KR100215616B1 - 3-(1-티아졸리디닐부틸-4-피페라지닐)-1h-인다졸,이의 제조방법및 이를함유하는약제학적조성물 - Google Patents
3-(1-티아졸리디닐부틸-4-피페라지닐)-1h-인다졸,이의 제조방법및 이를함유하는약제학적조성물 Download PDFInfo
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- KR100215616B1 KR100215616B1 KR1019910008144A KR910008144A KR100215616B1 KR 100215616 B1 KR100215616 B1 KR 100215616B1 KR 1019910008144 A KR1019910008144 A KR 1019910008144A KR 910008144 A KR910008144 A KR 910008144A KR 100215616 B1 KR100215616 B1 KR 100215616B1
- Authority
- KR
- South Korea
- Prior art keywords
- compound
- piperazinyl
- methyl
- indazol
- butyl
- Prior art date
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Psychiatry (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
Abstract
본 발명은 하기 일반식(Ⅰ)의 3-[1-티아졸리디닐부틸-4-피페라지닐]-1H-인다졸 및 약제학적으로 허용되는 이의 산 부가염, 경우에 따라, 이의 광학적, 기하학적 및 입체 이성체, 및 이의 라세미 혼합물에 관한 것이다.
상기식에서,
R1및 R2는 각각 수소 또는 저급 알킬이거나, 또는 이들이 결합된 탄소원자와 함께 사이클로펜탄, 사이클로헥산 또는 사이클로 헵탄 환을 형성하고, R3및 R4는 각각 수소 또는 저급 알칼이거나, 또는 이들이 결합된 탄소원자와 함께 사이클로펜탄, 사이클로헥산 또는 사이클로 헵탄 환을 형성하며, R5는 수소, 저급 알킬, 알카노일 또는 아로일이고, x는 할로겐, 저급 알킬 또는 알콕시이며, m은 0 내지 3 의 정수이다.
본 발명의 화합물은 정신병 치료제로서 유용하다.
Description
본 발명은 하기 일반식(Ⅰ)의 화합물 및 약제학적으로 허용되는 이의 산 부가염 및 경우에 따라, 이의 광학 및 기하 입체 이성체 및 이들의 라세미 혼합물에 관한 것이다;
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Claims (10)
- (2회 정정) 하기 일반식(Ⅰ)의 화합물 및 약제학적으로 허용되는 이의 산 부가염, 이의 광학 및 기하 입체 이성체 및 이의 라세미 혼합물.상기식에서,R1및 R2는 각각 독립적으로 수소 또는 메틸이거나, 이들이 결합되어 있는 탄소원자와 함께 사이클로펜탄 환 또는 사이클로헥산 환을 형성하고,R3및 R4는 각각 독립적으로 수소 또는 메틸이거나, 이들이 결합되어 있는 탄소원자와 함께 사이클로펜탄 환 또는 사이클로헥산 환을 형성하며,R5는 수소이고X는 할로겐 또는 메틸이며,m은 0 또는 1 의 정수이다.
- (2회 정정) 제 1 항에 있어서, R3및 R4가 각각 독립적으로 수소 또는 메틸이고, R5가 수소이며, X가 할로겐이고 m이 0 또는 1 인 화합물.
- 제 2 항에 있어서, R3및 R4가 각각 독립적으로 수소 또는 메틸이고, R5가 수소이며, X가 불소이고, m이 0 또는 1 인 화합물.
- 제 1 항에 있어서, 2-(4-(1-[1H-인다졸-3-일]-4-피페라지닐)부틸)-1-티아-3-아자스피로[4,5]데칸-4-온인 화합물.
- 제 1 항에 있어서, 3-(4-[1-(6-플루오르-1H-인다졸-3-일)-4-피페라지닐]부틸)-5-메틸-4-티아졸리디논인 화합물.
- 제 1 항에 있어서 3-(4-[1-(6-플루오르-1H-인다졸-3-일)-4-피페라지닐]부틸)-1-티아-3-아자스피로[4,5]데칸-4-온인 화합물.
- 제 1 항에 있어서, 3-(4-(1-[1H-인다졸-3-일]-4-피페라지닐)부틸)-1-티아-3-아자스피로[4,4]노난-4-온인 화합물.
- 제 1 항에 있어서, 3-(4-(1-[1H-인다졸-3-일]-4-피페라지닐)부틸)-5,5-디메틸-4-티아졸리디논인 화합물.
- 활성 성분으로서의 제 1 항의 화합물과 약제학적으로 허용되는 이의 담체를 포함하는, 정신병 치료용 약제학적 조성물.
- (2회 정정) 하기 일반식(Ⅱ)의 화합물을 하기 일반식(Ⅲ)의 화합물과 반응시킴을 포함하여 제 1 항에 따른 하기 일반식(Ⅰ)의 화합물을 제조하는 방법.상기식에서,R1, R2, R3, R4, R3, X 및 m은 제 1 항에서 정의한 바와 같다.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/526,089 US5041445A (en) | 1990-05-21 | 1990-05-21 | 3-[1-thiazolidinylbutyl-4-piperazinyl]-1H-indazoles |
US526,089 | 1990-05-21 |
Publications (2)
Publication Number | Publication Date |
---|---|
KR910020007A KR910020007A (ko) | 1991-12-19 |
KR100215616B1 true KR100215616B1 (ko) | 1999-08-16 |
Family
ID=24095872
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019910008144A KR100215616B1 (ko) | 1990-05-21 | 1991-05-20 | 3-(1-티아졸리디닐부틸-4-피페라지닐)-1h-인다졸,이의 제조방법및 이를함유하는약제학적조성물 |
Country Status (23)
Country | Link |
---|---|
US (1) | US5041445A (ko) |
EP (1) | EP0458234B1 (ko) |
JP (1) | JP3161755B2 (ko) |
KR (1) | KR100215616B1 (ko) |
AT (1) | ATE178327T1 (ko) |
AU (1) | AU642243B2 (ko) |
CA (1) | CA2042982A1 (ko) |
CZ (1) | CZ280005B6 (ko) |
DE (1) | DE69131057T2 (ko) |
DK (1) | DK0458234T3 (ko) |
ES (1) | ES2130125T3 (ko) |
FI (1) | FI94757C (ko) |
GR (1) | GR3030233T3 (ko) |
HU (1) | HU215845B (ko) |
IE (1) | IE911708A1 (ko) |
IL (1) | IL98184A (ko) |
MX (1) | MX25858A (ko) |
NO (1) | NO179749C (ko) |
NZ (1) | NZ238184A (ko) |
PL (1) | PL165731B1 (ko) |
PT (1) | PT97720B (ko) |
RU (2) | RU2038355C1 (ko) |
ZA (1) | ZA913794B (ko) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3875073T2 (de) * | 1987-11-20 | 1993-03-11 | Hoechst Roussel Pharma | 3-(4(1-substituierte-4-piperazinyl)butyl)-4-thiazolidinone, verfahren zu deren herstellung und ihre anwendung als arzneimittel. |
US5801186A (en) | 1987-11-20 | 1998-09-01 | Hoechst Marion Roussel, Inc. | 3- 4-(1-substituted-4-piperazinyl)butyl!-4-thiazolidinone and related compounds |
CA2157348A1 (en) * | 1994-09-01 | 1996-03-02 | Aventis Pharmaceuticals Inc. | 3-¬4-(1-substituted-4-piperazinyl)butyl|-4-thiazolidinone and related compounds |
CA2637531A1 (en) * | 2006-02-17 | 2007-08-30 | Memory Pharmaceuticals Corporation | Compounds having 5-ht6 receptor affinity |
KR20100053626A (ko) * | 2007-08-15 | 2010-05-20 | 메모리 파마슈티칼스 코포레이션 | 5-ht6 수용체 친화성을 나타내는 3'-치환된 화합물 |
US20100016297A1 (en) * | 2008-06-24 | 2010-01-21 | Memory Pharmaceuticals Corporation | Alkyl-substituted 3' compounds having 5-ht6 receptor affinity |
US20100029629A1 (en) * | 2008-07-25 | 2010-02-04 | Memory Pharmaceuticals Corporation | Acyclic compounds having 5-ht6 receptor affinity |
US20100056531A1 (en) * | 2008-08-22 | 2010-03-04 | Memory Pharmaceuticals Corporation | Alkyl-substituted 3' compounds having 5-ht6 receptor affinity |
