ES2074618T3 - 3-(1h-indazol-3-il)-4-piridinaminas, un procedimiento e intermediarios para su preparacion y su uso como medicamentos. - Google Patents

3-(1h-indazol-3-il)-4-piridinaminas, un procedimiento e intermediarios para su preparacion y su uso como medicamentos.

Info

Publication number
ES2074618T3
ES2074618T3 ES91115280T ES91115280T ES2074618T3 ES 2074618 T3 ES2074618 T3 ES 2074618T3 ES 91115280 T ES91115280 T ES 91115280T ES 91115280 T ES91115280 T ES 91115280T ES 2074618 T3 ES2074618 T3 ES 2074618T3
Authority
ES
Spain
Prior art keywords
hydrogen
loweralkyl
indazol
preparation
piridinamines
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91115280T
Other languages
English (en)
Inventor
Richard Charles Effland
Joseph Thomas Klein
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharmaceuticals Inc
Original Assignee
Hoechst Roussel Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Roussel Pharmaceuticals Inc filed Critical Hoechst Roussel Pharmaceuticals Inc
Application granted granted Critical
Publication of ES2074618T3 publication Critical patent/ES2074618T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/73—Unsubstituted amino or imino radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

Abstract

LA INVENCION SE REFIERE A 4-(1H-INDAZOL-3-IL)-4-PIRIDINAMINAS QUE TIENEN LA FORMULA I DONDE R SUB 1 ES HIDROGENO, ALQUILO INFERIOR, ARILALQUILO O ACILO; R SUB 2 ES HIDROGENO, ALQUILO INFERIOR O ARILALQUILO; R SUB 3 ES HIDROGENO, ALQUILO INFERIOR O ARILO Y X ES HIDROGENO, HALOGENO, NITRO O AMINO O LAS SALES DE ADICION FARMACEUTICAMENTE ACEPTABLES DE LOS MISMOS, Y CUANDO SE PUEDE APLICAR, LOS ISOMEROS GEOMETRICOS Y OPTICOS Y LAS MEZCLAS RACEMICAS DE LOS MISMOS. LOS COMPUESTOS DE LA INVENCION SON UTILES COMO ANALGESICOS Y AGENTES ANTIINFLAMATORIOS TOPICOS PARA EL TRATAMIENTO DE VARIAS DERMATOSIS. LA INVENCION SE REFIERE ADEMAS A INTERMEDIOS REPRESENTADOS POR LA FORMULA II DONDE R SUB 1, R SUB 2 Y R SUB 3 TIENEN EL SIGNIFICADO ARRIBA MENCIONADO, QUE TIENEN ADEMAS UNA ACTIVIDAD ANALGESICA, ASI COMO A PROCESOS PARA LA PREPARACION DE COMPUESTOS QUE TIENEN AMBAS FORMULAS.
ES91115280T 1990-09-10 1991-09-10 3-(1h-indazol-3-il)-4-piridinaminas, un procedimiento e intermediarios para su preparacion y su uso como medicamentos. Expired - Lifetime ES2074618T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/579,751 US5051430A (en) 1990-09-10 1990-09-10 3-(1H-indazol-3-yl)-4-pyridinamines

Publications (1)

Publication Number Publication Date
ES2074618T3 true ES2074618T3 (es) 1995-09-16

Family

ID=24318208

Family Applications (1)

Application Number Title Priority Date Filing Date
ES91115280T Expired - Lifetime ES2074618T3 (es) 1990-09-10 1991-09-10 3-(1h-indazol-3-il)-4-piridinaminas, un procedimiento e intermediarios para su preparacion y su uso como medicamentos.

Country Status (20)

Country Link
US (1) US5051430A (es)
EP (1) EP0475352B1 (es)
JP (1) JP3042915B2 (es)
KR (1) KR100203236B1 (es)
AT (1) ATE123493T1 (es)
AU (1) AU640590B2 (es)
CA (1) CA2050875C (es)
CZ (1) CZ280883B6 (es)
DE (1) DE69110219T2 (es)
DK (1) DK0475352T3 (es)
ES (1) ES2074618T3 (es)
FI (1) FI914219A (es)
HU (1) HUT59126A (es)
IE (1) IE67442B1 (es)
IL (1) IL99434A (es)
NO (1) NO913543L (es)
NZ (1) NZ239692A (es)
PL (1) PL295728A1 (es)
PT (1) PT98911B (es)
ZA (1) ZA917141B (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NO905543L (no) * 1989-12-27 1991-06-28 Hoechst Roussel Pharma Fremgangsmaate for fremstilling og anvendelse av aminopyridinylmetanoler og aminometylpyridinaminer.
US6897231B2 (en) 2000-07-31 2005-05-24 Signal Pharmaceuticals, Inc. Indazole derivatives as JNK inhibitors and compositions and methods related thereto
US7211594B2 (en) 2000-07-31 2007-05-01 Signal Pharmaceuticals, Llc Indazole compounds and compositions thereof as JNK inhibitors and for the treatment of diseases associated therewith
DE60234510D1 (de) 2001-04-16 2010-01-07 Eisai R&D Man Co Ltd 1h-indazolverbindungen die jnk hemmen
US20070185152A1 (en) * 2004-03-02 2007-08-09 Smithkline Beecham Corporation Inhibitors of akt activity
JP5055263B2 (ja) * 2005-03-30 2012-10-24 ダエウン ファーマシューティカル カンパニー リミテッド 抗真菌性トリアゾール誘導体

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU198036B (en) * 1983-08-22 1989-07-28 Hoechst Roussel Pharma Process for production of derivatives of 3-piperidil-/1h/-indasole and medical preparatives containing them

Also Published As

Publication number Publication date
PT98911A (pt) 1992-07-31
HU912901D0 (en) 1992-01-28
KR920006346A (ko) 1992-04-27
KR100203236B1 (ko) 1999-06-15
CZ280883B6 (cs) 1996-04-17
AU8371691A (en) 1992-03-12
JPH04247079A (ja) 1992-09-03
IL99434A (en) 1995-08-31
FI914219A0 (fi) 1991-09-06
ATE123493T1 (de) 1995-06-15
AU640590B2 (en) 1993-08-26
NO913543L (no) 1992-03-11
PL295728A1 (en) 1993-05-04
PT98911B (pt) 1999-02-26
IL99434A0 (en) 1992-08-18
CS277691A3 (en) 1992-04-15
CA2050875A1 (en) 1992-03-11
JP3042915B2 (ja) 2000-05-22
US5051430A (en) 1991-09-24
FI914219A (fi) 1992-03-11
ZA917141B (en) 1992-04-29
IE67442B1 (en) 1996-04-03
CA2050875C (en) 2002-07-16
IE913157A1 (en) 1992-03-11
DE69110219T2 (de) 1995-11-09
EP0475352B1 (en) 1995-06-07
NO913543D0 (no) 1991-09-09
NZ239692A (en) 1994-01-26
DK0475352T3 (da) 1995-10-16
HUT59126A (en) 1992-04-28
DE69110219D1 (de) 1995-07-13
EP0475352A1 (en) 1992-03-18

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