MX2016016565A - Polipeptidos de fusion relacionados con omega-hidroxilasa con propiedades mejoradas. - Google Patents

Polipeptidos de fusion relacionados con omega-hidroxilasa con propiedades mejoradas.

Info

Publication number
MX2016016565A
MX2016016565A MX2016016565A MX2016016565A MX2016016565A MX 2016016565 A MX2016016565 A MX 2016016565A MX 2016016565 A MX2016016565 A MX 2016016565A MX 2016016565 A MX2016016565 A MX 2016016565A MX 2016016565 A MX2016016565 A MX 2016016565A
Authority
MX
Mexico
Prior art keywords
omega
hydroxylase
fusion polypeptides
related fusion
improved properties
Prior art date
Application number
MX2016016565A
Other languages
English (en)
Inventor
W Schirmer Andreas
Zhu Baolong
Chang Cindy
Original Assignee
Reg Life Sciences Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Reg Life Sciences Llc filed Critical Reg Life Sciences Llc
Publication of MX2016016565A publication Critical patent/MX2016016565A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
    • C12N9/0077—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14) with a reduced iron-sulfur protein as one donor (1.14.15)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/18—Carboxylic ester hydrolases (3.1.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
    • C12P7/6409—Fatty acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y114/00—Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14)
    • C12Y114/15—Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14) with reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen (1.14.15)
    • C12Y114/15003—Alkane 1-monooxygenase (1.14.15.3)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y301/00—Hydrolases acting on ester bonds (3.1)
    • C12Y301/01—Carboxylic ester hydrolases (3.1.1)
    • C12Y301/01005—Lysophospholipase (3.1.1.5)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y301/00—Hydrolases acting on ester bonds (3.1)
    • C12Y301/02—Thioester hydrolases (3.1.2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y301/00—Hydrolases acting on ester bonds (3.1)
    • C12Y301/02—Thioester hydrolases (3.1.2)
    • C12Y301/02014—Oleoyl-[acyl-carrier-protein] hydrolase (3.1.2.14), i.e. ACP-thioesterase
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02E—REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
    • Y02E50/00—Technologies for the production of fuel of non-fossil origin
    • Y02E50/10—Biofuels, e.g. bio-diesel

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)

Abstract

La descripción se refiere a polipéptidos de fusión relacionados con omega-hidroxilasa que dan por resultado una producción de derivados de ácidos grasos omega-hidroxilados mejorados cuando se expresan en células hospederas recombinantes. La descripción se refiere además de microorganismos para expresar los polipéptidos de fusión relacionados con omega-hidroxilasa para la producción de derivados de ácido graso omega-hidroxilados.
MX2016016565A 2014-06-16 2015-06-16 Polipeptidos de fusion relacionados con omega-hidroxilasa con propiedades mejoradas. MX2016016565A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201462012970P 2014-06-16 2014-06-16
PCT/US2015/036078 WO2015195697A1 (en) 2014-06-16 2015-06-16 Omega-hydroxylase-related fusion polypeptides with improved properties

Publications (1)

Publication Number Publication Date
MX2016016565A true MX2016016565A (es) 2017-04-25

Family

ID=53491691

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2016016565A MX2016016565A (es) 2014-06-16 2015-06-16 Polipeptidos de fusion relacionados con omega-hidroxilasa con propiedades mejoradas.

Country Status (14)

Country Link
US (3) US11441130B2 (es)
EP (2) EP3690035A3 (es)
JP (3) JP6826435B2 (es)
KR (2) KR102663049B1 (es)
CN (2) CN106604990B (es)
AU (2) AU2015277261B2 (es)
BR (1) BR112016029235B1 (es)
CA (1) CA2951925A1 (es)
ES (1) ES2803560T3 (es)
MX (1) MX2016016565A (es)
MY (1) MY198268A (es)
PL (1) PL3087179T3 (es)
SI (1) SI3087179T1 (es)
WO (1) WO2015195697A1 (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105378486B (zh) 2013-06-14 2024-05-14 基因组股份公司 生产omega-羟基化的脂肪酸衍生物的方法
EP3690035A3 (en) * 2014-06-16 2020-10-21 Genomatica, Inc. Omega-hydroxylase-related fusion polypeptides with improved properties
WO2017101987A1 (en) * 2015-12-15 2017-06-22 REG Life Sciences, LLC Omega-hydroxylase-related fusion polypeptide variants with improved properties
US11339384B2 (en) 2017-04-03 2022-05-24 Genomatica, Inc. Thioesterase variants having improved activity for the production of medium-chain fatty acid derivatives

