ES2129040T3 - Nuevos derivados de 3,4-dihidroisoquinolina y nueva utilizacion farmaceutica de dihidropiridinas carbociclica y heterociclicamente condensadas. - Google Patents

Nuevos derivados de 3,4-dihidroisoquinolina y nueva utilizacion farmaceutica de dihidropiridinas carbociclica y heterociclicamente condensadas.

Info

Publication number
ES2129040T3
ES2129040T3 ES92901178T ES92901178T ES2129040T3 ES 2129040 T3 ES2129040 T3 ES 2129040T3 ES 92901178 T ES92901178 T ES 92901178T ES 92901178 T ES92901178 T ES 92901178T ES 2129040 T3 ES2129040 T3 ES 2129040T3
Authority
ES
Spain
Prior art keywords
new
heterociclicamadas
dihidropiridinas
dihidroisoquinolina
carbociclica
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92901178T
Other languages
English (en)
Inventor
Walter Losel
Otto Roos
Dietrich Arndts
Franz Josef Kuhn
Ilse Streller
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim Pharma GmbH and Co KG
Boehringer Ingelheim Pharmaceuticals Inc
Original Assignee
Boehringer Ingelheim Pharma GmbH and Co KG
Boehringer Ingelheim Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Pharma GmbH and Co KG, Boehringer Ingelheim Pharmaceuticals Inc filed Critical Boehringer Ingelheim Pharma GmbH and Co KG
Application granted granted Critical
Publication of ES2129040T3 publication Critical patent/ES2129040T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/18—Aralkyl radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system having sulfur as a ring hetero atom, e.g. ticlopidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4741—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having oxygen as a ring hetero atom, e.g. tubocuraran derivatives, noscapine, bicuculline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/475—Quinolines; Isoquinolines having an indole ring, e.g. yohimbine, reserpine, strychnine, vinblastine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/541—Non-condensed thiazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Pulmonology (AREA)
  • Psychiatry (AREA)
  • Cardiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pretreatment Of Seeds And Plants (AREA)

Abstract

LA INVENCION CONCIERNE A LA UTILIZACION DE DIHIDROPIRIDINAS ANILLADAS CARBOCICLICAMENTE Y HETEROCICLICAMENTE, DE FORMULA (I), ASI COMO DE SUS FORMAS TAUTOMERAS, DE FORMULA (II'') O (II''''), DONDE A EQUIVALE A LOS SISTEMAS DE ANILLO ANILLADOS (A),(B),(C),(D), Y X A OR1, NHR2 O NR3R4, COMO AGENTE DE PROTECCION CEREBRAL, COMO AGENTE TERAPEUTICO PARA EL TRATAMIENTO DE PROCESOS CRONICOS INFLAMATORIOS Y COMO AGENTE INHIBIDOR DE LA COAGULACION DE LA SANGRE. ADEMAS LA INVENCION CONCIERNE A NUEVOS COMPUESTOS DE FORMULA GENERAL (IE), QUE ESTA DEFINIDA EN LA DESCRIPCION Y QUE ESTA COMPRENDIDA EN LA FORMULA GENERAL (I).
ES92901178T 1990-12-22 1991-12-20 Nuevos derivados de 3,4-dihidroisoquinolina y nueva utilizacion farmaceutica de dihidropiridinas carbociclica y heterociclicamente condensadas. Expired - Lifetime ES2129040T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4041482A DE4041482A1 (de) 1990-12-22 1990-12-22 Neue pharmazeutische verwendung carbocyclisch und heterocyclisch annelierter dihydropyridine

Publications (1)

Publication Number Publication Date
ES2129040T3 true ES2129040T3 (es) 1999-06-01

Family

ID=6421218

Family Applications (1)

Application Number Title Priority Date Filing Date
ES92901178T Expired - Lifetime ES2129040T3 (es) 1990-12-22 1991-12-20 Nuevos derivados de 3,4-dihidroisoquinolina y nueva utilizacion farmaceutica de dihidropiridinas carbociclica y heterociclicamente condensadas.

Country Status (32)

