MX2017012223A - Metodo de produccion con iones de cobre controlados. - Google Patents

Metodo de produccion con iones de cobre controlados.

Info

Publication number
MX2017012223A
MX2017012223A MX2017012223A MX2017012223A MX2017012223A MX 2017012223 A MX2017012223 A MX 2017012223A MX 2017012223 A MX2017012223 A MX 2017012223A MX 2017012223 A MX2017012223 A MX 2017012223A MX 2017012223 A MX2017012223 A MX 2017012223A
Authority
MX
Mexico
Prior art keywords
medium
production method
copper ion
controlled production
cells
Prior art date
Application number
MX2017012223A
Other languages
English (en)
Inventor
Yamamoto Seiko
Doi Hiroyuki
Terashima Isamu
Original Assignee
Chugai Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chugai Pharmaceutical Co Ltd filed Critical Chugai Pharmaceutical Co Ltd
Publication of MX2017012223A publication Critical patent/MX2017012223A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0018—Culture media for cell or tissue culture
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0681—Cells of the genital tract; Non-germinal cells from gonads
    • C12N5/0682—Cells of the female genital tract, e.g. endometrium; Non-germinal cells from ovaries, e.g. ovarian follicle cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
    • C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/05—Inorganic components
    • C12N2500/10—Metals; Metal chelators
    • C12N2500/20—Transition metals
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/70—Undefined extracts
    • C12N2500/80—Undefined extracts from animals
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00—Genetically modified cells
    • C12N2510/02—Cells for production

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Cell Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • Reproductive Health (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)

Abstract

La presente invención proporciona un método de cultivo celular que comprende añadir un medio para siembra que contiene células a un medio inicial y comenzar a cultivar la célula en el medio inicial, en donde el medio inicial tiene un aditivo de medio de cultivo obtenido de organismos añadido al mismo y la cantidad de las especies amidadas C-terminal en la proteína producida es controlada por el contenido de cobre del medio inicial al inicio del cultivo de células.
MX2017012223A 2015-03-26 2016-03-25 Metodo de produccion con iones de cobre controlados. MX2017012223A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2015063662 2015-03-26
PCT/JP2016/059634 WO2016153041A1 (ja) 2015-03-26 2016-03-25 銅イオン制御製造方法

Publications (1)

Publication Number Publication Date
MX2017012223A true MX2017012223A (es) 2018-01-30

Family

ID=56977504

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2017012223A MX2017012223A (es) 2015-03-26 2016-03-25 Metodo de produccion con iones de cobre controlados.
MX2022003016A MX2022003016A (es) 2015-03-26 2017-09-25 Metodo de produccion con iones de cobre controlados.

Family Applications After (1)

Application Number Title Priority Date Filing Date
MX2022003016A MX2022003016A (es) 2015-03-26 2017-09-25 Metodo de produccion con iones de cobre controlados.

Country Status (13)

Country Link
US (2) US11046772B2 (es)
EP (2) EP3276001A4 (es)
JP (1) JP6752776B2 (es)
CN (1) CN107406832A (es)
AR (1) AR104050A1 (es)
AU (2) AU2016237086B2 (es)
BR (1) BR112017020401B1 (es)
CA (1) CA2980695A1 (es)
IL (1) IL254668B (es)
MX (2) MX2017012223A (es)
SG (1) SG11201707873TA (es)
TW (1) TWI716392B (es)
WO (1) WO2016153041A1 (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2401040A (en) 2003-04-28 2004-11-03 Chugai Pharmaceutical Co Ltd Method for treating interleukin-6 related diseases
PL2493922T3 (pl) 2009-10-26 2017-07-31 F.Hoffmann-La Roche Ag Sposób wytwarzania glikozylowanych immunoglobulin
EP4029881A1 (en) 2010-11-08 2022-07-20 F. Hoffmann-La Roche AG Subcutaneously administered anti-il-6 receptor antibody
AR104050A1 (es) * 2015-03-26 2017-06-21 Chugai Pharmaceutical Co Ltd Proceso de producción con iones de cobre controlados