Family Cites Families (58)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1305083C (en) 1987-02-18 1992-07-14 Yoshiharu Kimura Microorganism belonging to genus rhodococcus, and a process for producing alkene derivative and unsaturated fatty acid
US5000000A (en) 1988-08-31 1991-03-19 University Of Florida Ethanol production by Escherichia coli strains co-expressing Zymomonas PDC and ADH genes
US5424202A (en) 1988-08-31 1995-06-13 The University Of Florida Ethanol production by recombinant hosts
US5028539A (en) 1988-08-31 1991-07-02 The University Of Florida Ethanol production using engineered mutant E. coli
US5482846A (en) 1988-08-31 1996-01-09 University Of Florida Ethanol production in Gram-positive microbes
AU7791991A (en) 1990-04-24 1991-11-11 Stratagene Methods for phenotype creation from multiple gene populations
US5602030A (en) 1994-03-28 1997-02-11 University Of Florida Research Foundation Recombinant glucose uptake system
US6428767B1 (en) 1995-05-12 2002-08-06 E. I. Du Pont De Nemours And Company Method for identifying the source of carbon in 1,3-propanediol
US5939250A (en) 1995-12-07 1999-08-17 Diversa Corporation Production of enzymes having desired activities by mutagenesis
US5965408A (en) 1996-07-09 1999-10-12 Diversa Corporation Method of DNA reassembly by interrupting synthesis
BR0309359B1 (pt) 2002-04-29 2014-03-18 Dow Global Technologies Inc Composição de alfa,ômega-poliéster de poliol, composição de alfa,ômega-poliéster poliamina e composição de poliéster poliolefina
WO2006051729A1 (ja) 2004-11-10 2006-05-18 Marine Biotechnology Institute Co., Ltd. P450遺伝子の単離法
US20100242345A1 (en) 2006-05-19 2010-09-30 LS9, Inc Production of fatty acids & derivatives thereof
CA2650773C (en) 2006-05-19 2014-12-02 Jay D. Keasling Microorganisms transformed with acetyl-coa carboxylase and wax synthase for production of fatty acid derivatives
US8110670B2 (en) 2006-05-19 2012-02-07 Ls9, Inc. Enhanced production of fatty acid derivatives
WO2008046106A2 (en) 2006-10-13 2008-04-17 Elevance Renewable Sciences, Inc. Synthesis of terminal alkenes from internal alkenes via olefin metathesis
EP2121546B1 (en) 2006-10-13 2017-12-13 Elevance Renewable Sciences, Inc. Methods of making alpha, omega-dicarboxylic acid alkene derivatives by metathesis
US8110093B2 (en) 2007-03-14 2012-02-07 Ls9, Inc. Process for producing low molecular weight hydrocarbons from renewable resources
CA2678915C (en) 2007-03-28 2019-04-09 Ls9, Inc. Enhanced production of fatty acid derivatives
US20080293060A1 (en) 2007-04-23 2008-11-27 Ls9, Inc. Methods and Compositions for Identification of Hydrocarbon Response, Transport and Biosynthesis Genes
BRPI0813359A2 (pt) 2007-05-22 2014-10-14 Ls9 Inc Ácidos nucleicos isolados, vetor, células, métodos para produzir um hidrocarboneto, para produzir uma cetona alifática, para produzir um polipeptídeo purificado, para produzir um hidrocarboneto, para produzir biocombustíveis, hidrocarboneto, biocombustível, polipeptídeo isolado, ácido nucleico isolado, organismos geneticamente engenheirados, método para identificar uma enzima útil para a produção de hidrocarbonetos
JP5324129B2 (ja) 2007-05-25 2013-10-23 神戸天然物化学株式会社 Ｃｙｐ１５３による芳香族化合物の製造方法
WO2009009391A2 (en) 2007-07-06 2009-01-15 Ls9, Inc. Systems and methods for the production of fatty esters
FR2921362B1 (fr) 2007-09-20 2012-09-21 Arkema France Procede de synthese d'acides gras omega-insatures
CA2692266C (en) 2007-09-27 2019-04-16 Ls9, Inc. Reduction of the toxic effect of impurities from raw materials by extractive fermentation
TWI351779B (en) 2007-12-03 2011-11-01 Advance Smart Ind Ltd Apparatus and method for correcting residual capac
