CO4980868A1 - Composicion para tratar enfermedades respiratorias y de la piel - Google Patents

Composicion para tratar enfermedades respiratorias y de la piel

Info

Publication number
CO4980868A1
CO4980868A1 CO98075939A CO98075939A CO4980868A1 CO 4980868 A1 CO4980868 A1 CO 4980868A1 CO 98075939 A CO98075939 A CO 98075939A CO 98075939 A CO98075939 A CO 98075939A CO 4980868 A1 CO4980868 A1 CO 4980868A1
Authority
CO
Colombia
Prior art keywords
phenyl
thio
inflammation
propyl
hydroxy
Prior art date
Application number
CO98075939A
Other languages
English (en)
Inventor
K Jensen Peder
Richard R Lorber
Melvyn R Danzing
Paul T Medeiros
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Publication of CO4980868A1 publication Critical patent/CO4980868A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/10—Expectorants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/12—Mucolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/14—Antitussive agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Pain & Pain Management (AREA)
  • Immunology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Rheumatology (AREA)
  • Otolaryngology (AREA)
  • Biomedical Technology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)

Abstract

Una composición farmacéutica útil para el tratamiento delestornudo, picazón y goteo de la nariz, congestión nasal, enrojecimiento de los ojos, lagrimeo, picazón en los oídos o paladar, brevedad de la respiración, inflamación de la mucosa bronquial, Volumen Expiratorio Forzado En Un Segundo (FEV1 ) reducido, tos, erupción, picazón en la piel, dolores de cabeza y dolores persistentes y dolores asociados con la rinitis alérgica, rinitis alérgica permanente, resfríos comunes, otitis, sinusitis, alergia, asma, asma alérgico y/o inflamación, en un orgasmo de mamífero que necesita este tratamiento. La composición comprende: i) una cantidad efectiva de al menos un antagonista de leucotrieno seleccionado de g) montelukast, h) ácido 1-(((R)-(3-(2-(6,7-difluoro-2-quinolinil)etenil)fenil)-2-(2-(2-hidroxi-2-propil)fenil)tio)metilcilopropanoacético; i) ácido 1-(((1(R)-3(3-(2-(2,3-diclorotieno[3,2-b]piridin-5-il)-(E)-etenil)fenil-2-(2-(1-hidroxi-1-metiletil)fenil)propil)tio)metil)ciclopropano-acético; j) pranlukast; o k) zafirlukast; o l) ácido [2-[[2-(4-terc-butil-2-tiazolil)-5-benzofuranil]oximetil]fenil]acético; o su sal farmacéuticamente aceptable; mezclado con ii) una cantidad efectiva de al menos una antihistamina que es desacarboetoxiloratidina, cetirizina, fexofenadina, ebastina, astemizol, norastemizol, epinastina, efletirizina o su sal farmacéuticamente aceptable.
CO98075939A 1997-12-23 1998-12-22 Composicion para tratar enfermedades respiratorias y de la piel CO4980868A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US6863897P 1997-12-23 1997-12-23
US7863898P 1998-03-19 1998-03-19

Publications (1)

Publication Number Publication Date
CO4980868A1 true CO4980868A1 (es) 2000-11-27

Family

ID=26749192

Family Applications (1)

Application Number Title Priority Date Filing Date
CO98075939A CO4980868A1 (es) 1997-12-23 1998-12-22 Composicion para tratar enfermedades respiratorias y de la piel

Country Status (27)

Country Link
EP (1) EP1041990B1 (es)
JP (2) JP2001526232A (es)
KR (1) KR100737710B1 (es)
CN (1) CN1283115A (es)
AR (1) AR017224A1 (es)
AT (1) ATE331522T1 (es)
AU (1) AU758771B2 (es)
BR (1) BR9814417A (es)
CA (1) CA2315721C (es)
CO (1) CO4980868A1 (es)
CZ (1) CZ301349B6 (es)
DE (1) DE69835103T2 (es)
DK (1) DK1041990T3 (es)
ES (1) ES2263229T3 (es)
HK (1) HK1027502A1 (es)
HU (1) HUP0101369A3 (es)
ID (1) ID26390A (es)
IL (1) IL136461A0 (es)
MY (1) MY121744A (es)
NO (1) NO20003288L (es)
NZ (1) NZ520907A (es)
PE (1) PE20000126A1 (es)
PL (1) PL193131B1 (es)
PT (1) PT1041990E (es)
SA (1) SA99200013B1 (es)
SK (1) SK286103B6 (es)
WO (1) WO1999032125A1 (es)

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Also Published As

Publication number Publication date
SK8972000A3 (en) 2001-02-12
DK1041990T3 (da) 2006-10-02
PT1041990E (pt) 2006-10-31
AU758771B2 (en) 2003-03-27
ID26390A (id) 2000-12-21
CA2315721C (en) 2008-08-12
JP2011068679A (ja) 2011-04-07
DE69835103D1 (de) 2006-08-10
AU1907199A (en) 1999-07-12
MY121744A (en) 2006-02-28
SA99200013B1 (ar) 2006-10-02
ATE331522T1 (de) 2006-07-15
NZ520907A (en) 2004-05-28
DE69835103T2 (de) 2006-12-21
BR9814417A (pt) 2000-10-10
KR20010033485A (ko) 2001-04-25
NO20003288D0 (no) 2000-06-22
PL341343A1 (en) 2001-04-09
PL193131B1 (pl) 2007-01-31
HUP0101369A3 (en) 2002-11-28
EP1041990B1 (en) 2006-06-28
AR017224A1 (es) 2001-08-22
KR100737710B1 (ko) 2007-07-11
CZ301349B6 (cs) 2010-01-27
CZ20002198A3 (cs) 2000-11-15
JP2001526232A (ja) 2001-12-18
WO1999032125A1 (en) 1999-07-01
HUP0101369A2 (hu) 2002-03-28
EP1041990A1 (en) 2000-10-11
PE20000126A1 (es) 2000-02-23
CA2315721A1 (en) 1999-07-01
IL136461A0 (en) 2001-06-14
HK1027502A1 (en) 2001-01-19
CN1283115A (zh) 2001-02-07
SK286103B6 (sk) 2008-03-05
NO20003288L (no) 2000-08-22
ES2263229T3 (es) 2006-12-01

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