KR960014121A - 아로일-피페리딘 유도체 - Google Patents
아로일-피페리딘 유도체 Download PDFInfo
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- KR960014121A KR960014121A KR1019950035296A KR19950035296A KR960014121A KR 960014121 A KR960014121 A KR 960014121A KR 1019950035296 A KR1019950035296 A KR 1019950035296A KR 19950035296 A KR19950035296 A KR 19950035296A KR 960014121 A KR960014121 A KR 960014121A
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Abstract
본 발명은 하기 일반식(I)의 신규한 N-(3,5-비스-트리플루오로메틸-벤조일)-2-벤질-4-(아자나프토일-아미노)-피페리딘 및 그의 염, 그의 용도, 그의 제조 방법 및 본 발명에 따른 화합물 또는 그의 제약상 허용되는 염을 포함하는 제약 조성물에 관한 것이다.
상기 식 중, X 및 Y는 각각 독립해서 다른 N 및 (또는) CH이고, 고리 A는 비치환되거나 또는 저급 알킬, 저급 알콕시, 할로겐, 니트로 및 트리플루오로메틸로 구성되는 군으로부터 선택되는 치환체에 의해 일- 또는 다-치환되는 것이다.
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (8)
- 하기 일반식(I)의 화합물 또는 그의 염.상기 식 중, X 및 Y는 각각 독립해서 다른 N 및 (또는) CH이고, 고리 A는 비치환되거나 또는 저급 알킬, 저급 알콕시, 할로겐, 니트로 및 트리플루오로메틸로 구성되는 군으로부터 선택되는 치환체에 의해 일- 또는 다-치환되는 것이다.
- 제1항에 있어서, 하기 일반식(IA)의 화합물 및 그의 염.상기 식 중, X는 CH 또는 N이고, Y는 N이며, Z는 수소, 할로겐 또는 니트로이다.
- 제2항에 있어서, X는N 또는 CH이고, Y는 X이며, X는 할로겐인 일반식 (IA)의 화합물 또는 그의 염.
- (2R, 4S)-N-〔1-(3,5-비스-트리풀루오로메틸-벤조일)-2-벤질-피페리딘-4-일〕-퀴놀린-4-카르복스아미드, (2R, 4S)-N-〔1-(3,5-비스-트리플루오로메틸-벤조일)-2-벤질-피페리딘-4-일〕-퀴나졸린-4-카르복스아미드, (2R, 4S)-N-〔1-(3,5-비스-트리풀루오로메틸-벤조일)-2-(4-클로로-벤질)-피페리딘-4-일〕-퀴놀린-4-카르복스아미드, (2R, 4S)-N-〔1-(3,5-비스-트리플루오로메틸-벤조일)-2-(4-클로로-벤질)-피페리딘-4-일〕-퀴나졸린-4-카르복스아미드, (2R, 4S)-N-〔1-(3,5-비스-트리플루오로메틸-벤조일)-2-(4-클로로-벤질)-피페리딘-4-일〕-이소퀴놀린-4-카르복스아미드 및 (2R, 4S)-N-〔1-(3,5-비스-트리플루오로메틸-벤조일)-2-(4-니트로-벤질)-피페리딘-4-일〕-퀴나졸린-4-카르복스아미드로 이루어지는 군으로 부터 선택되는 화합물 또는 그의 염.
- 사람 또는 동물의 신체를 치료하는 방법에 사용하기 위한 제1항 내지 제4항 중 어느 한 항에 따른 화합물 또는 그의 제약상 허용되는 염.
- 제1항 내지 제4항 중 어느 한 항에 따른 화합물 또는 그의 제약상 허용되는 염을 포함하는 제약 조성물.
- 물질 P에 의해 유발되는 질환을 치료하기 위한 제약 조성물 제조시 제1항 내지 제4항 중 어느 한 항에 따른 화합물의 용도
- a) 하기 일반식 (IIa)의 화합물을 하기 일반식(IIb)의 화합물 또는 그의 염과 반응시키거나, 또는(식 중, X 및 Y는 제1항에서 정의된 바와 같고, 고리 A는 비치환되건 또는 제1항에서 기술된 바와 같이 치환됨)(식 중, Q1은 유리 또는 에테르화 히드록시 또는 반응성 에스테르화 히드록시 또는의 기임), b) 하기 일반식 (IIIa)의 화합물을 하기 일반식 (IIIb)의 화합물 또는 그의 염과 반응시키고,(식 중, 고리 A는 비치환되거나 또는 제1항에 기술된 바와 같이 치환됨)(식 중, X 및 Y는 제1항에 정의된 바와 같고, Q1은 유리 또는 에테르화 히드록시 또는 반응성 에스테르화 히드록시 또는의 기임), 필요한 경우 이 방법에 의해 얻을 수 있는 이성질체 혼합물을 분리시키고, 목적하는 이성질체를 단리시키고(또는) 이 방법에 의해 얻을 수 있는 유리 화합물 (I) 또는 (IA)를 염으로 전환시키거나 또는 이 방법에 의해 얻을 수 있는 화합물 (I) 또는 (IA)의 염을 유리 화합물 (I) 또는 (IA) 또는 상이한 염으로 전환시키는 것을 포함하는, 제1항 내지 제4항 중 어느 한 항에 따른 화합물의 제조 방법.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CH3091/94-2 | 1994-10-14 | ||
CH309194 | 1994-10-14 |
Publications (2)
Publication Number | Publication Date |
---|---|
KR960014121A true KR960014121A (ko) | 1996-05-22 |
KR100413985B1 KR100413985B1 (ko) | 2004-03-26 |
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ID=4248427
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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KR1019950035296A KR100413985B1 (ko) | 1994-10-14 | 1995-10-13 | 아로일-피페리딘유도체 |
Country Status (23)
Country | Link |
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US (1) | US5965562A (ko) |
EP (1) | EP0707006B1 (ko) |
JP (1) | JP3022951B2 (ko) |
KR (1) | KR100413985B1 (ko) |
CN (1) | CN1066445C (ko) |
AT (1) | ATE178602T1 (ko) |
AU (1) | AU705851B2 (ko) |
CA (1) | CA2160444C (ko) |
DE (1) | DE59505575D1 (ko) |
DK (1) | DK0707006T3 (ko) |
ES (1) | ES2132580T3 (ko) |
FI (1) | FI114795B (ko) |
GR (1) | GR3030515T3 (ko) |
HU (1) | HUT74103A (ko) |
IL (1) | IL115572A (ko) |
MX (1) | MX9504349A (ko) |
MY (1) | MY114679A (ko) |
NO (1) | NO308034B1 (ko) |
NZ (1) | NZ280212A (ko) |
RU (1) | RU2158731C2 (ko) |
SA (1) | SA96160637B1 (ko) |
TW (1) | TW397825B (ko) |
ZA (1) | ZA958647B (ko) |
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WO2015034925A1 (en) | 2013-09-03 | 2015-03-12 | Moderna Therapeutics, Inc. | Circular polynucleotides |
EP3706742B1 (en) | 2017-11-08 | 2023-03-15 | Merck Sharp & Dohme LLC | Prmt5 inhibitors |
WO2020033284A1 (en) | 2018-08-07 | 2020-02-13 | Merck Sharp & Dohme Corp. | Prmt5 inhibitors |
US11993602B2 (en) | 2018-08-07 | 2024-05-28 | Merck Sharp & Dohme Llc | PRMT5 inhibitors |
CN111808017B (zh) * | 2020-08-05 | 2023-11-28 | 国家纳米科学中心 | 一种含氮杂环化合物及其制备方法和应用 |
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Publication number | Priority date | Publication date | Assignee | Title |
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MX18467A (es) * | 1988-11-23 | 1993-07-01 | Pfizer | Agentes terapeuticos de quinuclidinas |
US5145967A (en) * | 1989-04-20 | 1992-09-08 | Anaquest, Inc. | Method for preparing 4-alkoxyalkyl-4-phenylaminopiperdines and derivatives thereof |
FI97540C (fi) * | 1989-11-06 | 1997-01-10 | Sanofi Sa | Menetelmä terapeuttisesti käyttökelpoisten, aromaattisesti substituoitujen piperidiini- ja piperatsiinijohdannaisten valmistamiseksi |
FR2654725B1 (fr) * | 1989-11-23 | 1992-02-14 | Rhone Poulenc Sante | Nouveaux derives de l'isoindolone, leur preparation et les compositions pharmaceutiques qui les contiennent. |
US5126455A (en) * | 1989-12-13 | 1992-06-30 | Glaxo Inc. | Preparation of substituted alkali metal piperidine-4-carboxylates |
KR0160142B1 (ko) * | 1990-05-31 | 1998-12-01 | 알렌 제이. 스피겔 | 치환된 피페리딘의 제조방법 |
JPH072740B2 (ja) * | 1990-06-01 | 1995-01-18 | フアイザー・インコーポレイテツド | 3―アミノ―2―アリールキヌクリジン |
AU651145B2 (en) * | 1990-09-28 | 1994-07-14 | Pfizer Inc. | Fused ring analogs of nitrogen containing nonaromatic heterocycles |
MY110227A (en) * | 1991-08-12 | 1998-03-31 | Ciba Geigy Ag | 1-acylpiperindine compounds. |
TW397825B (en) * | 1994-10-14 | 2000-07-11 | Novartis Ag | Aroyl-piperidine derivatives |
-
1995
- 1995-10-02 TW TW084110255A patent/TW397825B/zh not_active IP Right Cessation
- 1995-10-05 AT AT95810628T patent/ATE178602T1/de active
- 1995-10-05 DE DE59505575T patent/DE59505575D1/de not_active Expired - Lifetime
- 1995-10-05 DK DK95810628T patent/DK0707006T3/da active
- 1995-10-05 EP EP95810628A patent/EP0707006B1/de not_active Expired - Lifetime
- 1995-10-05 ES ES95810628T patent/ES2132580T3/es not_active Expired - Lifetime
- 1995-10-10 AU AU33174/95A patent/AU705851B2/en not_active Ceased
- 1995-10-10 MY MYPI95003026A patent/MY114679A/en unknown
- 1995-10-11 IL IL11557295A patent/IL115572A/en not_active IP Right Cessation
- 1995-10-11 FI FI954829A patent/FI114795B/fi not_active IP Right Cessation
- 1995-10-12 CA CA002160444A patent/CA2160444C/en not_active Expired - Fee Related
- 1995-10-12 NZ NZ280212A patent/NZ280212A/en not_active IP Right Cessation
- 1995-10-13 NO NO954067A patent/NO308034B1/no not_active IP Right Cessation
- 1995-10-13 ZA ZA958647A patent/ZA958647B/xx unknown
- 1995-10-13 KR KR1019950035296A patent/KR100413985B1/ko not_active IP Right Cessation
- 1995-10-13 MX MX9504349A patent/MX9504349A/es unknown
- 1995-10-13 RU RU95117719/04A patent/RU2158731C2/ru not_active IP Right Cessation
- 1995-10-13 CN CN95116776A patent/CN1066445C/zh not_active Expired - Fee Related
- 1995-10-13 JP JP7265610A patent/JP3022951B2/ja not_active Expired - Fee Related
- 1995-10-13 HU HU9502973A patent/HUT74103A/hu not_active Application Discontinuation
-
1996
- 1996-03-02 SA SA96160637A patent/SA96160637B1/ar unknown
-
1997
- 1997-10-30 US US08/961,546 patent/US5965562A/en not_active Expired - Fee Related
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1999
- 1999-06-15 GR GR990401590T patent/GR3030515T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
CN1133839A (zh) | 1996-10-23 |
DE59505575D1 (de) | 1999-05-12 |
NO954067D0 (no) | 1995-10-13 |
IL115572A0 (en) | 1996-01-19 |
HUT74103A (en) | 1996-11-28 |
JP3022951B2 (ja) | 2000-03-21 |
AU3317495A (en) | 1996-04-26 |
CA2160444C (en) | 2006-11-28 |
MX9504349A (es) | 1997-03-29 |
IL115572A (en) | 2001-05-20 |
KR100413985B1 (ko) | 2004-03-26 |
DK0707006T3 (da) | 1999-10-18 |
EP0707006A1 (de) | 1996-04-17 |
ZA958647B (en) | 1996-04-15 |
ES2132580T3 (es) | 1999-08-16 |
CA2160444A1 (en) | 1996-04-15 |
NO308034B1 (no) | 2000-07-10 |
US5965562A (en) | 1999-10-12 |
NZ280212A (en) | 2001-10-26 |
GR3030515T3 (en) | 1999-10-29 |
AU705851B2 (en) | 1999-06-03 |
HU9502973D0 (en) | 1995-12-28 |
SA96160637B1 (ar) | 2005-06-14 |
FI114795B (fi) | 2004-12-31 |
MY114679A (en) | 2002-12-31 |
JPH08176145A (ja) | 1996-07-09 |
RU2158731C2 (ru) | 2000-11-10 |
CN1066445C (zh) | 2001-05-30 |
NO954067L (no) | 1996-04-15 |
ATE178602T1 (de) | 1999-04-15 |
TW397825B (en) | 2000-07-11 |
FI954829A (fi) | 1996-04-15 |
FI954829A0 (fi) | 1995-10-11 |
EP0707006B1 (de) | 1999-04-07 |
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