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU668349B2 (en) 1991-04-25 1996-05-02 Chugai Seiyaku Kabushiki Kaisha Reconstituted human antibody against human interleukin 6 receptor
JP3630453B2 (ja) 1994-09-30 2005-03-16 中外製薬株式会社 Ｉｌ−６レセプター抗体を有効成分とする未熟型骨髄腫細胞治療剤
JP3822137B2 (ja) * 2002-05-20 2006-09-13 中外製薬株式会社 動物細胞培養用培地の添加剤およびそれを用いたタンパク質の製造方法
EP3736295A1 (en) 2004-03-24 2020-11-11 Chugai Seiyaku Kabushiki Kaisha Subtypes of humanized antibody against interleukin-6 receptor
AU2005323643B2 (en) * 2005-01-05 2011-07-21 Chugai Seiyaku Kabushiki Kaisha Cell culture method and utilization of the same
JP5586235B2 (ja) * 2007-03-02 2014-09-10 ワイス・エルエルシー ポリペプチドの産生のための細胞培養における銅およびグルタミン酸塩の使用
TW200902708A (en) 2007-04-23 2009-01-16 Wyeth Corp Methods of protein production using anti-senescence compounds
PL2493922T3 (pl) * 2009-10-26 2017-07-31 F.Hoffmann-La Roche Ag Sposób wytwarzania glikozylowanych immunoglobulin
JP5953502B2 (ja) 2010-07-08 2016-07-20 バクスアルタ ゲーエムベーハー 細胞培養による組換え型高分子量ｖＷＦ産生方法
WO2013012022A1 (ja) * 2011-07-19 2013-01-24 中外製薬株式会社 アルギニンアミドまたはその類似化合物を含む安定なタンパク質含有製剤
EP2968544A4 (en) * 2013-03-15 2016-10-12 Hoffmann La Roche CELL CULTURE MEDIA AND METHOD FOR PRODUCING ANTIBODY
CN105473614B (zh) * 2013-08-20 2019-11-01 斯洛文尼亚莱柯制药股份有限公司 用于控制多肽的α-酰胺化和/或C-末端氨基酸分裂的细胞培养基和方法
AU2015234611A1 (en) 2014-03-23 2016-11-10 Advantech Bioscience Farmaceutica Ltda. Enhancement of recombinant protein expression with copper
AR104050A1 (es) * 2015-03-26 2017-06-21 Chugai Pharmaceutical Co Ltd Proceso de producción con iones de cobre controlados

Also Published As

Publication number Publication date
AR104050A1 (es) 2017-06-21
TWI716392B (zh) 2021-01-21
CN107406832A (zh) 2017-11-28
AU2016237086B2 (en) 2022-04-14
US20210269536A1 (en) 2021-09-02
EP3276001A4 (en) 2018-09-12
IL254668B (en) 2021-01-31
BR112017020401A2 (pt) 2018-06-05
BR112017020401B1 (pt) 2021-04-06
CA2980695A1 (en) 2016-09-29
US11046772B2 (en) 2021-06-29
EP3276001A1 (en) 2018-01-31
US20180051090A1 (en) 2018-02-22
EP4219694A1 (en) 2023-08-02
TW201708532A (zh) 2017-03-01
JPWO2016153041A1 (ja) 2018-01-18
AU2016237086A1 (en) 2017-10-19
AU2022204600A1 (en) 2022-07-21
JP6752776B2 (ja) 2020-09-09
SG11201707873TA (en) 2017-10-30
MX2022003016A (es) 2022-04-07
WO2016153041A1 (ja) 2016-09-29
IL254668A0 (en) 2017-11-30

Similar Documents

Publication Publication Date Title
IL282352B (en) Methods for the production of autologous t cells used in the treatment of b-cell malignancies and other types of cancer and preparations thereof
PH12016502153A1 (en) Method for improving the production of cultured aquatic animals in combined rice-aquaculture systems
MX2016016886A (es) Anticuerpos anti-axl.
SG10201807693YA (en) Methods for recombinant production of saffron compounds
MX2022003016A (es) Metodo de produccion con iones de cobre controlados.
EA201791424A1 (ru) Получение белка
SA515361251B1 (ar) طريقة لزيادة تكوين حمض بيرو-جلوتاميك من بروتين
MY182924A (en) Enzyme compositions and uses thereof
MX2016013893A (es) Composiciones cementicias ultralivianas y metodos relacionados.
SG11201901093PA (en) Production method for insoluble recombinant protein aggregate
IL258633B (en) System and method for regulating cell culture based production of biologics
MX2018015298A (es) Metodo para estabilizar proteinas.
MY193444A (en) Cell-free production of ribonucleic acid
MX2020001357A (es) Produccion microbiana de aminas grasas.
MY183321A (en) Microorganism producing o-acetyl-homoserine and method for producing o-acetylhomoserine using the same
MX2019002223A (es) Procedimiento mejorado para el cultivo de algas.
PL3140392T3 (pl) Produkcja białek heteromultimerycznych z wykorzystaniem komórek ssaków
PH12018500069A1 (en) Novel lactobacillus sp. microorganisms, and composition for animal feed comprising same
MX2018007298A (es) Variantes con mejores propiedades de polipéptidos de fusión relacionados con omega-hidroxilasa.
IN2014DN09097A (es)
PH12015502693A1 (en) A composition, process and a kit for sugar processing
MX2016016565A (es) Polipeptidos de fusion relacionados con omega-hidroxilasa con propiedades mejoradas.
MY181195A (en) Method for producing single cell oil from lignocellulosic materials
EA038364B9 (ru) Способ получения гидролизата биомассы с пониженным содержанием солей
MX2016013363A (es) Metodo para aumentar la capacidad de sintesis de biomasa de microorganismos y microorganismos modificados a partir de ellos.