CY1104989T1 - Μεθοδος παρασκευης αιθυλεστερος του (-)-(2r,4s)-4-[(3,5-δiς-tpiφθopomeθyλo-βενζυλο)-μεθοξυκαρβονυλαμινο]-2-αιθυλο-6-τριφθορο-μεθυλο-3,4-διϋδρο-2η-κινολινο-1-καρβοξυλικου οξεος - Google Patents

Μεθοδος παρασκευης αιθυλεστερος του (-)-(2r,4s)-4-[(3,5-δiς-tpiφθopomeθyλo-βενζυλο)-μεθοξυκαρβονυλαμινο]-2-αιθυλο-6-τριφθορο-μεθυλο-3,4-διϋδρο-2η-κινολινο-1-καρβοξυλικου οξεος

Info

Publication number
CY1104989T1
CY1104989T1 CY20061100287T CY061100287T CY1104989T1 CY 1104989 T1 CY1104989 T1 CY 1104989T1 CY 20061100287 T CY20061100287 T CY 20061100287T CY 061100287 T CY061100287 T CY 061100287T CY 1104989 T1 CY1104989 T1 CY 1104989T1
Authority
CY
Cyprus
Prior art keywords
ethyl
quinoline
dihydro
bis
carboxylic acid
Prior art date
Application number
CY20061100287T
Other languages
English (en)
Inventor
David Burns Damon
Robert Wayne Dugger
Original Assignee
Pfizer Products Incorporated
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Products Incorporated filed Critical Pfizer Products Incorporated
Publication of CY1104989T1 publication Critical patent/CY1104989T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • C07D215/42—Nitrogen atoms attached in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Obesity (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Steroid Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Μέθοδος παρασκευής αιθυλεστέρος του (-)-(2R,4S)-4-[(3,5-δις-τριφθορομεθυλο-βενζυλο)-μεθοξυκαρβονυλαμινο]-2-αιθυλο-6-τριφθορο-μεθυλο-3,4-διϋδρο-2Η-κινολινο-1-καρβοξυλικού οξέος περιλαμβάνουσα τον συνδυασμό αιθυλεστέρος του (-)-(2R,4S)-4-(3,5-δις-τριφθορομεθυλο-βενζυλαμινο)-2-αιθυλο-6-τριφθορομεθυλο-3,4-διϋδρο-2Η-κινολινο-1-καρβοξυλικού οξέος, 4-τολουολο-σουλφονικού και ανθρακικού νατρίου εντός τετραϋδροφουρανίου σε θερμοκρασία περίπου 20-25°C, παρουσία χλωρομυρμηκικού μεθυλεστέρος.
CY20061100287T 1999-11-30 2006-03-01 Μεθοδος παρασκευης αιθυλεστερος του (-)-(2r,4s)-4-[(3,5-δiς-tpiφθopomeθyλo-βενζυλο)-μεθοξυκαρβονυλαμινο]-2-αιθυλο-6-τριφθορο-μεθυλο-3,4-διϋδρο-2η-κινολινο-1-καρβοξυλικου οξεος CY1104989T1 (el)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US16796799P 1999-11-30 1999-11-30

Publications (1)

Publication Number Publication Date
CY1104989T1 true CY1104989T1 (el) 2010-03-03

Family

ID=22609556

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20061100287T CY1104989T1 (el) 1999-11-30 2006-03-01 Μεθοδος παρασκευης αιθυλεστερος του (-)-(2r,4s)-4-[(3,5-δiς-tpiφθopomeθyλo-βενζυλο)-μεθοξυκαρβονυλαμινο]-2-αιθυλο-6-τριφθορο-μεθυλο-3,4-διϋδρο-2η-κινολινο-1-καρβοξυλικου οξεος

Country Status (45)

