BR0005636A - Método para a produção de 4-carboxiamino-1,2,3,4-tetrahidroquinolina 2-substituìda - Google Patents

Método para a produção de 4-carboxiamino-1,2,3,4-tetrahidroquinolina 2-substituìda

Info

Publication number
BR0005636A
BR0005636A BR0005636-7A BR0005636A BR0005636A BR 0005636 A BR0005636 A BR 0005636A BR 0005636 A BR0005636 A BR 0005636A BR 0005636 A BR0005636 A BR 0005636A
Authority
BR
Brazil
Prior art keywords
tetrahydroquinoline
production
carboxyamino
substituted
carboxyamine
Prior art date
Application number
BR0005636-7A
Other languages
English (en)
Inventor
David Burns Damon
Robert Wayne Dugger
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of BR0005636A publication Critical patent/BR0005636A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • C07D215/42—Nitrogen atoms attached in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Patente de Invenção: <B>"MéTODO PARA A PRODUçãO DE 4-CARBOXIAMINO-1,2,3,4-TETRAHIDROQUINOLINA 2-SUBSTITUìDA"<D>. Descreve-se métodos para a preparação de inibidores de CETP.
BR0005636-7A 1999-11-30 2000-11-30 Método para a produção de 4-carboxiamino-1,2,3,4-tetrahidroquinolina 2-substituìda BR0005636A (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US16796799P 1999-11-30 1999-11-30

Publications (1)

Publication Number Publication Date
BR0005636A true BR0005636A (pt) 2001-07-17

Family

ID=22609556

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0005636-7A BR0005636A (pt) 1999-11-30 2000-11-30 Método para a produção de 4-carboxiamino-1,2,3,4-tetrahidroquinolina 2-substituìda

Country Status (45)

Country Link
US (1) US6313142B1 (pt)
EP (1) EP1125929B1 (pt)
JP (1) JP3579345B2 (pt)
KR (1) KR100408177B1 (pt)
CN (1) CN1173953C (pt)
AP (1) AP2000002011A0 (pt)
AR (1) AR029775A1 (pt)
AT (1) ATE315028T1 (pt)
AU (1) AU784694B2 (pt)
BG (1) BG105009A (pt)
BR (1) BR0005636A (pt)
CA (1) CA2327029C (pt)
CO (1) CO5261552A1 (pt)
CY (1) CY1104989T1 (pt)
CZ (1) CZ20004407A3 (pt)
DE (1) DE60025317T2 (pt)
DK (1) DK1125929T3 (pt)
DZ (1) DZ3079A1 (pt)
EA (1) EA003668B1 (pt)
EE (1) EE200000659A (pt)
ES (1) ES2254109T3 (pt)
GE (1) GEP20022798B (pt)
GT (1) GT200000190A (pt)
HK (1) HK1038007A1 (pt)
HN (1) HN2000000203A (pt)
HR (1) HRP20000804A2 (pt)
HU (1) HUP0004747A3 (pt)
ID (1) ID28489A (pt)
IL (1) IL139849A (pt)
IS (1) IS5715A (pt)
MA (1) MA25223A1 (pt)
NO (1) NO20006039L (pt)
NZ (1) NZ508509A (pt)
OA (1) OA11494A (pt)
PA (1) PA8503801A1 (pt)
PE (1) PE20010913A1 (pt)
PL (1) PL344208A1 (pt)
SG (1) SG102603A1 (pt)
SK (1) SK17792000A3 (pt)
TN (1) TNSN00230A1 (pt)
TW (1) TW591016B (pt)
UA (1) UA65615C2 (pt)
UY (1) UY26451A1 (pt)
YU (1) YU71500A (pt)
ZA (1) ZA200006947B (pt)

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HN2000000203A (es) * 1999-11-30 2001-06-13 Pfizer Prod Inc Procedimiento para la obtencion de 1,2,3,4-tetrahidroquinolinas 4-carboxiamino-2- sustituidas.
US7202247B2 (en) 2001-12-19 2007-04-10 Atherogenics, Inc. 1,3-bis-(substituted-phenyl)-2-propyn-1-ones and their use to treat disorders
IL162533A0 (en) * 2001-12-19 2005-11-20 Atherogenics Inc Chalcone derivatives and their use to treat diseases
US7279297B2 (en) * 2002-04-11 2007-10-09 Roar Holding Llc Ex vivo method for determination of CETP activity and efficacy of heart disease treatment
US20090181966A1 (en) * 2002-10-04 2009-07-16 Millennium Pharmaceuticals, Inc. PGD2 receptor antagonists for the treatment of inflammatory diseases
US7211672B2 (en) * 2002-10-04 2007-05-01 Millennium Pharmaceuticals, Inc. PGD2 receptor antagonists for the treatment of inflammatory diseases
US7504508B2 (en) * 2002-10-04 2009-03-17 Millennium Pharmaceuticals, Inc. PGD2 receptor antagonists for the treatment of inflammatory diseases
US7223870B2 (en) 2002-11-01 2007-05-29 Pfizer Inc. Methods for preparing N-arylated oxazolidinones via a copper catalyzed cross coupling reaction
AU2003303239A1 (en) * 2002-12-19 2004-07-14 Atherogenics, Inc. Process of making chalcone derivatives
US20040132771A1 (en) * 2002-12-20 2004-07-08 Pfizer Inc Compositions of choleseteryl ester transfer protein inhibitors and HMG-CoA reductase inhibitors
EP1961419B1 (en) 2002-12-20 2010-03-24 Pfizer Products Inc. Dosage forms comprising a CETP inhibitor and an HMG-CoA reductase inhibitor
WO2004078730A2 (en) * 2003-03-04 2004-09-16 Takasago International Corporation Method for producing optically active amines
BRPI0408442A (pt) * 2003-03-17 2006-04-04 Japan Tobacco Inc método para aumento da biodisponibilidade oral de s-[2-([[1-(2-etilbutil)ciclohexil]carbonil]amino)fenil]2- metilpropanotioato
NZ542852A (en) * 2003-03-17 2008-09-26 Japan Tobacco Inc Pharmaceutical compositions of CETP inhibitors
TWI393560B (zh) * 2003-05-02 2013-04-21 Japan Tobacco Inc 包含ｓ-〔２（〔〔１-（２-乙基丁基）環己基〕羰基〕胺基）苯基〕２-甲基丙烷硫酯及ｈｍｇ輔酶ａ還原酶抑制劑之組合
EP2098512A1 (en) * 2003-10-08 2009-09-09 Eli Lilly &amp; Company Compounds and methods for treating dyslipidemia
UA90269C2 (ru) * 2004-04-02 2010-04-26 Мицубиси Танабе Фарма Корпорейшн Тетрагидрохинолиновые производные и способ их получения
US20080269284A1 (en) * 2004-06-24 2008-10-30 Eli Lilly And Company Compounds and Methods for Treating Dyslipidemia
DOP2005000123A (es) 2004-07-02 2011-07-15 Merck Sharp & Dohme Inhibidores de cetp
WO2006033001A1 (en) * 2004-09-23 2006-03-30 Pfizer Products Inc. Quinoline compounds
WO2006069162A1 (en) * 2004-12-20 2006-06-29 Reddy Us Therapeutics, Inc. Novel heterocyclic compounds and their pharmaceutical compositions
AU2006216713A1 (en) * 2005-02-24 2006-08-31 Millennium Pharmaceuticals, Inc. PGD2 receptor antagonists for the treatment of inflammatory diseases
UY30244A1 (es) 2006-03-30 2007-11-30 Tanabe Seiyaku Co Un proceso para preparar derivados de tetrahidroquinolina
EP2134169A2 (en) 2007-03-09 2009-12-23 Indigene Pharmaceuticals Inc. Combination of metformin r-(+) lipoate and antihyperlipidemic agents for the treatment of diabetic hyperglycemia and diabetic complications
CN101429160B (zh) * 2007-11-06 2011-10-19 上海药明康德新药开发有限公司 一种1-r-4-氨基-1,2,3,4-四氢喹啉的合成方法
TWI450896B (zh) 2009-06-30 2014-09-01 Lilly Co Eli 反式－４－〔〔（５ｓ）－５－〔〔〔３，５－雙（三氟甲基）苯基〕甲基〕（２－甲基－２ｈ－四唑－５－基）胺基〕－２，３，４，５－四氫－７，９－二甲基－１ｈ－１－苯并氮呯－１－基〕甲基〕－環己基羧酸
TW202409008A (zh) 2022-07-05 2024-03-01 荷蘭商新阿姆斯特丹製藥公司 奧比特拉(obicetrapib)鹽及彼等之製造方法與中間體