US8183028B2 (en) 2007-12-21 2012-05-22 Ls9, Inc. Methods and compositions for producing olefins
CN105483068A (zh) 2008-05-16 2016-04-13 Reg生命科学有限责任公司 产生碳氢化合物的方法和组合物
US8232924B2 (en) 2008-05-23 2012-07-31 Alliant Techsystems Inc. Broadband patch antenna and antenna system
US8273694B2 (en) 2008-07-28 2012-09-25 Jeffrey A Brown Synthetic compositions obtained from algae
WO2010022090A1 (en) 2008-08-18 2010-02-25 Ls9, Inc. Systems and methods for the production of mixed fatty esters
EP2330091A4 (en) 2008-08-28 2013-02-06 Mitsui Chemicals Inc PREPARATION FOR OLEFIN
JP2012504963A (ja) 2008-10-07 2012-03-01 エルエス９・インコーポレイテッド 脂肪アルデヒドを生産するための方法および組成物
CA3041892C (en) 2008-10-28 2022-03-15 REG Life Sciences, LLC Methods for producing a fatty alcohol in a host cell
US7989875B2 (en) 2008-11-24 2011-08-02 Nxp B.V. BiCMOS integration of multiple-times-programmable non-volatile memories
MX368526B (es) 2008-12-23 2019-10-07 Reg Life Sciences Llc Metodos y composiciones relacionados con tioesterasa enzima.
US8071799B2 (en) 2009-01-29 2011-12-06 Energy & Environmental Research Center Foundation Chain-selective synthesis of fuel components and chemical feedstocks
CN102459569B (zh) 2009-04-10 2018-02-23 Reg生命科学有限责任公司 脂肪酸衍生物的产生
CA2759273C (en) 2009-04-27 2018-01-09 Ls9, Inc. Production of fatty acid esters
BRPI1009980A2 (pt) 2009-05-01 2015-08-25 Univ California Produtos de ésteres de ácidos graxos a partir de polímeros de biomassa
US20110162259A1 (en) 2009-09-25 2011-07-07 Ls9, Inc. Production of fatty acid derivatives
US8237003B2 (en) 2009-11-09 2012-08-07 Exxonmobil Chemical Patents Inc. Metathesis catalyst and process for use thereof
US8809563B2 (en) 2009-11-09 2014-08-19 Exxonmobil Chemical Patents Inc. Metathesis catalyst and process for use thereof
US8361769B1 (en) 2009-11-16 2013-01-29 U.S. Department Of Energy Regioselective alkane hydroxylation with a mutant CYP153A6 enzyme
WO2011062987A2 (en) 2009-11-17 2011-05-26 Ls9, Inc. Methods and compositions for producing hydrocarbons
US8530221B2 (en) 2010-01-14 2013-09-10 Ls9, Inc. Production of branched chain fatty acids and derivatives thereof in recombinant microbial cells
WO2011127409A2 (en) 2010-04-08 2011-10-13 Ls9, Inc. Methods and compositions related to fatty alcohol biosynthetic enzymes
CA3039432A1 (en) 2010-05-28 2011-12-01 Corbion Biotech, Inc. Tailored oils produced from recombinant heterotrophic microorganisms
US8372610B2 (en) 2010-09-15 2013-02-12 Ls9, Inc. Production of odd chain fatty acid derivatives in recombinant microbial cells
WO2012071439A1 (en) 2010-11-22 2012-05-31 The Regents Of The University Of California Host cells and methods for producing diacid compounds
US9249436B2 (en) 2011-02-02 2016-02-02 Solazyme, Inc. Tailored oils produced from recombinant oleaginous microorganisms
CA3051939C (en) 2011-07-06 2023-08-01 Verdezyne, Inc. Genetically modified yeast with increased alcohol dehydrogenase activity for preparing a fatty dicarboxylic acid
DE102011110946A1 (de) 2011-08-15 2016-01-21 Evonik Degussa Gmbh Biotechnologisches Syntheseverfahren von omegafunktionalisierten Carbonsäuren und Carbonsäure-Estern aus einfachen Kohlenstoffquellen
EP2639308A1 (de) * 2012-03-12 2013-09-18 Evonik Industries AG Enzymatische omega-Oxidation und -Aminierung von Fettsäuren
FR3003577B1 (fr) 2013-03-19 2016-05-06 Ferropem Inoculant a particules de surface
CN105378486B (zh) * 2013-06-14 2024-05-14 基因组股份公司 生产omega-羟基化的脂肪酸衍生物的方法
EP3690035A3 (en) 2014-06-16 2020-10-21 Genomatica, Inc. Omega-hydroxylase-related fusion polypeptides with improved properties
WO2017101987A1 (en) 2015-12-15 2017-06-22 REG Life Sciences, LLC Omega-hydroxylase-related fusion polypeptide variants with improved properties

