ES2168926B1 - DERIVATIVES OF CICLOPENTA- CICLOHEXA- AND CICLOHEPTA (B) QUINOLEINA, PROCEDURE FOR THE MANUFACTURING, USE AND CORRESPONDING PHARMACEUTICAL COMPOSITION. - Google Patents

DERIVATIVES OF CICLOPENTA- CICLOHEXA- AND CICLOHEPTA (B) QUINOLEINA, PROCEDURE FOR THE MANUFACTURING, USE AND CORRESPONDING PHARMACEUTICAL COMPOSITION.

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Publication number
ES2168926B1
ES2168926B1 ES9902726A ES9902726A ES2168926B1 ES 2168926 B1 ES2168926 B1 ES 2168926B1 ES 9902726 A ES9902726 A ES 9902726A ES 9902726 A ES9902726 A ES 9902726A ES 2168926 B1 ES2168926 B1 ES 2168926B1
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ES
Spain
Prior art keywords
sub
derivatives
pharmaceutical composition
quinoleina
ciclohexa
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
ES9902726A
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Spanish (es)
Other versions
ES2168926A1 (en
Inventor
Blancafort Jose Prous
Gargallo Juan Castaner
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Prous Science SA
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Prous Science SA
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Publication date
Application filed by Prous Science SA filed Critical Prous Science SA
Priority to ES9902726A priority Critical patent/ES2168926B1/en
Publication of ES2168926A1 publication Critical patent/ES2168926A1/en
Application granted granted Critical
Publication of ES2168926B1 publication Critical patent/ES2168926B1/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Derivados de ciclopenta-, ciclohexa- y ciclohepta[b]quinoleína, procedimiento para su fabricación, utilización y composición farmacéutica correspondiente, o una sal o solvato farmaceuticamente aceptable de los mismos, de fórmula general (I), donde: - X{sub,1} y X{sub,2} son cada uno independientemente hidrógeno, flúor, cloro, metilo, etilo, hidroxi o amino. - Los sustituyentes X{sub,1} y X{sub,2} sobre el anillo fenilo pueden estar en cualquier posición. - X{sub,1} X{sub,2} pueden formar conjuntamente un grupo metoximetilen. - n = 3, 4, 5 - X{sub,3} y X{sub,4} son cada uno independientemente metilo, etilo, metoxi, etoxi - X{sub,3} y X{sub,4} pueden formar conjuntamente un ciclo conteniendo 2 heteroátomos de oxígeno o nitrógeno. La utilización es para la manufactura de medicamentos destinados al tratamiento de patologías con déficit del sistema colinérgico, como la enfermedad de Alzheimer. El procedimiento comprende la condensación de las correspondientes ciclopenta-, ciclohexa- y ciclohepta[b]quinoleínas con derivados del tipo (IV), donde - R = C{sub,1}-C{sub,4} alquilo.Derivatives of cyclopenta-, cyclohexa- and cyclohepta [b] quinolein, process for their manufacture, use and corresponding pharmaceutical composition, or a pharmaceutically acceptable salt or solvate thereof, of general formula (I), where: - X {sub, 1} and X {sub, 2} are each independently hydrogen, fluorine, chlorine, methyl, ethyl, hydroxy or amino. - The substituents X {sub, 1} and X {sub, 2} on the phenyl ring may be in any position. - X {sub, 1} X {sub, 2} can together form a methoxymethylene group. - n = 3, 4, 5-X {sub, 3} and X {sub, 4} are each independently methyl, ethyl, methoxy, ethoxy-X {sub, 3} and X {sub, 4} can form together a cycle containing 2 oxygen or nitrogen heteroatoms. The use is for the manufacture of medicines for the treatment of pathologies with deficits of the cholinergic system, such as Alzheimer's disease. The process comprises the condensation of the corresponding cyclopenta-, cyclohexa- and cyclohepta [b] quinoleins with derivatives of type (IV), where - R = C {sub, 1} -C {sub, 4} alkyl.

ES9902726A 1999-12-14 1999-12-14 DERIVATIVES OF CICLOPENTA- CICLOHEXA- AND CICLOHEPTA (B) QUINOLEINA, PROCEDURE FOR THE MANUFACTURING, USE AND CORRESPONDING PHARMACEUTICAL COMPOSITION. Expired - Fee Related ES2168926B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
ES9902726A ES2168926B1 (en) 1999-12-14 1999-12-14 DERIVATIVES OF CICLOPENTA- CICLOHEXA- AND CICLOHEPTA (B) QUINOLEINA, PROCEDURE FOR THE MANUFACTURING, USE AND CORRESPONDING PHARMACEUTICAL COMPOSITION.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES9902726A ES2168926B1 (en) 1999-12-14 1999-12-14 DERIVATIVES OF CICLOPENTA- CICLOHEXA- AND CICLOHEPTA (B) QUINOLEINA, PROCEDURE FOR THE MANUFACTURING, USE AND CORRESPONDING PHARMACEUTICAL COMPOSITION.

Publications (2)

Publication Number Publication Date
ES2168926A1 ES2168926A1 (en) 2002-06-16
ES2168926B1 true ES2168926B1 (en) 2003-10-16

Family

ID=8310894

Family Applications (1)

Application Number Title Priority Date Filing Date
ES9902726A Expired - Fee Related ES2168926B1 (en) 1999-12-14 1999-12-14 DERIVATIVES OF CICLOPENTA- CICLOHEXA- AND CICLOHEPTA (B) QUINOLEINA, PROCEDURE FOR THE MANUFACTURING, USE AND CORRESPONDING PHARMACEUTICAL COMPOSITION.

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ES (1) ES2168926B1 (en)

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0268871A1 (en) * 1986-10-31 1988-06-01 Sumitomo Pharmaceuticals Company, Limited Quinoline derivatives
EP0282959A3 (en) * 1987-03-17 1989-05-31 Hoechst-Roussel Pharmaceuticals Incorporated Substituted 9-amino-tetrahydro-acridines and related compounds, a process for their preparation and their use as medicaments
US4957915A (en) * 1989-02-27 1990-09-18 Biomeasure, Inc. Benzodiazepine analogs
US4999430A (en) * 1989-07-31 1991-03-12 Warner-Lambert Company Derivatives of 1,2,3,4-tetrahydro-9-acrisinamine
US5783584A (en) * 1995-12-11 1998-07-21 Mayo Foundation For Medical Education And Research THA analogs useful as cholinesterase inhibitors

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Publication number Publication date
ES2168926A1 (en) 2002-06-16

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