EA201791424A1 - Получение белка - Google Patents

Получение белка

Info

Publication number
EA201791424A1
EA201791424A1 EA201791424A EA201791424A EA201791424A1 EA 201791424 A1 EA201791424 A1 EA 201791424A1 EA 201791424 A EA201791424 A EA 201791424A EA 201791424 A EA201791424 A EA 201791424A EA 201791424 A1 EA201791424 A1 EA 201791424A1
Authority
EA
Eurasian Patent Office
Prior art keywords
protein
producing
getting
getting protein
expressed
Prior art date
Application number
EA201791424A
Other languages
English (en)
Inventor
Филип Бассетт
Ричард Дэвис
Элена Гонсалес
Марк Пирс-Хиггинз
Original Assignee
Юсб Биофарма Спрл
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=52292664&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA201791424(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Юсб Биофарма Спрл filed Critical Юсб Биофарма Спрл
Publication of EA201791424A1 publication Critical patent/EA201791424A1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/145—Extraction; Separation; Purification by extraction or solubilisation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/241—Tumor Necrosis Factors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2875—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF/TNF superfamily, e.g. CD70, CD95L, CD153, CD154
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins

Abstract

Настоящее изобретение предоставляет новый способ получения белка, где белок экспрессируется в клетке-хозяине, и, более конкретно, относится к способу получения белка, который приводит к пониженному содержанию родственных примесей.
EA201791424A 2014-12-22 2015-12-18 Получение белка EA201791424A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP14199717 2014-12-22
PCT/EP2015/080561 WO2016102383A1 (en) 2014-12-22 2015-12-18 Protein manufacture

Publications (1)

Publication Number Publication Date
EA201791424A1 true EA201791424A1 (ru) 2017-10-31

Family

ID=52292664

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201791424A EA201791424A1 (ru) 2014-12-22 2015-12-18 Получение белка

Country Status (24)

Country Link
US (1) US10358460B2 (ru)
EP (2) EP3237432B1 (ru)
JP (1) JP6807327B2 (ru)
KR (1) KR102533455B1 (ru)
CN (1) CN107108692B (ru)
AU (1) AU2015371346B2 (ru)
BR (1) BR112017013394B1 (ru)
CA (1) CA2969889A1 (ru)
CL (1) CL2017001632A1 (ru)
CO (1) CO2017006156A2 (ru)
DK (1) DK3237432T3 (ru)
EA (1) EA201791424A1 (ru)
ES (1) ES2965032T3 (ru)
FI (1) FI3237432T3 (ru)
HR (1) HRP20231408T1 (ru)
IL (1) IL252696B (ru)
LT (1) LT3237432T (ru)
MX (1) MX2017007684A (ru)
MY (1) MY180732A (ru)
PL (1) PL3237432T3 (ru)
PT (1) PT3237432T (ru)
SG (1) SG11201704836XA (ru)
SI (1) SI3237432T1 (ru)
WO (1) WO2016102383A1 (ru)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201001791D0 (en) * 2010-02-03 2010-03-24 Ucb Pharma Sa Process for obtaining antibodies
WO2012149197A2 (en) 2011-04-27 2012-11-01 Abbott Laboratories Methods for controlling the galactosylation profile of recombinantly-expressed proteins
US9334319B2 (en) 2012-04-20 2016-05-10 Abbvie Inc. Low acidic species compositions
US9067990B2 (en) 2013-03-14 2015-06-30 Abbvie, Inc. Protein purification using displacement chromatography
WO2013158273A1 (en) 2012-04-20 2013-10-24 Abbvie Inc. Methods to modulate c-terminal lysine variant distribution
US9512214B2 (en) 2012-09-02 2016-12-06 Abbvie, Inc. Methods to control protein heterogeneity
US9017687B1 (en) 2013-10-18 2015-04-28 Abbvie, Inc. Low acidic species compositions and methods for producing and using the same using displacement chromatography
WO2014151878A2 (en) 2013-03-14 2014-09-25 Abbvie Inc. Methods for modulating protein glycosylation profiles of recombinant protein therapeutics using monosaccharides and oligosacharides
US9598667B2 (en) 2013-10-04 2017-03-21 Abbvie Inc. Use of metal ions for modulation of protein glycosylation profiles of recombinant proteins
US9181337B2 (en) 2013-10-18 2015-11-10 Abbvie, Inc. Modulated lysine variant species compositions and methods for producing and using the same
US9085618B2 (en) 2013-10-18 2015-07-21 Abbvie, Inc. Low acidic species compositions and methods for producing and using the same
WO2015073884A2 (en) 2013-11-15 2015-05-21 Abbvie, Inc. Glycoengineered binding protein compositions
AU2015371341B2 (en) 2014-12-22 2021-05-20 Ucb Biopharma Sprl Method of protein manufacture

