PE10897A1 - Compuestos benzo fusionados - Google Patents
Compuestos benzo fusionadosInfo
- Publication number
- PE10897A1 PE10897A1 PE1995281391A PE28139195A PE10897A1 PE 10897 A1 PE10897 A1 PE 10897A1 PE 1995281391 A PE1995281391 A PE 1995281391A PE 28139195 A PE28139195 A PE 28139195A PE 10897 A1 PE10897 A1 PE 10897A1
- Authority
- PE
- Peru
- Prior art keywords
- alkyl
- phenyl
- fused benzo
- optionally substituted
- benzo compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/42—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms in positions 2 and 4
- C07D311/56—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms in positions 2 and 4 without hydrogen atoms in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C39/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring
- C07C39/12—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring polycyclic with no unsaturation outside the aromatic rings
- C07C39/14—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring polycyclic with no unsaturation outside the aromatic rings with at least one hydroxy group on a condensed ring system containing two rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Transplantation (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
SE REFIERE A LOS ANTAGONISTAS DE LEUCOTRIENO B4, DE FORMULA (I),O SUS SALES FARMACEUTICAMENTE ACEPTABLES, DONDE: R1=TETRAZOLIO, CARBOXI, CIS/TRANS -(CH2)m-CX1=CX2-COOH, -(CH2)mCX3X4X5, -C0-NG1G2; m=0,1,2; X1,X2= H, ALQUILO(C1-C6); X3,X4=X1,X2 O SE UNEN PARA FORMAR UN CICLOALQUILO(C3-C7); G1,G2= H, ALQUILO(C1-C4), FENIL SUBSTITUIDO CON (Q`)a, ENTRE OTROS; a=1,2; R2=Q'= F,CL,ALQUILO(C1-C6), ENTRE OTROS; R3=-H,-OH,=O; A1= O,CH2,S,ENTRE OTROS; A2= -R4R5-, -R4R5-R6-R7-, -R4R5-CH2-R6R7-; R5=(CH2)nCHX9X10, (CH2)nX10, CH(OH)X10; n=O,1,2,3; X9= H,ALQUILO(C1-C6), FENILO SUBSTITUIDO OPCIONALMENTE CON (Q')a; X10= H, ALQUILO(C1-C6), CICLOALQUILO(C3-C8), UN ANILLO(FENILO, TIENILO, PIRIDILO, ENTRE OTROS) SUBSTITUIDO OPCIONALMENTE CON (Q')a. SE USA PARA EL TRATAMIENTO DE ENFERMEDADES INDUCIDAS POR EL LTB4, TALES COMO TRANSTORNOS INFLAMATORIOS, RECHAZO DE INJERTO, ENTRE OTRAS
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US32287694A | 1994-10-13 | 1994-10-13 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE10897A1 true PE10897A1 (es) | 1997-04-21 |
Family
ID=23256829
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE1995281391A PE10897A1 (es) | 1994-10-13 | 1995-10-10 | Compuestos benzo fusionados |
Country Status (23)
Country | Link |
---|---|
US (2) | US6051601A (es) |
EP (1) | EP0785930A1 (es) |
JP (1) | JP2983295B2 (es) |
KR (1) | KR100232341B1 (es) |
CN (1) | CN1160399A (es) |
AU (1) | AU696890B2 (es) |
BR (1) | BR9504385A (es) |
CA (1) | CA2201742A1 (es) |
CO (1) | CO4480024A1 (es) |
CZ (1) | CZ111797A3 (es) |
FI (1) | FI971524A0 (es) |
HU (1) | HUT77515A (es) |
IL (1) | IL115529A0 (es) |
MX (1) | MX9702731A (es) |
NO (1) | NO971672L (es) |
NZ (1) | NZ285156A (es) |
PE (1) | PE10897A1 (es) |
PL (1) | PL319688A1 (es) |
RU (1) | RU2128655C1 (es) |
TR (1) | TR199501270A2 (es) |
TW (1) | TW304941B (es) |
WO (1) | WO1996011920A1 (es) |
ZA (1) | ZA958597B (es) |
Families Citing this family (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU713701B2 (en) * | 1996-09-16 | 1999-12-09 | Pfizer Inc. | Processes and intermediates for preparing substituted chromanol derivatives |
US5817684A (en) * | 1996-12-13 | 1998-10-06 | Eli Lilly And Company | Leukotriene antagonists for use in the treatment or inhibition of cerebral focal stroke |
IL128731A0 (en) * | 1998-03-12 | 2000-01-31 | Pfizer Prod Inc | Method of preventing allograft rejection |
EP0963755A3 (en) * | 1998-04-16 | 2001-03-14 | Pfizer Products Inc. | Use of benzopyranes for preventing allograft rejection |
SE0004245D0 (sv) | 2000-11-20 | 2000-11-20 | Pharmacia Ab | Novel compounds and their use |
WO2002060888A1 (en) * | 2001-01-30 | 2002-08-08 | Pfizer Products Inc. | Processes for preparing chromanylbenzoic acids |
AU4239302A (en) * | 2001-06-28 | 2003-01-02 | Pfizer Products Inc. | Benzoic acid substituted benzopyrans for the treatment of atherosclerosis |
EP1513831B1 (en) | 2002-06-19 | 2010-01-06 | Biovitrum AB (publ) | Novel compounds, their use and preparation |
WO2006011048A1 (en) * | 2004-07-22 | 2006-02-02 | Pharmacia Corporation | Compositions for treatment of inflammation and pain using a combination of a cox-2 selective inhibitor and a ltb4 receptor antagonist |
US7674822B2 (en) | 2004-11-24 | 2010-03-09 | Wyeth | PTP1b inhibitors |
BRPI0519013A2 (pt) * | 2004-12-13 | 2009-11-03 | Lilly Co Eli | composto ou esteroisÈmeros únicos, misturas de esteroisÈmeros, sais, tautÈmeros ou pró-drogas destes farmaceuticamente aceitáveis, composição farmacêutica, e, uso de um composto |
MX2007010328A (es) | 2005-02-25 | 2008-03-13 | Lilly Co Eli | Cromanos, tiocromanos y dihidroquinolinas espiro-heterociclicos. |
US7842713B2 (en) * | 2006-04-20 | 2010-11-30 | Pfizer Inc | Fused phenyl amido heterocyclic compounds |
JP2009536953A (ja) | 2006-05-11 | 2009-10-22 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | Cetp阻害剤としての1,2,3,4−テトラヒドロ−キノリン誘導体 |
JP2009536954A (ja) | 2006-05-11 | 2009-10-22 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | Cetp阻害剤としての3,4−ジヒドロ−2h−ベンゾ[1,4]オキサジンおよびチアジン誘導体 |
PE20110303A1 (es) | 2008-09-11 | 2011-05-21 | Pfizer | Derivados de heteroaril acetamidas como activadores de glucoquinasa |
CA2754681C (en) | 2009-03-11 | 2014-01-07 | Pfizer Inc. | Benzofuranyl derivatives used as glucokinase inhibitors |
WO2013123081A2 (en) * | 2012-02-14 | 2013-08-22 | Children's Hospital Medical Center | Use of small molecule inhibitors targeting the interaction between rac gtpase and p67 (phox) |
CN102920692A (zh) * | 2012-10-25 | 2013-02-13 | 中国人民解放军第二军医大学 | (e)-2-(1-羟基-4-环己酮)乙基咖啡酸酯在制备防治类风湿关节炎的药物中的应用 |
CN107531660A (zh) | 2015-03-13 | 2018-01-02 | 福马治疗股份有限公司 | 作为HDAC8抑制剂的α‑肉桂酰胺化合物和组合物 |
TW201711999A (zh) | 2015-09-03 | 2017-04-01 | 佛瑪治療公司 | ﹝6,6﹞稠合雙環組蛋白脫乙醯基酶8(hdac8)抑制劑 |
US10450309B2 (en) | 2015-11-30 | 2019-10-22 | Merch Sharp & Dohme Corp. | Aryl sulfonamides as BLT1 antagonists |
EP3383388B1 (en) | 2015-11-30 | 2021-04-14 | Merck Sharp & Dohme Corp. | Aryl acylsulfonamides as blt1 antagonists |
EP3383389B1 (en) | 2015-11-30 | 2021-04-28 | Merck Sharp & Dohme Corp. | Aryl acylsulfonamides as blt1 antagonists |
US20190382363A1 (en) * | 2015-11-30 | 2019-12-19 | Merck Sharp & Dohme Corp. | Aryl sulfonamides as blt1 antagonists |
WO2018071687A1 (en) * | 2016-10-13 | 2018-04-19 | The Regents Of The University Of California | Methods of treating pruritis |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4565882A (en) * | 1984-01-06 | 1986-01-21 | G. D. Searle & Co. | Substituted dihydrobenzopyran-2-carboxylates |
CA1320490C (en) * | 1987-01-12 | 1993-07-20 | Darrel M. Gapinski | Anti-inflammatory agents |
US4889871A (en) * | 1987-05-29 | 1989-12-26 | G. D. Searle & Co. | Alkoxy-substituted dihydrobenzopyran-2-carboxylate derivatives |
CA2019335C (en) * | 1989-06-27 | 2000-08-01 | Mitoshi Konno | Phenylalkan (en)oic acids |
US4996230A (en) * | 1990-02-16 | 1991-02-26 | Eli Lilly And Company | Leukotriene antagonists |
US5073562A (en) * | 1990-05-10 | 1991-12-17 | G. D. Searle & Co. | Alkoxy-substituted dihydrobenzopyran-2-carboxylic acids and derivatives thereof |
US5051438A (en) * | 1990-05-16 | 1991-09-24 | G. D. Searle & Co. | Alkoxy-substituted dihydrobenzopyran-2-carboxylic acids and derivatives thereof, compositions and use |
US5124350A (en) * | 1990-06-28 | 1992-06-23 | G. D. Searle & Co. | Leukotriene b4 antagonists |
DK0623122T3 (da) * | 1992-01-23 | 1997-04-21 | Pfizer | Benzopyran og beslægtede LTB4-antagonister |
MX9300312A (es) * | 1992-01-23 | 1993-07-31 | Pfizer | Antagonistas benzopiranicos y relacionado de ltb. |
-
1995
- 1995-05-26 AU AU24167/95A patent/AU696890B2/en not_active Ceased
- 1995-05-26 US US08/809,728 patent/US6051601A/en not_active Expired - Fee Related
- 1995-05-26 WO PCT/IB1995/000401 patent/WO1996011920A1/en not_active Application Discontinuation
- 1995-05-26 RU RU97105834A patent/RU2128655C1/ru active
- 1995-05-26 CN CN95195608A patent/CN1160399A/zh active Pending
- 1995-05-26 PL PL95319688A patent/PL319688A1/xx unknown
- 1995-05-26 MX MX9702731A patent/MX9702731A/es unknown
- 1995-05-26 KR KR1019970702392A patent/KR100232341B1/ko not_active IP Right Cessation
- 1995-05-26 CZ CZ971117A patent/CZ111797A3/cs unknown
- 1995-05-26 HU HU9702048A patent/HUT77515A/hu unknown
- 1995-05-26 NZ NZ285156A patent/NZ285156A/xx unknown
- 1995-05-26 JP JP8513057A patent/JP2983295B2/ja not_active Expired - Lifetime
- 1995-05-26 CA CA002201742A patent/CA2201742A1/en not_active Abandoned
- 1995-05-26 EP EP95918114A patent/EP0785930A1/en not_active Withdrawn
- 1995-10-04 CO CO95046243A patent/CO4480024A1/es unknown
- 1995-10-06 IL IL11552995A patent/IL115529A0/xx unknown
- 1995-10-10 PE PE1995281391A patent/PE10897A1/es not_active Application Discontinuation
- 1995-10-11 BR BR9504385A patent/BR9504385A/pt not_active Application Discontinuation
- 1995-10-12 ZA ZA958597A patent/ZA958597B/xx unknown
- 1995-10-13 TR TR95/01270A patent/TR199501270A2/xx unknown
- 1995-10-13 TW TW084110874A patent/TW304941B/zh active
-
1997
- 1997-04-11 NO NO971672A patent/NO971672L/no not_active Application Discontinuation
- 1997-04-11 FI FI971524A patent/FI971524A0/fi unknown
-
2000
- 2000-01-28 US US09/493,707 patent/US6133286A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
JPH09512035A (ja) | 1997-12-02 |
PL319688A1 (en) | 1997-08-18 |
JP2983295B2 (ja) | 1999-11-29 |
EP0785930A1 (en) | 1997-07-30 |
FI971524A (fi) | 1997-04-11 |
CO4480024A1 (es) | 1997-07-09 |
KR100232341B1 (ko) | 2000-07-01 |
CZ111797A3 (cs) | 1998-07-15 |
TW304941B (es) | 1997-05-11 |
ZA958597B (en) | 1997-04-14 |
NO971672D0 (no) | 1997-04-11 |
KR970706270A (ko) | 1997-11-03 |
WO1996011920A1 (en) | 1996-04-25 |
US6051601A (en) | 2000-04-18 |
US6133286A (en) | 2000-10-17 |
CA2201742A1 (en) | 1996-04-25 |
HUT77515A (hu) | 1998-05-28 |
MX9702731A (es) | 1997-06-28 |
IL115529A0 (en) | 1996-01-19 |
FI971524A0 (fi) | 1997-04-11 |
NO971672L (no) | 1997-06-11 |
NZ285156A (en) | 1999-01-28 |
TR199501270A2 (tr) | 1996-06-21 |
CN1160399A (zh) | 1997-09-24 |
AU2416795A (en) | 1996-05-06 |
RU2128655C1 (ru) | 1999-04-10 |
AU696890B2 (en) | 1998-09-24 |
BR9504385A (pt) | 1997-05-27 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG | Grant, registration | ||
FD | Application declared void or lapsed |