CO4700469A1 - 3-[4-(4(4-cianofenil)-1-piperazinanil)butil]-5]ciannoindol y su proceso de obtencion . - Google Patents

3-[4-(4(4-cianofenil)-1-piperazinanil)butil]-5]ciannoindol y su proceso de obtencion .

Info

Publication number
CO4700469A1
CO4700469A1 CO96016455A CO96016455A CO4700469A1 CO 4700469 A1 CO4700469 A1 CO 4700469A1 CO 96016455 A CO96016455 A CO 96016455A CO 96016455 A CO96016455 A CO 96016455A CO 4700469 A1 CO4700469 A1 CO 4700469A1
Authority
CO
Colombia
Prior art keywords
piperazinanil
cianofenil
ciannoindol
butil
obtaining
Prior art date
Application number
CO96016455A
Other languages
English (en)
Spanish (es)
Inventor
Bottcher Henning
Karl Ulrich Buhring
Hartmut Greiner
Gerd Bartoszyk
Christoph Seyfried
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of CO4700469A1 publication Critical patent/CO4700469A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Cardiology (AREA)
  • Anesthesiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
CO96016455A 1995-04-05 1996-04-03 3-[4-(4(4-cianofenil)-1-piperazinanil)butil]-5]ciannoindol y su proceso de obtencion . CO4700469A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19512639A DE19512639A1 (de) 1995-04-05 1995-04-05 Benzonitrile und -fluoride

Publications (1)

Publication Number Publication Date
CO4700469A1 true CO4700469A1 (es) 1998-12-29

Family

ID=7758788

Family Applications (1)

Application Number Title Priority Date Filing Date
CO96016455A CO4700469A1 (es) 1995-04-05 1996-04-03 3-[4-(4(4-cianofenil)-1-piperazinanil)butil]-5]ciannoindol y su proceso de obtencion .

Country Status (28)

Country Link
US (1) US6310068B1 (OSRAM)
EP (1) EP0736525B1 (OSRAM)
JP (1) JP3834098B2 (OSRAM)
KR (1) KR100437751B1 (OSRAM)
CN (1) CN1072209C (OSRAM)
AR (1) AR002982A1 (OSRAM)
AT (1) ATE194595T1 (OSRAM)
AU (1) AU709708B2 (OSRAM)
BR (1) BR9601275A (OSRAM)
CA (1) CA2173418C (OSRAM)
CO (1) CO4700469A1 (OSRAM)
CY (1) CY2242B1 (OSRAM)
CZ (1) CZ289449B6 (OSRAM)
DE (2) DE19512639A1 (OSRAM)
DK (1) DK0736525T3 (OSRAM)
ES (1) ES2150039T3 (OSRAM)
GR (1) GR3034514T3 (OSRAM)
HU (1) HUP9600876A3 (OSRAM)
NO (1) NO305903B1 (OSRAM)
PL (1) PL183147B1 (OSRAM)
PT (1) PT736525E (OSRAM)
RU (1) RU2168508C2 (OSRAM)
SI (1) SI0736525T1 (OSRAM)
SK (1) SK281457B6 (OSRAM)
TR (1) TR199600286A2 (OSRAM)
TW (1) TW323279B (OSRAM)
UA (1) UA45325C2 (OSRAM)
ZA (1) ZA962768B (OSRAM)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR004229A1 (es) * 1995-11-06 1998-11-04 Wyeth Corp Derivados indolalquilo de benzodioxanmetilamina y su uso para preparar medicamentos
US7189753B1 (en) 1997-11-06 2007-03-13 Cady Roger K Preemptive prophylaxis of migraine
US7517880B2 (en) 1997-12-22 2009-04-14 Bayer Pharmaceuticals Corporation Inhibition of p38 kinase using symmetrical and unsymmetrical diphenyl ureas
PT1147083E (pt) * 1999-01-07 2004-09-30 Wyeth Corp Derivados de arilpiperazinil-ciclohexilindole para o tratamento da depressao
EP1140840B1 (en) * 1999-01-13 2006-03-22 Bayer Pharmaceuticals Corp. -g(v)-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors
IL144144A0 (en) 1999-01-13 2002-05-23 Bayer Ag Omega-carboxy aryl substituted diphenyl ureas as p38 kinase inhibitors
US8124630B2 (en) 1999-01-13 2012-02-28 Bayer Healthcare Llc ω-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors
ME00275B (me) 1999-01-13 2011-02-10 Bayer Corp ω-KARBOKSIARIL SUPSTITUISANI DIFENIL KARBAMIDI KAO INHIBITORI RAF KINAZE
CZ302484B6 (cs) * 2000-11-14 2011-06-08 Merck Patent Gmbh Nové použití kombinovaných 5-HT1A agonistu a inhibitoru reabsorpce serotoninu
UA76130C2 (en) * 2000-11-20 2006-07-17 Merck Patent Gmbh Use of compounds combining properties of selective inhibitors of serotonin re-uptake and agonists of 5-ht1a receptor for treatment of irritable bowel syndrome
AR035521A1 (es) * 2000-12-22 2004-06-02 Lundbeck & Co As H Derivados de 3-indolina y composicion farmaceutica que los comprende
US7371763B2 (en) * 2001-04-20 2008-05-13 Bayer Pharmaceuticals Corporation Inhibition of raf kinase using quinolyl, isoquinolyl or pyridyl ureas
WO2003047579A1 (en) * 2001-12-03 2003-06-12 Bayer Pharmaceuticals Corporation Aryl urea compounds in combination with other cytostatic or cytotoxic agents for treating human cancers
US20030207872A1 (en) * 2002-01-11 2003-11-06 Bayer Corporation Omega-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors
WO2003068228A1 (en) 2002-02-11 2003-08-21 Bayer Pharmaceuticals Corporation Aryl ureas with angiogenesis inhibiting activity
WO2003068229A1 (en) 2002-02-11 2003-08-21 Bayer Pharmaceuticals Corporation Pyridine, quinoline, and isoquinoline n-oxides as kinase inhibitors
UY28213A1 (es) 2003-02-28 2004-09-30 Bayer Pharmaceuticals Corp Nuevos derivados de cianopiridina útiles en el tratamiento de cáncer y otros trastornos.
CA2526617C (en) 2003-05-20 2015-04-28 Bayer Pharmaceuticals Corporation Diaryl ureas with kinase inhibiting activity
CN102816113B (zh) 2003-07-23 2015-05-13 拜耳医药保健有限责任公司 用于治疗和预防疾病和疾病症状的氟代ω-羧芳基二苯基脲
TWI367098B (en) * 2004-12-23 2012-07-01 Kowa Co Treating agent for glaucoma
CN102875538A (zh) * 2012-10-16 2013-01-16 北京诚创思达医药科技有限公司 维拉唑酮或其盐酸盐的制备方法
WO2015014256A1 (en) 2013-07-29 2015-02-05 Sunshine Lake Pharma Co., Ltd. Substituted heteroaryl compounds and methods of use thereof
WO2015090235A1 (en) 2013-12-20 2015-06-25 Sunshine Lake Pharma Co., Ltd. Substituted piperazine compounds and methods of use thereof
WO2016192657A1 (en) 2015-06-03 2016-12-08 Sunshine Lake Pharma Co., Ltd. Substituted piperazine compounds and methods of use and use thereof
EP3687989B1 (en) 2017-09-29 2024-02-28 Sunshine Lake Pharma Co., Ltd. Substituted pyrimidine piperazine compound and use thereof
CN118834152B (zh) * 2023-04-23 2025-09-23 复旦大学附属肿瘤医院 一种维拉佐酮衍生物v02及其合成方法和在制备抗肿瘤药物中的应用

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1075156A (en) 1963-08-27 1967-07-12 Luso Farmaco Inst Substituted piperazines
US3468882A (en) 1966-10-07 1969-09-23 Sterling Drug Inc Phenylhydrazone derivatives as intermediates for preparing indoles
DE2138865A1 (de) 1970-08-15 1973-02-22 Sumitomo Chemical Co 3-indolylpiperazine, verfahren zu ihrer herstellung und arzneimittel
GB8830312D0 (en) 1988-12-28 1989-02-22 Lundbeck & Co As H Heterocyclic compounds
DE3923045A1 (de) * 1989-07-13 1991-01-17 Merck Patent Gmbh Indolderivate
DE4101686A1 (de) * 1991-01-22 1992-07-23 Merck Patent Gmbh Indolderivate
CA2092112A1 (en) * 1992-03-23 1993-09-24 Nobuyoshi Iwata Indole and indazole derivatives, for the treatment and prophylaxis of cerebral disorders, their preparation and their use

Also Published As

Publication number Publication date
CZ289449B6 (cs) 2002-01-16
ES2150039T3 (es) 2000-11-16
UA45325C2 (uk) 2002-04-15
CZ96496A3 (en) 1996-10-16
KR960037675A (ko) 1996-11-19
US6310068B1 (en) 2001-10-30
NO305903B1 (no) 1999-08-16
AU5040896A (en) 1996-10-17
PL313632A1 (en) 1996-10-14
EP0736525B1 (de) 2000-07-12
DE19512639A1 (de) 1996-10-10
DE59605568D1 (de) 2000-08-17
HUP9600876A3 (en) 2000-04-28
NO961346L (no) 1996-10-07
TW323279B (OSRAM) 1997-12-21
AU709708B2 (en) 1999-09-02
JP3834098B2 (ja) 2006-10-18
HUP9600876A2 (hu) 1998-09-28
TR199600286A2 (tr) 1997-03-21
ATE194595T1 (de) 2000-07-15
CN1072209C (zh) 2001-10-03
CA2173418C (en) 2007-06-12
PT736525E (pt) 2000-12-29
DK0736525T3 (da) 2000-10-30
SI0736525T1 (en) 2001-02-28
AR002982A1 (es) 1998-05-27
SK40396A3 (en) 1996-11-06
HU9600876D0 (en) 1996-05-28
CA2173418A1 (en) 1996-10-06
GR3034514T3 (en) 2000-12-29
PL183147B1 (pl) 2002-05-31
NO961346D0 (no) 1996-04-02
CY2242B1 (en) 2003-07-04
BR9601275A (pt) 1998-01-13
RU2168508C2 (ru) 2001-06-10
ZA962768B (en) 1996-11-13
SK281457B6 (sk) 2001-03-12
CN1137036A (zh) 1996-12-04
EP0736525A1 (de) 1996-10-09
KR100437751B1 (ko) 2004-08-25
JPH09151174A (ja) 1997-06-10

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