Also Published As

Publication number Publication date
US11421206B2 (en) 2022-08-23
EP3690035A3 (en) 2020-10-21
US11441130B2 (en) 2022-09-13
EP3690035A2 (en) 2020-08-05
US20230167419A1 (en) 2023-06-01
JP2017518060A (ja) 2017-07-06
SI3087179T1 (sl) 2020-10-30
CN114605558A (zh) 2022-06-10
AU2021202194A1 (en) 2021-05-06
KR20220124292A (ko) 2022-09-13
CN106604990A (zh) 2017-04-26
ES2803560T3 (es) 2021-01-27
CN106604990B (zh) 2022-04-05
US20200370024A1 (en) 2020-11-26
KR20170066306A (ko) 2017-06-14
US20170145390A1 (en) 2017-05-25
EP3087179A1 (en) 2016-11-02
CA2951925A1 (en) 2015-12-23
MY198268A (en) 2023-08-18
WO2015195697A9 (en) 2016-02-25
JP2022023237A (ja) 2022-02-07
AU2015277261B2 (en) 2021-02-18
JP6826435B2 (ja) 2021-02-03
BR112016029235A2 (pt) 2018-07-10
BR112016029235B1 (pt) 2023-11-28
EP3087179B1 (en) 2020-04-08
KR102663049B1 (ko) 2024-05-13
PL3087179T3 (pl) 2020-09-21
JP2020036610A (ja) 2020-03-12
WO2015195697A1 (en) 2015-12-23
AU2015277261A1 (en) 2017-02-02
KR102439589B1 (ko) 2022-09-06

Similar Documents

Publication Publication Date Title
EP3102609A4 (en) Methods for producing autologous t cells useful to treat b cell malignancies and other cancers and compositions thereof
IL273504A (en) Compositions for cell culture with antioxidants and methods for polypeptide production
HUE060246T2 (hu) Rekombináns mikroorganizmus, fokozott termékhozamú eljárásban történõ alkalmazásra
EP3004218A4 (en) Integrated biorefineries for production of sugars, fermentation products, and coproducts
MX2016013893A (es) Composiciones cementicias ultralivianas y metodos relacionados.
EP3230446A4 (en) Oleic acid production in yeast
MY182924A (en) Enzyme compositions and uses thereof
EP3374490A4 (en) HETEROLOGICAL EXPRESSION OF TAURINE IN MICROORGANISMS
EP3492592A4 (en) FIBRONEKTIN FRAGMENT FOR STEM CELL PRODUCTION
EP3380611A4 (en) PRODUCTION OF VIRUSES IN A CELL CULTURE
EP3191578A4 (en) Cells expressing apolipoprotein e and uses thereof
MX2016015893A (es) Produccion de fragmentos de fragmento cristalizable (fc).
EP3237441A4 (en) Methods of improving yield in recombinant protein production
MX2018007298A (es) Variantes con mejores propiedades de polipéptidos de fusión relacionados con omega-hidroxilasa.
EP3285565A4 (en) Macroalgae biomass production
EP3140392A4 (en) Production of heteromultimeric proteins using mammalian cells
EP3162891A4 (en) Cultured cell differentiation promotion method and cultured cell differentiation promoter
MX2016016565A (es) Polipeptidos de fusion relacionados con omega-hidroxilasa con propiedades mejoradas.
EP3155076A4 (en) Processed biomass pellets from beneficiated organic-carbon-containing feedstock
PL3359655T3 (pl) Komórka eukariotyczna ze zwiększonym wytwarzaniem produktu fermentacji
EP3119877A4 (en) Methods relating to pluripotent cells
EP3240870A4 (en) PROCESS FOR THE THERMOLYSIS OF BIOMASS IN THE PRESENCE OF SULFUR HYDROGEN
EP3194573A4 (en) Mammalian pluripotent stem cells, methods for their production, and uses thereof
IL253124A0 (en) Unnatural auxotrophs and their uses to increase the stability of compound production inside host microbial cells
EP3119871A4 (en) Clarification of mammalian cell culture

Legal Events

Date Code Title Description
FG Grant or registration