CN1756763A - 二聚体化肽 - Google Patents
二聚体化肽 Download PDFInfo
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- CN1756763A CN1756763A CNA2004800058473A CN200480005847A CN1756763A CN 1756763 A CN1756763 A CN 1756763A CN A2004800058473 A CNA2004800058473 A CN A2004800058473A CN 200480005847 A CN200480005847 A CN 200480005847A CN 1756763 A CN1756763 A CN 1756763A
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- HNKJADCVZUBCPG-UHFFFAOYSA-N thioanisole Chemical compound CSC1=CC=CC=C1 HNKJADCVZUBCPG-UHFFFAOYSA-N 0.000 description 1
- 125000000341 threoninyl group Chemical group [H]OC([H])(C([H])([H])[H])C([H])(N([H])[H])C(*)=O 0.000 description 1
- ZGYICYBLPGRURT-UHFFFAOYSA-N tri(propan-2-yl)silicon Chemical compound CC(C)[Si](C(C)C)C(C)C ZGYICYBLPGRURT-UHFFFAOYSA-N 0.000 description 1
- BYGOPQKDHGXNCD-UHFFFAOYSA-N tripotassium;iron(3+);hexacyanide Chemical compound [K+].[K+].[K+].[Fe+3].N#[C-].N#[C-].N#[C-].N#[C-].N#[C-].N#[C-] BYGOPQKDHGXNCD-UHFFFAOYSA-N 0.000 description 1
- 125000002221 trityl group Chemical group [H]C1=C([H])C([H])=C([H])C([H])=C1C([*])(C1=C(C(=C(C(=C1[H])[H])[H])[H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 description 1
- 125000000430 tryptophan group Chemical group [H]N([H])C(C(=O)O*)C([H])([H])C1=C([H])N([H])C2=C([H])C([H])=C([H])C([H])=C12 0.000 description 1
- 108010058119 tryptophyl-glycyl-glycine Proteins 0.000 description 1
- 108010084932 tryptophyl-proline Proteins 0.000 description 1
- 210000004881 tumor cell Anatomy 0.000 description 1
- 239000000439 tumor marker Substances 0.000 description 1
- 230000002476 tumorcidal effect Effects 0.000 description 1
- 108010020532 tyrosyl-proline Proteins 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
- 108010073969 valyllysine Proteins 0.000 description 1
- 235000013311 vegetables Nutrition 0.000 description 1
- 230000009385 viral infection Effects 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 150000003722 vitamin derivatives Chemical class 0.000 description 1
- 108010027345 wheylin-1 peptide Proteins 0.000 description 1
Images
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/82—Translation products from oncogenes
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
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- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
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- Peptides Or Proteins (AREA)
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- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Description
位置 | 氨基酸序列 | SEQ ID NO: |
137-145 | CLESQPAIR | 2 |
80-88 | GAEPHEEQC | 3 |
354-362 | QCDFKDCER | 4 |
409-417 | TSEKPFSCR | 5 |
386-394 | KTCQRKFSR | 6 |
325-333 | CAYPGCNKR | 7 |
232-240 | QLECMTWNQ | 8 |
317-325 | TSEKRPFMC | 9 |
位置 | 氨基酸序列 | SEQ ID NO: |
280-288 | ILCGAQYRI | 10 |
235-243 | CMTWNQMNL | 11 |
227-235 | YQMTSQLEC | 12 |
408-416 | KTSEKPFSC | 13 |
228-236 | QMTSQLECM | 14 |
86-94 | EQCLSAFTV | 15 |
位置 | 氨基酸序列 | SEQ ID NO: |
235-243 | CMTWNQMNL | 11 |
227-235 | YQMTSQLEC | 12 |
194-202 | SVPPPVYGC | 16 |
280-288 | ILCGAQYRI | 10 |
81-89 | AEPHEEQCL | 17 |
位置 | 氨基酸序列 | SEQ ID NO: |
356-364 | DFKDCERRF | 18 |
326-334 | AYPGCNKRY | 19 |
130-138 | NAPYLPSCL | 20 |
329-337 | GCNKRYFKL | 21 |
417-425 | RWPSCQKKF | 22 |
207-215 | DSCTGSQAL | 23 |
235-243 | CMTWNQMNL | 11 |
235*-243 | CYTWNQMNL | 44 |
位置 | 氨基酸序列 | SEQ ID NO: |
88-96 | CLSAFTVHF | 24 |
137-145 | CLESQPAIR | 2 |
280-288 | ILCGAQYRI | 10 |
386-394 | KTCQRKFSR | 6 |
235-243 | CMTWNQMNL | 11 |
383-391 | FQCKTCQRK | 25 |
194-202 | SVPPPVYGC | 16 |
位置 | 氨基酸序列 | SEQ ID NO: |
100-108 | FTGTAGACR | 26 |
386-394 | KTCQRKFSR | 6 |
409-417 | TSEKPFSCR | 5 |
325-333 | CAYPGCNKR | 7 |
354-362 | QCDFKDCER | 4 |
324-332 | MCAYPGCNK | 27 |
379-387 | GVKPFQCKT | 28 |
137-145 | CLESQPAIR | 2 |
位置 | 氨基酸序列 | SEQ ID NO: |
386-394 | KTCQRKFSR | 6 |
383-391 | FQCKTCQRK | 25 |
100-108 | FTGTAGACR | 26 |
324-332 | MCAYPGCNK | 27 |
415-423 | SCRWPSCQK | 29 |
137-145 | CLESQPAIR | 2 |
325-333 | CAYPGCNKR | 7 |
位置 | 氨基酸序列 | SEQ ID NO: |
386-394 | KTCQRKFSR | 6 |
137-145 | CLESQPAIR | 2 |
100-108 | FTGTAGACR | 26 |
325-333 | CAYPGCNKR | 7 |
279-287 | PILCGAQYR | 30 |
354-362 | QCDFKDCER | 4 |
383-391 | FQCKTCQRK | 25 |
358-366 | KDCERRFSR | 31 |
位置 | 氨基酸序列 | SEQ ID NO: |
409-417 | TSEKPFSCR | 5 |
137-145 | CLESQPAIR | 2 |
354-362 | QCDFKDCER | 4 |
100-108 | FTGTAGACR | 26 |
325-333 | CAYPGCNKR | 7 |
207-215 | DSCTGSQAL | 23 |
419-427 | PSCQKKFAR | 32 |
位置 | 氨基酸序列 | SEQ ID NO: |
329-337 | GCNKRYFKL | 33 |
位置 | 氨基酸序列 | SEQ ID NO: |
81-89 | AEPHEEQCL | 17 |
410-418 | SEKPFSCRW | 34 |
318-326 | SEKRPFMCA | 35 |
233-241 | LECMTWNQM | 36 |
349-357 | GEKPYQCDF | 37 |
85-93 | EEQCLSAFT | 38 |
23-31 | GCALPVSGA | 39 |
206-214 | TDSCTGSQA | 40 |
24-32 | CALPVSGAA | 41 |
84-92 | HEEQCLSAF | 42 |
位置 | 氨基酸序列 | SEQ ID NO: |
81-89 | AEPHEEQCL | 17 |
233-241 | LECMTWNQM | 36 |
209-217 | CTGSQALLL | 43 |
318-326 | SEKRPFMCA | 35 |
329-337 | GCNKRYFKL | 33 |
130-138 | NAPYLPSCL | 20 |
85-93 | EEQCLSAFT | 38 |
208-216 | SCTGSQALL | 45 |
207-215 | DSCTGSQAL | 23 |
18-26 | LGGGGGCAL | 46 |
位置 | 氨基酸序列 | SEQ ID NO: |
318-326 | SEKRPFMCA | 35 |
81-89 | AEPHEEQCL | 17 |
233-241 | LECMTWNQM | 36 |
85-93 | EEQCLSAFT | 38 |
206-214 | TDSCTGSQA | 40 |
20-28 | GGGGCALPV | 47 |
23-31 | GCALPVSGA | 39 |
位置 | 氨基酸序列 | SEQ ID NO: |
88-96 | CLSAFTVHF | 24 |
17-25 | SLGGGGGCA | 48 |
384-392 | QCKTCQRKF | 49 |
227-235 | YQMTSQLEC | 12 |
86-94 | EQCLSAFTV | 15 |
101-109 | TGTAGACRY | 50 |
280-288 | ILCGAQYRI | 10 |
位置 | 氨基酸序列 | SEQ ID NO: |
130-138 | NAPYLPSCL | 20 |
208-216 | SCTGSQALL | 45 |
18-26 | LGGGGGCAL | 46 |
207-215 | DSCTGSQAL | 23 |
209-217 | CTGSQALLL | 43 |
329-337 | GCNKRYFKL | 33 |
235-243 | CMTWNQMNL | 11 |
位置 | 氨基酸序列 | SEQ ID NO: |
329-337 | GCNKRYFKL | 33 |
208-216 | SCTGSQALL | 45 |
130-138 | NAPYLPSCL | 20 |
420-428 | SCQKKFARS | 51 |
387-395 | TCQRKFSRS | 52 |
207-215 | DSCTGSQAL | 23 |
384-392 | QCKTCQRKF | 49 |
136-144 | SCLESQPAI | 53 |
347-355 | HTGEKPYQC | 54 |
位置 | 氨基酸序列 | SEQ ID NO: |
416-424 | CRWPSCQKK | 55 |
107-115 | CRYGPFGPP | 56 |
位置 | 氨基酸序列 | SEQ ID NO: |
416-424 | CRWPSCQKK | 55 |
383-391 | FQCKTCQRK | 25 |
位置 | 氨基酸序列 | SEQ ID NO: |
278-286 | TPILCGAQY | 57 |
327-335 | YPGCNKRYF | 58 |
82-90 | EPHEEQCLS | 59 |
207-215 | DSCTGSQAL | 23 |
412-420 | KPFSCRWPS | 60 |
位置 | 氨基酸序列 | SEQ ID NO: |
81-89 | AEPHEEQCL | 17 |
85-93 | EEQCLSAFT | 38 |
208-216 | SCTGSQALL | 45 |
209-217 | CTGSQALLL | 43 |
206-214 | TDSCTGSQA | 40 |
84-92 | HEEQCLSAF | 42 |
233-241 | LECMTWNQM | 36 |
349-357 | GEKPYQCDF | 37 |
位置 | 氨基酸序列 | SEQ ID NO: |
202-210 | CHTPTDSCT | 61 |
417-425 | RWPSCQKKF | 22 |
327-335 | YPGCNKRYF | 58 |
208-216 | SCTGSQALL | 45 |
18-26 | LGGGGGCAL | 46 |
83-91 | PHEEQCLSA | 62 |
位置 | 氨基酸序列 | SEQ ID NO: |
136-144 | SCLESQPAI | 53 |
208-216 | SCTGSQALL | 45 |
207-215 | DSCTGSQAL | 23 |
位置 | 氨基酸序列 | SEQ ID NO: |
130-138 | NAPYLPSCL | 20 |
209-217 | CTGSQALLL | 43 |
207-215 | DSCTGSQAL | 23 |
208-216 | SCTGSQALL | 45 |
329-337 | GCNKRYFKL | 33 |
位置 | 氨基酸序列 | SEQ ID NO: |
349-357 | GEKPYQCDF | 37 |
84-92 | HEEQCLSAF | 42 |
410-418 | SEKPFSCRW | 34 |
278-286 | TPILCGAQY | 57 |
318-326 | SEKRPFMCA | 35 |
81-89 | AEPHEEQCL | 17 |
101-109 | TGTAGACRY | 50 |
85-93 | EEQCLSAFT | 38 |
233-241 | LECMTWNQM | 36 |
104-112 | AGACRYGPF | 63 |
位置 | 氨基酸序列 | SEQ ID NO: |
130-138 | NAPYLPSCL | 20 |
20-28 | GGGGCALPV | 47 |
18-26 | LGGGGGCAL | 46 |
418-426 | WPSCQKKFA | 64 |
82-90 | EPHEEQCLS | 59 |
280-288 | ILCGAQYRI | 10 |
204-212 | TPTDSCTGS | 65 |
位置 | 氨基酸序列 | SEQ ID NO: |
130-138 | NAPYLPSCL | 20 |
20-28 | GGGGCALPV | 47 |
412-420 | KPFSCRWPS | 60 |
18-26 | LGGGGGCAL | 46 |
24-32 | CALPVSGAA | 66 |
136-144 | SCLESQPAI | 53 |
418-426 | WPSCQKKFA | 64 |
351-359 | KPYQCDFKD | 67 |
位置 | 氨基酸序列 | SEQ ID NO: |
86-94 | EQCLSAFTV | 15 |
20-28 | GGGGCALPV | 47 |
327-335 | YPGCNKRYF | 58 |
104-112 | AGACRYGPF | 63 |
位置 | 氨基酸序列 | SEQ ID NO: |
230-238 | TSQLECMTW | 68 |
408-416 | KTSEKPFSC | 13 |
276-284 | HTTPILCGA | 69 |
347-355 | HTGEKPYQC | 54 |
317-325 | TSEKRPFMC | 9 |
位置 | 氨基酸序列 | SEQ ID NO: |
329-337 | GCNKRYFKL | 21 |
