sweden AB
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NSAB Filial af Neurosearch Sweden AB
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Assigned to NSAB, FILIAL AF NEUROSEARCH SWEDEN AB, SVERIGE reassignment NSAB, FILIAL AF NEUROSEARCH SWEDEN AB, SVERIGE Amend patent request/document other than specification (104) Assignors: NSAB, FILIAL OF NEUROSEARCH SWEDEN AB SVERIGE
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/12—Oxygen or sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
AU2008258599A 2007-06-05 2008-06-04 Disubstituted phenylpyrrolidines as modulators of cortical catecholaminergic neurotransmission Expired - Fee Related AU2008258599B2 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US94199407P 2007-06-05 2007-06-05
US60/941,994 2007-06-05
SE0701387-3 2007-06-05
SE0701387 2007-06-05
PCT/EP2008/056915 WO2008148801A2 (en) 2007-06-05 2008-06-04 Disubstituted phenylpyrrolidines as modulators of cortical catecholaminergic neurotransmission

Publications (2)

Publication Number Publication Date
AU2008258599A1 AU2008258599A1 (en) 2008-12-11
AU2008258599B2 true AU2008258599B2 (en) 2013-06-13

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
AU2008258599A Expired - Fee Related AU2008258599B2 (en) 2007-06-05 2008-06-04 Disubstituted phenylpyrrolidines as modulators of cortical catecholaminergic neurotransmission

Country Status (16)

Country Link
US (1) US8188301B2 (cg-RX-API-DMAC7.html)
EP (1) EP2155671B8 (cg-RX-API-DMAC7.html)
JP (1) JP5444535B2 (cg-RX-API-DMAC7.html)
KR (1) KR20100038295A (cg-RX-API-DMAC7.html)
CN (1) CN101808987A (cg-RX-API-DMAC7.html)
AU (1) AU2008258599B2 (cg-RX-API-DMAC7.html)
BR (1) BRPI0812740A2 (cg-RX-API-DMAC7.html)
CA (1) CA2690091A1 (cg-RX-API-DMAC7.html)
CO (1) CO6251288A2 (cg-RX-API-DMAC7.html)
IL (1) IL202045A0 (cg-RX-API-DMAC7.html)
MX (1) MX2009012787A (cg-RX-API-DMAC7.html)
NZ (1) NZ581364A (cg-RX-API-DMAC7.html)
RU (1) RU2471781C2 (cg-RX-API-DMAC7.html)
UA (1) UA98783C2 (cg-RX-API-DMAC7.html)
WO (1) WO2008148801A2 (cg-RX-API-DMAC7.html)
ZA (1) ZA200908592B (cg-RX-API-DMAC7.html)

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KR20100038295A (ko) 2007-06-05 2010-04-14 엔에스아베 필리알 아프 뉴로서치 스웨덴 아베 스베리게 피질 카테콜아민성 신경 전달의 조정자로서의 이치환된 페닐피롤리딘
US20110257148A1 (en) * 2008-11-24 2011-10-20 Nsab, Filial Af Neurosearch Sweden Ab, Sverige Novel 1-alkyl-3-hydroxy-3-phenylazetidine derivatives useful as modulators of cortical catecholaminergic neurotransmission
CN102224135A (zh) 2008-11-24 2011-10-19 Nsab神经研究瑞典公司分公司 用作皮质儿茶酚胺能神经传递调节剂的新3-苯基-氮杂环丁烷衍生物
EP2367788A1 (en) 2008-11-24 2011-09-28 NSAB, Filial af NeuroSearch Sweden AB, Sverige 3-phenyl-3-methoxypyrrolidine derivatives as modulators of cortical catecholaminergic neurotransmission
CN102282155B (zh) 2008-12-02 2017-06-09 日本波涛生命科学公司 磷原子修饰的核酸的合成方法
AR074755A1 (es) * 2008-12-16 2011-02-09 Astrazeneca Ab Derivados cuaternarios de piperidina y sus usos
BR112012000828A8 (pt) 2009-07-06 2017-10-10 Ontorii Inc Novas pró-drogas de ácido nucleico e métodos de uso das mesmas
EP2620428B1 (en) 2010-09-24 2019-05-22 Wave Life Sciences Ltd. Asymmetric auxiliary group
ES2626488T3 (es) 2011-07-19 2017-07-25 Wave Life Sciences Pte. Ltd. Procedimientos para la síntesis de ácidos nucleicos funcionalizados
ES2862073T3 (es) 2012-07-13 2021-10-06 Wave Life Sciences Ltd Grupo auxiliar asimétrico
BR112015000723A2 (pt) 2012-07-13 2017-06-27 Shin Nippon Biomedical Laboratories Ltd adjuvante de ácido nucléico quiral
ES2940887T3 (es) 2012-07-13 2023-05-12 Wave Life Sciences Ltd Método de preparación de oligonucleótidos quirales
JPWO2015108048A1 (ja) 2014-01-15 2017-03-23 株式会社新日本科学 抗腫瘍作用を有するキラル核酸アジュバンド及び抗腫瘍剤
WO2015108047A1 (ja) 2014-01-15 2015-07-23 株式会社新日本科学 免疫誘導活性を有するキラル核酸アジュバンド及び免疫誘導活性剤
US10322173B2 (en) 2014-01-15 2019-06-18 Shin Nippon Biomedical Laboratories, Ltd. Chiral nucleic acid adjuvant having anti-allergic activity, and anti-allergic agent
CN113278617A (zh) 2014-01-16 2021-08-20 波涛生命科学有限公司 手性设计
EP3297987B1 (en) 2015-05-20 2019-05-15 Integrative Research Laboratories Sweden AB Novel azetidine derivatives useful as modulators of cortical cathecolaminergic neurotransmission
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ES2943252T3 (es) * 2017-05-19 2023-06-12 Integrative Res Laboratories Sweden Ab Fumarato de (+)-3-(2,3-difluorofenil)-3-metoxipirrolidina, un proceso para su preparación y sus usos

Citations (1)

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Also Published As

Publication number Publication date
RU2009143104A (ru) 2011-07-20
EP2155671A2 (en) 2010-02-24
JP2010529081A (ja) 2010-08-26
JP5444535B2 (ja) 2014-03-19
US8188301B2 (en) 2012-05-29
AU2008258599A1 (en) 2008-12-11
EP2155671B1 (en) 2017-12-20
CA2690091A1 (en) 2008-12-11
US20100179211A1 (en) 2010-07-15
KR20100038295A (ko) 2010-04-14
WO2008148801A3 (en) 2009-01-29
NZ581364A (en) 2011-10-28
UA98783C2 (en) 2012-06-25
RU2471781C2 (ru) 2013-01-10
CN101808987A (zh) 2010-08-18
EP2155671B8 (en) 2018-02-21
IL202045A0 (en) 2010-06-16
CO6251288A2 (es) 2011-02-21
WO2008148801A2 (en) 2008-12-11
BRPI0812740A2 (pt) 2016-07-19
WO2008148801A8 (en) 2009-12-10
MX2009012787A (es) 2009-12-15
ZA200908592B (en) 2011-02-23

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MK4 Application lapsed section 142(2)(d) - no continuation fee paid for the application