ES2131513T3 - Utilizacion de interferon-beta 2a humano para la preparacion de medicamentos. - Google Patents

Utilizacion de interferon-beta 2a humano para la preparacion de medicamentos.

Info

Publication number
ES2131513T3
ES2131513T3 ES92114478T ES92114478T ES2131513T3 ES 2131513 T3 ES2131513 T3 ES 2131513T3 ES 92114478 T ES92114478 T ES 92114478T ES 92114478 T ES92114478 T ES 92114478T ES 2131513 T3 ES2131513 T3 ES 2131513T3
Authority
ES
Spain
Prior art keywords
beta
ifn
human
interferone
genes
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92114478T
Other languages
English (en)
Inventor
Michael Revel
Asher Zilberstein
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Yeda Research and Development Co Ltd
Original Assignee
Yeda Research and Development Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26321482&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2131513(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from IL76714A external-priority patent/IL76714A0/xx
Application filed by Yeda Research and Development Co Ltd filed Critical Yeda Research and Development Co Ltd
Application granted granted Critical
Publication of ES2131513T3 publication Critical patent/ES2131513T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/555—Interferons [IFN]
    • C07K14/565—IFN-beta
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/21—Interferons [IFN]
    • A61K38/215—IFN-beta
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/5412—IL-6
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Abstract

LA INTERFERONA-BETA2A Y LA INTERFERONA-BETA2B HUMANAS SE PRODUCEN EN FORMA PURIFICADA MEDIANTE TECNICAS RECOMBINANTES DE DNA. SE HAN IDENTIFICADO DOS GENES HUMANOS SEPARADOS QUE CODIFICAN LA PRODUCCION DE LA IFN-(BETA)2A Y LA IFN-(BETA)2B, RESPECTIVAMENTE. SE HA ESTABLECIDO LA SECUENCIA DE CDNA DE LA IFN-(BETA)2A. ESTOS GENES Y EL CDNA HAN SIDO CLONADOS EN CELULAS DE MAMIFEROS CON UNA SECUENCIA PROMOTORA PRECOZ DE SV40 Y TALES CLONOS GENOMICOS SON CAPACES DE PRODUCIR IFN-(BETA)2A E IFN-(BETA)2B. LA ACTIVIDAD ANTIVIRAL DE TALES IFN-(BETA)2A Y IFN-(BETA)2B RECOMBINANTES ESTA DEMOSTRADA ASI COMO OTRAS ACTIVIDADES BIOLOGICAS QUE LAS IDENTIFICAN COMO INTERFERONAS HUMANAS. SE HA DEMOSTRADO QUE LA SECRECION DE LA IFN-(BETA)2 SE INDUCE EN CELULAS HUMANAS MEDIANTE CITOQUINAS ESTIMULADORAS DEL CRECIMIENTO. LA IFN-(BETA)2A PUEDE USARSE PARA PREPARAR COMPOSICIONES FARMACEUTICAS UTILES EN LOS CAMPOS DE LA RESPUESTA DE LA FASE AGUDA DE LAS INFLAMACIONES O EN LA REGULACION DE LA PROLIFERACION CELULAR. TAMBIEN SE SUGIEREN OTROS USOS COMPLEMENTARIOS.
ES92114478T 1985-10-14 1986-10-10 Utilizacion de interferon-beta 2a humano para la preparacion de medicamentos. Expired - Lifetime ES2131513T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IL76714A IL76714A0 (en) 1985-10-14 1985-10-14 Recombined human interferon beta-2 and a method of producing same
US86088386A 1986-05-08 1986-05-08

Publications (1)

Publication Number Publication Date
ES2131513T3 true ES2131513T3 (es) 1999-08-01

Family

ID=26321482

Family Applications (2)

Application Number Title Priority Date Filing Date
ES86114049T Expired - Lifetime ES2058053T5 (es) 1985-10-14 1986-10-10 Interferon beta2a humano; vectores que contienen genes codantes para el indicado interferon, lineas de celulas que lo producen y utilizacion de dicho interferon a titulo de medicamento.
ES92114478T Expired - Lifetime ES2131513T3 (es) 1985-10-14 1986-10-10 Utilizacion de interferon-beta 2a humano para la preparacion de medicamentos.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES86114049T Expired - Lifetime ES2058053T5 (es) 1985-10-14 1986-10-10 Interferon beta2a humano; vectores que contienen genes codantes para el indicado interferon, lineas de celulas que lo producen y utilizacion de dicho interferon a titulo de medicamento.

Country Status (6)

Country Link
EP (4) EP0835661B1 (es)
AU (1) AU602872B2 (es)
CA (1) CA1341369C (es)
DE (4) DE3688671T3 (es)
ES (2) ES2058053T5 (es)
GR (2) GR3030150T3 (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE67035B1 (en) * 1986-07-08 1996-02-21 Genetics Inst Production and use of non-glycosylated IL-6
US6284237B1 (en) 1986-07-08 2001-09-04 Steven C. Clark Methods of treatment using IL-6
DE3750106T3 (de) * 1986-08-06 1999-04-22 Ajinomoto Kk Rekombinanter B-Zell-Differenzierungsfaktor.
US4973478A (en) * 1987-07-20 1990-11-27 Allelix Biopharmaceuticals, Inc. Treating inflammation with hepatocyte stimulating factor interferon β2
NZ226799A (en) * 1987-11-06 1991-08-27 Oncogen Breast cancer inhibitory factor and method for inhibiting proliferation of neoplastic cells and compositions therefor
IL85204A0 (en) * 1988-01-26 1988-07-31 Yeda Res & Dev Recombinant human interferon beta2,its preparation and pharmaceutical compositions comprising it
JPH0372429A (ja) * 1988-10-07 1991-03-27 Chugai Pharmaceut Co Ltd 血小板減少症の治療剤
US5641868A (en) * 1991-04-18 1997-06-24 Toray Industries, Inc. Interlekin-6 compositions, and a production process thereof
IT1254359B (it) * 1992-05-11 1995-09-14 Serono Cesare Ist Ricerca Composizioni farmaceutiche contenenti il-6
US5902576A (en) * 1992-10-22 1999-05-11 Yeda Research And Development Co. Ltd. At Weizmann Institute Of Science Antitumor pharmaceutical composition comprising IL-6 transfected cells
US5338834A (en) * 1993-01-26 1994-08-16 Allelix Biopharmaceuticals Inc. Ultrapure human interleukin-6
IL147414A0 (en) 2001-12-31 2002-08-14 Yeda Res & Dev Ifnar2 mutants, their production and use
ES2399749T3 (es) * 2002-08-29 2013-04-03 Cytocure Llc Composiciones farmacéuticas que comprenden Interferón beta para su uso en el tratamiento de melanoma
ATE471720T1 (de) 2003-03-28 2010-07-15 Faron Pharmaceuticals Oy Erhöhung des adenosin-spiegels durch cytokin- induzierte expression von cd73
CN108004270B (zh) * 2017-11-24 2021-06-18 上海交通大学 利用双荧光素酶报告基因检测鸭IFN-β启动子活性的方法
CN112442504B (zh) * 2020-12-10 2023-01-24 电子科技大学 一种重组草鱼白介素-12活性蛋白的制备方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL58765A (en) * 1979-11-21 1986-09-30 Yeda Res & Dev Process for the production of essentially pure messenger rna of human fibroblast interferon and process for the production of interferon beta
JPS60169424A (ja) * 1984-02-15 1985-09-02 Chuzo Kishimoto 新規ヒトｂ細胞分化因子，その製造法およびその使用法
JPS61246197A (ja) * 1985-04-24 1986-11-01 Ajinomoto Co Inc Ｄｎａ
IE67035B1 (en) * 1986-07-08 1996-02-21 Genetics Inst Production and use of non-glycosylated IL-6
DE3750106T3 (de) * 1986-08-06 1999-04-22 Ajinomoto Kk Rekombinanter B-Zell-Differenzierungsfaktor.

Also Published As

Publication number Publication date
AU6386786A (en) 1987-04-16
EP0645452A1 (en) 1995-03-29
EP0835661A2 (en) 1998-04-15
DE3688671D1 (de) 1993-08-12
EP0835661B1 (en) 2007-08-29
ES2058053T5 (es) 2000-11-01
AU602872B2 (en) 1990-11-01
EP0835661A3 (en) 1998-05-20
EP0220574B1 (en) 1993-07-07
EP0536520B1 (en) 1999-03-03
DE3650715T2 (de) 1999-06-24
DE3650715D1 (de) 1999-04-08
GR3030150T3 (en) 1999-08-31
ES2058053T3 (es) 1994-11-01
DE3650790T2 (de) 2008-01-24
EP0220574B2 (en) 2000-04-12
DE3650790D1 (de) 2007-10-11
DE3688671T2 (de) 1993-10-14
CA1341369C (en) 2002-06-18
DE220574T1 (de) 1987-11-26
GR3033769T3 (en) 2000-10-31
EP0536520A1 (en) 1993-04-14
DE3688671T3 (de) 2001-05-03
EP0220574A1 (en) 1987-05-06

Similar Documents

Publication Publication Date Title
ES2131513T3 (es) Utilizacion de interferon-beta 2a humano para la preparacion de medicamentos.
BR7600206A (pt) Processo para obter uma preparacao estavel de insulina de acao prolongada,bem como composicao e processo terapeuticos
DE3855523D1 (de) Proteine mit Faktor-VIII-Aktivität, Verfahren zu deren Herstellung unter Verwendung von genetisch modifizierten Zellen und diese enthaltende pharmazeutische Zusammensetzungen
DE3751406D1 (de) Herstellung und Verwendung von nicht-glycosiliertem IL-6.
AR241314A1 (es) Aislado de adn, vector en base en dicho aislado cultivo de celulas tratadas con dicho vector y preparacion de factor viii humano funcional.
SE8604875L (sv) Nya naftalenderivat med retinal verkan, forfarande for framstellning derav och lekemedelskompositioner och kosmetiska kompositioner innehallande dessa
ES2056854T3 (es) Tiadiazinonas.
IT1040273B (it) Oli perfluoropolieterei selezionati ad altissima purezza ea bassa volatilita
FR2578540B1 (fr) Nouveaux derives de pyridylmethoxy- et -methylmercaptoanilines, utilses notamment comme antiasthmatiques, leur fabrication et medicaments les contenant
ES555379A0 (es) Distribuidor de gotas en la fabricacion de articulos de cristal
BR8502704A (pt) Composicao dentaria fotopolimerisavel para preparar coroas e pontes
IT1183181B (it) Derivati del 3-metil-imidazo(4,5-c)pirazolo con attivita' terapeutica e procedimento per la loropreparazione
DE3853013T2 (de) Hochfestigkeitsporzellane für Isolatoren und Herstellung derselben.
ES2036530T3 (es) Utilizacion de un factor estimulante de las colonias granulociticas humano para preparar una composicion farmaceutica para el tratamiento de la leucemia mielogena.
ES544664A0 (es) Procedimiento para el diagnostico in vitro del sexo
ES2061218T3 (es) Composiciones farmaceuticas estabilizadas.
ITMI920710A0 (it) Siringa di sicurezza con ago retrattile dopo l'uso in modo da evitare il riutilizzo della siringa e la diffusione di malattie contagiose per punture accidentali dell'ago.
MX170424B (es) Mejoras en composiciones para el cuidado de la piel con actividad anti-inflamatoria y queratolitica
IT1230116B (it) Derivati dell'acido furanuronico, loro preparazione e loro impiego come medicamenti
MX163682B (es) Proceso para la produccion de alfa-amilasa estable en solucion y alfa-amilasa liquida producida por el mismo
IT1234977B (it) Espressione in e. coli polipeptidi ibridi contenenti la sequenza del fattore di rilascio dell'ormone della crescita
IT1170618B (it) Preparato farmacologico di frutto sio-1,6-difosfato ad azione terapeutica nei pazienti ustionati
ES2080954T3 (es) Uso de beta-aletina en cultivos de celulas y en terapia.
BR8601232A (pt) Composicao para controle de ervas daninhas,processos para fabricacao de compostos,para fabricacao de uma composicao de controle de ervas daninhas,e para controle de ervas daninhas,bem como uso de tal composicao
DE3560633D1 (de) Fenoldopam 4', 8-bis-hydrogen sulfates

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 536520

Country of ref document: ES