24-32 | CALPVSGAA | 41 |
136-144 | SCLESQPAI | 53 |
130-138 | NAPYLPSCL | 20 |
位置 | 氨基酸序列 | SEQ ID NO: |
356-364 | DFKDCERRF | 18 |
327-335 | YPGCNKRYF | 58 |
326-334 | AYPGCNKRY | 19 |
417-425 | RWPSCQKKF | 22 |
278-286 | TPILCGAQY | 57 |
99-107 | QFTGTAGAC | 70 |
位置 | 氨基酸序列 | SEQ ID NO: |
130-138 | NAPYLPSCL | 20 |
319-327 | EKRPFMCAY | 71 |
207-215 | DSCTGSQAL | 23 |
位置 | 氨基酸序列 | SEQ ID NO: |
319-327 | EKRPFMCAY | 71 |
326-334 | AYPGCNKRY | 19 |
278-286 | TPILCGAQY | 57 |
327-335 | YPGCNKRYF | 58 |
101-109 | TGTAGACRY | 50 |
130-138 | NAPYLPSCL | 20 |
84-92 | HEEQCLSAF | 42 |
步骤 | 试剂 | 处理数 | 时间(分钟) |
1)洗涤 | DMFMeOHDMF | 100ml×6100ml×1100ml×3 | 0.30.30.3 |
2)去保护 | 25%哌啶/DMF | 100ml100ml | 3.015.0 |
3)偶联 | 氨基-保护的氨基酸(每种5当量)、HOBT(5当量)、DIPCI(5当量)/NMP | 150ml | 30×1 |
4)洗涤 | NMP | 100ml×2 | 0.3 |
5)偶联* | 氨基-保护的氨基酸(每种5当量)、HOBT(5当量)、DIPCI(5当量)/NMP | 150ml | 30×1 |
6)洗涤 | DMFMeOHDMF | 100ml×5100ml×1100ml×2 | 0.30.30.3 |
Claims (10)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2003007122 | 2003-01-15 | ||
JP007122/2003 | 2003-01-15 | ||
PCT/JP2004/000254 WO2004063217A1 (ja) | 2003-01-15 | 2004-01-15 | 二量体化ペプチド |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201010156098A Division CN101851275A (zh) | 2003-01-15 | 2004-01-15 | 二聚体化肽 |
Publications (2)
Publication Number | Publication Date |
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CN1756763A true CN1756763A (zh) | 2006-04-05 |
CN1756763B CN1756763B (zh) | 2010-05-26 |
Family
ID=32709100
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
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CN2004800058473A Expired - Lifetime CN1756763B (zh) | 2003-01-15 | 2004-01-15 | 二聚体化肽 |
CN201010156098A Pending CN101851275A (zh) | 2003-01-15 | 2004-01-15 | 二聚体化肽 |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
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CN201010156098A Pending CN101851275A (zh) | 2003-01-15 | 2004-01-15 | 二聚体化肽 |
Country Status (13)
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US (2) | US20060217297A1 (zh) |
EP (2) | EP2154145B1 (zh) |
JP (2) | JP4498274B2 (zh) |
KR (2) | KR101399678B1 (zh) |
CN (2) | CN1756763B (zh) |
AT (1) | ATE444969T1 (zh) |
AU (1) | AU2004204031B2 (zh) |
BR (1) | BRPI0406800B8 (zh) |
CA (1) | CA2513701C (zh) |
DE (1) | DE602004023476D1 (zh) |
ES (1) | ES2332590T3 (zh) |
HK (2) | HK1081975A1 (zh) |
WO (1) | WO2004063217A1 (zh) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8653038B2 (en) | 2006-12-28 | 2014-02-18 | International Institute Of Cancer Immunology, Inc. | HLA-A* 1101-restricted WT1 peptide and pharmaceutical composition comprising the same |
CN105308063A (zh) * | 2013-03-29 | 2016-02-03 | 大日本住友制药株式会社 | Wt1抗原肽缀合物疫苗 |