Country Link
US (3) US6034094A (es)
EP (2) EP0563128B1 (es)
JP (1) JP3283877B2 (es)
KR (1) KR100227953B1 (es)
AT (1) ATE177948T1 (es)
AU (1) AU666107B2 (es)
BR (1) BR1100520A (es)
CA (1) CA2098917A1 (es)
CZ (3) CZ284695A3 (es)
DE (3) DE9017900U1 (es)
DK (1) DK0563128T3 (es)
ES (1) ES2129040T3 (es)
FI (1) FI105026B (es)
GR (1) GR3030341T3 (es)
HR (1) HRP940721B1 (es)
HU (1) HU217819B (es)
ID (1) ID16001A (es)
IE (3) IE990430A1 (es)
IL (1) IL100450A (es)
MX (1) MX9102765A (es)
NO (1) NO179515C (es)
NZ (1) NZ241140A (es)
PL (1) PL172262B1 (es)
PT (1) PT99901B (es)
RU (2) RU2115647C1 (es)
SG (1) SG43064A1 (es)
SI (1) SI9111975B (es)
SK (1) SK281017B6 (es)
TW (1) TW283145B (es)
WO (1) WO1992011010A1 (es)
YU (1) YU48063B (es)
ZA (1) ZA9110116B (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100291706B1 (ko) * 1992-06-22 2001-10-24 베링거 인겔하임 카게 폐환된디하이드로피리딘,이의제조방법및이를포함하는약제학적조성물
DE4343683A1 (de) * 1993-12-21 1995-06-22 Boehringer Ingelheim Kg Anellierte Dihydropyridine und deren Verwendung für die Herstellung von pharmazeutischen Zubereitungen
ATE197706T1 (de) 1993-12-21 2000-12-15 Boehringer Ingelheim Pharma Anellierte dihydropyridine und deren verwendung für die herstellung von pharmazeutischen zubereitungen
GB2341318A (en) * 1998-09-14 2000-03-15 Boehringer Ingelheim Pharma A Dihydroisoquinoline (LOE 908) and Traumatic Brain Injury.
IT1318650B1 (it) * 2000-07-28 2003-08-27 Dompe Spa 1,3-diossolani ad attivita' antitosse.
AU2003215119B2 (en) * 2002-02-11 2008-11-20 Gold-T Tech, Inc. Method for preventing thrombus formation
KR20050114242A (ko) * 2003-03-26 2005-12-05 액테리온 파마슈티칼 리미티드 오렉신 수용체 길항제로서 이용되는테트라하이드로이소퀴놀릴 아세트아마이드 유도체
JP2007508338A (ja) * 2003-10-16 2007-04-05 エフ．ホフマン−ラ　ロシュ　アーゲー グルタミンフルクトース−６−リン酸アミドトランスフェラーゼ（ｇｆａｔ）インヒビター
DE102004055633A1 (de) * 2004-11-12 2006-05-18 Schering Ag 5-substituierte Chinolin- und Isochinolin-Derivate, ein Verfahren zu ihrer Herstellung und ihre Verwendung als Entzündungshemmer
JP5148636B2 (ja) * 2007-03-15 2013-02-20 エフ．ホフマン−ラ ロシュ アーゲー オレキシンアンタゴニストとしてのマロンアミド
CZ302637B6 (cs) * 2010-01-05 2011-08-10 Zentiva, K. S Zpusob prípravy 6,7-dimethoxy-1-[2-(4-trifluormethylfenyl)ethyl]-3,4-dihydroisochinolinu
EP2420237A1 (en) 2010-08-11 2012-02-22 Ville Takio Fluorinated derivatives of endogenous isoquinolines for use in the treatment of diseases mediated through endogenous isoquinoline pathways
KR101645930B1 (ko) 2014-12-16 2016-08-05 (주) 우수 타월 거치대

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3013906A1 (de) * 1980-04-11 1981-10-15 C.H. Boehringer Sohn, 6507 Ingelheim Substituierte (alpha) -aminocarbonyl-l-benzyl-3,4-dihydro-isochinoline, verfahren zu deren herstellung und deren verwendung
DE3621413A1 (de) * 1986-06-26 1988-01-07 Boehringer Ingelheim Kg Verwendung carbocyclisch und heterocyclisch annelierter dihydropyridine als cardioprotektive mittel sowie neue heterocyclisch und carbocyclisch anellierte dihydropyridine, verfahren zu deren herstellung und zwischenstufen fuer deren herstellung
IL86131A0 (en) * 1987-04-24 1988-11-15 Boehringer Ingelheim Kg Benzo-and thieno-3,4-dihydropyridine derivatives,their preparation and pharmaceutical compositions containing them
DE3827727A1 (de) * 1988-08-16 1990-02-22 Boehringer Ingelheim Kg Anellierte tetrahydropyridinessigsaeurederivate, verfahren zu deren herstellung und verwendung solcher verbindungen zur kardioprotektion

