BR112017020401A2 - processo de produção com íons de cobre controlados - Google Patents
processo de produção com íons de cobre controladosInfo
- Publication number
- BR112017020401A2 BR112017020401A2 BR112017020401-0A BR112017020401A BR112017020401A2 BR 112017020401 A2 BR112017020401 A2 BR 112017020401A2 BR 112017020401 A BR112017020401 A BR 112017020401A BR 112017020401 A2 BR112017020401 A2 BR 112017020401A2
- Authority
- BR
- Brazil
- Prior art keywords
- medium
- production process
- cell culture
- copper ions
- controlled copper
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/0018—Culture media for cell or tissue culture
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0681—Cells of the genital tract; Non-germinal cells from gonads
- C12N5/0682—Cells of the female genital tract, e.g. endometrium; Non-germinal cells from ovaries, e.g. ovarian follicle cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
- C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/05—Inorganic components
- C12N2500/10—Metals; Metal chelators
- C12N2500/20—Transition metals
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/70—Undefined extracts
- C12N2500/80—Undefined extracts from animals
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2510/00—Genetically modified cells
- C12N2510/02—Cells for production
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Cell Biology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biophysics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Reproductive Health (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
Abstract
a presente invenção refere-se a um método de cultura de células, em que um meio de semente contendo células é adicionado a um meio inicial, e a cultura de células é iniciada no meio inicial, o método sendo caracterizado por um aditivo do meio derivado biologicamente ser adicionado ao meio inicial, e a quantidade das espécies amidadas do terminal c na proteína produzida é controlada por meio do teor de cobre do meio inicial no início da cultura da célula.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2015063662 | 2015-03-26 | ||
| JP2015-063662 | 2015-03-26 | ||
| PCT/JP2016/059634 WO2016153041A1 (ja) | 2015-03-26 | 2016-03-25 | 銅イオン制御製造方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| BR112017020401A2 true BR112017020401A2 (pt) | 2018-06-05 |
| BR112017020401B1 BR112017020401B1 (pt) | 2021-04-06 |
Family
ID=56977504
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112017020401-0A BR112017020401B1 (pt) | 2015-03-26 | 2016-03-25 | Métodos de cultura de células alimentada em batelada para produção de íons de cobre controlados |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US11046772B2 (pt) |
| EP (2) | EP3276001A4 (pt) |
| JP (1) | JP6752776B2 (pt) |
| CN (1) | CN107406832A (pt) |
| AR (1) | AR104050A1 (pt) |
| AU (2) | AU2016237086B2 (pt) |
| BR (1) | BR112017020401B1 (pt) |
| CA (1) | CA2980695A1 (pt) |
| IL (1) | IL254668B (pt) |
| MX (2) | MX2017012223A (pt) |
| SG (1) | SG11201707873TA (pt) |
| TW (1) | TWI716392B (pt) |
| WO (1) | WO2016153041A1 (pt) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2401040A (en) | 2003-04-28 | 2004-11-03 | Chugai Pharmaceutical Co Ltd | Method for treating interleukin-6 related diseases |
| SI3202785T1 (sl) | 2009-10-26 | 2024-08-30 | F. Hoffmann-La Roche Ag | Postopek za proizvodnjo glikoziliranega imunoglobulina |
| WO2012064627A2 (en) | 2010-11-08 | 2012-05-18 | Genentech, Inc. | Subcutaneously administered anti-il-6 receptor antibody |
| AR104050A1 (es) * | 2015-03-26 | 2017-06-21 | Chugai Pharmaceutical Co Ltd | Proceso de producción con iones de cobre controlados |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK0628639T3 (da) | 1991-04-25 | 2000-01-24 | Chugai Pharmaceutical Co Ltd | Rekonstitueret humant antistof mod human interleukin-6-receptor |
| JP3630453B2 (ja) | 1994-09-30 | 2005-03-16 | 中外製薬株式会社 | Ｉｌ−６レセプター抗体を有効成分とする未熟型骨髄腫細胞治療剤 |
| JP3822137B2 (ja) * | 2002-05-20 | 2006-09-13 | 中外製薬株式会社 | 動物細胞培養用培地の添加剤およびそれを用いたタンパク質の製造方法 |