CN106687129A (zh) * | 2014-09-27 | 2017-05-17 | 大日本住友制药株式会社 | 注射用药物组合物 |
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BRPI9912663B8 (pt) * | 1998-07-31 | 2021-07-06 | Int Inst Cancer Immunology Inc | vacina contra cáncer e polipeptìdeo. |
TWI318630B (en) * | 2001-03-22 | 2009-12-21 | Int Inst Cancer Immunology Inc | Wt1 modified peptide |
CA2448109A1 (en) * | 2001-05-25 | 2002-12-05 | Thomas Jefferson University | Alternative splice forms of proteins as basis for multiple therapeutic modalities |
WO2004024175A1 (ja) * | 2002-09-12 | 2004-03-25 | Haruo Sugiyama | 癌抗原ペプチド製剤 |
ES2378264T3 (es) | 2003-11-05 | 2012-04-10 | International Institute Of Cancer Immunology, Inc. | Péptido antigénico de unión a HLA-DR derivado de WT1 |
ATE462003T1 (de) * | 2004-03-31 | 2010-04-15 | Int Inst Cancer Immunology Inc | Aus wt1 stammende krebsantigenpeptide |
JP2008528643A (ja) * | 2005-02-04 | 2008-07-31 | スルバック アーぺーエス | サバイビンペプチドワクチン |
KR101385805B1 (ko) * | 2005-11-30 | 2014-04-16 | 인터내셔널 인스티튜트 오브 캔서 이무놀로지 인코퍼레이티드 | 신규 펩티드 화합물 |
PL1988163T3 (pl) | 2006-02-22 | 2012-11-30 | Int Inst Cancer Immunology Inc | Ograniczony do hla-a*3303 peptyd wt1 i zawierająca go kompozycja farmaceutyczna |
DK1987063T3 (da) * | 2006-02-23 | 2010-01-04 | Fibrex Medical Res & Dev Gmbh | Peptider og peptidderivater, fremstilling deraf samt deres anvendelse til fremstilling af en terapeutisk og/eller præventivt aktiv farmaceutisk sammensætning |
CN103103246B (zh) | 2007-02-27 | 2018-05-01 | 株式会社癌免疫研究所 | 活化辅助t细胞的方法以及用于该方法的组合物 |
EP2193142B1 (en) * | 2007-08-30 | 2015-01-07 | CureDM Group Holdings, LLC | Compositions and methods of using proislet peptides and analogs thereof |
WO2012046730A1 (ja) | 2010-10-05 | 2012-04-12 | 国立大学法人大阪大学 | ヘルパーt細胞の活性化方法 |
NZ611176A (en) | 2010-12-02 | 2015-07-31 | Bionor Immuno As | Peptide scaffold design |
EP2655402A1 (en) * | 2010-12-23 | 2013-10-30 | Intercell Austria AG | Oprf/i agents and their use in hospitalized and other patients |
US9493514B2 (en) | 2011-01-06 | 2016-11-15 | Bionor Immuno As | Dimeric scaffold proteins comprising HIV-1 GP120 and GP41 epitopes |
WO2012105224A1 (ja) * | 2011-01-31 | 2012-08-09 | オリンパス株式会社 | ワクチン・アジュバント |
JP6163486B2 (ja) | 2012-07-02 | 2017-07-12 | 大日本住友製薬株式会社 | 癌抗原ペプチド経皮剤 |
EP2933261B1 (en) | 2012-12-17 | 2020-06-10 | Otsuka Pharmaceutical Co., Ltd. | Method for activating helper t cell |
ES2694328T3 (es) | 2013-03-12 | 2018-12-19 | Sumitomo Dainippon Pharma Co., Ltd. | Composición acuosa líquida |
JP6671956B2 (ja) * | 2013-03-29 | 2020-03-25 | 大日本住友製薬株式会社 | Erap1によるトリミング機能をきっかけとしたコンジュゲートワクチン |
WO2015057009A1 (ko) | 2013-10-17 | 2015-04-23 | 서울대학교산학협력단 | 알파나선형 세포 투과 펩타이드 다합체, 이의 제조방법 및 그 용도 |
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DE69636339T2 (de) * | 1995-06-01 | 2007-07-19 | Kishimoto, Tadamitsu, Tondabayashi | Wachstumsinhibitor gegen leukämische zellen, der antisense-oligonukleotidderivate gegen das wilms-tumorgen enthält |
JP3060287B2 (ja) | 1995-10-09 | 2000-07-10 | 参天製薬株式会社 | アパファントを主薬とする水性点眼剤 |
BRPI9912663B8 (pt) * | 1998-07-31 | 2021-07-06 | Int Inst Cancer Immunology Inc | vacina contra cáncer e polipeptìdeo. |
US7063854B1 (en) * | 1998-09-30 | 2006-06-20 | Corixa Corporation | Composition and methods for WTI specific immunotherapy |
MY139226A (en) * | 1998-09-30 | 2009-08-28 | Corixa Corp | Compositions and methods for wt1 specific immunotherapy |
GB9823897D0 (en) * | 1998-11-02 | 1998-12-30 | Imp College Innovations Ltd | Immunotherapeutic methods and molecules |
JPWO2002047474A1 (ja) | 2000-12-13 | 2004-04-15 | 住友製薬株式会社 | Hla−a24発現トランスジェニック動物及びその利用 |
TWI318630B (en) * | 2001-03-22 | 2009-12-21 | Int Inst Cancer Immunology Inc | Wt1 modified peptide |
US20050002951A1 (en) * | 2001-09-28 | 2005-01-06 | Haruo Sugiyama | Novel method of inducing antigen-specific t cells |
EP1447091A4 (en) * | 2001-09-28 | 2008-02-13 | Institute Of Can International | NEW METHOD FOR INDUCTION OF ANTIGEN SPECIFIC T CELLS |
CN101113163B (zh) * | 2002-06-12 | 2010-10-06 | 株式会社国际癌症免疫研究所 | Hla-a24限制性癌抗原肽 |
ES2378264T3 (es) | 2003-11-05 | 2012-04-10 | International Institute Of Cancer Immunology, Inc. | Péptido antigénico de unión a HLA-DR derivado de WT1 |
ATE462003T1 (de) | 2004-03-31 | 2010-04-15 | Int Inst Cancer Immunology Inc | Aus wt1 stammende krebsantigenpeptide |
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2004
- 2004-01-15 US US10/541,821 patent/US20060217297A1/en not_active Abandoned
- 2004-01-15 EP EP09172205.8A patent/EP2154145B1/en not_active Expired - Lifetime
- 2004-01-15 WO PCT/JP2004/000254 patent/WO2004063217A1/ja active Application Filing
- 2004-01-15 JP JP2005508011A patent/JP4498274B2/ja not_active Expired - Lifetime
- 2004-01-15 CN CN2004800058473A patent/CN1756763B/zh not_active Expired - Lifetime
- 2004-01-15 ES ES04702444T patent/ES2332590T3/es not_active Expired - Lifetime
- 2004-01-15 CN CN201010156098A patent/CN101851275A/zh active Pending
- 2004-01-15 AU AU2004204031A patent/AU2004204031B2/en not_active Expired
- 2004-01-15 KR KR1020057012761A patent/KR101399678B1/ko active IP Right Grant
- 2004-01-15 BR BRPI0406800A patent/BRPI0406800B8/pt active IP Right Grant
- 2004-01-15 EP EP04702444A patent/EP1584627B1/en not_active Expired - Lifetime
- 2004-01-15 AT AT04702444T patent/ATE444969T1/de not_active IP Right Cessation
- 2004-01-15 CA CA2513701A patent/CA2513701C/en not_active Expired - Lifetime
- 2004-01-15 KR KR1020127008760A patent/KR20120054644A/ko not_active Application Discontinuation
- 2004-01-15 DE DE602004023476T patent/DE602004023476D1/de not_active Expired - Lifetime
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- 2006-02-23 HK HK06102442.4A patent/HK1081975A1/xx not_active IP Right Cessation
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2009
- 2009-11-16 JP JP2009260957A patent/JP4926231B2/ja not_active Expired - Lifetime
-
2010
- 2010-06-07 US US12/795,187 patent/US8242084B2/en not_active Expired - Fee Related
- 2010-08-16 HK HK10107803.0A patent/HK1141539A1/xx not_active IP Right Cessation
Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
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US8653038B2 (en) | 2006-12-28 | 2014-02-18 | International Institute Of Cancer Immunology, Inc. | HLA-A* 1101-restricted WT1 peptide and pharmaceutical composition comprising the same |
CN102335439B (zh) * | 2006-12-28 | 2015-04-22 | 株式会社癌免疫研究所 | Hla-a*1101限制的wt1肽及含有其的药物组合物 |
US9272026B2 (en) | 2006-12-28 | 2016-03-01 | International Institute Of Cancer Immunology, Inc. | HLA-A*1101-restricted WT1 peptide and pharmaceutical composition comprising the same |
CN105308063A (zh) * | 2013-03-29 | 2016-02-03 | 大日本住友制药株式会社 | Wt1抗原肽缀合物疫苗 |
CN105308063B (zh) * | 2013-03-29 | 2019-11-08 | 大日本住友制药株式会社 | Wt1抗原肽缀合物疫苗 |
CN106687129A (zh) * | 2014-09-27 | 2017-05-17 | 大日本住友制药株式会社 | 注射用药物组合物 |
CN106687129B (zh) * | 2014-09-27 | 2021-07-20 | 大日本住友制药株式会社 | 注射用药物组合物 |
Also Published As
Publication number | Publication date |
---|---|
EP2154145A3 (en) | 2010-05-19 |
EP1584627B1 (en) | 2009-10-07 |
BRPI0406800A (pt) | 2006-01-17 |
AU2004204031B2 (en) | 2010-03-04 |
HK1141539A1 (en) | 2010-11-12 |
DE602004023476D1 (de) | 2009-11-19 |
JP4926231B2 (ja) | 2012-05-09 |
BRPI0406800A8 (pt) | 2016-11-01 |
KR20050098863A (ko) | 2005-10-12 |
EP1584627A1 (en) | 2005-10-12 |
HK1081975A1 (en) | 2006-05-26 |
US20060217297A1 (en) | 2006-09-28 |
AU2004204031A1 (en) | 2004-07-29 |
EP2154145A2 (en) | 2010-02-17 |
CA2513701C (en) | 2013-06-18 |
JP2010047603A (ja) | 2010-03-04 |
CN101851275A (zh) | 2010-10-06 |
US8242084B2 (en) | 2012-08-14 |
EP1584627A4 (en) | 2006-03-15 |
EP2154145B1 (en) | 2013-04-24 |
CN1756763B (zh) | 2010-05-26 |
WO2004063217A1 (ja) | 2004-07-29 |
KR101399678B1 (ko) | 2014-05-27 |
BRPI0406800B1 (pt) | 2020-08-11 |
JP4498274B2 (ja) | 2010-07-07 |
BRPI0406800B8 (pt) | 2021-05-25 |
CA2513701A1 (en) | 2004-07-29 |
ES2332590T3 (es) | 2010-02-09 |
ATE444969T1 (de) | 2009-10-15 |
US20100292164A1 (en) | 2010-11-18 |
JPWO2004063217A1 (ja) | 2006-06-01 |
KR20120054644A (ko) | 2012-05-30 |
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