CO5200845A1 - Derivados del acido monociclico 4-fenilbutanoico como antagonista del receptor vitronectina - Google Patents

Derivados del acido monociclico 4-fenilbutanoico como antagonista del receptor vitronectina

Info

Publication number
CO5200845A1
CO5200845A1 CO00067158A CO00067158A CO5200845A1 CO 5200845 A1 CO5200845 A1 CO 5200845A1 CO 00067158 A CO00067158 A CO 00067158A CO 00067158 A CO00067158 A CO 00067158A CO 5200845 A1 CO5200845 A1 CO 5200845A1
Authority
CO
Colombia
Prior art keywords
pyridin
ethoxy
phenyl
butanoic acid
methylamino
Prior art date
Application number
CO00067158A
Other languages
English (en)
Inventor
Peter J Manley
William H Miller
Irene N Uzinkas
Original Assignee
Smithkline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Corp filed Critical Smithkline Beecham Corp
Publication of CO5200845A1 publication Critical patent/CO5200845A1/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pyridine Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • External Artificial Organs (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Un compuesto según la fórmula (l)<EMI FILE="00067158_1" ID="1" IMF=JPEG >en el queR1 es Het- o Ar;R2 es<EMI FILE="00067158_2" ID="2" IMF=JPEG >o una de sus sales farmacéuticamente aceptables.Un compuesto, que es:ácido ( + )-4-[4-[2-[6-(metilamino)piridin-2-il]-1-etoxi]-fenil]-3-[4-(trifluorometil)fenil]butanoico,ácido ( + )-4-[4-[2-[6-(metilamino)piridin-2-il]-etoxi]-fenil]-3- [4-[(N-metil-N-fenilamino)carbonil]-1,3-oxazol-2-il]butanoico;ácido ( + )-4-[4-[2-[6-(metilamino)piridin-2-iI]-1-etoxi]-fenil]- 3-[4-[(morfolin-4-il)carbonil]-1,3-oxazol-2-il]butanoico;ácido ( + )-4-[4-[2-[6-(metilamino)piridin-2-il]-1-etoxi]-fenil]-3-[4-[[N-metil-N-(2,2,2-trifluoroetil)amino]carbonil]-1,3-oxazol-2-il]butanoico;ácido ( + )-4-[4-[2-[6-(metilamino)piridin-2-il]-1-etoxi]-fenil]- 3-[4-(trifluorometil)tiazol-2-il]butanoico;ácido ( + )-4-[4[2-[6-(metilamino)piridin-2-il]-1-etoxi]-feniI]-3-(3-metiltiazol-2-il)butanoico; ácido ( S )-3-(3-fluorofenil)-4-[4-[2-(5,6,7,8-tetrahidro-1,8 -naftiridin-2-il)etoxi]fenil]butanoico;ácido ( + )-4-[4-[2-[6-(metilamino)piridin-2-il]-etoxi]-fenil]- 3-(piridin-3-il)butanoico;ácido ( S )-4-[4-[2-[6-(metilamino)piridin-2-il]-etoxi]-fenil]-3-(piridin-3-il)butanoico;oácido ( S )-3-(piridin-3-il)-4-[4-[2-(5,6,7,8-tetrahidro -1,8-naftiridin-2-il )etoxi]fenil]butanoico;o una de sus sales farmacéuticamente aceptables.
CO00067158A 1999-09-07 2000-09-06 Derivados del acido monociclico 4-fenilbutanoico como antagonista del receptor vitronectina CO5200845A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US15278099P 1999-09-07 1999-09-07

Publications (1)

Publication Number Publication Date
CO5200845A1 true CO5200845A1 (es) 2002-09-27

Family

ID=22544416

Family Applications (1)

Application Number Title Priority Date Filing Date
CO00067158A CO5200845A1 (es) 1999-09-07 2000-09-06 Derivados del acido monociclico 4-fenilbutanoico como antagonista del receptor vitronectina

Country Status (29)

Country Link
EP (1) EP1218005B1 (es)
JP (1) JP4685307B2 (es)
KR (1) KR100711170B1 (es)
CN (1) CN1236767C (es)
AR (1) AR025589A1 (es)
AT (1) ATE284870T1 (es)
AU (1) AU768918B2 (es)
BR (1) BR0013749A (es)
CA (1) CA2384671A1 (es)
CO (1) CO5200845A1 (es)
CZ (1) CZ2002822A3 (es)
DE (1) DE60016769T2 (es)
EG (1) EG24179A (es)
ES (1) ES2234658T3 (es)
GC (1) GC0000203A (es)
HK (1) HK1049110B (es)
HU (1) HUP0202710A3 (es)
IL (2) IL148325A0 (es)
MX (1) MXPA02002455A (es)
NO (1) NO322109B1 (es)
NZ (1) NZ517296A (es)
PE (1) PE20010582A1 (es)
PL (1) PL200404B1 (es)
PT (1) PT1218005E (es)
TR (1) TR200200614T2 (es)
TW (1) TWI255813B (es)
UY (1) UY26329A1 (es)
WO (1) WO2001017959A2 (es)
ZA (1) ZA200201780B (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6531494B1 (en) 2001-08-29 2003-03-11 Pharmacia Corporation Gem-substituted αvβ3 antagonists
US6982263B2 (en) 2001-06-08 2006-01-03 Boehringer Ingelheim Pharmaceuticals, Inc. Nitriles useful as reversible inhibitors of cysteine proteases
GB0315509D0 (en) 2003-07-02 2003-08-06 Meridica Ltd Dispensing device
AU2005219737B2 (en) * 2004-03-05 2009-11-19 Taisho Pharmaceutical Co., Ltd. Thiazole derivative
UA109786C2 (xx) 2010-07-14 2015-10-12 Гетероциклічні сполуки як агоністи ір-рецептора
EP2802589B1 (en) 2012-01-13 2016-01-06 Novartis AG Fused pyrroles as ip receptor agonists for the treatment of pulmonary arterial hypertension (pah) and related disorders
JP2016507582A (ja) 2013-02-13 2016-03-10 ノバルティス アーゲー Ｉｐ受容体アゴニスト複素環式化合物
CN108675954A (zh) * 2018-04-03 2018-10-19 爱斯特（成都）生物制药股份有限公司 2-氨基-3-羟甲基吡啶的一种制备方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH08325264A (ja) * 1995-05-31 1996-12-10 Sumitomo Metal Ind Ltd 新規２−芳香環置換−３−フェニルプロピオン酸またはアクリル酸誘導体
JPH08325263A (ja) * 1995-05-31 1996-12-10 Sumitomo Metal Ind Ltd 新規２−アミノ−３−フェニルプロピオン酸誘導体
TR199801255T2 (xx) * 1995-12-29 1998-10-21 Smithkline Beecham Corporation Vitronektin resept�r antagonistleri.
AU8750298A (en) * 1997-08-28 1999-03-22 Ono Pharmaceutical Co. Ltd. Peroxisome proliferator-activated receptor controllers
DZ2609A1 (fr) * 1997-09-19 2003-03-01 Smithkline Beecham Corp Composés nouveaux antagonistes des récepteurs de vitronectine et compositions pharmaceutiques les contenant.
AP2000001898A0 (en) * 1998-03-10 2000-09-30 Smithkline Beecham Corp Vitronectin receptor antagonists
AU748621B2 (en) * 1998-08-13 2002-06-06 Merck & Co., Inc. Integrin receptor antagonists

Also Published As

Publication number Publication date
HUP0202710A3 (en) 2003-06-30
PT1218005E (pt) 2005-05-31
PL354176A1 (en) 2003-12-29
AU7354300A (en) 2001-04-10
DE60016769D1 (de) 2005-01-20
WO2001017959A2 (en) 2001-03-15
ZA200201780B (en) 2003-05-28
HK1049110B (zh) 2005-07-22
NO20021113L (no) 2002-05-03
GC0000203A (en) 2006-03-29
NO322109B1 (no) 2006-08-14
DE60016769T2 (de) 2005-11-24
HK1049110A1 (en) 2003-05-02
UY26329A1 (es) 2001-07-31
CN1377269A (zh) 2002-10-30
KR20020027624A (ko) 2002-04-13
IL148325A0 (en) 2002-09-12
EP1218005B1 (en) 2004-12-15
EG24179A (en) 2008-09-28
JP2003508516A (ja) 2003-03-04
KR100711170B1 (ko) 2007-04-27
PE20010582A1 (es) 2001-06-23
ATE284870T1 (de) 2005-01-15
BR0013749A (pt) 2003-06-10
JP4685307B2 (ja) 2011-05-18
AR025589A1 (es) 2002-12-04
EP1218005A4 (en) 2002-10-09
MXPA02002455A (es) 2002-07-02
EP1218005A2 (en) 2002-07-03
ES2234658T3 (es) 2005-07-01
NO20021113D0 (no) 2002-03-06
IL148325A (en) 2007-06-03
CZ2002822A3 (cs) 2002-07-17
CA2384671A1 (en) 2001-03-15
TR200200614T2 (tr) 2002-07-22
TWI255813B (en) 2006-06-01
WO2001017959A3 (en) 2001-05-10
PL200404B1 (pl) 2009-01-30
AU768918B2 (en) 2004-01-08
HUP0202710A2 (hu) 2002-12-28
NZ517296A (en) 2003-11-28
CN1236767C (zh) 2006-01-18

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