ES2068955T3 - Derivados de 1,2,3,4-tetrahidro-9-acridinamina. - Google Patents

Derivados de 1,2,3,4-tetrahidro-9-acridinamina.

Info

Publication number
ES2068955T3
ES2068955T3 ES90114586T ES90114586T ES2068955T3 ES 2068955 T3 ES2068955 T3 ES 2068955T3 ES 90114586 T ES90114586 T ES 90114586T ES 90114586 T ES90114586 T ES 90114586T ES 2068955 T3 ES2068955 T3 ES 2068955T3
Authority
ES
Spain
Prior art keywords
acridinamine
tetrahydro
derivatives
agents
cerebral
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90114586T
Other languages
English (en)
Inventor
Colin Granger
Moos Walter Hamilton
Jeffrey Alan Kester
Anthony Jerome Thomas
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Warner Lambert Co LLC
Original Assignee
Warner Lambert Co LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co LLC filed Critical Warner Lambert Co LLC
Application granted granted Critical
Publication of ES2068955T3 publication Critical patent/ES2068955T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D219/00—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
    • C07D219/04—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D219/00—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
    • C07D219/04—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • C07D219/08—Nitrogen atoms
    • C07D219/10—Nitrogen atoms attached in position 9
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyridine Compounds (AREA)
  • Water Treatment By Electricity Or Magnetism (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

SON DESWCRITOS NUEVOS PRODUCTOS O DERIVADOS DE ACRIDINAMINA-9-TETRAHIDRO-1,2,3,4 DE FORMULA I COMO TAMBIEN METODOS PARA LA PREPARACION Y COMPOSICIONES FARMACEUTICAS DEL MISMO, QUE SON UTILES COMO AGENTES ANALGESICOS PARA EL TRATAMIENTO DE DOLORES, COMO AYUDA PARA DORMIR Y COMO AGENTES PARA TRATAR LOS SINTOMAS DE DEMENCIA SENIL, MAL DE ALZHEIMER, COREA DE HUNTINGTON, DISQUINESIA TARDIVA, HIPERQUINESIA, MANIAS, O CONDICIONES SIMILARES DE INSUFICIENCIA CEREBRAL, CARACTERIZADA POR LA PRODUCCION DE ACETILCOLINA CEREBRAL DISMINUIDA O LIBRE.
ES90114586T 1989-07-31 1990-07-30 Derivados de 1,2,3,4-tetrahidro-9-acridinamina. Expired - Lifetime ES2068955T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/387,722 US4999430A (en) 1989-07-31 1989-07-31 Derivatives of 1,2,3,4-tetrahydro-9-acrisinamine

Publications (1)

Publication Number Publication Date
ES2068955T3 true ES2068955T3 (es) 1995-05-01

Family

ID=23531113

Family Applications (2)

Application Number Title Priority Date Filing Date
ES90114586T Expired - Lifetime ES2068955T3 (es) 1989-07-31 1990-07-30 Derivados de 1,2,3,4-tetrahidro-9-acridinamina.
ES94112223T Expired - Lifetime ES2141787T3 (es) 1989-07-31 1990-07-30 Derivados de la 1,2,3,4-tetrahidro-9-acridinamina.

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES94112223T Expired - Lifetime ES2141787T3 (es) 1989-07-31 1990-07-30 Derivados de la 1,2,3,4-tetrahidro-9-acridinamina.

Country Status (17)

Country Link
US (1) US4999430A (es)
EP (2) EP0628548B1 (es)
JP (1) JP2930245B2 (es)
KR (1) KR910002802A (es)
AT (2) ATE119885T1 (es)
AU (1) AU5994590A (es)
CA (1) CA2022297C (es)
DE (2) DE69017789T2 (es)
DK (2) DK0411534T3 (es)
ES (2) ES2068955T3 (es)
FI (1) FI903752A0 (es)
GR (1) GR3032539T3 (es)
IE (1) IE66823B1 (es)
NO (1) NO903359L (es)
NZ (1) NZ234672A (es)
PT (1) PT94849A (es)
ZA (1) ZA905978B (es)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ223875A (en) * 1987-03-17 1991-01-29 Hoechst Roussel Pharma 9-aminotetrahydroacridines and related homologues and pharmaceutical compositions
FR2640508B1 (fr) * 1988-12-19 1994-07-01 Dietlin Francois Nouvelles compositions et nouveaux produits pharmaceutiques assurant la regeneration de leucocytes et leur emploi pour le traitement du syndrome immuno-deficitaire
JP2546919B2 (ja) * 1989-11-08 1996-10-23 三菱化学株式会社 ９ーアシルアミノテトラヒドロアクリジン誘導体
CA2029497C (en) * 1989-11-08 2002-06-04 Kunihiro Ninomiya (Deceased) 4-acylaminopyridine derivative
US5179100A (en) * 1992-03-09 1993-01-12 Hoechst-Roussel Pharmaceuticals Inc. 4,5-dihydropyrazolo[3,4-a]acridines
US5466696A (en) * 1992-09-10 1995-11-14 Warner Lambert Company Tacrine and cytochrome P450 oxidase inhibitors and methods of use
US5422350A (en) * 1992-09-10 1995-06-06 Warner-Lambert Company Nitrogen substituted acridine and cytochrome P450 inhibitors and methods of use
HU213107B (en) * 1994-02-23 1997-02-28 Egyt Gyogyszervegyeszeti Gyar Process for producing acetic acid derivatives and pharmaceutical compositions containing them
GB9716879D0 (en) * 1997-08-08 1997-10-15 Shire Int Licensing Bv Treatment of attention deficit disorders
US6218383B1 (en) 1998-08-07 2001-04-17 Targacept, Inc. Pharmaceutical compositions for the prevention and treatment of central nervous system disorders
ES2168926B1 (es) * 1999-12-14 2003-10-16 Prous Science S A Derivados de ciclopenta- ciclohexa- y ciclohepta (b)quinoleina, procedimiento para su fabricacion, utilizacion y composicion farmaceutica correspondiente.
JPWO2006004201A1 (ja) * 2004-07-01 2008-04-24 エーザイ・アール・アンド・ディー・マネジメント株式会社 神経再生促進剤
CN1315810C (zh) * 2004-08-30 2007-05-16 北京理工大学 哌嗪桥联他克林双体衍生物及其合成方法
US20080188510A1 (en) * 2005-05-23 2008-08-07 Eisai R & D Management Co., Ltd. Novel methods using zonisamide
CN104529945A (zh) * 2009-12-11 2015-04-22 基因密码公司 使用gdnf家族配体(gfl)模拟剂或ret信号传导通路活化剂促进神经细胞存活的方法
CA2789014C (en) 2010-02-09 2019-01-15 Michela Gallagher Methods and compositions for improving cognitive function
JP6440625B2 (ja) 2012-11-14 2018-12-19 ザ・ジョンズ・ホプキンス・ユニバーシティー 精神分裂病を処置するための方法および組成物
CA2904767C (en) 2013-03-15 2022-06-21 Agenebio, Inc. Methods and compositions for improving cognitive function
US10806717B2 (en) 2013-03-15 2020-10-20 The Johns Hopkins University Methods and compositions for improving cognitive function
CN107810002B (zh) 2015-05-22 2021-01-05 艾吉因生物股份有限公司 左乙拉西坦的延时释放药物组合物

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3889302T2 (de) * 1987-12-03 1994-10-20 Mitsubishi Chem Ind 9-(Acylamino)tetrahydroacridinderivate und wahrnehmungssteigernde Mittel davon als aktiver Wirkstoff.

Also Published As

Publication number Publication date
EP0628548A1 (en) 1994-12-14
ES2141787T3 (es) 2000-04-01
PT94849A (pt) 1991-04-18
DE69033369T2 (de) 2000-05-11
EP0628548B1 (en) 1999-11-24
AU5994590A (en) 1991-01-31
DK0411534T3 (da) 1995-07-24
EP0411534B1 (en) 1995-03-15
JPH0366670A (ja) 1991-03-22
EP0411534A3 (en) 1991-06-05
IE66823B1 (en) 1996-02-07
CA2022297C (en) 2001-09-18
NO903359D0 (no) 1990-07-30
DE69017789D1 (de) 1995-04-20
ATE186908T1 (de) 1999-12-15
GR3032539T3 (en) 2000-05-31
ZA905978B (en) 1992-04-29
DE69033369D1 (de) 1999-12-30
ATE119885T1 (de) 1995-04-15
KR910002802A (ko) 1991-02-26
DE69017789T2 (de) 1995-07-13
IE902751A1 (en) 1991-02-27
NO903359L (no) 1991-02-01
JP2930245B2 (ja) 1999-08-03
CA2022297A1 (en) 1991-02-01
DK0628548T3 (da) 2000-05-08
US4999430A (en) 1991-03-12
EP0411534A2 (en) 1991-02-06
NZ234672A (en) 1991-11-26
FI903752A0 (fi) 1990-07-27

Similar Documents

Publication Publication Date Title
ES2068955T3 (es) Derivados de 1,2,3,4-tetrahidro-9-acridinamina.
IT1229203B (it) Impiego di acido 5 metiltetraidrofolico, di acido 5 formiltetraidrofolico e dei loro sali farmaceuticamente accettabili per la preparazione di composizioni farmaceutiche in forma a rilascio controllato attive nella terapia dei disturbi mentali organici e composizioni farmaceutiche relative.
FI904204A0 (fi) Foerfarande foer framstaellning av cykliska aminosyraderivat och mellanprodukter.
ZA906057B (en) 4-(n-substituted amino)-2-butynyl-1-ureas and thioureas and derivatives thereof as centrally acting muscarinic agents
FI900365A0 (fi) Menetelmä terapeuttisesti käyttökelpoisten 3-fenyyli-5,6-dihydrobents/C/akridiini-7-karboksyylihappojohdannnaisten valmistamiseksi
ES2009689A6 (es) Procedimiento para preparar derivados de 3-piperidina-carbaldehido-oxima.
GR3006606T3 (es)
AU653802B2 (en) Condensed diazepinones
EP0276805A3 (en) Substituted 3-phenyl-7h-thiazoloû3,2-b¨û1,2,4¨triazin-7-ones, processes for their preparation, medicaments containing them and their use as well as some of the intermediates obtained during the preparation of said compounds
ES2008421A6 (es) Procedimiento para la obtencion de derivados de la pilocarpina.
DK0950053T3 (da) Hidtil ukendte benzoylalkyl.1,2,3,6-tetrahydropyridinderivater

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 411534

Country of ref document: ES