ES2130125T3 - 3-(1-tiazolidinilbutil-4-piperazinil)-1h-indazoles, un procedimiento para su preparacion y su uso como medicamentos. - Google Patents

3-(1-tiazolidinilbutil-4-piperazinil)-1h-indazoles, un procedimiento para su preparacion y su uso como medicamentos.

Info

Publication number
ES2130125T3
ES2130125T3 ES91108124T ES91108124T ES2130125T3 ES 2130125 T3 ES2130125 T3 ES 2130125T3 ES 91108124 T ES91108124 T ES 91108124T ES 91108124 T ES91108124 T ES 91108124T ES 2130125 T3 ES2130125 T3 ES 2130125T3
Authority
ES
Spain
Prior art keywords
loweralkyl
thiazolidinylbutyl
indazoles
piperazinyl
medicines
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91108124T
Other languages
English (en)
Inventor
Nicholas J Hrib
Joseph T Strupczewski
John G Jurcak
Kenneth Bordeau
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharmaceuticals Inc
Original Assignee
Hoechst Marion Roussel Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Marion Roussel Inc filed Critical Hoechst Marion Roussel Inc
Application granted granted Critical
Publication of ES2130125T3 publication Critical patent/ES2130125T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia

Abstract

LA INVENCION SE REFIERE A 3-[1-TIAZOLIDINILBUTIL-4-PIPERAZINIL]-1H -INDAZOLES REPRESENTADOS POR LA FORMULA I DONDE R SUB 1 Y R SUB 2 SON CADA UNO INDEPENDIENTEMENTE HIDROGENO O ALQUILO INFERIOR O R SUB 1 Y R SUB 2 JUNTOS CON EL ATOMO DE CARBONO AL QUE ESTAN UNIDOS FORMAN UN ANILLO DE CICLOPENTANO, CICLOHEXANO O CICLOHEPTANO; R SUB 3 Y R SUB 4 SON INDEPENDIENTEMENTE HIDROGENO O ALQUILO INFERIOR O R SUB 3 Y R SUB 4 JUNTOS CON EL ATOMO DE CARBONO AL QUE ESTAN UNIDOS FORMAN UN ANILLO DE CICLOPENTANO, CICLOHEXANO O CICLOHEPTANO; R SUB 5 ES HIDROGENO, ALQUILO INFERIOR, ALCANOILO O AROILO; X ES HALOGENO, ALQUILO INFERIOR O ALCOXI; M ES UN ENTERO DE 0 A 3, LAS SALES DE ADICION ACIDAS FARMACEUTICAMENTE ACEPTABLES DE LOS MISMOS Y, CUANDO SEA PERTINENTE, LAS MEZCLAS OPTICAS, GEOMETRICAS Y DE ESTEREOISOMEROS Y RACEMICAS DE LOS MISMOS. LOS COMPUESTOS DE ESTA INVENCION SON UTILES COMO AGENTES ANTIPSICOTICOS.
ES91108124T 1990-05-21 1991-05-21 3-(1-tiazolidinilbutil-4-piperazinil)-1h-indazoles, un procedimiento para su preparacion y su uso como medicamentos. Expired - Lifetime ES2130125T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/526,089 US5041445A (en) 1990-05-21 1990-05-21 3-[1-thiazolidinylbutyl-4-piperazinyl]-1H-indazoles

Publications (1)

Publication Number Publication Date
ES2130125T3 true ES2130125T3 (es) 1999-07-01

Family

ID=24095872

Family Applications (1)

Application Number Title Priority Date Filing Date
ES91108124T Expired - Lifetime ES2130125T3 (es) 1990-05-21 1991-05-21 3-(1-tiazolidinilbutil-4-piperazinil)-1h-indazoles, un procedimiento para su preparacion y su uso como medicamentos.

Country Status (23)

Country Link
US (1) US5041445A (es)
EP (1) EP0458234B1 (es)
JP (1) JP3161755B2 (es)
KR (1) KR100215616B1 (es)
AT (1) ATE178327T1 (es)
AU (1) AU642243B2 (es)
CA (1) CA2042982A1 (es)
CZ (1) CZ280005B6 (es)
DE (1) DE69131057T2 (es)
DK (1) DK0458234T3 (es)
ES (1) ES2130125T3 (es)
FI (1) FI94757C (es)
GR (1) GR3030233T3 (es)
HU (1) HU215845B (es)
IE (1) IE911708A1 (es)
IL (1) IL98184A (es)
MX (1) MX25858A (es)
NO (1) NO179749C (es)
NZ (1) NZ238184A (es)
PL (1) PL165731B1 (es)
PT (1) PT97720B (es)
RU (2) RU2038355C1 (es)
ZA (1) ZA913794B (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0316723B1 (en) * 1987-11-20 1992-09-30 Hoechst-Roussel Pharmaceuticals Incorporated 3-[4(1-Substituted-4-piperazinyl)butyl]-4-thiazolidinones a process for their preparation and their use as medicaments
US5801186A (en) 1987-11-20 1998-09-01 Hoechst Marion Roussel, Inc. 3- 4-(1-substituted-4-piperazinyl)butyl!-4-thiazolidinone and related compounds
CA2157348A1 (en) * 1994-09-01 1996-03-02 Aventis Pharmaceuticals Inc. 3-¬4-(1-substituted-4-piperazinyl)butyl|-4-thiazolidinone and related compounds
US7696229B2 (en) * 2006-02-17 2010-04-13 Memory Pharmaceuticals Corporation Compounds having 5-HT6 receptor affinity
MX2010001576A (es) * 2007-08-15 2010-09-14 Memory Pharm Corp Compuestos 3´sustituidos que tienen afinidad con el receptor 5-hidroxitriptamina 6 (5-ht6).
US20100016297A1 (en) * 2008-06-24 2010-01-21 Memory Pharmaceuticals Corporation Alkyl-substituted 3' compounds having 5-ht6 receptor affinity
US20100029629A1 (en) * 2008-07-25 2010-02-04 Memory Pharmaceuticals Corporation Acyclic compounds having 5-ht6 receptor affinity
US20100056531A1 (en) * 2008-08-22 2010-03-04 Memory Pharmaceuticals Corporation Alkyl-substituted 3' compounds having 5-ht6 receptor affinity
JP5760300B2 (ja) 2009-09-10 2015-08-05 株式会社リコー インクジェット用インク組成物材料及びインクジェット用インク組成物

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4100282A (en) * 1972-12-23 1978-07-11 Boehringer Ingelheim Gmbh N-Aryl-N'-(phenyl- or phenoxy-alkyl)-piperazines and salts thereof
DE3132916A1 (de) * 1981-08-20 1983-03-03 Kali-Chemie Pharma Gmbh, 3000 Hannover 1-phenylindazol-3-on-verbindungen sowie verfahren und zwischenprodukte zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
US4775761A (en) * 1983-08-22 1988-10-04 Hoechst-Roussel Pharmaceuticals, Inc. 3-(piperidinyl)- and 3-(pyrrolidinyl)-1H-indazoles
EP0302423A3 (en) * 1987-08-07 1991-01-09 Hoechst-Roussel Pharmaceuticals Incorporated 1-phenyl-3-(1-piperazinyl)-1h-indazoles, a process and intermediates for their preparation, and the use thereof as medicaments
EP0316723B1 (en) * 1987-11-20 1992-09-30 Hoechst-Roussel Pharmaceuticals Incorporated 3-[4(1-Substituted-4-piperazinyl)butyl]-4-thiazolidinones a process for their preparation and their use as medicaments
NZ230045A (en) * 1988-08-05 1990-11-27 Janssen Pharmaceutica Nv 3-piperazinylbenzazole derivatives and pharmaceutical compositions

Also Published As

Publication number Publication date
NO179749C (no) 1996-12-11
GR3030233T3 (en) 1999-08-31
MX25858A (es) 1993-09-01
FI912401A0 (fi) 1991-05-17
NO911921L (no) 1991-11-22
NZ238184A (en) 1993-01-27
ZA913794B (en) 1992-02-26
AU7618191A (en) 1991-11-21
DE69131057T2 (de) 1999-09-09
PT97720B (pt) 1998-09-30
NO911921D0 (no) 1991-05-16
HU911697D0 (en) 1991-11-28
ATE178327T1 (de) 1999-04-15
PT97720A (pt) 1992-02-28
AU642243B2 (en) 1993-10-14
DE69131057D1 (de) 1999-05-06
KR100215616B1 (ko) 1999-08-16
RU2038355C1 (ru) 1995-06-27
HU215845B (hu) 1999-04-28
PL165731B1 (pl) 1995-02-28
RU2105765C1 (ru) 1998-02-27
JPH04226979A (ja) 1992-08-17
NO179749B (no) 1996-09-02
CZ280005B6 (cs) 1995-09-13
IL98184A0 (en) 1992-06-21
US5041445A (en) 1991-08-20
IE911708A1 (en) 1991-12-04
PL290327A1 (en) 1992-05-04
CZ148091A3 (en) 1993-08-11
EP0458234B1 (en) 1999-03-31
FI912401A (fi) 1991-11-22
DK0458234T3 (da) 1999-10-11
FI94757C (fi) 1995-10-25
EP0458234A2 (en) 1991-11-27
CA2042982A1 (en) 1991-11-22
KR910020007A (ko) 1991-12-19
EP0458234A3 (en) 1992-09-30
JP3161755B2 (ja) 2001-04-25
IL98184A (en) 1995-03-15
FI94757B (fi) 1995-07-14
HUT61018A (en) 1992-11-30

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