NO20054598L - Beta-karboliner anvendbare for behandling av betennelsessykdommer - Google Patents

Beta-karboliner anvendbare for behandling av betennelsessykdommer

Info

Publication number
NO20054598L
NO20054598L NO20054598A NO20054598A NO20054598L NO 20054598 L NO20054598 L NO 20054598L NO 20054598 A NO20054598 A NO 20054598A NO 20054598 A NO20054598 A NO 20054598A NO 20054598 L NO20054598 L NO 20054598L
Authority
NO
Norway
Prior art keywords
inflammatory diseases
beta
treating inflammatory
useful
carbolines
Prior art date
Application number
NO20054598A
Other languages
English (en)
Norwegian (no)
Other versions
NO20054598D0 (no
Inventor
Hormoz Mazdiyasni
Alfredo Castro
Michael E Hepperle
Julie Fields Liu
Francois Soucy
Yingchun Ye
Robert S Murray
Raman Prakash
Jeremy D Little
Paul E Fleming
Dominic Reynolds
Original Assignee
Millennium Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Millennium Pharm Inc filed Critical Millennium Pharm Inc
Publication of NO20054598D0 publication Critical patent/NO20054598D0/no
Publication of NO20054598L publication Critical patent/NO20054598L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Rheumatology (AREA)
  • Oncology (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Hematology (AREA)
  • Hospice & Palliative Care (AREA)
  • Dermatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
NO20054598A 2003-04-09 2005-10-06 Beta-karboliner anvendbare for behandling av betennelsessykdommer NO20054598L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US46146803P 2003-04-09 2003-04-09
PCT/US2004/011080 WO2004092167A1 (en) 2003-04-09 2004-04-09 Beta-carbolines useful for treating inflammatory disease

Publications (2)

Publication Number Publication Date
NO20054598D0 NO20054598D0 (no) 2005-10-06
NO20054598L true NO20054598L (no) 2005-10-27

Family

ID=33299818

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20054598A NO20054598L (no) 2003-04-09 2005-10-06 Beta-karboliner anvendbare for behandling av betennelsessykdommer

Country Status (22)