JP5760300B2 (ja) | 2009-09-10 | 2015-08-05 | 株式会社リコー | インクジェット用インク組成物材料及びインクジェット用インク組成物 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4100282A (en) * | 1972-12-23 | 1978-07-11 | Boehringer Ingelheim Gmbh | N-Aryl-N'-(phenyl- or phenoxy-alkyl)-piperazines and salts thereof |
DE3132916A1 (de) * | 1981-08-20 | 1983-03-03 | Kali-Chemie Pharma Gmbh, 3000 Hannover | 1-phenylindazol-3-on-verbindungen sowie verfahren und zwischenprodukte zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
US4775761A (en) * | 1983-08-22 | 1988-10-04 | Hoechst-Roussel Pharmaceuticals, Inc. | 3-(piperidinyl)- and 3-(pyrrolidinyl)-1H-indazoles |
EP0302423A3 (en) * | 1987-08-07 | 1991-01-09 | Hoechst-Roussel Pharmaceuticals Incorporated | 1-phenyl-3-(1-piperazinyl)-1h-indazoles, a process and intermediates for their preparation, and the use thereof as medicaments |
DE3875073T2 (de) * | 1987-11-20 | 1993-03-11 | Hoechst Roussel Pharma | 3-(4(1-substituierte-4-piperazinyl)butyl)-4-thiazolidinone, verfahren zu deren herstellung und ihre anwendung als arzneimittel. |
NZ230045A (en) * | 1988-08-05 | 1990-11-27 | Janssen Pharmaceutica Nv | 3-piperazinylbenzazole derivatives and pharmaceutical compositions |
-
1990
- 1990-05-21 US US07/526,089 patent/US5041445A/en not_active Expired - Fee Related
-
1991
- 1991-04-29 AU AU76181/91A patent/AU642243B2/en not_active Ceased
- 1991-05-16 NO NO911921A patent/NO179749C/no not_active IP Right Cessation
- 1991-05-17 FI FI912401A patent/FI94757C/fi active
- 1991-05-17 NZ NZ238184A patent/NZ238184A/en unknown
- 1991-05-17 IL IL9818491A patent/IL98184A/en unknown
- 1991-05-20 PT PT97720A patent/PT97720B/pt not_active IP Right Cessation
- 1991-05-20 IE IE170891A patent/IE911708A1/en not_active IP Right Cessation
- 1991-05-20 RU SU914895498A patent/RU2038355C1/ru active
- 1991-05-20 ZA ZA913794A patent/ZA913794B/xx unknown
- 1991-05-20 PL PL91290327A patent/PL165731B1/pl unknown
- 1991-05-20 KR KR1019910008144A patent/KR100215616B1/ko not_active IP Right Cessation
- 1991-05-20 CZ CS911480A patent/CZ280005B6/cs not_active IP Right Cessation
- 1991-05-20 JP JP14277791A patent/JP3161755B2/ja not_active Expired - Fee Related
- 1991-05-20 MX MX2585891A patent/MX25858A/es unknown
- 1991-05-21 EP EP91108124A patent/EP0458234B1/en not_active Expired - Lifetime
- 1991-05-21 HU HU1697/91A patent/HU215845B/hu not_active IP Right Cessation
- 1991-05-21 ES ES91108124T patent/ES2130125T3/es not_active Expired - Lifetime
- 1991-05-21 CA CA002042982A patent/CA2042982A1/en not_active Abandoned
- 1991-05-21 DK DK91108124T patent/DK0458234T3/da active
- 1991-05-21 DE DE69131057T patent/DE69131057T2/de not_active Expired - Fee Related
- 1991-05-21 AT AT91108124T patent/ATE178327T1/de not_active IP Right Cessation
-
1993
- 1993-05-18 RU RU93005087A patent/RU2105765C1/ru active
-
1999
- 1999-05-14 GR GR990401320T patent/GR3030233T3/el unknown
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