| EP3269738A1 (en) | 2004-03-24 | 2018-01-17 | Chugai Seiyaku Kabushiki Kaisha | Subtypes of humanized antibody against interleukin-6 receptor |
| EP1835022B1 (en) * | 2005-01-05 | 2015-02-11 | Chugai Seiyaku Kabushiki Kaisha | Cell culture method and utilization of the same |
| RU2009132986A (ru) | 2007-03-02 | 2011-04-10 | Уайт (Us) | Применение меди и глутамата в культуре клеток для производства полипептидов |
| TW200902708A (en) | 2007-04-23 | 2009-01-16 | Wyeth Corp | Methods of protein production using anti-senescence compounds |
| SI3202785T1 (sl) * | 2009-10-26 | 2024-08-30 | F. Hoffmann-La Roche Ag | Postopek za proizvodnjo glikoziliranega imunoglobulina |
| IL286298B (en) * | 2010-07-08 | 2022-08-01 | Baxalta Inc | A method to generate high molecular weight substituted vwf in cell culture |
| US9574005B2 (en) * | 2011-07-19 | 2017-02-21 | Chugai Seiyaku Kabushiki Kaisha | Stable Protein-containing preparation containing argininamide or analogous compound thereof |
| AR095348A1 (es) * | 2013-03-15 | 2015-10-07 | Genentech Inc | Medios de cultivo celular y métodos de producción de anticuerpos |
| US10196601B2 (en) * | 2013-08-20 | 2019-02-05 | Lek Pharmaceuticals D.D. | Cell culture medium and process for controlling α-amidation and/or C-terminal amino acid cleavage of polypeptides |
| KR20160138477A (ko) * | 2014-03-23 | 2016-12-05 | 어드밴텍 바이오사이언스 파마큐티카 엘티디에이 | 구리를 이용한 재조합 단백질의 발현 증가 방법 |
| AR104050A1 (es) * | 2015-03-26 | 2017-06-21 | Chugai Pharmaceutical Co Ltd | Proceso de producción con iones de cobre controlados |
-
2016
- 2016-03-23 AR ARP160100777A patent/AR104050A1/es unknown
- 2016-03-25 MX MX2017012223A patent/MX2017012223A/es unknown
- 2016-03-25 CN CN201680017702.8A patent/CN107406832A/zh active Pending
- 2016-03-25 TW TW105109543A patent/TWI716392B/zh active
- 2016-03-25 SG SG11201707873TA patent/SG11201707873TA/en unknown
- 2016-03-25 JP JP2017508467A patent/JP6752776B2/ja active Active
- 2016-03-25 CA CA2980695A patent/CA2980695A1/en active Pending
- 2016-03-25 WO PCT/JP2016/059634 patent/WO2016153041A1/ja active Application Filing
- 2016-03-25 US US15/561,154 patent/US11046772B2/en active Active
- 2016-03-25 EP EP16768944.7A patent/EP3276001A4/en active Pending
- 2016-03-25 EP EP23160911.6A patent/EP4219694A1/en active Pending
- 2016-03-25 AU AU2016237086A patent/AU2016237086B2/en active Active
- 2016-03-25 BR BR112017020401-0A patent/BR112017020401B1/pt active IP Right Grant
-
2017
- 2017-09-25 MX MX2022003016A patent/MX2022003016A/es unknown
- 2017-09-25 IL IL254668A patent/IL254668B/en active IP Right Grant
-
2021
- 2021-05-21 US US17/326,551 patent/US20210269536A1/en active Pending
-
2022
- 2022-06-29 AU AU2022204600A patent/AU2022204600B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| EP4219694A1 (en) | 2023-08-02 |
| BR112017020401B1 (pt) | 2021-04-06 |
| IL254668B (en) | 2021-01-31 |
| US20180051090A1 (en) | 2018-02-22 |
| IL254668A0 (en) | 2017-11-30 |
| WO2016153041A1 (ja) | 2016-09-29 |
| EP3276001A1 (en) | 2018-01-31 |
| JP6752776B2 (ja) | 2020-09-09 |
| CA2980695A1 (en) | 2016-09-29 |
| AU2016237086B2 (en) | 2022-04-14 |
| AR104050A1 (es) | 2017-06-21 |
| MX2017012223A (es) | 2018-01-30 |
| MX2022003016A (es) | 2022-04-07 |
| TW201708532A (zh) | 2017-03-01 |
| EP3276001A4 (en) | 2018-09-12 |
| AU2022204600A1 (en) | 2022-07-21 |
| TWI716392B (zh) | 2021-01-21 |
| AU2022204600B2 (en) | 2024-10-17 |
| AU2016237086A1 (en) | 2017-10-19 |
| SG11201707873TA (en) | 2017-10-30 |
| US11046772B2 (en) | 2021-06-29 |
| JPWO2016153041A1 (ja) | 2018-01-18 |
| US20210269536A1 (en) | 2021-09-02 |
| CN107406832A (zh) | 2017-11-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] |
Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS. |
|
| B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] | ||
| B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
| B06A | Patent application procedure suspended [chapter 6.1 patent gazette] | ||
| B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
| B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] |
Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 25/03/2016, OBSERVADAS AS CONDICOES LEGAIS. |