TW304941B - - Google Patents
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- Publication number
- TW304941B TW304941B TW084110874A TW84110874A TW304941B TW 304941 B TW304941 B TW 304941B TW 084110874 A TW084110874 A TW 084110874A TW 84110874 A TW84110874 A TW 84110874A TW 304941 B TW304941 B TW 304941B
- Authority
- TW
- Taiwan
- Prior art keywords
- substituted
- alkyl
- group
- compound
- phenyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/42—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms in positions 2 and 4
- C07D311/56—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms in positions 2 and 4 without hydrogen atoms in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C39/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring
- C07C39/12—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring polycyclic with no unsaturation outside the aromatic rings
- C07C39/14—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring polycyclic with no unsaturation outside the aromatic rings with at least one hydroxy group on a condensed ring system containing two rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Transplantation (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Pyrane Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US32287694A | 1994-10-13 | 1994-10-13 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TW304941B true TW304941B (cg-RX-API-DMAC7.html) | 1997-05-11 |
Family
ID=23256829
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW084110874A TW304941B (cg-RX-API-DMAC7.html) | 1994-10-13 | 1995-10-13 |
Country Status (23)
| Country | Link |
|---|---|
| US (2) | US6051601A (cg-RX-API-DMAC7.html) |
| EP (1) | EP0785930A1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP2983295B2 (cg-RX-API-DMAC7.html) |
| KR (1) | KR100232341B1 (cg-RX-API-DMAC7.html) |
| CN (1) | CN1160399A (cg-RX-API-DMAC7.html) |
| AU (1) | AU696890B2 (cg-RX-API-DMAC7.html) |
| BR (1) | BR9504385A (cg-RX-API-DMAC7.html) |
| CA (1) | CA2201742A1 (cg-RX-API-DMAC7.html) |
| CO (1) | CO4480024A1 (cg-RX-API-DMAC7.html) |
| CZ (1) | CZ111797A3 (cg-RX-API-DMAC7.html) |
| FI (1) | FI971524A7 (cg-RX-API-DMAC7.html) |
| HU (1) | HUT77515A (cg-RX-API-DMAC7.html) |
| IL (1) | IL115529A0 (cg-RX-API-DMAC7.html) |
| MX (1) | MX9702731A (cg-RX-API-DMAC7.html) |
| NO (1) | NO971672L (cg-RX-API-DMAC7.html) |
| NZ (1) | NZ285156A (cg-RX-API-DMAC7.html) |
| PE (1) | PE10897A1 (cg-RX-API-DMAC7.html) |
| PL (1) | PL319688A1 (cg-RX-API-DMAC7.html) |
| RU (1) | RU2128655C1 (cg-RX-API-DMAC7.html) |
| TR (1) | TR199501270A2 (cg-RX-API-DMAC7.html) |
| TW (1) | TW304941B (cg-RX-API-DMAC7.html) |
| WO (1) | WO1996011920A1 (cg-RX-API-DMAC7.html) |
| ZA (1) | ZA958597B (cg-RX-API-DMAC7.html) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| YU13299A (sh) * | 1996-09-16 | 2001-03-07 | Pfizer Inc. | Postupak i intermedijari za dobijanje hromanolnih derivata |
| US5817684A (en) * | 1996-12-13 | 1998-10-06 | Eli Lilly And Company | Leukotriene antagonists for use in the treatment or inhibition of cerebral focal stroke |
| IL128731A0 (en) * | 1998-03-12 | 2000-01-31 | Pfizer Prod Inc | Method of preventing allograft rejection |
| EP0963755A3 (en) * | 1998-04-16 | 2001-03-14 | Pfizer Products Inc. | Use of benzopyranes for preventing allograft rejection |
| SE0004245D0 (sv) | 2000-11-20 | 2000-11-20 | Pharmacia Ab | Novel compounds and their use |
