KR960014121A - 아로일-피페리딘 유도체 - Google Patents

아로일-피페리딘 유도체 Download PDF

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KR960014121A
KR960014121A KR1019950035296A KR19950035296A KR960014121A KR 960014121 A KR960014121 A KR 960014121A KR 1019950035296 A KR1019950035296 A KR 1019950035296A KR 19950035296 A KR19950035296 A KR 19950035296A KR 960014121 A KR960014121 A KR 960014121A
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compound
salt
formula
benzoyl
benzyl
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KR1019950035296A
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KR100413985B1 (ko
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오프네르 질비오
자코프 베엔스트라 지엠
쉴링 발테르
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베르너 발데크
시바-가이기 아게
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    • C07—ORGANIC CHEMISTRY
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    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
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    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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Abstract

본 발명은 하기 일반식(I)의 신규한 N-(3,5-비스-트리플루오로메틸-벤조일)-2-벤질-4-(아자나프토일-아미노)-피페리딘 및 그의 염, 그의 용도, 그의 제조 방법 및 본 발명에 따른 화합물 또는 그의 제약상 허용되는 염을 포함하는 제약 조성물에 관한 것이다.
상기 식 중, X 및 Y는 각각 독립해서 다른 N 및 (또는) CH이고, 고리 A는 비치환되거나 또는 저급 알킬, 저급 알콕시, 할로겐, 니트로 및 트리플루오로메틸로 구성되는 군으로부터 선택되는 치환체에 의해 일- 또는 다-치환되는 것이다.

Description

아로일-피페리딘 유도체
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (8)

  1. 하기 일반식(I)의 화합물 또는 그의 염.
    상기 식 중, X 및 Y는 각각 독립해서 다른 N 및 (또는) CH이고, 고리 A는 비치환되거나 또는 저급 알킬, 저급 알콕시, 할로겐, 니트로 및 트리플루오로메틸로 구성되는 군으로부터 선택되는 치환체에 의해 일- 또는 다-치환되는 것이다.
  2. 제1항에 있어서, 하기 일반식(IA)의 화합물 및 그의 염.
    상기 식 중, X는 CH 또는 N이고, Y는 N이며, Z는 수소, 할로겐 또는 니트로이다.
  3. 제2항에 있어서, X는N 또는 CH이고, Y는 X이며, X는 할로겐인 일반식 (IA)의 화합물 또는 그의 염.
  4. (2R, 4S)-N-〔1-(3,5-비스-트리풀루오로메틸-벤조일)-2-벤질-피페리딘-4-일〕-퀴놀린-4-카르복스아미드, (2R, 4S)-N-〔1-(3,5-비스-트리플루오로메틸-벤조일)-2-벤질-피페리딘-4-일〕-퀴나졸린-4-카르복스아미드, (2R, 4S)-N-〔1-(3,5-비스-트리풀루오로메틸-벤조일)-2-(4-클로로-벤질)-피페리딘-4-일〕-퀴놀린-4-카르복스아미드, (2R, 4S)-N-〔1-(3,5-비스-트리플루오로메틸-벤조일)-2-(4-클로로-벤질)-피페리딘-4-일〕-퀴나졸린-4-카르복스아미드, (2R, 4S)-N-〔1-(3,5-비스-트리플루오로메틸-벤조일)-2-(4-클로로-벤질)-피페리딘-4-일〕-이소퀴놀린-4-카르복스아미드 및 (2R, 4S)-N-〔1-(3,5-비스-트리플루오로메틸-벤조일)-2-(4-니트로-벤질)-피페리딘-4-일〕-퀴나졸린-4-카르복스아미드로 이루어지는 군으로 부터 선택되는 화합물 또는 그의 염.
  5. 사람 또는 동물의 신체를 치료하는 방법에 사용하기 위한 제1항 내지 제4항 중 어느 한 항에 따른 화합물 또는 그의 제약상 허용되는 염.
  6. 제1항 내지 제4항 중 어느 한 항에 따른 화합물 또는 그의 제약상 허용되는 염을 포함하는 제약 조성물.
  7. 물질 P에 의해 유발되는 질환을 치료하기 위한 제약 조성물 제조시 제1항 내지 제4항 중 어느 한 항에 따른 화합물의 용도
  8. a) 하기 일반식 (IIa)의 화합물을 하기 일반식(IIb)의 화합물 또는 그의 염과 반응시키거나, 또는
    (식 중, X 및 Y는 제1항에서 정의된 바와 같고, 고리 A는 비치환되건 또는 제1항에서 기술된 바와 같이 치환됨)
    (식 중, Q1은 유리 또는 에테르화 히드록시 또는 반응성 에스테르화 히드록시 또는
    의 기임), b) 하기 일반식 (IIIa)의 화합물을 하기 일반식 (IIIb)의 화합물 또는 그의 염과 반응시키고,
    (식 중, 고리 A는 비치환되거나 또는 제1항에 기술된 바와 같이 치환됨)
    (식 중, X 및 Y는 제1항에 정의된 바와 같고, Q1은 유리 또는 에테르화 히드록시 또는 반응성 에스테르화 히드록시 또는
    의 기임), 필요한 경우 이 방법에 의해 얻을 수 있는 이성질체 혼합물을 분리시키고, 목적하는 이성질체를 단리시키고(또는) 이 방법에 의해 얻을 수 있는 유리 화합물 (I) 또는 (IA)를 염으로 전환시키거나 또는 이 방법에 의해 얻을 수 있는 화합물 (I) 또는 (IA)의 염을 유리 화합물 (I) 또는 (IA) 또는 상이한 염으로 전환시키는 것을 포함하는, 제1항 내지 제4항 중 어느 한 항에 따른 화합물의 제조 방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019950035296A 1994-10-14 1995-10-13 아로일-피페리딘유도체 KR100413985B1 (ko)

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CH3091/94-2 1994-10-14
CH309194 1994-10-14

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KR960014121A true KR960014121A (ko) 1996-05-22
KR100413985B1 KR100413985B1 (ko) 2004-03-26

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EP (1) EP0707006B1 (ko)
JP (1) JP3022951B2 (ko)
KR (1) KR100413985B1 (ko)
CN (1) CN1066445C (ko)
AT (1) ATE178602T1 (ko)
AU (1) AU705851B2 (ko)
CA (1) CA2160444C (ko)
DE (1) DE59505575D1 (ko)
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IL (1) IL115572A (ko)
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NO (1) NO308034B1 (ko)
NZ (1) NZ280212A (ko)
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IL115572A (en) 2001-05-20
MY114679A (en) 2002-12-31
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FI954829A0 (fi) 1995-10-11
KR100413985B1 (ko) 2004-03-26
HU9502973D0 (en) 1995-12-28
NO954067D0 (no) 1995-10-13
NO308034B1 (no) 2000-07-10
NZ280212A (en) 2001-10-26
JP3022951B2 (ja) 2000-03-21
IL115572A0 (en) 1996-01-19
AU705851B2 (en) 1999-06-03
EP0707006A1 (de) 1996-04-17
DE59505575D1 (de) 1999-05-12
CA2160444C (en) 2006-11-28
RU2158731C2 (ru) 2000-11-10
FI114795B (fi) 2004-12-31
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EP0707006B1 (de) 1999-04-07
TW397825B (en) 2000-07-11
CA2160444A1 (en) 1996-04-15
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AU3317495A (en) 1996-04-26
HUT74103A (en) 1996-11-28
ATE178602T1 (de) 1999-04-15
NO954067L (no) 1996-04-15
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