CO5261552A1 - Procedimiento para la obtencion de 1,2,3,4-tetrahidroquino- linas 4-carboxiamino-2-sustituidas - Google Patents
Procedimiento para la obtencion de 1,2,3,4-tetrahidroquino- linas 4-carboxiamino-2-sustituidasInfo
- Publication number
- CO5261552A1 CO5261552A1 CO00085289A CO00085289A CO5261552A1 CO 5261552 A1 CO5261552 A1 CO 5261552A1 CO 00085289 A CO00085289 A CO 00085289A CO 00085289 A CO00085289 A CO 00085289A CO 5261552 A1 CO5261552 A1 CO 5261552A1
- Authority
- CO
- Colombia
- Prior art keywords
- ethyl
- salt
- quinoline
- dihydro
- trifluoromethyl
- Prior art date
Links
- 150000003839 salts Chemical class 0.000 abstract 5
- JOXIMZWYDAKGHI-UHFFFAOYSA-M toluene-4-sulfonate Chemical compound CC1=CC=C(S([O-])(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-M 0.000 abstract 2
- CMIBUZBMZCBCAT-HZPDHXFCSA-N (2r,3r)-2,3-bis[(4-methylbenzoyl)oxy]butanedioic acid Chemical class C1=CC(C)=CC=C1C(=O)O[C@@H](C(O)=O)[C@H](C(O)=O)OC(=O)C1=CC=C(C)C=C1 CMIBUZBMZCBCAT-HZPDHXFCSA-N 0.000 abstract 1
- QOTDBJKZKHHPCY-SCZZXKLOSA-N (2r,4s)-4-amino-2-ethyl-6-(trifluoromethyl)-3,4-dihydro-2h-quinoline-1-carboxylic acid Chemical compound FC(F)(F)C1=CC=C2N(C(O)=O)[C@H](CC)C[C@H](N)C2=C1 QOTDBJKZKHHPCY-SCZZXKLOSA-N 0.000 abstract 1
- -1 3,5-Bis-Trifluoromethylbenzylamino Chemical group 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000004494 ethyl ester group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/38—Nitrogen atoms
- C07D215/42—Nitrogen atoms attached in position 4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Obesity (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Quinoline Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US16796799P | 1999-11-30 | 1999-11-30 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO5261552A1 true CO5261552A1 (es) | 2003-03-31 |
Family
ID=22609556
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CO00085289A CO5261552A1 (es) | 1999-11-30 | 2000-11-09 | Procedimiento para la obtencion de 1,2,3,4-tetrahidroquino- linas 4-carboxiamino-2-sustituidas |
Country Status (44)
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HN2000000203A (es) * | 1999-11-30 | 2001-06-13 | Pfizer Prod Inc | Procedimiento para la obtencion de 1,2,3,4-tetrahidroquinolinas 4-carboxiamino-2- sustituidas. |
| HUP0500165A2 (en) * | 2001-12-19 | 2006-09-28 | Atherogenics Inc | Chalcone derivatives and their use to treat diseases |
| US7202247B2 (en) | 2001-12-19 | 2007-04-10 | Atherogenics, Inc. | 1,3-bis-(substituted-phenyl)-2-propyn-1-ones and their use to treat disorders |
| DE60323954D1 (de) * | 2002-04-11 | 2008-11-20 | Roar Holding Llc | Ex-vivo-verfahren zur bestimmung der cetp-aktivität und der wirksamkeit der behandlung von herzerkrankungen |
| US7504508B2 (en) * | 2002-10-04 | 2009-03-17 | Millennium Pharmaceuticals, Inc. | PGD2 receptor antagonists for the treatment of inflammatory diseases |
| EA011385B1 (ru) * | 2002-10-04 | 2009-02-27 | Миллениум Фармасьютикалз, Инк. | Антагонисты рецептора pgd2 для лечения воспалительных заболеваний |
| US20090181966A1 (en) * | 2002-10-04 | 2009-07-16 | Millennium Pharmaceuticals, Inc. | PGD2 receptor antagonists for the treatment of inflammatory diseases |
| US7223870B2 (en) * | 2002-11-01 | 2007-05-29 | Pfizer Inc. | Methods for preparing N-arylated oxazolidinones via a copper catalyzed cross coupling reaction |
| US20040181075A1 (en) * | 2002-12-19 | 2004-09-16 | Weingarten M. David | Process of making chalcone derivatives |
| US20040132771A1 (en) * | 2002-12-20 | 2004-07-08 | Pfizer Inc | Compositions of choleseteryl ester transfer protein inhibitors and HMG-CoA reductase inhibitors |
| BR0317521A (pt) | 2002-12-20 | 2005-11-16 | Pfizer Prod Inc | Formas de dosagem compreendendo um inibidor da cetp e um inibidor da redutase hmg-coa |
| US20060100239A1 (en) * | 2003-03-04 | 2006-05-11 | Izuru Nagasaki | Method for producing optically active amines |
| EP2289507A1 (en) * | 2003-03-17 | 2011-03-02 | Japan Tobacco, Inc. | Pharmaceutical compositions of CETP inhibitors |
| US7276536B2 (en) * | 2003-03-17 | 2007-10-02 | Japan Tobacco Inc. | Method for increasing the bioavailability of the active form of S-[2-([[1-(2-ethylbutyl)cyclohexyl]carbonyl]amino) phenyl] 2-methylpropanethioate |
| TWI393560B (zh) * | 2003-05-02 | 2013-04-21 | Japan Tobacco Inc | 包含ｓ-〔２（〔〔１-（２-乙基丁基）環己基〕羰基〕胺基）苯基〕２-甲基丙烷硫酯及ｈｍｇ輔酶ａ還原酶抑制劑之組合 |
| EA200600737A1 (ru) * | 2003-10-08 | 2006-10-27 | Эли Лилли Энд Компани | Соединения и способы для лечения дислипидемии |
| UA90269C2 (ru) * | 2004-04-02 | 2010-04-26 | Мицубиси Танабе Фарма Корпорейшн | Тетрагидрохинолиновые производные и способ их получения |
| US20080269284A1 (en) * | 2004-06-24 | 2008-10-30 | Eli Lilly And Company | Compounds and Methods for Treating Dyslipidemia |
| DOP2005000123A (es) * | 2004-07-02 | 2011-07-15 | Merck Sharp & Dohme | Inhibidores de cetp |
| WO2006033001A1 (en) * | 2004-09-23 | 2006-03-30 | Pfizer Products Inc. | Quinoline compounds |
| WO2006069162A1 (en) * | 2004-12-20 | 2006-06-29 | Reddy Us Therapeutics, Inc. | Novel heterocyclic compounds and their pharmaceutical compositions |
| MX2007010215A (es) * | 2005-02-24 | 2007-11-07 | Millennium Pharm Inc | Antagonistas del receptor pgd2 para el tratamiento de enfermedades inflamatorias. |
| UY30244A1 (es) | 2006-03-30 | 2007-11-30 | Tanabe Seiyaku Co | Un proceso para preparar derivados de tetrahidroquinolina |
| CL2008000684A1 (es) | 2007-03-09 | 2008-08-01 | Indigene Pharmaceuticals Inc | Composicion farmaceutica que comprende metformina r-(+) lipoato y un inhibidor de reductasa hmg-coa; formulacion de dosis unitaria; y uso en el tratamiento de una complicacion diabetica. |
| CN101429160B (zh) * | 2007-11-06 | 2011-10-19 | 上海药明康德新药开发有限公司 | 一种1-r-4-氨基-1,2,3,4-四氢喹啉的合成方法 |
| AR077208A1 (es) * | 2009-06-30 | 2011-08-10 | Lilly Co Eli | Derivados del acido trans-4-[[(5s)-5-[[[3,5-bis(trifluorometil) fenil] metil] (2-metil-2h-tetrazol-5-il) amino) -2,3,4,5-tetrahidro-7,9-dimetil-1h-1-benzazepin-1-il) metil)-ciclohexancarboxilico y sus formas cristalinas, composiciones farmaceuticas que los comprenden, su uso para preparar un medicam |
| US12006305B2 (en) | 2022-07-05 | 2024-06-11 | Newamsterdam Pharma B.V. | Salts of obicetrapib and processes for their manufacture and intermediates thereof |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR7870M (forum.php) * | 1968-11-08 | 1970-04-27 | ||
| US3971789A (en) | 1972-10-21 | 1976-07-27 | John Wyeth & Brother Limited | O-(4-Quinolylamino)benzamides |
| GB8432091D0 (en) | 1984-12-19 | 1985-01-30 | Wyeth John & Brother Ltd | 4-aminoquinoline derivatives |
| US4839368A (en) | 1986-05-02 | 1989-06-13 | Mochida Pharmaceutical Co., Ltd. | 1-acyl-2,3-dihydro-4(1H)-quinolinone-4-oxime derivatives |
| GB8804444D0 (en) | 1988-02-25 | 1988-03-23 | Smithkline Beckman Intercredit | Compounds |
| US5231102A (en) | 1989-03-08 | 1993-07-27 | Merck Sharp & Dohme, Ltd. | Tetrahydroquinoline derivatives useful for neurodegenerative disorders |
| PT100905A (pt) * | 1991-09-30 | 1994-02-28 | Eisai Co Ltd | Compostos heterociclicos azotados biciclicos contendo aneis de benzeno, ciclo-hexano ou piridina e de pirimidina, piridina ou imidazol substituidos e composicoes farmaceuticas que os contem |
| US6197786B1 (en) | 1998-09-17 | 2001-03-06 | Pfizer Inc | 4-Carboxyamino-2-substituted-1,2,3,4-tetrahydroquinolines |
| US6140342A (en) | 1998-09-17 | 2000-10-31 | Pfizer Inc. | Oxy substituted 4-carboxyamino-2-methyl-1,2,3,4-tetrahydroquinolines |
| US6147089A (en) | 1998-09-17 | 2000-11-14 | Pfizer Inc. | Annulated 4-carboxyamino-2-methyl-1,2,3,4,-tetrahydroquinolines |
| HN2000000203A (es) * | 1999-11-30 | 2001-06-13 | Pfizer Prod Inc | Procedimiento para la obtencion de 1,2,3,4-tetrahidroquinolinas 4-carboxiamino-2- sustituidas. |
-
2000
- 2000-09-14 HN HN2000000203A patent/HN2000000203A/es unknown
- 2000-09-27 PA PA20008503801A patent/PA8503801A1/es unknown
- 2000-09-29 OA OA1200000268A patent/OA11494A/en unknown
- 2000-10-10 US US09/684,830 patent/US6313142B1/en not_active Expired - Fee Related
- 2000-11-03 GT GT200000190A patent/GT200000190A/es unknown
- 2000-11-09 CO CO00085289A patent/CO5261552A1/es not_active Application Discontinuation
- 2000-11-13 AT AT00310064T patent/ATE315028T1/de not_active IP Right Cessation
- 2000-11-13 DE DE60025317T patent/DE60025317T2/de not_active Expired - Fee Related
- 2000-11-13 EP EP00310064A patent/EP1125929B1/en not_active Expired - Lifetime
- 2000-11-13 ES ES00310064T patent/ES2254109T3/es not_active Expired - Lifetime
- 2000-11-13 DK DK00310064T patent/DK1125929T3/da active
- 2000-11-16 YU YU71500A patent/YU71500A/sh unknown
- 2000-11-17 IS IS5715A patent/IS5715A/is unknown
- 2000-11-22 HR HR20000804A patent/HRP20000804A2/hr not_active Application Discontinuation
- 2000-11-23 AU AU71789/00A patent/AU784694B2/en not_active Ceased
- 2000-11-23 IL IL139849A patent/IL139849A/en not_active IP Right Cessation
- 2000-11-24 SK SK1779-2000A patent/SK17792000A3/sk unknown
- 2000-11-24 TW TW089125066A patent/TW591016B/zh not_active IP Right Cessation
- 2000-11-27 UY UY26451A patent/UY26451A1/es not_active Application Discontinuation
- 2000-11-27 ZA ZA200006947A patent/ZA200006947B/xx unknown
- 2000-11-27 CZ CZ20004407A patent/CZ20004407A3/cs unknown
- 2000-11-27 ID IDP20001022D patent/ID28489A/id unknown
- 2000-11-28 CA CA002327029A patent/CA2327029C/en not_active Expired - Fee Related
- 2000-11-28 SG SG200006869A patent/SG102603A1/en unknown
- 2000-11-28 PE PE2000001266A patent/PE20010913A1/es not_active Application Discontinuation
- 2000-11-28 CN CNB001283820A patent/CN1173953C/zh not_active Expired - Fee Related
- 2000-11-28 UA UA2000116782A patent/UA65615C2/uk unknown
- 2000-11-29 TN TNTNSN00230A patent/TNSN00230A1/fr unknown
- 2000-11-29 JP JP2000362153A patent/JP3579345B2/ja not_active Expired - Fee Related
- 2000-11-29 MA MA26112A patent/MA25223A1/fr unknown
- 2000-11-29 NZ NZ508509A patent/NZ508509A/en unknown
- 2000-11-29 NO NO20006039A patent/NO20006039L/no not_active Application Discontinuation
- 2000-11-29 EA EA200001129A patent/EA003668B1/ru not_active IP Right Cessation
- 2000-11-29 AR ARP000106287A patent/AR029775A1/es unknown
- 2000-11-29 DZ DZ000153A patent/DZ3079A1/xx active
- 2000-11-29 HU HU0004747A patent/HUP0004747A3/hu unknown
- 2000-11-29 KR KR10-2000-0071527A patent/KR100408177B1/ko not_active Expired - Fee Related
- 2000-11-30 AP APAP/P/2000/002011A patent/AP2000002011A0/en unknown
- 2000-11-30 BG BG105009A patent/BG105009A/xx unknown
- 2000-11-30 EE EEP200000659A patent/EE200000659A/xx unknown
- 2000-11-30 GE GEAP20005651A patent/GEP20022798B/en unknown
- 2000-11-30 PL PL00344208A patent/PL344208A1/xx not_active Application Discontinuation
- 2000-11-30 BR BR0005636-7A patent/BR0005636A/pt not_active Application Discontinuation
-
2006
- 2006-03-01 CY CY20061100287T patent/CY1104989T1/el unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC | Application refused |