Country Link
US (2) US7727985B2 (enExample)
EP (1) EP1611134A1 (enExample)
JP (1) JP2006522824A (enExample)
KR (1) KR20060006031A (enExample)
CN (1) CN1802375A (enExample)
AU (1) AU2004230952A1 (enExample)
BR (1) BRPI0409263A (enExample)
CA (1) CA2521300A1 (enExample)
CO (1) CO5700746A2 (enExample)
CR (1) CR8042A (enExample)
EA (1) EA009121B1 (enExample)
EC (1) ECSP056145A (enExample)
HR (1) HRP20050926A2 (enExample)
MA (1) MA27837A1 (enExample)
MX (1) MXPA05010793A (enExample)
NI (1) NI200500174A (enExample)
NO (1) NO20054598L (enExample)
OA (1) OA13115A (enExample)
RS (1) RS20050832A (enExample)
TN (1) TNSN05257A1 (enExample)
WO (1) WO2004092167A1 (enExample)
ZA (1) ZA200508198B (enExample)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2006522824A (ja) 2003-04-09 2006-10-05 ミレニアム・ファーマシューティカルズ・インコーポレイテッド 炎症性疾患を処置するために有用なβ−カルボリン
BRPI0509660A (pt) * 2004-04-09 2007-10-09 Millennium Pharm Inc compostos de beta-carbolina de utilidade no tratamento de doenças inflamatórias
US8119655B2 (en) * 2005-10-07 2012-02-21 Takeda Pharmaceutical Company Limited Kinase inhibitors
AU2006316322B2 (en) * 2005-11-22 2011-08-25 Merck Canada Inc. Tricyclic compounds useful as inhibitors of kinases
US8426355B2 (en) * 2006-03-15 2013-04-23 Theralogics, Inc. Methods of treating muscular wasting diseases using NF-κB activation inhibitors
WO2008002246A1 (en) * 2006-06-28 2008-01-03 Astrazeneca Ab A pharmaceutical composition comprising an ikk2 inhibitor and a second active ingrdient.
AU2007334541A1 (en) * 2006-12-13 2008-06-26 Gilead Sciences, Inc. Monophosphates as mutual prodrugs of anti-inflammatory signal transduction modulators (AISTM's) and beta-agonists for the treatment of pulmonary inflammation and bronchoconstriction
WO2009054970A1 (en) * 2007-10-23 2009-04-30 Millennium Pharmaceuticals, Inc. Mesylate salt of an ikk inhibitor
WO2009054965A1 (en) * 2007-10-23 2009-04-30 Millennium Pharmaceuticals, Inc. Salts of n- (6-chloro-9h-pyrido [3,4-b] ind0l-8-yl) -4- [2- (2, 6-dimethyl-4-morpholinyl) -2-0x0e thyl] -6, 6-dimethyl-morpholinecarboxamide
EP2297347B1 (en) 2008-05-14 2017-03-08 Millennium Pharmaceuticals, Inc. Methods and kits for monitoring the effects of immunomodulators on adaptive immunity
CN102171204B (zh) 2008-10-02 2014-08-20 旭化成制药株式会社 8位取代异喹啉衍生物及其用途
WO2011120911A1 (en) 2010-03-30 2011-10-06 Novartis Ag Pkc inhibitors for the treatment of b-cell lymphoma having chronic active b-cell-receptor signalling
US9440966B2 (en) * 2011-03-28 2016-09-13 Sjt Molecular Research, S.L. Compounds for treatment of metabolic syndrome
CN102416014B (zh) * 2011-09-13 2012-11-21 河南中医学院 一种生物碱类成分组合物在制备抗甲型h1n1流感病毒药物中的应用
CN102391323B (zh) * 2011-10-18 2013-09-25 首都医科大学 四氢-β-咔啉衍生物、其制备方法及其用途
KR101646916B1 (ko) 2015-07-13 2016-08-09 강원대학교산학협력단 베타-카르볼린 알칼로이드 화합물을 함유하는 염증성 질환의 예방 또는 치료용 조성물
CN108271369A (zh) 2015-10-23 2018-07-10 法尔玛赞公司 用于制备色胺及其衍生物的新工艺
CN109593089B (zh) * 2019-01-24 2022-01-28 西南大学 二氮杂螺癸烷哌啶甲酰胺类化合物制备和应用
CN112824387B (zh) * 2019-11-21 2023-03-21 济南尚博生物科技有限公司 一种2-甲基烟酸酯及其制备方法和应用
CN117510494B (zh) * 2023-11-07 2024-04-19 桂林医学院附属医院 β-咔啉-沙利度胺偶联物及其在制备逆转ABT-199耐药的药物中的应用

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE297908T1 (de) * 1998-08-12 2005-07-15 Pfizer Prod Inc Tace inhibitoren
DE19951360A1 (de) 1999-10-26 2001-05-03 Aventis Pharma Gmbh Substituierte Indole
EP1268477B1 (en) 2000-03-15 2010-04-21 Sanofi-Aventis Deutschland GmbH Substituted beta-carbolines with ikb-kinase inhibiting activity
MXPA02007981A (es) 2000-03-15 2004-04-05 Aventis Pharma Gmbh Beta-carbolinas sustituidas con actividad que inhibe la ikb-cinasa.
BR0212617A (pt) * 2001-09-19 2005-02-09 Pharmacia Corp Compostos de pirazolila substituìdo para o tratamento de inflamação
AU2002352498A1 (en) * 2001-11-07 2003-05-19 Millennium Pharmaceuticals, Inc. Carboline derivatives as inhibitors of ikb in the treatment of multiple myeloma and others cancers
WO2004080996A1 (en) * 2003-03-07 2004-09-23 Eli Lilly And Company Opioid receptor antagonists
JP2006522824A (ja) 2003-04-09 2006-10-05 ミレニアム・ファーマシューティカルズ・インコーポレイテッド 炎症性疾患を処置するために有用なβ−カルボリン

Also Published As

Publication number Publication date
WO2004092167A1 (en) 2004-10-28
OA13115A (en) 2006-11-10
HRP20050926A2 (en) 2006-06-30
AU2004230952A1 (en) 2004-10-28
MXPA05010793A (es) 2005-12-05
US20100093713A1 (en) 2010-04-15
ECSP056145A (es) 2006-04-19
EP1611134A1 (en) 2006-01-04
RS20050832A (sr) 2007-12-31
US20040235839A1 (en) 2004-11-25
ZA200508198B (en) 2007-01-31
EA200501584A1 (ru) 2006-06-30
MA27837A1 (fr) 2006-04-03
WO2004092167A8 (en) 2006-01-05
JP2006522824A (ja) 2006-10-05
EA009121B1 (ru) 2007-10-26
CO5700746A2 (es) 2006-11-30
US7727985B2 (en) 2010-06-01
CR8042A (es) 2006-05-30
TNSN05257A1 (en) 2007-07-10
KR20060006031A (ko) 2006-01-18
CN1802375A (zh) 2006-07-12
BRPI0409263A (pt) 2006-03-28
NI200500174A (es) 2006-04-17
NO20054598D0 (no) 2005-10-06
CA2521300A1 (en) 2004-10-28

Similar Documents

Publication Publication Date Title
NO20054598L (no) Beta-karboliner anvendbare for behandling av betennelsessykdommer
NZ533310A (en) Benzimidazoles useful as protein kinase inhibitors
NO20062357L (no) Indolinderivater og anvendelse av dem ved behandling av sykdomstilstander som cancer
NO20064763L (no) Forbindelser og fremgangsmater for behandling av dyslipidemi
NO20060665L (no) N-substituerte pyrazolyl-amidyl-benzimidazolyl C-kit inhibitorer
NO20060670L (no) N3-substituerte imidazopyridin C-kit inhibitorer
DK1474395T3 (da) Nicotinamidderivater, der er nyttige som p38-inhibitorer
NO20060664L (no) N-substituerte benzimidazolyl C-kit inhibitorer
ATE433967T1 (de) 2-aminopyridin-substituierteheterocyclen als inhibitoren der zellulären proliferation
EA200600317A1 (ru) Производные омега-карбоксиарилдифенилмочевины (варианты), фармацевтическая композиция (варианты) и способ лечения и предупреждения заболеваний и состояний с их использованием (варианты)
NO20082414L (no) Inhibitorer av AKT-aktivitet
MY142018A (en) Thiophene derivatives as chk 1 inihibitors
NO20082594L (no) Pyrimidinylbenzotiofenforbindelser
NO20051103L (no) Indol-3-karboksamider som Glukokinase-(GK)-Aktivatorer
NO20060230L (no) Nye aminobenzofenonforbindelser
CY1107747T1 (el) Υποκατεστημενα τετρακυκλικα παραγωγα πυρρολοκινολονης χρησιμα ως αναστολεις της φωσφοδιεστερασης
NO20061363L (no) Pyrazolo- og imidazo- pyrimidinderivater
NO20071574L (no) Arylsulfonylstilbenderivater for behandling av insomni og beslektede tilstander.
MXPA05012129A (es) Haloalquilo que contiene compuestos como inhibidores de la proteasa de cisteina.
NO20044526L (no) Hemisterlinderivater og anvendelser derav
NO20054340L (no) Nye sammenkoplede heterocykler og deres anvendelse
DK1483251T3 (da) C3-cyano-epothilon-derivater
NO20064894L (no) Beta-karboliner anvendbare for behandling av inflammatoriske sykdommer
NO20054361L (no) Benzensylfonamidderivater, fremgangsmate for fremstilling og anvendelse derav for behandlig av smerte
NO20072060L (no) 2-acylaminotiazolderivater

Legal Events

Date Code Title Description
FC2A Withdrawal, rejection or dismissal of laid open patent application