| BR0206771A (pt) * | 2001-01-30 | 2004-02-25 | Pfizer Prod Inc | Processos para a preparação de cidos cromanilbenzóicos |
| AU4239302A (en) * | 2001-06-28 | 2003-01-02 | Pfizer Products Inc. | Benzoic acid substituted benzopyrans for the treatment of atherosclerosis |
| NZ536664A (en) | 2002-06-19 | 2007-07-27 | Biovitrum Ab | Piperazinylpyrazine derivative compounds, their use and preparation |
| JP2008506768A (ja) * | 2004-07-22 | 2008-03-06 | ファルマシア コーポレーション | Ｃｏｘ−２選択的阻害剤とｌｔｂ４受容体アンタゴニストを組み合わせて用いる炎症および疼痛を治療するための組成物 |
| US7674822B2 (en) | 2004-11-24 | 2010-03-09 | Wyeth | PTP1b inhibitors |
| MX2007007103A (es) | 2004-12-13 | 2008-03-10 | Lilly Co Eli | Derivados espiro como inhibidores de lipoxigenasa. |
| BRPI0520097A2 (pt) | 2005-02-25 | 2009-08-25 | Lilly Co Eli | composto ou estereoisÈmeros únicos, misturas de estereoisÈmeros, ou sais farmaceuticamente aceitáveis dos mesmos, composição farmacêutica, e, uso de um composto ou um sal farmaceuticamente aceitável do mesmo |
| US7842713B2 (en) * | 2006-04-20 | 2010-11-30 | Pfizer Inc | Fused phenyl amido heterocyclic compounds |
| US7928238B2 (en) | 2006-05-11 | 2011-04-19 | Janssen Pharmaceutica Nv | 1,2,3,4-tetrahydro-quinoline derivatives as CETP inhibitors |
| JP2009536954A (ja) | 2006-05-11 | 2009-10-22 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | Ｃｅｔｐ阻害剤としての３，４−ジヒドロ−２ｈ−ベンゾ［１，４］オキサジンおよびチアジン誘導体 |
| KR101258331B1 (ko) | 2008-09-11 | 2013-04-26 | 화이자 인코포레이티드 | 헤테로아릴 아미드 유도체 및 글루코키나제 활성화제로서의 그의 용도 |
| AU2010222589B2 (en) * | 2009-03-11 | 2012-08-16 | Pfizer Inc. | Benzofuranyl derivatives used as glucokinase inhibitors |
| CA2864331C (en) | 2012-02-14 | 2018-10-09 | Children's Hospital Medical Center | Use of small molecule inhibitors targeting the interaction between rac gtpase and p67(phox) |
| CN102920692A (zh) * | 2012-10-25 | 2013-02-13 | 中国人民解放军第二军医大学 | (e)-2-(1-羟基-4-环己酮)乙基咖啡酸酯在制备防治类风湿关节炎的药物中的应用 |
| EA201792028A1 (ru) | 2015-03-13 | 2018-04-30 | Форма Терапьютикс, Инк. | Альфа-цинамидные соединения и композиции как ингибиторы hdac8 |
| TW201711999A (zh) | 2015-09-03 | 2017-04-01 | 佛瑪治療公司 | ﹝６，６﹞稠合雙環組蛋白脫乙醯基酶８（ｈｄａｃ８）抑制劑 |
| EP3383868B1 (en) | 2015-11-30 | 2022-10-05 | Merck Sharp & Dohme LLC | Aryl sulfonamides as blt1 antagonists |
| EP3383389B1 (en) | 2015-11-30 | 2021-04-28 | Merck Sharp & Dohme Corp. | Aryl acylsulfonamides as blt1 antagonists |
| US10450309B2 (en) | 2015-11-30 | 2019-10-22 | Merch Sharp & Dohme Corp. | Aryl sulfonamides as BLT1 antagonists |
| WO2017095722A1 (en) | 2015-11-30 | 2017-06-08 | Merck Sharp & Dohme Corp. | Aryl acylsulfonamides as blt1 antagonists |
| US20190216790A1 (en) * | 2016-10-13 | 2019-07-18 | The Regents Of The University Of California | Methods for Treating Pruritis |
| CN119700747B (zh) * | 2025-02-26 | 2025-05-06 | 云南农业大学 | 苦杏碱醇a在制备防治骨质疏松症产品中的应用 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SU469247A3 (ru) * | 1972-01-14 | 1975-04-30 | Майлз Лабораториз Инк (Фирма) | Способ получени производных хромона |
| US4565882A (en) * | 1984-01-06 | 1986-01-21 | G. D. Searle & Co. | Substituted dihydrobenzopyran-2-carboxylates |
| CA1320490C (en) * | 1987-01-12 | 1993-07-20 | Darrel M. Gapinski | Anti-inflammatory agents |
| US4889871A (en) * | 1987-05-29 | 1989-12-26 | G. D. Searle & Co. | Alkoxy-substituted dihydrobenzopyran-2-carboxylate derivatives |
| CA2019335C (en) * | 1989-06-27 | 2000-08-01 | Mitoshi Konno | Phenylalkan (en)oic acids |
| US4996230A (en) * | 1990-02-16 | 1991-02-26 | Eli Lilly And Company | Leukotriene antagonists |
| US5073562A (en) * | 1990-05-10 | 1991-12-17 | G. D. Searle & Co. | Alkoxy-substituted dihydrobenzopyran-2-carboxylic acids and derivatives thereof |
| US5051438A (en) * | 1990-05-16 | 1991-09-24 | G. D. Searle & Co. | Alkoxy-substituted dihydrobenzopyran-2-carboxylic acids and derivatives thereof, compositions and use |
| US5124350A (en) * | 1990-06-28 | 1992-06-23 | G. D. Searle & Co. | Leukotriene b4 antagonists |
| EP0623122B1 (en) | 1992-01-23 | 1997-03-05 | Pfizer Inc. | Benzopyran and related LTB4-antagonists. |
| MX9300312A (es) * | 1992-01-23 | 1993-07-31 | Pfizer | Antagonistas benzopiranicos y relacionado de ltb. |
-
1995
- 1995-05-26 NZ NZ285156A patent/NZ285156A/xx unknown
- 1995-05-26 CN CN95195608A patent/CN1160399A/zh active Pending
- 1995-05-26 KR KR1019970702392A patent/KR100232341B1/ko not_active Expired - Fee Related
- 1995-05-26 CZ CZ971117A patent/CZ111797A3/cs unknown
- 1995-05-26 CA CA002201742A patent/CA2201742A1/en not_active Abandoned
- 1995-05-26 US US08/809,728 patent/US6051601A/en not_active Expired - Fee Related
- 1995-05-26 HU HU9702048A patent/HUT77515A/hu unknown
- 1995-05-26 AU AU24167/95A patent/AU696890B2/en not_active Ceased
- 1995-05-26 JP JP8513057A patent/JP2983295B2/ja not_active Expired - Lifetime
- 1995-05-26 PL PL95319688A patent/PL319688A1/xx unknown
- 1995-05-26 EP EP95918114A patent/EP0785930A1/en not_active Withdrawn
- 1995-05-26 MX MX9702731A patent/MX9702731A/es unknown
- 1995-05-26 RU RU97105834A patent/RU2128655C1/ru active
- 1995-05-26 WO PCT/IB1995/000401 patent/WO1996011920A1/en not_active Ceased
- 1995-10-04 CO CO95046243A patent/CO4480024A1/es unknown
- 1995-10-06 IL IL11552995A patent/IL115529A0/xx unknown
- 1995-10-10 PE PE1995281391A patent/PE10897A1/es not_active Application Discontinuation
- 1995-10-11 BR BR9504385A patent/BR9504385A/pt not_active Application Discontinuation
- 1995-10-12 ZA ZA958597A patent/ZA958597B/xx unknown
- 1995-10-13 TR TR95/01270A patent/TR199501270A2/xx unknown
- 1995-10-13 TW TW084110874A patent/TW304941B/zh active
-
1997
- 1997-04-11 FI FI971524A patent/FI971524A7/fi unknown
- 1997-04-11 NO NO971672A patent/NO971672L/no not_active Application Discontinuation
-
2000
- 2000-01-28 US US09/493,707 patent/US6133286A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| FI971524A0 (fi) | 1997-04-11 |
| ZA958597B (en) | 1997-04-14 |
| CO4480024A1 (es) | 1997-07-09 |
| KR970706270A (ko) | 1997-11-03 |
| AU696890B2 (en) | 1998-09-24 |
| TR199501270A2 (tr) | 1996-06-21 |
| AU2416795A (en) | 1996-05-06 |
| NO971672D0 (no) | 1997-04-11 |
| FI971524A7 (fi) | 1997-04-11 |
| CZ111797A3 (cs) | 1998-07-15 |
| JP2983295B2 (ja) | 1999-11-29 |
| JPH09512035A (ja) | 1997-12-02 |
| BR9504385A (pt) | 1997-05-27 |
| IL115529A0 (en) | 1996-01-19 |
| PL319688A1 (en) | 1997-08-18 |
| KR100232341B1 (ko) | 2000-07-01 |
| MX9702731A (es) | 1997-06-28 |
| EP0785930A1 (en) | 1997-07-30 |
| NO971672L (no) | 1997-06-11 |
| CN1160399A (zh) | 1997-09-24 |
| PE10897A1 (es) | 1997-04-21 |
| US6133286A (en) | 2000-10-17 |
| HUT77515A (hu) | 1998-05-28 |
| CA2201742A1 (en) | 1996-04-25 |
| RU2128655C1 (ru) | 1999-04-10 |
| US6051601A (en) | 2000-04-18 |
| NZ285156A (en) | 1999-01-28 |
| WO1996011920A1 (en) | 1996-04-25 |
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