CN1802375A - 用于治疗炎性疾病的β－咔啉 - Google Patents
用于治疗炎性疾病的β－咔啉 Download PDFInfo
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- CN1802375A CN1802375A CNA2004800160170A CN200480016017A CN1802375A CN 1802375 A CN1802375 A CN 1802375A CN A2004800160170 A CNA2004800160170 A CN A2004800160170A CN 200480016017 A CN200480016017 A CN 200480016017A CN 1802375 A CN1802375 A CN 1802375A
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
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- Medicinal Chemistry (AREA)
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102391323A (zh) * | 2011-10-18 | 2012-03-28 | 首都医科大学 | 四氢-β-咔啉衍生物、其制备方法及其用途 |
| CN109593089A (zh) * | 2019-01-24 | 2019-04-09 | 西南大学 | 二氮杂螺癸烷哌啶甲酰胺类化合物制备和应用 |
| CN117510494A (zh) * | 2023-11-07 | 2024-02-06 | 桂林医学院附属医院 | β-咔啉-沙利度胺偶联物及其在制备逆转ABT-199耐药的药物中的应用 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| JP2006522824A (ja) | 2003-04-09 | 2006-10-05 | ミレニアム・ファーマシューティカルズ・インコーポレイテッド | 炎症性疾患を処置するために有用なβ−カルボリン |
| BRPI0509660A (pt) * | 2004-04-09 | 2007-10-09 | Millennium Pharm Inc | compostos de beta-carbolina de utilidade no tratamento de doenças inflamatórias |
| US8119655B2 (en) * | 2005-10-07 | 2012-02-21 | Takeda Pharmaceutical Company Limited | Kinase inhibitors |
| AU2006316322B2 (en) * | 2005-11-22 | 2011-08-25 | Merck Canada Inc. | Tricyclic compounds useful as inhibitors of kinases |
| US8426355B2 (en) * | 2006-03-15 | 2013-04-23 | Theralogics, Inc. | Methods of treating muscular wasting diseases using NF-κB activation inhibitors |
| WO2008002246A1 (en) * | 2006-06-28 | 2008-01-03 | Astrazeneca Ab | A pharmaceutical composition comprising an ikk2 inhibitor and a second active ingrdient. |
| AU2007334541A1 (en) * | 2006-12-13 | 2008-06-26 | Gilead Sciences, Inc. | Monophosphates as mutual prodrugs of anti-inflammatory signal transduction modulators (AISTM's) and beta-agonists for the treatment of pulmonary inflammation and bronchoconstriction |
| WO2009054970A1 (en) * | 2007-10-23 | 2009-04-30 | Millennium Pharmaceuticals, Inc. | Mesylate salt of an ikk inhibitor |
| WO2009054965A1 (en) * | 2007-10-23 | 2009-04-30 | Millennium Pharmaceuticals, Inc. | Salts of n- (6-chloro-9h-pyrido [3,4-b] ind0l-8-yl) -4- [2- (2, 6-dimethyl-4-morpholinyl) -2-0x0e thyl] -6, 6-dimethyl-morpholinecarboxamide |
| EP2297347B1 (en) | 2008-05-14 | 2017-03-08 | Millennium Pharmaceuticals, Inc. | Methods and kits for monitoring the effects of immunomodulators on adaptive immunity |
| CN102171204B (zh) | 2008-10-02 | 2014-08-20 | 旭化成制药株式会社 | 8位取代异喹啉衍生物及其用途 |
| WO2011120911A1 (en) | 2010-03-30 | 2011-10-06 | Novartis Ag | Pkc inhibitors for the treatment of b-cell lymphoma having chronic active b-cell-receptor signalling |
| US9440966B2 (en) * | 2011-03-28 | 2016-09-13 | Sjt Molecular Research, S.L. | Compounds for treatment of metabolic syndrome |
| CN102416014B (zh) * | 2011-09-13 | 2012-11-21 | 河南中医学院 | 一种生物碱类成分组合物在制备抗甲型h1n1流感病毒药物中的应用 |
| KR101646916B1 (ko) | 2015-07-13 | 2016-08-09 | 강원대학교산학협력단 | 베타-카르볼린 알칼로이드 화합물을 함유하는 염증성 질환의 예방 또는 치료용 조성물 |
| CN108271369A (zh) | 2015-10-23 | 2018-07-10 | 法尔玛赞公司 | 用于制备色胺及其衍生物的新工艺 |
| CN112824387B (zh) * | 2019-11-21 | 2023-03-21 | 济南尚博生物科技有限公司 | 一种2-甲基烟酸酯及其制备方法和应用 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE297908T1 (de) * | 1998-08-12 | 2005-07-15 | Pfizer Prod Inc | Tace inhibitoren |
| DE19951360A1 (de) | 1999-10-26 | 2001-05-03 | Aventis Pharma Gmbh | Substituierte Indole |
| EP1268477B1 (en) | 2000-03-15 | 2010-04-21 | Sanofi-Aventis Deutschland GmbH | Substituted beta-carbolines with ikb-kinase inhibiting activity |
| MXPA02007981A (es) | 2000-03-15 | 2004-04-05 | Aventis Pharma Gmbh | Beta-carbolinas sustituidas con actividad que inhibe la ikb-cinasa. |
| BR0212617A (pt) * | 2001-09-19 | 2005-02-09 | Pharmacia Corp | Compostos de pirazolila substituìdo para o tratamento de inflamação |
| AU2002352498A1 (en) * | 2001-11-07 | 2003-05-19 | Millennium Pharmaceuticals, Inc. | Carboline derivatives as inhibitors of ikb in the treatment of multiple myeloma and others cancers |
| WO2004080996A1 (en) * | 2003-03-07 | 2004-09-23 | Eli Lilly And Company | Opioid receptor antagonists |
| JP2006522824A (ja) | 2003-04-09 | 2006-10-05 | ミレニアム・ファーマシューティカルズ・インコーポレイテッド | 炎症性疾患を処置するために有用なβ−カルボリン |
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- 2004-04-09 US US10/821,545 patent/US7727985B2/en active Active
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- 2005-11-09 MA MA28592A patent/MA27837A1/fr unknown
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102391323A (zh) * | 2011-10-18 | 2012-03-28 | 首都医科大学 | 四氢-β-咔啉衍生物、其制备方法及其用途 |
| CN102391323B (zh) * | 2011-10-18 | 2013-09-25 | 首都医科大学 | 四氢-β-咔啉衍生物、其制备方法及其用途 |
| CN109593089A (zh) * | 2019-01-24 | 2019-04-09 | 西南大学 | 二氮杂螺癸烷哌啶甲酰胺类化合物制备和应用 |
| CN109593089B (zh) * | 2019-01-24 | 2022-01-28 | 西南大学 | 二氮杂螺癸烷哌啶甲酰胺类化合物制备和应用 |
| CN117510494A (zh) * | 2023-11-07 | 2024-02-06 | 桂林医学院附属医院 | β-咔啉-沙利度胺偶联物及其在制备逆转ABT-199耐药的药物中的应用 |
| CN117510494B (zh) * | 2023-11-07 | 2024-04-19 | 桂林医学院附属医院 | β-咔啉-沙利度胺偶联物及其在制备逆转ABT-199耐药的药物中的应用 |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2004092167A1 (en) | 2004-10-28 |
| OA13115A (en) | 2006-11-10 |
| HRP20050926A2 (en) | 2006-06-30 |
| AU2004230952A1 (en) | 2004-10-28 |
| NO20054598L (no) | 2005-10-27 |
| MXPA05010793A (es) | 2005-12-05 |
| US20100093713A1 (en) | 2010-04-15 |
| ECSP056145A (es) | 2006-04-19 |
| EP1611134A1 (en) | 2006-01-04 |
| RS20050832A (sr) | 2007-12-31 |
| US20040235839A1 (en) | 2004-11-25 |
| ZA200508198B (en) | 2007-01-31 |
| EA200501584A1 (ru) | 2006-06-30 |
| MA27837A1 (fr) | 2006-04-03 |
| WO2004092167A8 (en) | 2006-01-05 |
| JP2006522824A (ja) | 2006-10-05 |
| EA009121B1 (ru) | 2007-10-26 |
| CO5700746A2 (es) | 2006-11-30 |
| US7727985B2 (en) | 2010-06-01 |
| CR8042A (es) | 2006-05-30 |
| TNSN05257A1 (en) | 2007-07-10 |
| KR20060006031A (ko) | 2006-01-18 |
| BRPI0409263A (pt) | 2006-03-28 |
| NI200500174A (es) | 2006-04-17 |
| NO20054598D0 (no) | 2005-10-06 |
| CA2521300A1 (en) | 2004-10-28 |
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