AU5994590A - Derivatives of 1,2,3,4-tetrahydro-9-acridinamine - Google Patents
Derivatives of 1,2,3,4-tetrahydro-9-acridinamineInfo
- Publication number
- AU5994590A AU5994590A AU59945/90A AU5994590A AU5994590A AU 5994590 A AU5994590 A AU 5994590A AU 59945/90 A AU59945/90 A AU 59945/90A AU 5994590 A AU5994590 A AU 5994590A AU 5994590 A AU5994590 A AU 5994590A
- Authority
- AU
- Australia
- Prior art keywords
- acridinamine
- tetrahydro
- derivatives
- agents
- cerebral
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D219/00—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
- C07D219/04—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D219/00—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
- C07D219/04—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
- C07D219/08—Nitrogen atoms
- C07D219/10—Nitrogen atoms attached in position 9
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pyridine Compounds (AREA)
- Water Treatment By Electricity Or Magnetism (AREA)
Abstract
Novel prodrugs or depot derivatives of 1,2,3,4-tetrahydro-9-acridinamine of formula I <CHEM> are described, as well as methods for the preparation and pharmaceutical compositions of same, which are useful as analgesic agents for the treatment of pain, as sleep aids and as agents for treating the symptoms of senile dementia, Alzheimer's disease, Huntington's chorea, tardive dyskinesia, hyperkinesia, mania, or similar conditions of cerebral insufficiency characterized by decreased cerebral acetylcholine production or release.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US387722 | 1989-07-31 | ||
US07/387,722 US4999430A (en) | 1989-07-31 | 1989-07-31 | Derivatives of 1,2,3,4-tetrahydro-9-acrisinamine |
Publications (1)
Publication Number | Publication Date |
---|---|
AU5994590A true AU5994590A (en) | 1991-01-31 |
Family
ID=23531113
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU59945/90A Abandoned AU5994590A (en) | 1989-07-31 | 1990-07-27 | Derivatives of 1,2,3,4-tetrahydro-9-acridinamine |
Country Status (17)
Country | Link |
---|---|
US (1) | US4999430A (en) |
EP (2) | EP0628548B1 (en) |
JP (1) | JP2930245B2 (en) |
KR (1) | KR910002802A (en) |
AT (2) | ATE186908T1 (en) |
AU (1) | AU5994590A (en) |
CA (1) | CA2022297C (en) |
DE (2) | DE69033369T2 (en) |
DK (2) | DK0628548T3 (en) |
ES (2) | ES2068955T3 (en) |
FI (1) | FI903752A0 (en) |
GR (1) | GR3032539T3 (en) |
IE (1) | IE66823B1 (en) |
NO (1) | NO903359L (en) |
NZ (1) | NZ234672A (en) |
PT (1) | PT94849A (en) |
ZA (1) | ZA905978B (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU666725B2 (en) * | 1988-12-19 | 1996-02-22 | S.C.R. Newpharm | New pharmaceutical compositions and new pharmaceutical products allowing the regeneration of leukocytes and their use in the treatment of acquired immuno-deficient syndrom |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FI91401C (en) * | 1987-03-17 | 1994-06-27 | Hoechst Roussel Pharma | Process for the preparation of therapeutically active substituted 9-aminotetrahydroacrines and related compounds |
JP2546919B2 (en) * | 1989-11-08 | 1996-10-23 | 三菱化学株式会社 | 9-acylaminotetrahydroacridine derivative |
CA2029497C (en) * | 1989-11-08 | 2002-06-04 | Kunihiro Ninomiya (Deceased) | 4-acylaminopyridine derivative |
US5179100A (en) * | 1992-03-09 | 1993-01-12 | Hoechst-Roussel Pharmaceuticals Inc. | 4,5-dihydropyrazolo[3,4-a]acridines |
US5422350A (en) * | 1992-09-10 | 1995-06-06 | Warner-Lambert Company | Nitrogen substituted acridine and cytochrome P450 inhibitors and methods of use |
US5466696A (en) * | 1992-09-10 | 1995-11-14 | Warner Lambert Company | Tacrine and cytochrome P450 oxidase inhibitors and methods of use |
HU213107B (en) * | 1994-02-23 | 1997-02-28 | Egyt Gyogyszervegyeszeti Gyar | Process for producing acetic acid derivatives and pharmaceutical compositions containing them |
GB9716879D0 (en) * | 1997-08-08 | 1997-10-15 | Shire Int Licensing Bv | Treatment of attention deficit disorders |
US6218383B1 (en) | 1998-08-07 | 2001-04-17 | Targacept, Inc. | Pharmaceutical compositions for the prevention and treatment of central nervous system disorders |
ES2168926B1 (en) * | 1999-12-14 | 2003-10-16 | Prous Science S A | DERIVATIVES OF CICLOPENTA- CICLOHEXA- AND CICLOHEPTA (B) QUINOLEINA, PROCEDURE FOR THE MANUFACTURING, USE AND CORRESPONDING PHARMACEUTICAL COMPOSITION. |
WO2006004201A1 (en) * | 2004-07-01 | 2006-01-12 | Eisai R & D Management Co., Ltd. | Nerve reveneration promoter |
CN1315810C (en) * | 2004-08-30 | 2007-05-16 | 北京理工大学 | Piperazine-bridged tacrine binary derivatives and synthesis method thereof |
US20080188510A1 (en) * | 2005-05-23 | 2008-08-07 | Eisai R & D Management Co., Ltd. | Novel methods using zonisamide |
WO2011070177A2 (en) * | 2009-12-11 | 2011-06-16 | Baltic Technology Development, Ltd. | Methods of facilitating neural cell survival using gdnf family ligand (gfl) mimetics or ret signaling pathway activators |
EA037187B1 (en) | 2010-02-09 | 2021-02-17 | Дзе Джонс Хопкинс Юниверсити | Method and composition for treating a cognitive disorder |
US10154988B2 (en) | 2012-11-14 | 2018-12-18 | The Johns Hopkins University | Methods and compositions for treating schizophrenia |
WO2014144663A1 (en) | 2013-03-15 | 2014-09-18 | The Johns Hopkins University | Methods and compositions for improving cognitive function |
WO2014144801A1 (en) | 2013-03-15 | 2014-09-18 | Agenebio Inc. | Methods and compositions for improving cognitive function |
US10925834B2 (en) | 2015-05-22 | 2021-02-23 | Agenebio, Inc. | Extended release pharmaceutical compositions of levetiracetam |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4985430A (en) * | 1987-12-03 | 1991-01-15 | Mitsubishi Kasei Corporation | 9-acylamino-tetrahydroacridine derivatives and memory enhancing agent containing said derivative as active ingredient |
-
1989
- 1989-07-31 US US07/387,722 patent/US4999430A/en not_active Expired - Lifetime
-
1990
- 1990-07-27 NZ NZ234672A patent/NZ234672A/en unknown
- 1990-07-27 FI FI903752A patent/FI903752A0/en not_active Application Discontinuation
- 1990-07-27 AU AU59945/90A patent/AU5994590A/en not_active Abandoned
- 1990-07-30 ZA ZA905978A patent/ZA905978B/en unknown
- 1990-07-30 NO NO90903359A patent/NO903359L/en unknown
- 1990-07-30 CA CA002022297A patent/CA2022297C/en not_active Expired - Fee Related
- 1990-07-30 IE IE275190A patent/IE66823B1/en not_active IP Right Cessation
- 1990-07-30 PT PT94849A patent/PT94849A/en not_active Application Discontinuation
- 1990-07-30 ES ES90114586T patent/ES2068955T3/en not_active Expired - Lifetime
- 1990-07-30 DK DK94112223T patent/DK0628548T3/en active
- 1990-07-30 JP JP2199361A patent/JP2930245B2/en not_active Expired - Fee Related
- 1990-07-30 AT AT94112223T patent/ATE186908T1/en not_active IP Right Cessation
- 1990-07-30 EP EP94112223A patent/EP0628548B1/en not_active Expired - Lifetime
- 1990-07-30 DK DK90114586.2T patent/DK0411534T3/en active
- 1990-07-30 DE DE69033369T patent/DE69033369T2/en not_active Expired - Fee Related
- 1990-07-30 EP EP90114586A patent/EP0411534B1/en not_active Expired - Lifetime
- 1990-07-30 KR KR1019900011578A patent/KR910002802A/en not_active Application Discontinuation
- 1990-07-30 ES ES94112223T patent/ES2141787T3/en not_active Expired - Lifetime
- 1990-07-30 DE DE69017789T patent/DE69017789T2/en not_active Expired - Fee Related
- 1990-07-30 AT AT90114586T patent/ATE119885T1/en not_active IP Right Cessation
-
2000
- 2000-02-02 GR GR20000400235T patent/GR3032539T3/en not_active IP Right Cessation
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU666725B2 (en) * | 1988-12-19 | 1996-02-22 | S.C.R. Newpharm | New pharmaceutical compositions and new pharmaceutical products allowing the regeneration of leukocytes and their use in the treatment of acquired immuno-deficient syndrom |
Also Published As
Publication number | Publication date |
---|---|
EP0411534A3 (en) | 1991-06-05 |
DE69017789D1 (en) | 1995-04-20 |
ATE186908T1 (en) | 1999-12-15 |
CA2022297A1 (en) | 1991-02-01 |
US4999430A (en) | 1991-03-12 |
NZ234672A (en) | 1991-11-26 |
KR910002802A (en) | 1991-02-26 |
ATE119885T1 (en) | 1995-04-15 |
NO903359L (en) | 1991-02-01 |
ZA905978B (en) | 1992-04-29 |
DE69033369D1 (en) | 1999-12-30 |
DK0628548T3 (en) | 2000-05-08 |
IE902751A1 (en) | 1991-02-27 |
DE69033369T2 (en) | 2000-05-11 |
EP0628548A1 (en) | 1994-12-14 |
GR3032539T3 (en) | 2000-05-31 |
ES2068955T3 (en) | 1995-05-01 |
IE66823B1 (en) | 1996-02-07 |
CA2022297C (en) | 2001-09-18 |
JPH0366670A (en) | 1991-03-22 |
ES2141787T3 (en) | 2000-04-01 |
FI903752A0 (en) | 1990-07-27 |
EP0411534B1 (en) | 1995-03-15 |
DK0411534T3 (en) | 1995-07-24 |
JP2930245B2 (en) | 1999-08-03 |
EP0628548B1 (en) | 1999-11-24 |
PT94849A (en) | 1991-04-18 |
EP0411534A2 (en) | 1991-02-06 |
NO903359D0 (en) | 1990-07-30 |
DE69017789T2 (en) | 1995-07-13 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
AU5994590A (en) | Derivatives of 1,2,3,4-tetrahydro-9-acridinamine | |
IT1229203B (en) | USE OF 5 METHYLTHETRAHYDROPHOLIC ACID, 5 FORMYLTHETRAHYDROPHOLIC ACID AND THEIR PHARMACEUTICALLY ACCEPTABLE SALTS FOR THE PREPARATION OF PHARMACEUTICAL COMPOSITIONS IN THE FORM OF CONTROLLED RELEASE ACTIVE IN THE THERAPY OF MENTAL AND ORGANIC DISORDERS. | |
AU7217696A (en) | New polycyclic aminopyridine compounds which are acetylcholinesterase inhibitors, process for preparing them and their use | |
AU1331588A (en) | Method for treatment of alcohol abuse | |
EP0807633A3 (en) | Novel 2,3-disubstituted-(5,6)- heteroarylfused-pyrimidine-4-ones | |
AU6001990A (en) | 4-(n-substituted amino)-2-butynyl-1-ureas and thioureas and derivatives thereof as centrally acting muscarinic agents | |
SI9720060B (en) | Use of 2-phenyl-1, 2-benzisoselenazol-3(2h)-one for producing a pharmaceutical preparation intended for treatment of the alzheimer's disease | |
AU1579688A (en) | Bisphenylalkylpiperazine derivatives, a method of their preparation and a pharmaceutical preparation | |
NZ232207A (en) | Dihydrobenz(c)acridine derivatives and pharmaceutical compositions | |
ES2009689A6 (en) | Derivatives of 3-piperidine carbaldehyde oxime and their use as medicaments | |
AU5992990A (en) | 14,17alpha-etheno- and -ethanoestratrienes, processes for the preparation of these compounds, as well as their use for the production of medicinal agents | |
AU3126289A (en) | 4,5,6,7-tetrahydro isothiazolo (4,5-c) pyridine derivatives | |
AU1099688A (en) | Substituted 3-phenyl-7h-thiazolo(2,2-b)(1,2,4)triazin-7-ones, a process for the preparation thereof, medicaments containing same and the use thereof, and also some intermediates formed in the preparation of the compounds mentioned | |
ES2008421A6 (en) | Pilocarpine derivatives | |
AU5768298A (en) | Use of benzoylalkyl-1,2,3,6-tetrahydropyridins | |
GB9301354D0 (en) | Process for the production of flavonic compounds combined or otherwise by in vitro culture of ginkgo biloba tissues |