Also Published As

Publication number Publication date
EP0563128B1 (de) 1999-03-24
CZ121393A3 (en) 1994-02-16
EP0781556A1 (de) 1997-07-02
HK1010683A1 (en) 1999-06-25
IL100450A (en) 1997-01-10
MX9102765A (es) 1994-03-31
YU197591A (sh) 1994-06-24
PT99901A (pt) 1992-12-31
KR930702973A (ko) 1993-11-29
JP3283877B2 (ja) 2002-05-20
BR1100520A (pt) 2000-06-06
SK281017B6 (sk) 2000-10-09
CZ282454B6 (cs) 1997-07-16
IE20001043A1 (en) 2001-05-30
NZ241140A (en) 1997-06-24
SI9111975A (en) 1997-06-30
GR3030341T3 (en) 1999-09-30
SK61793A3 (en) 1994-01-12
SI9111975B (en) 2001-06-30
IE990430A1 (en) 2000-11-15
FI932709A7 (fi) 1993-06-14
ATE177948T1 (de) 1999-04-15
TW283145B (es) 1996-08-11
FI932709A0 (fi) 1993-06-14
HU9301820D0 (en) 1993-09-28
NO932279L (no) 1993-06-21
JPH06504277A (ja) 1994-05-19
CZ284695A3 (en) 1997-07-16
NO932279D0 (no) 1993-06-21
RU2115647C1 (ru) 1998-07-20
CZ289533B6 (cs) 2002-02-13
KR100227953B1 (ko) 1999-11-01
HUT74639A (en) 1997-01-28
FI105026B (fi) 2000-05-31
NO179515B (no) 1996-07-15
IL100450A0 (en) 1992-09-06
US5686462A (en) 1997-11-11
PL172262B1 (pl) 1997-08-29
YU48063B (sh) 1996-10-18
ID16001A (id) 1997-08-21
NO179515C (no) 1996-10-23
HRP940721B1 (en) 2000-02-29
DK0563128T3 (da) 1999-10-11
WO1992011010A1 (de) 1992-07-09
US5665729A (en) 1997-09-09
PT99901B (pt) 1999-06-30
DE59109115D1 (de) 1999-04-29
AU666107B2 (en) 1996-02-01
ZA9110116B (en) 1992-08-26
HU217819B (hu) 2000-04-28
RU2149000C1 (ru) 2000-05-20
SG43064A1 (en) 1997-10-17
DE4041482A1 (de) 1992-06-25
EP0563128A1 (de) 1993-10-06
IE914486A1 (en) 1992-07-01
CZ289685B6 (cs) 2002-03-13
DE9017900U1 (de) 1993-01-28
CA2098917A1 (en) 1992-06-23
US6034094A (en) 2000-03-07
HRP940721A2 (en) 1996-12-31
AU9080291A (en) 1992-07-22

Similar Documents

Publication Publication Date Title
ES2129040T3 (es) Nuevos derivados de 3,4-dihidroisoquinolina y nueva utilizacion farmaceutica de dihidropiridinas carbociclica y heterociclicamente condensadas.
ES2093979T3 (es) Esteres nitricos de derivados del acido 2-(2,6-dihalofenilamino)fenilacetico y su procedimiento de preparacion.
MX9100160A (es) Procedimiento para preparar un medicamento que contiene flupirtina como sustancia activa para combatir contracturas musculares
DE3779500D1 (de) Levodopa-methyl-ester enthaltende pharmazeutische zusammensetzungen, ihre herstellung und therapeutische verwendungen.
DK0654264T3 (da) Anvendelse af venlafaxin eller en aryloxypropanaminforbindelse til fremstilling af et lægemiddel til behandling af urininkontinens
DE69828603D1 (de) Verwendung von a-Glycosylceramiden zur Herstellung eines therapeutischen Mittelszur Behandlung von Autoimmunkrankheiten
ES2064130T3 (es) Utilizacion de droloxifeno para el tratamiento de enfermedades de los huesos.
AR218795A1 (es) Instrumento porta-clips para el "clipado" de vasos sanguineos
DE3382458D1 (de) Haarwuchsmittel.
BR9607212A (pt) Uso de uma nsaid-r em uma composição de proteção para o tratamento de cancer de colo retal
ES2162942T3 (es) Nuevos derivados de acidos carboxilicos, su obtencion y empleo.
FI954228A0 (fi) Infuusiolaite hoitoaineen jaksottaista tai jatkuvaa antamista varten
ES2131973T3 (es) Empleo de 2-amino-4-(4-fluorobencilamino)-1-etoxicarbonilaminobencenos para la profilaxis y el tratamiento de las secuelas de la disminucion aguda y cronica del riego sanguineo cerebral, asi como de afecciones neurodegenerativas.
BR0015939A (pt) Sistemas terapêuticos transdérmicos com estabilidade aperfeiçoada e um processo para a sua preparação
PT920865E (pt) Utilizacao de ""norastemizole"" para o tratamento de disturbios alergicos
ES537300A0 (es) Procedimiento para la preparacion de gangliosidos y sus derivados administrables por nebulizacion
PA8401801A1 (es) Agentes bloqueadores neuromusculares
IT9041503A0 (it) Dispositivo per la cura chirurgica dell'ametropia
EA200000242A1 (ru) Применение фанхинона для лечения болезни альцгеймера
DE69313261D1 (de) Verwendung von LACTOFERRIN zur Herstellung eines THERAPEUTISCHEN MITTELS zur Behandlung von RHEUMATISMUS
MX164619B (es) Composicion para el tratamiento de lesiones cutaneas
LV10391A (lv) Alkilfosforskabes savienojumu izmantosana psoriazes tipa slimibu arstesanai
ES2098186A1 (es) Composiciones farmaceuticas a base de aminometilindoles para su aplicacion terapeutica como neuroprotectores en las enfermedades de parkinson y alzheimer.
PE73099A1 (es) Utilizacion de las heparinas de bajo peso molecular para la prevencion y el tratamiento de los edemas cerebrales
DE69118955D1 (de) Ascorbinsäure Derivate

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 563128

Country of ref document: ES