CO4480024A1 - Nuevos benzopiranos y otros antagonistas de b4(ltb4) leuco- triena fusionada con benzo - Google Patents
Nuevos benzopiranos y otros antagonistas de b4(ltb4) leuco- triena fusionada con benzoInfo
- Publication number
- CO4480024A1 CO4480024A1 CO95046243A CO95046243A CO4480024A1 CO 4480024 A1 CO4480024 A1 CO 4480024A1 CO 95046243 A CO95046243 A CO 95046243A CO 95046243 A CO95046243 A CO 95046243A CO 4480024 A1 CO4480024 A1 CO 4480024A1
- Authority
- CO
- Colombia
- Prior art keywords
- ltb4
- antagonists
- benzopyrans
- benzo
- new
- Prior art date
Links
- VNYSSYRCGWBHLG-AMOLWHMGSA-N leukotriene B4 Chemical compound CCCCC\C=C/C[C@@H](O)\C=C\C=C\C=C/[C@@H](O)CCCC(O)=O VNYSSYRCGWBHLG-AMOLWHMGSA-N 0.000 title abstract 4
- 239000005557 antagonist Substances 0.000 title abstract 3
- 150000001562 benzopyrans Chemical class 0.000 title abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 2
- 201000010099 disease Diseases 0.000 abstract 2
- 208000002874 Acne Vulgaris Diseases 0.000 abstract 1
- 208000023275 Autoimmune disease Diseases 0.000 abstract 1
- 201000004624 Dermatitis Diseases 0.000 abstract 1
- 201000004681 Psoriasis Diseases 0.000 abstract 1
- 206010000496 acne Diseases 0.000 abstract 1
- 206010003246 arthritis Diseases 0.000 abstract 1
- 208000006673 asthma Diseases 0.000 abstract 1
- 208000010668 atopic eczema Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 208000027866 inflammatory disease Diseases 0.000 abstract 1
- 230000003448 neutrophilic effect Effects 0.000 abstract 1
- 230000010412 perfusion Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/42—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms in positions 2 and 4
- C07D311/56—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms in positions 2 and 4 without hydrogen atoms in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C39/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring
- C07C39/12—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring polycyclic with no unsaturation outside the aromatic rings
- C07C39/14—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring polycyclic with no unsaturation outside the aromatic rings with at least one hydroxy group on a condensed ring system containing two rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Transplantation (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrane Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US32287694A | 1994-10-13 | 1994-10-13 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO4480024A1 true CO4480024A1 (es) | 1997-07-09 |
Family
ID=23256829
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CO95046243A CO4480024A1 (es) | 1994-10-13 | 1995-10-04 | Nuevos benzopiranos y otros antagonistas de b4(ltb4) leuco- triena fusionada con benzo |
Country Status (23)
| Country | Link |
|---|---|
| US (2) | US6051601A (cg-RX-API-DMAC7.html) |
| EP (1) | EP0785930A1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP2983295B2 (cg-RX-API-DMAC7.html) |
| KR (1) | KR100232341B1 (cg-RX-API-DMAC7.html) |
| CN (1) | CN1160399A (cg-RX-API-DMAC7.html) |
| AU (1) | AU696890B2 (cg-RX-API-DMAC7.html) |
| BR (1) | BR9504385A (cg-RX-API-DMAC7.html) |
| CA (1) | CA2201742A1 (cg-RX-API-DMAC7.html) |
| CO (1) | CO4480024A1 (cg-RX-API-DMAC7.html) |
| CZ (1) | CZ111797A3 (cg-RX-API-DMAC7.html) |
| FI (1) | FI971524A7 (cg-RX-API-DMAC7.html) |
| HU (1) | HUT77515A (cg-RX-API-DMAC7.html) |
| IL (1) | IL115529A0 (cg-RX-API-DMAC7.html) |
| MX (1) | MX9702731A (cg-RX-API-DMAC7.html) |
| NO (1) | NO971672L (cg-RX-API-DMAC7.html) |
| NZ (1) | NZ285156A (cg-RX-API-DMAC7.html) |
| PE (1) | PE10897A1 (cg-RX-API-DMAC7.html) |
| PL (1) | PL319688A1 (cg-RX-API-DMAC7.html) |
| RU (1) | RU2128655C1 (cg-RX-API-DMAC7.html) |
| TR (1) | TR199501270A2 (cg-RX-API-DMAC7.html) |
| TW (1) | TW304941B (cg-RX-API-DMAC7.html) |
| WO (1) | WO1996011920A1 (cg-RX-API-DMAC7.html) |
| ZA (1) | ZA958597B (cg-RX-API-DMAC7.html) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6096906A (en) * | 1996-09-16 | 2000-08-01 | Pfizer Inc. | Processes for preparing substituted chromanol derivatives |
| EP0961617A4 (en) * | 1996-12-13 | 2002-08-07 | Lilly Co Eli | LEUKOTRINE ANTAGONISTS FOR TREATING FOCAL BRAIN CHEMISTRY |
| IL128731A0 (en) * | 1998-03-12 | 2000-01-31 | Pfizer Prod Inc | Method of preventing allograft rejection |
| EP0963755A3 (en) * | 1998-04-16 | 2001-03-14 | Pfizer Products Inc. | Use of benzopyranes for preventing allograft rejection |
| SE0004245D0 (sv) | 2000-11-20 | 2000-11-20 | Pharmacia Ab | Novel compounds and their use |
| JP2004518685A (ja) * | 2001-01-30 | 2004-06-24 | ファイザー・プロダクツ・インク | クロマニル安息香酸の調製方法 |
| AU4239302A (en) * | 2001-06-28 | 2003-01-02 | Pfizer Products Inc. | Benzoic acid substituted benzopyrans for the treatment of atherosclerosis |
| NZ536664A (en) | 2002-06-19 | 2007-07-27 | Biovitrum Ab | Piperazinylpyrazine derivative compounds, their use and preparation |
| CN101014369A (zh) * | 2004-07-22 | 2007-08-08 | 法玛西亚公司 | 利用cox—2选择性抑制剂和ltb4受体拮抗剂的组合用于治疗炎症和疼痛的组合物 |
| US7674822B2 (en) | 2004-11-24 | 2010-03-09 | Wyeth | PTP1b inhibitors |
| AU2005316739A1 (en) | 2004-12-13 | 2006-06-22 | Galileo Pharmaceuticals, Inc. | Spiro derivatives as lipoxygenase inhibitors |
| BRPI0520097A2 (pt) | 2005-02-25 | 2009-08-25 | Lilly Co Eli | composto ou estereoisÈmeros únicos, misturas de estereoisÈmeros, ou sais farmaceuticamente aceitáveis dos mesmos, composição farmacêutica, e, uso de um composto ou um sal farmaceuticamente aceitável do mesmo |
| US7842713B2 (en) * | 2006-04-20 | 2010-11-30 | Pfizer Inc | Fused phenyl amido heterocyclic compounds |
| EP2034998A1 (en) | 2006-05-11 | 2009-03-18 | Janssen Pharmaceutica, N.V. | 1,2,3,4-tetrahydro-quinoline derivatives as cetp inhibitors |
| CA2651817A1 (en) | 2006-05-11 | 2007-11-22 | Janssen Pharmaceutica N.V. | 3,4-dihydro-2h-benzo[1,4]oxazine and thiazine derivatives as cetp inhibitors |
| GEP20135793B (en) | 2008-09-11 | 2013-03-25 | Pfizer | Heteroaryls amide derivatives and their use as glucokinase activators |
| ES2427279T3 (es) * | 2009-03-11 | 2013-10-29 | Pfizer Inc. | Derivados de benzofuranilo usados como inhibidores de glucocinasa |
| US9453022B2 (en) | 2012-02-14 | 2016-09-27 | Children's Hospital Medical Center | Use of small molecule inhibitors targeting the interaction between Rac GTPase and p67 (phox) |
| CN102920692A (zh) * | 2012-10-25 | 2013-02-13 | 中国人民解放军第二军医大学 | (e)-2-(1-羟基-4-环己酮)乙基咖啡酸酯在制备防治类风湿关节炎的药物中的应用 |
| CR20170420A (es) | 2015-03-13 | 2017-10-03 | Forma Therapeutics Inc | Compuestos y composiciones de alfa-cinamida como inhibidores de hdac8 |
| US10029995B2 (en) | 2015-09-03 | 2018-07-24 | Forma Therapeutics, Inc. | [6,6] fused bicyclic HDAC8 inhibitors |
| EP3383868B1 (en) | 2015-11-30 | 2022-10-05 | Merck Sharp & Dohme LLC | Aryl sulfonamides as blt1 antagonists |
| EP3383389B1 (en) | 2015-11-30 | 2021-04-28 | Merck Sharp & Dohme Corp. | Aryl acylsulfonamides as blt1 antagonists |
| WO2017095725A1 (en) | 2015-11-30 | 2017-06-08 | Merck Sharp & Dohme Corp. | Aryl sulfonamides as blt1 antagonists |
| EP3383388B1 (en) | 2015-11-30 | 2021-04-14 | Merck Sharp & Dohme Corp. | Aryl acylsulfonamides as blt1 antagonists |
| WO2018071687A1 (en) * | 2016-10-13 | 2018-04-19 | The Regents Of The University Of California | Methods of treating pruritis |
| CN119700747B (zh) * | 2025-02-26 | 2025-05-06 | 云南农业大学 | 苦杏碱醇a在制备防治骨质疏松症产品中的应用 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SU469247A3 (ru) * | 1972-01-14 | 1975-04-30 | Майлз Лабораториз Инк (Фирма) | Способ получени производных хромона |
| US4565882A (en) * | 1984-01-06 | 1986-01-21 | G. D. Searle & Co. | Substituted dihydrobenzopyran-2-carboxylates |
| CA1320490C (en) * | 1987-01-12 | 1993-07-20 | Darrel M. Gapinski | Anti-inflammatory agents |
| US4889871A (en) * | 1987-05-29 | 1989-12-26 | G. D. Searle & Co. | Alkoxy-substituted dihydrobenzopyran-2-carboxylate derivatives |
| CA2019335C (en) * | 1989-06-27 | 2000-08-01 | Mitoshi Konno | Phenylalkan (en)oic acids |
| US4996230A (en) * | 1990-02-16 | 1991-02-26 | Eli Lilly And Company | Leukotriene antagonists |
| US5073562A (en) * | 1990-05-10 | 1991-12-17 | G. D. Searle & Co. | Alkoxy-substituted dihydrobenzopyran-2-carboxylic acids and derivatives thereof |
| US5051438A (en) * | 1990-05-16 | 1991-09-24 | G. D. Searle & Co. | Alkoxy-substituted dihydrobenzopyran-2-carboxylic acids and derivatives thereof, compositions and use |
| US5124350A (en) * | 1990-06-28 | 1992-06-23 | G. D. Searle & Co. | Leukotriene b4 antagonists |
| MX9300312A (es) * | 1992-01-23 | 1993-07-31 | Pfizer | Antagonistas benzopiranicos y relacionado de ltb. |
| AU2773392A (en) * | 1992-01-23 | 1993-09-01 | Pfizer Inc. | Benzopyran and related LTB4 antagonists |
-
1995
- 1995-05-26 CZ CZ971117A patent/CZ111797A3/cs unknown
- 1995-05-26 PL PL95319688A patent/PL319688A1/xx unknown
- 1995-05-26 RU RU97105834A patent/RU2128655C1/ru active
- 1995-05-26 JP JP8513057A patent/JP2983295B2/ja not_active Expired - Lifetime
- 1995-05-26 KR KR1019970702392A patent/KR100232341B1/ko not_active Expired - Fee Related
- 1995-05-26 MX MX9702731A patent/MX9702731A/es unknown
- 1995-05-26 CN CN95195608A patent/CN1160399A/zh active Pending
- 1995-05-26 HU HU9702048A patent/HUT77515A/hu unknown
- 1995-05-26 CA CA002201742A patent/CA2201742A1/en not_active Abandoned
- 1995-05-26 AU AU24167/95A patent/AU696890B2/en not_active Ceased
- 1995-05-26 US US08/809,728 patent/US6051601A/en not_active Expired - Fee Related
- 1995-05-26 NZ NZ285156A patent/NZ285156A/xx unknown
- 1995-05-26 EP EP95918114A patent/EP0785930A1/en not_active Withdrawn
- 1995-05-26 WO PCT/IB1995/000401 patent/WO1996011920A1/en not_active Ceased
- 1995-10-04 CO CO95046243A patent/CO4480024A1/es unknown
- 1995-10-06 IL IL11552995A patent/IL115529A0/xx unknown
- 1995-10-10 PE PE1995281391A patent/PE10897A1/es not_active Application Discontinuation
- 1995-10-11 BR BR9504385A patent/BR9504385A/pt not_active Application Discontinuation
- 1995-10-12 ZA ZA958597A patent/ZA958597B/xx unknown
- 1995-10-13 TR TR95/01270A patent/TR199501270A2/xx unknown
- 1995-10-13 TW TW084110874A patent/TW304941B/zh active
-
1997
- 1997-04-11 NO NO971672A patent/NO971672L/no not_active Application Discontinuation
- 1997-04-11 FI FI971524A patent/FI971524A7/fi unknown
-
2000
- 2000-01-28 US US09/493,707 patent/US6133286A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US6051601A (en) | 2000-04-18 |
| BR9504385A (pt) | 1997-05-27 |
| AU2416795A (en) | 1996-05-06 |
| JPH09512035A (ja) | 1997-12-02 |
| CZ111797A3 (cs) | 1998-07-15 |
| NO971672L (no) | 1997-06-11 |
| FI971524A0 (fi) | 1997-04-11 |
| CN1160399A (zh) | 1997-09-24 |
| KR970706270A (ko) | 1997-11-03 |
| NZ285156A (en) | 1999-01-28 |
| WO1996011920A1 (en) | 1996-04-25 |
| MX9702731A (es) | 1997-06-28 |
| ZA958597B (en) | 1997-04-14 |
| TW304941B (cg-RX-API-DMAC7.html) | 1997-05-11 |
| JP2983295B2 (ja) | 1999-11-29 |
| PE10897A1 (es) | 1997-04-21 |
| PL319688A1 (en) | 1997-08-18 |
| KR100232341B1 (ko) | 2000-07-01 |
| US6133286A (en) | 2000-10-17 |
| NO971672D0 (no) | 1997-04-11 |
| EP0785930A1 (en) | 1997-07-30 |
| CA2201742A1 (en) | 1996-04-25 |
| HUT77515A (hu) | 1998-05-28 |
| IL115529A0 (en) | 1996-01-19 |
| RU2128655C1 (ru) | 1999-04-10 |
| TR199501270A2 (tr) | 1996-06-21 |
| AU696890B2 (en) | 1998-09-24 |
| FI971524A7 (fi) | 1997-04-11 |
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