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HN2000000203A (es) * 1999-11-30 2001-06-13 Pfizer Prod Inc Procedimiento para la obtencion de 1,2,3,4-tetrahidroquinolinas 4-carboxiamino-2- sustituidas.

Also Published As

Publication number Publication date
EA200001129A3 (ru) 2001-10-22
EP1125929A1 (en) 2001-08-22
CY1104989T1 (el) 2010-03-03
CZ20004407A3 (cs) 2002-06-12
CA2327029A1 (en) 2001-05-30
IL139849A0 (en) 2002-02-10
HN2000000203A (es) 2001-06-13
DE60025317D1 (de) 2006-03-30
TNSN00230A1 (fr) 2005-11-10
SK17792000A3 (sk) 2002-10-08
HK1038007A1 (en) 2002-03-01
IL139849A (en) 2006-10-31
JP3579345B2 (ja) 2004-10-20
PL344208A1 (en) 2001-06-04
AU784694B2 (en) 2006-06-01
YU71500A (sh) 2003-02-28
NO20006039L (no) 2001-05-31
SG102603A1 (en) 2004-03-26
DK1125929T3 (da) 2006-04-03
OA11494A (en) 2004-05-07
GT200000190A (es) 2002-04-27
DZ3079A1 (fr) 2004-10-24
EP1125929B1 (en) 2006-01-04
HUP0004747A2 (hu) 2001-10-28
AR029775A1 (es) 2003-07-16
NZ508509A (en) 2001-06-29
EA200001129A2 (ru) 2001-06-25
EE200000659A (et) 2001-08-15
TW591016B (en) 2004-06-11
GEP20022798B (en) 2002-09-25
ES2254109T3 (es) 2006-06-16
AU7178900A (en) 2001-05-31
ID28489A (id) 2001-05-31
NO20006039D0 (no) 2000-11-29
UA65615C2 (uk) 2004-04-15
KR100408177B1 (ko) 2003-12-01
CN1173953C (zh) 2004-11-03
EA003668B1 (ru) 2003-08-28
KR20010052012A (ko) 2001-06-25
IS5715A (is) 2001-05-31
PA8503801A1 (es) 2002-07-30
US6313142B1 (en) 2001-11-06
ZA200006947B (en) 2002-05-27
HU0004747D0 (pt) 2001-02-28
ATE315028T1 (de) 2006-02-15
AP2000002011A0 (en) 2000-12-31
UY26451A1 (es) 2001-06-29
MA25223A1 (fr) 2001-07-02
BG105009A (en) 2001-11-30
CA2327029C (en) 2005-08-09
CO5261552A1 (es) 2003-03-31
CN1302800A (zh) 2001-07-11
DE60025317T2 (de) 2006-08-03
HUP0004747A3 (en) 2002-12-28
HRP20000804A2 (en) 2001-06-30
JP2001163859A (ja) 2001-06-19
PE20010913A1 (es) 2001-09-10

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Legal Events

Date Code Title Description
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B11B Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements