DE69033369T2 - 1,2,3,4-Tetrahydro-9-Akridinamine-Derivate - Google Patents

1,2,3,4-Tetrahydro-9-Akridinamine-Derivate

Info

Publication number
DE69033369T2
DE69033369T2 DE69033369T DE69033369T DE69033369T2 DE 69033369 T2 DE69033369 T2 DE 69033369T2 DE 69033369 T DE69033369 T DE 69033369T DE 69033369 T DE69033369 T DE 69033369T DE 69033369 T2 DE69033369 T2 DE 69033369T2
Authority
DE
Germany
Prior art keywords
acridinamine
tetrahydro
derivatives
agents
cerebral
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69033369T
Other languages
English (en)
Other versions
DE69033369D1 (de
Inventor
Colin Granger
Jeffrey Alan Kester
Walter Hamilton Moos
Anthony Jerome Thomas
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Warner Lambert Co LLC
Original Assignee
Warner Lambert Co LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co LLC filed Critical Warner Lambert Co LLC
Publication of DE69033369D1 publication Critical patent/DE69033369D1/de
Application granted granted Critical
Publication of DE69033369T2 publication Critical patent/DE69033369T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D219/00—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
    • C07D219/04—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D219/00—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
    • C07D219/04—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • C07D219/08—Nitrogen atoms
    • C07D219/10—Nitrogen atoms attached in position 9
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hospice & Palliative Care (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Psychiatry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Water Treatment By Electricity Or Magnetism (AREA)
  • Pyridine Compounds (AREA)
DE69033369T 1989-07-31 1990-07-30 1,2,3,4-Tetrahydro-9-Akridinamine-Derivate Expired - Fee Related DE69033369T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/387,722 US4999430A (en) 1989-07-31 1989-07-31 Derivatives of 1,2,3,4-tetrahydro-9-acrisinamine

Publications (2)

Publication Number Publication Date
DE69033369D1 DE69033369D1 (de) 1999-12-30
DE69033369T2 true DE69033369T2 (de) 2000-05-11

Family

ID=23531113

Family Applications (2)

Application Number Title Priority Date Filing Date
DE69017789T Expired - Fee Related DE69017789T2 (de) 1989-07-31 1990-07-30 1,2,3,4-Tetrahydro-9-Akridinaminderivate.
DE69033369T Expired - Fee Related DE69033369T2 (de) 1989-07-31 1990-07-30 1,2,3,4-Tetrahydro-9-Akridinamine-Derivate

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE69017789T Expired - Fee Related DE69017789T2 (de) 1989-07-31 1990-07-30 1,2,3,4-Tetrahydro-9-Akridinaminderivate.

Country Status (17)

Country Link
US (1) US4999430A (de)
EP (2) EP0411534B1 (de)
JP (1) JP2930245B2 (de)
KR (1) KR910002802A (de)
AT (2) ATE119885T1 (de)
AU (1) AU5994590A (de)
CA (1) CA2022297C (de)
DE (2) DE69017789T2 (de)
DK (2) DK0628548T3 (de)
ES (2) ES2068955T3 (de)
FI (1) FI903752A0 (de)
GR (1) GR3032539T3 (de)
IE (1) IE66823B1 (de)
NO (1) NO903359L (de)
NZ (1) NZ234672A (de)
PT (1) PT94849A (de)
ZA (1) ZA905978B (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ223875A (en) * 1987-03-17 1991-01-29 Hoechst Roussel Pharma 9-aminotetrahydroacridines and related homologues and pharmaceutical compositions
FR2640508B1 (fr) * 1988-12-19 1994-07-01 Dietlin Francois Nouvelles compositions et nouveaux produits pharmaceutiques assurant la regeneration de leucocytes et leur emploi pour le traitement du syndrome immuno-deficitaire
JP2546919B2 (ja) * 1989-11-08 1996-10-23 三菱化学株式会社 ９ーアシルアミノテトラヒドロアクリジン誘導体
CA2029497C (en) * 1989-11-08 2002-06-04 Kunihiro Ninomiya (Deceased) 4-acylaminopyridine derivative
US5179100A (en) * 1992-03-09 1993-01-12 Hoechst-Roussel Pharmaceuticals Inc. 4,5-dihydropyrazolo[3,4-a]acridines
US5466696A (en) * 1992-09-10 1995-11-14 Warner Lambert Company Tacrine and cytochrome P450 oxidase inhibitors and methods of use
US5422350A (en) * 1992-09-10 1995-06-06 Warner-Lambert Company Nitrogen substituted acridine and cytochrome P450 inhibitors and methods of use
HU213107B (en) * 1994-02-23 1997-02-28 Egyt Gyogyszervegyeszeti Gyar Process for producing acetic acid derivatives and pharmaceutical compositions containing them
GB9716879D0 (en) * 1997-08-08 1997-10-15 Shire Int Licensing Bv Treatment of attention deficit disorders
US6218383B1 (en) 1998-08-07 2001-04-17 Targacept, Inc. Pharmaceutical compositions for the prevention and treatment of central nervous system disorders
ES2168926B1 (es) * 1999-12-14 2003-10-16 Prous Science S A Derivados de ciclopenta- ciclohexa- y ciclohepta (b)quinoleina, procedimiento para su fabricacion, utilizacion y composicion farmaceutica correspondiente.
US20080045500A1 (en) * 2004-07-01 2008-02-21 Eisai R&D Management Co., Ltd. Nerve Regeneration Stimulator
CN1315810C (zh) * 2004-08-30 2007-05-16 北京理工大学 哌嗪桥联他克林双体衍生物及其合成方法
US20080188510A1 (en) * 2005-05-23 2008-08-07 Eisai R & D Management Co., Ltd. Novel methods using zonisamide
MX2012006580A (es) * 2009-12-11 2012-09-28 Genecode As Metodo para facilitar la sobrevivencia de celulas neurales usando mimeticos de ligandos (gfl) de la familia gdnf o activadores de la ruta de señalizacion de ret.
CN102905532A (zh) 2010-02-09 2013-01-30 约翰斯.霍普金斯大学 用于改善认知功能的方法和组合物
CA2891122C (en) 2012-11-14 2021-07-20 The Johns Hopkins University Methods and compositions for treating schizophrenia
WO2014144663A1 (en) 2013-03-15 2014-09-18 The Johns Hopkins University Methods and compositions for improving cognitive function
WO2014144801A1 (en) 2013-03-15 2014-09-18 Agenebio Inc. Methods and compositions for improving cognitive function
EA034167B8 (ru) 2015-05-22 2021-04-27 Эйджинбайо, Инк. Фармацевтические композиции леветирацетама пролонгированного высвобождения

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0319429B1 (de) * 1987-12-03 1994-04-27 Mitsubishi Kasei Corporation 9-(Acylamino)tetrahydroacridinderivate und wahrnehmungssteigernde Mittel davon als aktiver Wirkstoff

Also Published As

Publication number Publication date
DE69017789T2 (de) 1995-07-13
CA2022297A1 (en) 1991-02-01
FI903752A0 (fi) 1990-07-27
DE69033369D1 (de) 1999-12-30
EP0628548B1 (de) 1999-11-24
JPH0366670A (ja) 1991-03-22
NO903359D0 (no) 1990-07-30
ATE119885T1 (de) 1995-04-15
GR3032539T3 (en) 2000-05-31
IE66823B1 (en) 1996-02-07
JP2930245B2 (ja) 1999-08-03
ES2068955T3 (es) 1995-05-01
PT94849A (pt) 1991-04-18
ATE186908T1 (de) 1999-12-15
US4999430A (en) 1991-03-12
DK0628548T3 (da) 2000-05-08
CA2022297C (en) 2001-09-18
AU5994590A (en) 1991-01-31
ZA905978B (en) 1992-04-29
DE69017789D1 (de) 1995-04-20
DK0411534T3 (da) 1995-07-24
IE902751A1 (en) 1991-02-27
EP0411534B1 (de) 1995-03-15
EP0411534A2 (de) 1991-02-06
KR910002802A (ko) 1991-02-26
EP0628548A1 (de) 1994-12-14
NO903359L (no) 1991-02-01
NZ234672A (en) 1991-11-26
ES2141787T3 (es) 2000-04-01
EP0411534A3 (en) 1991-06-05

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee