DE69017789D1 - 1,2,3,4-Tetrahydro-9-Akridinaminderivate. - Google Patents

1,2,3,4-Tetrahydro-9-Akridinaminderivate.

Info

Publication number
DE69017789D1
DE69017789D1 DE69017789T DE69017789T DE69017789D1 DE 69017789 D1 DE69017789 D1 DE 69017789D1 DE 69017789 T DE69017789 T DE 69017789T DE 69017789 T DE69017789 T DE 69017789T DE 69017789 D1 DE69017789 D1 DE 69017789D1
Authority
DE
Germany
Prior art keywords
acridinamine
tetrahydro
derivatives
agents
cerebral
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69017789T
Other languages
English (en)
Other versions
DE69017789T2 (de
Inventor
Colin Granger
Moos Walter Hamilton
Jeffrey Alan Kester
Anthony Jerome Thomas
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Warner Lambert Co LLC
Original Assignee
Warner Lambert Co LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co LLC filed Critical Warner Lambert Co LLC
Publication of DE69017789D1 publication Critical patent/DE69017789D1/de
Application granted granted Critical
Publication of DE69017789T2 publication Critical patent/DE69017789T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D219/00—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
    • C07D219/04—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D219/00—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
    • C07D219/04—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • C07D219/08—Nitrogen atoms
    • C07D219/10—Nitrogen atoms attached in position 9
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hospice & Palliative Care (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Psychiatry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyridine Compounds (AREA)
  • Water Treatment By Electricity Or Magnetism (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DE69017789T 1989-07-31 1990-07-30 1,2,3,4-Tetrahydro-9-Akridinaminderivate. Expired - Fee Related DE69017789T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/387,722 US4999430A (en) 1989-07-31 1989-07-31 Derivatives of 1,2,3,4-tetrahydro-9-acrisinamine

Publications (2)

Publication Number Publication Date
DE69017789D1 true DE69017789D1 (de) 1995-04-20
DE69017789T2 DE69017789T2 (de) 1995-07-13

Family

ID=23531113

Family Applications (2)

Application Number Title Priority Date Filing Date
DE69017789T Expired - Fee Related DE69017789T2 (de) 1989-07-31 1990-07-30 1,2,3,4-Tetrahydro-9-Akridinaminderivate.
DE69033369T Expired - Fee Related DE69033369T2 (de) 1989-07-31 1990-07-30 1,2,3,4-Tetrahydro-9-Akridinamine-Derivate

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE69033369T Expired - Fee Related DE69033369T2 (de) 1989-07-31 1990-07-30 1,2,3,4-Tetrahydro-9-Akridinamine-Derivate

Country Status (17)

Country Link
US (1) US4999430A (de)
EP (2) EP0628548B1 (de)
JP (1) JP2930245B2 (de)
KR (1) KR910002802A (de)
AT (2) ATE119885T1 (de)
AU (1) AU5994590A (de)
CA (1) CA2022297C (de)
DE (2) DE69017789T2 (de)
DK (2) DK0411534T3 (de)
ES (2) ES2068955T3 (de)
FI (1) FI903752A0 (de)
GR (1) GR3032539T3 (de)
IE (1) IE66823B1 (de)
NO (1) NO903359L (de)
NZ (1) NZ234672A (de)
PT (1) PT94849A (de)
ZA (1) ZA905978B (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0282959A3 (de) * 1987-03-17 1989-05-31 Hoechst-Roussel Pharmaceuticals Incorporated Substituierte 9-Amino-tetrahydroacridine und verwandte Verbindungen, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
FR2640508B1 (fr) * 1988-12-19 1994-07-01 Dietlin Francois Nouvelles compositions et nouveaux produits pharmaceutiques assurant la regeneration de leucocytes et leur emploi pour le traitement du syndrome immuno-deficitaire
CA2029497C (en) * 1989-11-08 2002-06-04 Kunihiro Ninomiya (Deceased) 4-acylaminopyridine derivative
JP2546919B2 (ja) * 1989-11-08 1996-10-23 三菱化学株式会社 ９ーアシルアミノテトラヒドロアクリジン誘導体
US5179100A (en) * 1992-03-09 1993-01-12 Hoechst-Roussel Pharmaceuticals Inc. 4,5-dihydropyrazolo[3,4-a]acridines
US5466696A (en) * 1992-09-10 1995-11-14 Warner Lambert Company Tacrine and cytochrome P450 oxidase inhibitors and methods of use
US5422350A (en) * 1992-09-10 1995-06-06 Warner-Lambert Company Nitrogen substituted acridine and cytochrome P450 inhibitors and methods of use
HU213107B (en) * 1994-02-23 1997-02-28 Egyt Gyogyszervegyeszeti Gyar Process for producing acetic acid derivatives and pharmaceutical compositions containing them
GB9716879D0 (en) * 1997-08-08 1997-10-15 Shire Int Licensing Bv Treatment of attention deficit disorders
US6218383B1 (en) 1998-08-07 2001-04-17 Targacept, Inc. Pharmaceutical compositions for the prevention and treatment of central nervous system disorders
ES2168926B1 (es) * 1999-12-14 2003-10-16 Prous Science S A Derivados de ciclopenta- ciclohexa- y ciclohepta (b)quinoleina, procedimiento para su fabricacion, utilizacion y composicion farmaceutica correspondiente.
WO2006004201A1 (ja) * 2004-07-01 2006-01-12 Eisai R & D Management Co., Ltd. 神経再生促進剤
CN1315810C (zh) * 2004-08-30 2007-05-16 北京理工大学 哌嗪桥联他克林双体衍生物及其合成方法
US20080188510A1 (en) * 2005-05-23 2008-08-07 Eisai R & D Management Co., Ltd. Novel methods using zonisamide
EP2509953B1 (de) 2009-12-11 2016-03-30 Genecode AS Verfahren für das überleben von nervenzellen mit ligandenmimetika der gdnf-familie oder aktivatoren des ret-signalweges
BR112012019923A2 (pt) 2010-02-09 2016-08-09 Univ Johns Hopkins métodos e composições para melhorar a função cognitiva
CA2891122C (en) 2012-11-14 2021-07-20 The Johns Hopkins University Methods and compositions for treating schizophrenia
EP2968220B1 (de) 2013-03-15 2021-05-05 Agenebio, Inc. Verfahren und zusammensetzungen zur verbesserung von kognitiven funktionen
WO2014144663A1 (en) 2013-03-15 2014-09-18 The Johns Hopkins University Methods and compositions for improving cognitive function
CN107810002B (zh) 2015-05-22 2021-01-05 艾吉因生物股份有限公司 左乙拉西坦的延时释放药物组合物

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0319429B1 (de) * 1987-12-03 1994-04-27 Mitsubishi Kasei Corporation 9-(Acylamino)tetrahydroacridinderivate und wahrnehmungssteigernde Mittel davon als aktiver Wirkstoff

Also Published As

Publication number Publication date
JP2930245B2 (ja) 1999-08-03
ATE186908T1 (de) 1999-12-15
DK0628548T3 (da) 2000-05-08
CA2022297C (en) 2001-09-18
IE66823B1 (en) 1996-02-07
EP0411534A3 (en) 1991-06-05
AU5994590A (en) 1991-01-31
ES2141787T3 (es) 2000-04-01
IE902751A1 (en) 1991-02-27
DE69033369T2 (de) 2000-05-11
DK0411534T3 (da) 1995-07-24
ATE119885T1 (de) 1995-04-15
NO903359L (no) 1991-02-01
NZ234672A (en) 1991-11-26
JPH0366670A (ja) 1991-03-22
CA2022297A1 (en) 1991-02-01
GR3032539T3 (en) 2000-05-31
DE69033369D1 (de) 1999-12-30
FI903752A0 (fi) 1990-07-27
NO903359D0 (no) 1990-07-30
EP0628548B1 (de) 1999-11-24
KR910002802A (ko) 1991-02-26
ZA905978B (en) 1992-04-29
EP0628548A1 (de) 1994-12-14
EP0411534B1 (de) 1995-03-15
ES2068955T3 (es) 1995-05-01
DE69017789T2 (de) 1995-07-13
US4999430A (en) 1991-03-12
PT94849A (pt) 1991-04-18
EP0411534A2 (de) 1991-02-06

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee