CO2022011682A2 - Método para producir linfocitos citolíticos naturales a partir de células madre pluripotentes - Google Patents

Método para producir linfocitos citolíticos naturales a partir de células madre pluripotentes

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Publication number
CO2022011682A2
CO2022011682A2 CONC2022/0011682A CO2022011682A CO2022011682A2 CO 2022011682 A2 CO2022011682 A2 CO 2022011682A2 CO 2022011682 A CO2022011682 A CO 2022011682A CO 2022011682 A2 CO2022011682 A2 CO 2022011682A2
Authority
CO
Colombia
Prior art keywords
cells
pluripotent stem
natural killer
producing natural
stem cells
Prior art date
Application number
CONC2022/0011682A
Other languages
English (en)
Spanish (es)
Inventor
Lan Cao
Hui-Hsin Chang
Jianxin Hu
Yu Qian
Xi Shi
Original Assignee
Takeda Pharmaceuticals Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Pharmaceuticals Co filed Critical Takeda Pharmaceuticals Co
Publication of CO2022011682A2 publication Critical patent/CO2022011682A2/es

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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0646—Natural killers cells [NK], NKT cells
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/15—Natural-killer [NK] cells; Natural-killer T [NKT] cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
    • A61K40/31—Chimeric antigen receptors [CAR]
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K40/00—Cellular immunotherapy
    • A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
    • A61K40/35—Cytokines
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    • C07K14/54—Interleukins [IL]
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0647—Haematopoietic stem cells; Uncommitted or multipotent progenitors
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    • A—HUMAN NECESSITIES
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    • A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the cancer treated
    • A61K2239/48—Blood cells, e.g. leukemia or lymphoma
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    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment
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CONC2022/0011682A 2020-02-28 2022-08-19 Método para producir linfocitos citolíticos naturales a partir de células madre pluripotentes CO2022011682A2 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202062983511P 2020-02-28 2020-02-28
PCT/US2021/019917 WO2021174004A1 (en) 2020-02-28 2021-02-26 Method for producing natural killer cells from pluripotent stem cells

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CO2022011682A2 true CO2022011682A2 (es) 2022-08-30

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Country Link
US (1) US12351824B2 (https=)
EP (1) EP4110904A1 (https=)
JP (1) JP7778708B2 (https=)
KR (1) KR20220148174A (https=)
CN (1) CN115427555A (https=)
AR (1) AR121455A1 (https=)
AU (1) AU2021225952A1 (https=)
BR (1) BR112022017216A2 (https=)
CA (1) CA3169617A1 (https=)
CO (1) CO2022011682A2 (https=)
IL (1) IL295964A (https=)
MX (1) MX2022010521A (https=)
TW (1) TWI886220B (https=)
WO (1) WO2021174004A1 (https=)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11459372B2 (en) 2020-11-30 2022-10-04 Crispr Therapeutics Ag Gene-edited natural killer cells
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CN113801846B (zh) * 2021-09-22 2024-06-04 南京艾尔普再生医学科技有限公司 一种从人诱导多能干细胞分化为自然杀伤细胞的方法
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