GEP20022798B - Method For Producing 4-Carboxyamino-2-Substituted-1,2,3,4- Tetrahydroquinoline - Google Patents

Method For Producing 4-Carboxyamino-2-Substituted-1,2,3,4- Tetrahydroquinoline

Info

Publication number
GEP20022798B
GEP20022798B GEAP20005651A GEAP2000005651A GEP20022798B GE P20022798 B GEP20022798 B GE P20022798B GE AP20005651 A GEAP20005651 A GE AP20005651A GE AP2000005651 A GEAP2000005651 A GE AP2000005651A GE P20022798 B GEP20022798 B GE P20022798B
Authority
GE
Georgia
Prior art keywords
carboxyamino
tetrahydroquinoline
substituted
producing
cetp
Prior art date
Application number
GEAP20005651A
Other languages
English (en)
Inventor
David Burns Damon
Robert Wayne Dugger
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of GEP20022798B publication Critical patent/GEP20022798B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • C07D215/42—Nitrogen atoms attached in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Obesity (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
GEAP20005651A 1999-11-30 2000-11-30 Method For Producing 4-Carboxyamino-2-Substituted-1,2,3,4- Tetrahydroquinoline GEP20022798B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US16796799P 1999-11-30 1999-11-30

Publications (1)

Publication Number Publication Date
GEP20022798B true GEP20022798B (en) 2002-09-25

Family

ID=22609556

Family Applications (1)

Application Number Title Priority Date Filing Date
GEAP20005651A GEP20022798B (en) 1999-11-30 2000-11-30 Method For Producing 4-Carboxyamino-2-Substituted-1,2,3,4- Tetrahydroquinoline

Country Status (44)

Country Link
US (1) US6313142B1 (forum.php)
EP (1) EP1125929B1 (forum.php)
JP (1) JP3579345B2 (forum.php)
KR (1) KR100408177B1 (forum.php)
CN (1) CN1173953C (forum.php)
AP (1) AP2000002011A0 (forum.php)
AR (1) AR029775A1 (forum.php)
AT (1) ATE315028T1 (forum.php)
AU (1) AU784694B2 (forum.php)
BG (1) BG105009A (forum.php)
BR (1) BR0005636A (forum.php)
CA (1) CA2327029C (forum.php)
CO (1) CO5261552A1 (forum.php)
CY (1) CY1104989T1 (forum.php)
CZ (1) CZ20004407A3 (forum.php)
DE (1) DE60025317T2 (forum.php)
DK (1) DK1125929T3 (forum.php)
DZ (1) DZ3079A1 (forum.php)
EA (1) EA003668B1 (forum.php)
EE (1) EE200000659A (forum.php)
ES (1) ES2254109T3 (forum.php)
GE (1) GEP20022798B (forum.php)
GT (1) GT200000190A (forum.php)
HN (1) HN2000000203A (forum.php)
HR (1) HRP20000804A2 (forum.php)
HU (1) HUP0004747A3 (forum.php)
ID (1) ID28489A (forum.php)
IL (1) IL139849A (forum.php)
IS (1) IS5715A (forum.php)
MA (1) MA25223A1 (forum.php)
NO (1) NO20006039L (forum.php)
NZ (1) NZ508509A (forum.php)
OA (1) OA11494A (forum.php)
PA (1) PA8503801A1 (forum.php)
PE (1) PE20010913A1 (forum.php)
PL (1) PL344208A1 (forum.php)
SG (1) SG102603A1 (forum.php)
SK (1) SK17792000A3 (forum.php)
TN (1) TNSN00230A1 (forum.php)
TW (1) TW591016B (forum.php)
UA (1) UA65615C2 (forum.php)
UY (1) UY26451A1 (forum.php)
YU (1) YU71500A (forum.php)
ZA (1) ZA200006947B (forum.php)

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HN2000000203A (es) * 1999-11-30 2001-06-13 Pfizer Prod Inc Procedimiento para la obtencion de 1,2,3,4-tetrahidroquinolinas 4-carboxiamino-2- sustituidas.
HUP0500165A2 (en) * 2001-12-19 2006-09-28 Atherogenics Inc Chalcone derivatives and their use to treat diseases
US7202247B2 (en) 2001-12-19 2007-04-10 Atherogenics, Inc. 1,3-bis-(substituted-phenyl)-2-propyn-1-ones and their use to treat disorders
DE60323954D1 (de) * 2002-04-11 2008-11-20 Roar Holding Llc Ex-vivo-verfahren zur bestimmung der cetp-aktivität und der wirksamkeit der behandlung von herzerkrankungen
US7504508B2 (en) * 2002-10-04 2009-03-17 Millennium Pharmaceuticals, Inc. PGD2 receptor antagonists for the treatment of inflammatory diseases
EA011385B1 (ru) * 2002-10-04 2009-02-27 Миллениум Фармасьютикалз, Инк. Антагонисты рецептора pgd2 для лечения воспалительных заболеваний
US20090181966A1 (en) * 2002-10-04 2009-07-16 Millennium Pharmaceuticals, Inc. PGD2 receptor antagonists for the treatment of inflammatory diseases
US7223870B2 (en) * 2002-11-01 2007-05-29 Pfizer Inc. Methods for preparing N-arylated oxazolidinones via a copper catalyzed cross coupling reaction
US20040181075A1 (en) * 2002-12-19 2004-09-16 Weingarten M. David Process of making chalcone derivatives
US20040132771A1 (en) * 2002-12-20 2004-07-08 Pfizer Inc Compositions of choleseteryl ester transfer protein inhibitors and HMG-CoA reductase inhibitors
BR0317521A (pt) 2002-12-20 2005-11-16 Pfizer Prod Inc Formas de dosagem compreendendo um inibidor da cetp e um inibidor da redutase hmg-coa
US20060100239A1 (en) * 2003-03-04 2006-05-11 Izuru Nagasaki Method for producing optically active amines
EP2289507A1 (en) * 2003-03-17 2011-03-02 Japan Tobacco, Inc. Pharmaceutical compositions of CETP inhibitors
US7276536B2 (en) * 2003-03-17 2007-10-02 Japan Tobacco Inc. Method for increasing the bioavailability of the active form of S-[2-([[1-(2-ethylbutyl)cyclohexyl]carbonyl]amino) phenyl] 2-methylpropanethioate
TWI393560B (zh) * 2003-05-02 2013-04-21 Japan Tobacco Inc 包含ｓ-〔２（〔〔１-（２-乙基丁基）環己基〕羰基〕胺基）苯基〕２-甲基丙烷硫酯及ｈｍｇ輔酶ａ還原酶抑制劑之組合
EA200600737A1 (ru) * 2003-10-08 2006-10-27 Эли Лилли Энд Компани Соединения и способы для лечения дислипидемии
UA90269C2 (ru) * 2004-04-02 2010-04-26 Мицубиси Танабе Фарма Корпорейшн Тетрагидрохинолиновые производные и способ их получения
US20080269284A1 (en) * 2004-06-24 2008-10-30 Eli Lilly And Company Compounds and Methods for Treating Dyslipidemia
DOP2005000123A (es) * 2004-07-02 2011-07-15 Merck Sharp & Dohme Inhibidores de cetp
WO2006033001A1 (en) * 2004-09-23 2006-03-30 Pfizer Products Inc. Quinoline compounds
WO2006069162A1 (en) * 2004-12-20 2006-06-29 Reddy Us Therapeutics, Inc. Novel heterocyclic compounds and their pharmaceutical compositions
MX2007010215A (es) * 2005-02-24 2007-11-07 Millennium Pharm Inc Antagonistas del receptor pgd2 para el tratamiento de enfermedades inflamatorias.
UY30244A1 (es) 2006-03-30 2007-11-30 Tanabe Seiyaku Co Un proceso para preparar derivados de tetrahidroquinolina
CL2008000684A1 (es) 2007-03-09 2008-08-01 Indigene Pharmaceuticals Inc Composicion farmaceutica que comprende metformina r-(+) lipoato y un inhibidor de reductasa hmg-coa; formulacion de dosis unitaria; y uso en el tratamiento de una complicacion diabetica.
CN101429160B (zh) * 2007-11-06 2011-10-19 上海药明康德新药开发有限公司 一种1-r-4-氨基-1,2,3,4-四氢喹啉的合成方法
AR077208A1 (es) * 2009-06-30 2011-08-10 Lilly Co Eli Derivados del acido trans-4-[[(5s)-5-[[[3,5-bis(trifluorometil) fenil] metil] (2-metil-2h-tetrazol-5-il) amino) -2,3,4,5-tetrahidro-7,9-dimetil-1h-1-benzazepin-1-il) metil)-ciclohexancarboxilico y sus formas cristalinas, composiciones farmaceuticas que los comprenden, su uso para preparar un medicam
US12006305B2 (en) 2022-07-05 2024-06-11 Newamsterdam Pharma B.V. Salts of obicetrapib and processes for their manufacture and intermediates thereof

Family Cites Families (11)

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Publication number Priority date Publication date Assignee Title
FR7870M (forum.php) * 1968-11-08 1970-04-27
US3971789A (en) 1972-10-21 1976-07-27 John Wyeth & Brother Limited O-(4-Quinolylamino)benzamides
GB8432091D0 (en) 1984-12-19 1985-01-30 Wyeth John & Brother Ltd 4-aminoquinoline derivatives
US4839368A (en) 1986-05-02 1989-06-13 Mochida Pharmaceutical Co., Ltd. 1-acyl-2,3-dihydro-4(1H)-quinolinone-4-oxime derivatives
GB8804444D0 (en) 1988-02-25 1988-03-23 Smithkline Beckman Intercredit Compounds
US5231102A (en) 1989-03-08 1993-07-27 Merck Sharp & Dohme, Ltd. Tetrahydroquinoline derivatives useful for neurodegenerative disorders
PT100905A (pt) * 1991-09-30 1994-02-28 Eisai Co Ltd Compostos heterociclicos azotados biciclicos contendo aneis de benzeno, ciclo-hexano ou piridina e de pirimidina, piridina ou imidazol substituidos e composicoes farmaceuticas que os contem
US6197786B1 (en) 1998-09-17 2001-03-06 Pfizer Inc 4-Carboxyamino-2-substituted-1,2,3,4-tetrahydroquinolines
US6140342A (en) 1998-09-17 2000-10-31 Pfizer Inc. Oxy substituted 4-carboxyamino-2-methyl-1,2,3,4-tetrahydroquinolines
US6147089A (en) 1998-09-17 2000-11-14 Pfizer Inc. Annulated 4-carboxyamino-2-methyl-1,2,3,4,-tetrahydroquinolines
HN2000000203A (es) * 1999-11-30 2001-06-13 Pfizer Prod Inc Procedimiento para la obtencion de 1,2,3,4-tetrahidroquinolinas 4-carboxiamino-2- sustituidas.

Also Published As

Publication number Publication date
SG102603A1 (en) 2004-03-26
PE20010913A1 (es) 2001-09-10
AR029775A1 (es) 2003-07-16
HN2000000203A (es) 2001-06-13
IL139849A (en) 2006-10-31
HUP0004747A2 (hu) 2001-10-28
KR100408177B1 (ko) 2003-12-01
CY1104989T1 (el) 2010-03-03
IS5715A (is) 2001-05-31
HRP20000804A2 (en) 2001-06-30
DE60025317T2 (de) 2006-08-03
HU0004747D0 (forum.php) 2001-02-28
TNSN00230A1 (fr) 2005-11-10
CZ20004407A3 (cs) 2002-06-12
AP2000002011A0 (en) 2000-12-31
PA8503801A1 (es) 2002-07-30
DE60025317D1 (de) 2006-03-30
EP1125929B1 (en) 2006-01-04
CA2327029C (en) 2005-08-09
JP2001163859A (ja) 2001-06-19
CA2327029A1 (en) 2001-05-30
CN1173953C (zh) 2004-11-03
EA003668B1 (ru) 2003-08-28
ATE315028T1 (de) 2006-02-15
EA200001129A3 (ru) 2001-10-22
NO20006039D0 (no) 2000-11-29
EE200000659A (et) 2001-08-15
CN1302800A (zh) 2001-07-11
KR20010052012A (ko) 2001-06-25
UY26451A1 (es) 2001-06-29
EP1125929A1 (en) 2001-08-22
AU784694B2 (en) 2006-06-01
BG105009A (en) 2001-11-30
GT200000190A (es) 2002-04-27
IL139849A0 (en) 2002-02-10
BR0005636A (pt) 2001-07-17
MA25223A1 (fr) 2001-07-02
ZA200006947B (en) 2002-05-27
SK17792000A3 (sk) 2002-10-08
OA11494A (en) 2004-05-07
DZ3079A1 (fr) 2004-10-24
CO5261552A1 (es) 2003-03-31
DK1125929T3 (da) 2006-04-03
AU7178900A (en) 2001-05-31
NO20006039L (no) 2001-05-31
UA65615C2 (uk) 2004-04-15
TW591016B (en) 2004-06-11
ID28489A (id) 2001-05-31
HUP0004747A3 (en) 2002-12-28
YU71500A (sh) 2003-02-28
ES2254109T3 (es) 2006-06-16
EA200001129A2 (ru) 2001-06-25
NZ508509A (en) 2001-06-29
US6313142B1 (en) 2001-11-06
JP3579345B2 (ja) 2004-10-20
PL344208A1 (en) 2001-06-04
HK1038007A1 (en) 2002-03-01

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