Country Link
US (1) US6313142B1 (el)
EP (1) EP1125929B1 (el)
JP (1) JP3579345B2 (el)
KR (1) KR100408177B1 (el)
CN (1) CN1173953C (el)
AP (1) AP2000002011A0 (el)
AR (1) AR029775A1 (el)
AT (1) ATE315028T1 (el)
AU (1) AU784694B2 (el)
BG (1) BG105009A (el)
BR (1) BR0005636A (el)
CA (1) CA2327029C (el)
CO (1) CO5261552A1 (el)
CY (1) CY1104989T1 (el)
CZ (1) CZ20004407A3 (el)
DE (1) DE60025317T2 (el)
DK (1) DK1125929T3 (el)
DZ (1) DZ3079A1 (el)
EA (1) EA003668B1 (el)
EE (1) EE200000659A (el)
ES (1) ES2254109T3 (el)
GE (1) GEP20022798B (el)
GT (1) GT200000190A (el)
HK (1) HK1038007A1 (el)
HN (1) HN2000000203A (el)
HR (1) HRP20000804A2 (el)
HU (1) HUP0004747A3 (el)
ID (1) ID28489A (el)
IL (1) IL139849A (el)
IS (1) IS5715A (el)
MA (1) MA25223A1 (el)
NO (1) NO20006039L (el)
NZ (1) NZ508509A (el)
OA (1) OA11494A (el)
PA (1) PA8503801A1 (el)
PE (1) PE20010913A1 (el)
PL (1) PL344208A1 (el)
SG (1) SG102603A1 (el)
SK (1) SK17792000A3 (el)
TN (1) TNSN00230A1 (el)
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UA (1) UA65615C2 (el)
UY (1) UY26451A1 (el)
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ZA (1) ZA200006947B (el)

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WO2003087396A1 (en) * 2002-04-11 2003-10-23 Roar Holding Llc Ex vivo method for determination of cetp activity and efficacy of heart disease treatment
US20090181966A1 (en) * 2002-10-04 2009-07-16 Millennium Pharmaceuticals, Inc. PGD2 receptor antagonists for the treatment of inflammatory diseases
US7504508B2 (en) * 2002-10-04 2009-03-17 Millennium Pharmaceuticals, Inc. PGD2 receptor antagonists for the treatment of inflammatory diseases
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US20040181075A1 (en) * 2002-12-19 2004-09-16 Weingarten M. David Process of making chalcone derivatives
US20040132771A1 (en) * 2002-12-20 2004-07-08 Pfizer Inc Compositions of choleseteryl ester transfer protein inhibitors and HMG-CoA reductase inhibitors
DE60331873D1 (de) 2002-12-20 2010-05-06 Pfizer Prod Inc Dosierungsform enthaltend einen CETP-Hemmer und einen HMG-CoA Reduktase Hemmer
JP2006523218A (ja) * 2003-03-04 2006-10-12 高砂香料工業株式会社 光学活性アミン類の製造方法
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TWI393560B (zh) * 2003-05-02 2013-04-21 Japan Tobacco Inc 包含ｓ-〔２（〔〔１-（２-乙基丁基）環己基〕羰基〕胺基）苯基〕２-甲基丙烷硫酯及ｈｍｇ輔酶ａ還原酶抑制劑之組合
MXPA06003927A (es) * 2003-10-08 2008-02-07 Lilly Co Eli Compuestos y metodos para tratar dislipidemia.
UA90269C2 (ru) * 2004-04-02 2010-04-26 Мицубиси Танабе Фарма Корпорейшн Тетрагидрохинолиновые производные и способ их получения
KR20070041452A (ko) * 2004-06-24 2007-04-18 일라이 릴리 앤드 캄파니 이상지혈증 치료를 위한 화합물 및 방법
DOP2005000123A (es) * 2004-07-02 2011-07-15 Merck Sharp & Dohme Inhibidores de cetp
WO2006033001A1 (en) * 2004-09-23 2006-03-30 Pfizer Products Inc. Quinoline compounds
WO2006069162A1 (en) * 2004-12-20 2006-06-29 Reddy Us Therapeutics, Inc. Novel heterocyclic compounds and their pharmaceutical compositions
WO2006091674A1 (en) * 2005-02-24 2006-08-31 Millennium Pharmaceuticals, Inc. Pgd2 receptor antagonists for the treatment of inflammatory diseases
UY30244A1 (es) 2006-03-30 2007-11-30 Tanabe Seiyaku Co Un proceso para preparar derivados de tetrahidroquinolina
TW200901959A (en) 2007-03-09 2009-01-16 Indigene Pharmaceuticals Inc Combination of metformin R-(+) lipoate and antihyperlipidemic agents for the treatment of diabetic hyperglycemia and diabetic complications
CN101429160B (zh) * 2007-11-06 2011-10-19 上海药明康德新药开发有限公司 一种1-r-4-氨基-1,2,3,4-四氢喹啉的合成方法
TWI450896B (zh) 2009-06-30 2014-09-01 Lilly Co Eli 反式－４－〔〔（５ｓ）－５－〔〔〔３，５－雙（三氟甲基）苯基〕甲基〕（２－甲基－２ｈ－四唑－５－基）胺基〕－２，３，４，５－四氫－７，９－二甲基－１ｈ－１－苯并氮呯－１－基〕甲基〕－環己基羧酸
US12006305B2 (en) 2022-07-05 2024-06-11 Newamsterdam Pharma B.V. Salts of obicetrapib and processes for their manufacture and intermediates thereof

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Also Published As

Publication number Publication date
GT200000190A (es) 2002-04-27
CN1302800A (zh) 2001-07-11
JP3579345B2 (ja) 2004-10-20
PL344208A1 (en) 2001-06-04
HUP0004747A3 (en) 2002-12-28
JP2001163859A (ja) 2001-06-19
EP1125929B1 (en) 2006-01-04
IL139849A (en) 2006-10-31
DE60025317T2 (de) 2006-08-03
OA11494A (en) 2004-05-07
TNSN00230A1 (fr) 2005-11-10
NO20006039L (no) 2001-05-31
KR100408177B1 (ko) 2003-12-01
HK1038007A1 (en) 2002-03-01
CO5261552A1 (es) 2003-03-31
SG102603A1 (en) 2004-03-26
UY26451A1 (es) 2001-06-29
BR0005636A (pt) 2001-07-17
AP2000002011A0 (en) 2000-12-31
SK17792000A3 (sk) 2002-10-08
TW591016B (en) 2004-06-11
PE20010913A1 (es) 2001-09-10
IL139849A0 (en) 2002-02-10
HN2000000203A (es) 2001-06-13
NO20006039D0 (no) 2000-11-29
UA65615C2 (uk) 2004-04-15
EE200000659A (et) 2001-08-15
BG105009A (en) 2001-11-30
AR029775A1 (es) 2003-07-16
EA003668B1 (ru) 2003-08-28
HUP0004747A2 (hu) 2001-10-28
DE60025317D1 (de) 2006-03-30
IS5715A (is) 2001-05-31
CA2327029A1 (en) 2001-05-30
ID28489A (id) 2001-05-31
US6313142B1 (en) 2001-11-06
DK1125929T3 (da) 2006-04-03
ES2254109T3 (es) 2006-06-16
AU784694B2 (en) 2006-06-01
EA200001129A3 (ru) 2001-10-22
MA25223A1 (fr) 2001-07-02
KR20010052012A (ko) 2001-06-25
HU0004747D0 (el) 2001-02-28
HRP20000804A2 (en) 2001-06-30
AU7178900A (en) 2001-05-31
YU71500A (sh) 2003-02-28
ZA200006947B (en) 2002-05-27
NZ508509A (en) 2001-06-29
EA200001129A2 (ru) 2001-06-25
GEP20022798B (en) 2002-09-25
CN1173953C (zh) 2004-11-03
CZ20004407A3 (cs) 2002-06-12
CA2327029C (en) 2005-08-09
PA8503801A1 (es) 2002-07-30
EP1125929A1 (en) 2001-08-22
ATE315028T1 (de) 2006-02-15
DZ3079A1 (fr) 2004-10-24

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