BR9814417A - Composição para o tratamento de doenças respiratórias e da pele, compreendendo pelo menos um antagonista de leucotrieno e pelo menos uma anti-histamina - Google Patents

Composição para o tratamento de doenças respiratórias e da pele, compreendendo pelo menos um antagonista de leucotrieno e pelo menos uma anti-histamina

Info

Publication number
BR9814417A
BR9814417A BR9814417-0A BR9814417A BR9814417A BR 9814417 A BR9814417 A BR 9814417A BR 9814417 A BR9814417 A BR 9814417A BR 9814417 A BR9814417 A BR 9814417A
Authority
BR
Brazil
Prior art keywords
phenyl
treatment
composition
antihistamine
respiratory
Prior art date
Application number
BR9814417-0A
Other languages
English (en)
Inventor
Peder K Jensen
Richard R Lorber
Melvyn R Danzig
Paul T Medeiros
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Publication of BR9814417A publication Critical patent/BR9814417A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/10—Expectorants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/12—Mucolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/14—Antitussive agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

Patente de Invenção: <B>"COMPOSIçãO PARA O TRATAMENTO DE DOENçAS RESPIRATóRIAS E DA PELE, COMPREENDENDO PELO MENOS UM ANTAGONISTA DE LEUCOTRIENO E PELO MENOS UMA ANTI-HISTAMINA"<D>. Composição farmacêutica utilizável no tratamento de espirros, nariz escorrendo coçando, congestão nasal, vermelhidão do olho, olhos lacrimejando, coceira das orelhas ou palato, falta da respiração, inflamação da mucosa bronquial, reduzido volume expiratório forçado em um segundo (FEV~ 1~), tosses, erupções, pele coçando, dores de cabeça, e dores associadas com rinite alérgica de estação, rinite alérgica perene, resfriados comuns, otite, sinusite, alergia, asma, asma alérgica e/ou inflamação, em um organismo de mamífero em necessidade deste tratamento. A composição compreende i) uma quantidade efetiva de pelo menos um antagonista de leucotrieno selecionado dentre a) um montelucasto, b) ácido 1-(((R)-(3-(2-(6,7-diflúor-2-quinolinil)etenil)fenil)-3-(2-(2-hidróxi-2-propil) fenil)tio) metilciclopropanoacético; c) ácido 1-(((1(R)-3-(3-(2-2,3-diclorotieno[3,2-b]piridin-5-il)(E)-etenil)fenil)-3-(2-( 1-hidróxi-1-metiletil)fenil)propil)tio) metil)ciclopropano acético; d) pranlucasto; ou e) zafirlucasto; ou f) ácido [2-[[2-(4-terc-butil-2-tiazolil)-5-benzofuranil]oximetil]fenil]acético; ou um sal farmaceuticamente aceitável do mesmo, em mistura com ii) uma quantidade efetiva de pelo menos uma anti-histamina que é descarboetoxiloratidina, cetirizina, fexofenadina, ebastina, astemizol, norastemizol, epinastina, efletirizina ou um sal farmaceuticamente aceitável da mesma.
BR9814417-0A 1997-12-23 1998-12-21 Composição para o tratamento de doenças respiratórias e da pele, compreendendo pelo menos um antagonista de leucotrieno e pelo menos uma anti-histamina BR9814417A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US6863897P 1997-12-23 1997-12-23
US7863898P 1998-03-19 1998-03-19
PCT/US1998/026223 WO1999032125A1 (en) 1997-12-23 1998-12-21 Composition for treating respiratory and skin diseases, comprising at least one leukotriene antagonist and at least one antihistamine

Publications (1)

Publication Number Publication Date
BR9814417A true BR9814417A (pt) 2000-10-10

Family

ID=26749192

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9814417-0A BR9814417A (pt) 1997-12-23 1998-12-21 Composição para o tratamento de doenças respiratórias e da pele, compreendendo pelo menos um antagonista de leucotrieno e pelo menos uma anti-histamina

Country Status (27)

Country Link
EP (1) EP1041990B1 (pt)
JP (2) JP2001526232A (pt)
KR (1) KR100737710B1 (pt)
CN (1) CN1283115A (pt)
AR (1) AR017224A1 (pt)
AT (1) ATE331522T1 (pt)
AU (1) AU758771B2 (pt)
BR (1) BR9814417A (pt)
CA (1) CA2315721C (pt)
CO (1) CO4980868A1 (pt)
CZ (1) CZ301349B6 (pt)
DE (1) DE69835103T2 (pt)
DK (1) DK1041990T3 (pt)
ES (1) ES2263229T3 (pt)
HK (1) HK1027502A1 (pt)
HU (1) HUP0101369A3 (pt)
ID (1) ID26390A (pt)
IL (1) IL136461A0 (pt)
MY (1) MY121744A (pt)
NO (1) NO20003288L (pt)
NZ (1) NZ520907A (pt)
PE (1) PE20000126A1 (pt)
PL (1) PL193131B1 (pt)
PT (1) PT1041990E (pt)
SA (1) SA99200013B1 (pt)
SK (1) SK286103B6 (pt)
WO (1) WO1999032125A1 (pt)

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Also Published As

Publication number Publication date
AR017224A1 (es) 2001-08-22
HK1027502A1 (en) 2001-01-19
DE69835103D1 (de) 2006-08-10
CA2315721A1 (en) 1999-07-01
CZ301349B6 (cs) 2010-01-27
AU1907199A (en) 1999-07-12
DK1041990T3 (da) 2006-10-02
IL136461A0 (en) 2001-06-14
SA99200013B1 (ar) 2006-10-02
NO20003288D0 (no) 2000-06-22
EP1041990B1 (en) 2006-06-28
KR20010033485A (ko) 2001-04-25
AU758771B2 (en) 2003-03-27
KR100737710B1 (ko) 2007-07-11
CZ20002198A3 (cs) 2000-11-15
PE20000126A1 (es) 2000-02-23
NO20003288L (no) 2000-08-22
SK286103B6 (sk) 2008-03-05
PT1041990E (pt) 2006-10-31
CN1283115A (zh) 2001-02-07
CA2315721C (en) 2008-08-12
SK8972000A3 (en) 2001-02-12
MY121744A (en) 2006-02-28
CO4980868A1 (es) 2000-11-27
JP2001526232A (ja) 2001-12-18
HUP0101369A3 (en) 2002-11-28
JP2011068679A (ja) 2011-04-07
PL193131B1 (pl) 2007-01-31
ID26390A (id) 2000-12-21
ES2263229T3 (es) 2006-12-01
EP1041990A1 (en) 2000-10-11
NZ520907A (en) 2004-05-28
ATE331522T1 (de) 2006-07-15
WO1999032125A1 (en) 1999-07-01
HUP0101369A2 (hu) 2002-03-28
DE69835103T2 (de) 2006-12-21
PL341343A1 (en) 2001-04-09

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