NO971672L - Benzofuran og benzokondenserte forbindelser, deres fremstilling og deres anvendelse som leukotrien B4(LTB4)antagonister - Google Patents

Benzofuran og benzokondenserte forbindelser, deres fremstilling og deres anvendelse som leukotrien B4(LTB4)antagonister

Info

Publication number
NO971672L
NO971672L NO971672A NO971672A NO971672L NO 971672 L NO971672 L NO 971672L NO 971672 A NO971672 A NO 971672A NO 971672 A NO971672 A NO 971672A NO 971672 L NO971672 L NO 971672L
Authority
NO
Norway
Prior art keywords
ltb4
antagonists
compounds
benzo
heteroatoms
Prior art date
Application number
NO971672A
Other languages
English (en)
Other versions
NO971672D0 (no
Inventor
Mark A Dombroski
Kevin Koch
Anthony D Piscopio
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of NO971672D0 publication Critical patent/NO971672D0/no
Publication of NO971672L publication Critical patent/NO971672L/no

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/42—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms in positions 2 and 4
    • C07D311/56—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms in positions 2 and 4 without hydrogen atoms in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C39/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring
    • C07C39/12—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring polycyclic with no unsaturation outside the aromatic rings
    • C07C39/14—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring polycyclic with no unsaturation outside the aromatic rings with at least one hydroxy group on a condensed ring system containing two rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Transplantation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Oppfinnelsen angår nye benzopyran-og andre benzo-kondenserte leukotrien B^- (LTBJ antagonistermed formel (!) og farmasøytisk godtagbare salter derav, hvor A' er O, CHj. S, NH eller N(G,-C8)alkyl; R^ er hydrogen eller hydroksy; A^ er (a), (b) eller (c); R^ er valgt fra gnjppen bestående av tetrazolyl, karboksy, cis- eller trans -(CHj)^- GX'=CX'-COOH, -(CH2)¿CX'X"'X=, -CO-NG'G^ (d) og en substituertfem- eller seks- leddet aromatisk ring som eventuelt har ett eller to heteroatomer hvor heteroatomene eventuelt er uavhengig valgt fra gruppen bestående av 0, S og N; R^ er hydrogen, fluor, klor, (C,-Ce)alkyl, (C,-Cg)alkoksy, (C,-COperfluoralkyl,(G,-C,)perfluoralkoksy, (C,-C8)alkyltio,(C,-Co)alkylsulfinyl, fenylsulfinyl, (G,-C8)alkylsulfonyl eller fenylsulfonyl; farmasøytiske preparater inneholdende slike forbindelser eller et farmasøytisk godtagbart salt derav og metoder for anvendelse av slike forbindelser som LTB^- antagonister. Forbindelsene og de fanriasøytisk godtagbare saltene ifølge oppfinnelsen hemmer virkningen av LTB4 og er derfor nyttige for behandling av LTB4- fremkalte sykdommer så som inflammatoriske lidelser innebefattet reumatoid artritt, osteoartritt, inflammatorisk tarmsykdom, psoriasis og andre hudlidelser så som eksem, erytem, pruritus og akne, slag og andre former for repert^usjonsskade, transplantat- avvisning, autoimmune sykdommer, astma og andre lidelser hvor markert neutrofil infiltrering forekommer.
NO971672A 1994-10-13 1997-04-11 Benzofuran og benzokondenserte forbindelser, deres fremstilling og deres anvendelse som leukotrien B4(LTB4)antagonister NO971672L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US32287694A 1994-10-13 1994-10-13
PCT/IB1995/000401 WO1996011920A1 (en) 1994-10-13 1995-05-26 Benzopyran and benzo-fused compounds, their preparation and their use as leukotriene b4 (ltb4) antagonists

Publications (2)

Publication Number Publication Date
NO971672D0 NO971672D0 (no) 1997-04-11
NO971672L true NO971672L (no) 1997-06-11

Family

ID=23256829

Family Applications (1)

Application Number Title Priority Date Filing Date
NO971672A NO971672L (no) 1994-10-13 1997-04-11 Benzofuran og benzokondenserte forbindelser, deres fremstilling og deres anvendelse som leukotrien B4(LTB4)antagonister

Country Status (23)

Country Link
US (2) US6051601A (no)
EP (1) EP0785930A1 (no)
JP (1) JP2983295B2 (no)
KR (1) KR100232341B1 (no)
CN (1) CN1160399A (no)
AU (1) AU696890B2 (no)
BR (1) BR9504385A (no)
CA (1) CA2201742A1 (no)
CO (1) CO4480024A1 (no)
CZ (1) CZ111797A3 (no)
FI (1) FI971524A (no)
HU (1) HUT77515A (no)
IL (1) IL115529A0 (no)
MX (1) MX9702731A (no)
NO (1) NO971672L (no)
NZ (1) NZ285156A (no)
PE (1) PE10897A1 (no)
PL (1) PL319688A1 (no)
RU (1) RU2128655C1 (no)
TR (1) TR199501270A2 (no)
TW (1) TW304941B (no)
WO (1) WO1996011920A1 (no)
ZA (1) ZA958597B (no)

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AU713701B2 (en) * 1996-09-16 1999-12-09 Pfizer Inc. Processes and intermediates for preparing substituted chromanol derivatives
EP0961617A4 (en) * 1996-12-13 2002-08-07 Lilly Co Eli LEUKOTRINE ANTAGONISTS FOR TREATING FOCAL BRAIN CHEMISTRY
IL128731A0 (en) * 1998-03-12 2000-01-31 Pfizer Prod Inc Method of preventing allograft rejection
EP0963755A3 (en) * 1998-04-16 2001-03-14 Pfizer Products Inc. Use of benzopyranes for preventing allograft rejection
SE0004245D0 (sv) 2000-11-20 2000-11-20 Pharmacia Ab Novel compounds and their use
BR0206771A (pt) * 2001-01-30 2004-02-25 Pfizer Prod Inc Processos para a preparação de cidos cromanilbenzóicos
AU4239302A (en) * 2001-06-28 2003-01-02 Pfizer Products Inc. Benzoic acid substituted benzopyrans for the treatment of atherosclerosis
AU2003243089B2 (en) 2002-06-19 2010-01-07 Biovitrum Ab (Publ) Novel compounds, their use and preparation
RU2007101510A (ru) * 2004-07-22 2008-08-27 Фармаци Корпорейшн (US) Композиции для лечения воспаления и боли с использованием комбинации селективного ингибитора сох-2 и антагониста рецептора ltb4
US7674822B2 (en) 2004-11-24 2010-03-09 Wyeth PTP1b inhibitors
MX2007007103A (es) 2004-12-13 2008-03-10 Lilly Co Eli Derivados espiro como inhibidores de lipoxigenasa.
WO2006093548A1 (en) 2005-02-25 2006-09-08 Galileo Pharmaceuticals, Inc. Spiro-heterocyclic chromans, thiochromans and dihydroquinolines
US7842713B2 (en) * 2006-04-20 2010-11-30 Pfizer Inc Fused phenyl amido heterocyclic compounds
CA2651817A1 (en) 2006-05-11 2007-11-22 Janssen Pharmaceutica N.V. 3,4-dihydro-2h-benzo[1,4]oxazine and thiazine derivatives as cetp inhibitors
JP2009536953A (ja) 2006-05-11 2009-10-22 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ Ｃｅｔｐ阻害剤としての１，２，３，４−テトラヒドロ−キノリン誘導体
AP2011005613A0 (en) 2008-09-11 2011-04-30 Pfizer Heteroaryls amide derivatives and their use as glucokinase activators.
AU2010222589B2 (en) 2009-03-11 2012-08-16 Pfizer Inc. Benzofuranyl derivatives used as glucokinase inhibitors
WO2013123081A2 (en) * 2012-02-14 2013-08-22 Children's Hospital Medical Center Use of small molecule inhibitors targeting the interaction between rac gtpase and p67 (phox)
CN102920692A (zh) * 2012-10-25 2013-02-13 中国人民解放军第二军医大学 (e)-2-(1-羟基-4-环己酮)乙基咖啡酸酯在制备防治类风湿关节炎的药物中的应用
US9745253B2 (en) 2015-03-13 2017-08-29 Forma Therapeutics, Inc. Alpha-cinnamide compounds and compositions as HDAC8 inhibitors
WO2017040963A1 (en) 2015-09-03 2017-03-09 Forma Therapeutics, Inc. [6,6] fused bicyclic hdac8 inhibitors
EP3383389B1 (en) 2015-11-30 2021-04-28 Merck Sharp & Dohme Corp. Aryl acylsulfonamides as blt1 antagonists
US10336733B2 (en) 2015-11-30 2019-07-02 Merk Sharp & Dohme Corp. Aryl acylsulfonamides as BLT1 antagonists
EP3383868B1 (en) 2015-11-30 2022-10-05 Merck Sharp & Dohme LLC Aryl sulfonamides as blt1 antagonists
US10450309B2 (en) 2015-11-30 2019-10-22 Merch Sharp & Dohme Corp. Aryl sulfonamides as BLT1 antagonists
WO2018071687A1 (en) * 2016-10-13 2018-04-19 The Regents Of The University Of California Methods of treating pruritis

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Also Published As

Publication number Publication date
JP2983295B2 (ja) 1999-11-29
US6133286A (en) 2000-10-17
ZA958597B (en) 1997-04-14
CO4480024A1 (es) 1997-07-09
KR970706270A (ko) 1997-11-03
KR100232341B1 (ko) 2000-07-01
FI971524A0 (fi) 1997-04-11
EP0785930A1 (en) 1997-07-30
NO971672D0 (no) 1997-04-11
CZ111797A3 (cs) 1998-07-15
FI971524A (fi) 1997-04-11
PL319688A1 (en) 1997-08-18
US6051601A (en) 2000-04-18
NZ285156A (en) 1999-01-28
CN1160399A (zh) 1997-09-24
TW304941B (no) 1997-05-11
HUT77515A (hu) 1998-05-28
RU2128655C1 (ru) 1999-04-10
BR9504385A (pt) 1997-05-27
PE10897A1 (es) 1997-04-21
AU696890B2 (en) 1998-09-24
JPH09512035A (ja) 1997-12-02
MX9702731A (es) 1997-06-28
TR199501270A2 (tr) 1996-06-21
IL115529A0 (en) 1996-01-19
CA2201742A1 (en) 1996-04-25
AU2416795A (en) 1996-05-06
WO1996011920A1 (en) 1996-04-25

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