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8720833D0 (en) 1987-09-04 1987-10-14 Celltech Ltd Recombinant dna product
GB9215540D0 (en) * 1992-07-22 1992-09-02 Celltech Ltd Protein expression system
FR2716640B1 (fr) 1994-02-28 1996-05-03 Procedes Machines Speciales Dispositif de centrage et de blocage d'une pièce en vue de son rodage à l'aide d'un rodoir à expansion.
US5655866A (en) 1995-03-20 1997-08-12 Bellanca; Joseph V. Method of folding a signature for use in bookbinding
GB9625640D0 (en) 1996-12-10 1997-01-29 Celltech Therapeutics Ltd Biological products
TWI327597B (en) 2001-08-01 2010-07-21 Centocor Inc Anti-tnf antibodies, compositions, methods and uses
US7052916B2 (en) 2002-05-24 2006-05-30 Immunex Corporation Polypeptide analyses using stable isotope labeling
GB0319601D0 (en) 2003-08-20 2003-09-24 Sandoz Ag Production process
GB0425534D0 (en) * 2004-11-19 2004-12-22 Celltech R&D Ltd Process for obtaining antibodies
US8470552B2 (en) 2009-10-12 2013-06-25 Keck Graduate Institute Strategy to reduce lactic acid production and control PH in animal cell culture
GB201000590D0 (en) 2010-01-14 2010-03-03 Ucb Pharma Sa Bacterial host strain
GB201000591D0 (en) 2010-01-14 2010-03-03 Ucb Pharma Sa Bacterial hoist strain
GB201000587D0 (en) 2010-01-14 2010-03-03 Ucb Pharma Sa Bacterial hoist strain
GB201001791D0 (en) 2010-02-03 2010-03-24 Ucb Pharma Sa Process for obtaining antibodies
GB201012599D0 (en) * 2010-07-27 2010-09-08 Ucb Pharma Sa Process for purifying proteins
PT2731973T (pt) 2011-07-13 2018-02-22 Ucb Biopharma Sprl Estirpe hospedeira bacteriana que expressa dsbc recombinante
AU2015371341B2 (en) 2014-12-22 2021-05-20 Ucb Biopharma Sprl Method of protein manufacture

Also Published As

Publication number Publication date
EP3237432A1 (en) 2017-11-01
IL252696B (en) 2021-04-29
JP2018505693A (ja) 2018-03-01
BR112017013394B1 (pt) 2024-02-06
DK3237432T3 (da) 2023-11-20
CL2017001632A1 (es) 2017-11-24
HRP20231408T1 (hr) 2024-02-16
MX2017007684A (es) 2017-10-27
IL252696A0 (en) 2017-08-31
PL3237432T3 (pl) 2024-03-04
CO2017006156A2 (es) 2017-09-11
SI3237432T1 (sl) 2023-12-29
KR20170093984A (ko) 2017-08-16
AU2015371346A1 (en) 2017-06-29
US10358460B2 (en) 2019-07-23
LT3237432T (lt) 2023-12-11
CN107108692A (zh) 2017-08-29
EP4253548A3 (en) 2024-01-03
EP3237432B1 (en) 2023-09-06
KR102533455B1 (ko) 2023-05-16
BR112017013394A2 (pt) 2018-03-06
PT3237432T (pt) 2023-11-28
MY180732A (en) 2020-12-08
SG11201704836XA (en) 2017-07-28
JP6807327B2 (ja) 2021-01-06
EP4253548A2 (en) 2023-10-04
ES2965032T3 (es) 2024-04-10
CA2969889A1 (en) 2016-06-30
FI3237432T3 (fi) 2023-11-03
US20170362272A1 (en) 2017-12-21
CN107108692B (zh) 2021-01-29
AU2015371346B2 (en) 2021-05-13
WO2016102383A1 (en) 2016-06-30

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