CN1751037A - 作为ppar调节剂的磺酰胺衍生物 - Google Patents
作为ppar调节剂的磺酰胺衍生物 Download PDFInfo
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- CN1751037A CN1751037A CNA2004800042507A CN200480004250A CN1751037A CN 1751037 A CN1751037 A CN 1751037A CN A2004800042507 A CNA2004800042507 A CN A2004800042507A CN 200480004250 A CN200480004250 A CN 200480004250A CN 1751037 A CN1751037 A CN 1751037A
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- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
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- C07C2601/14—The ring being saturated
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US44830703P | 2003-02-14 | 2003-02-14 | |
US60/448,307 | 2003-02-14 |
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CN1751037A true CN1751037A (zh) | 2006-03-22 |
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US (1) | US7655641B2 (de) |
EP (1) | EP1597248B1 (de) |
JP (1) | JP2006520755A (de) |
CN (1) | CN1751037A (de) |
AT (1) | ATE382043T1 (de) |
AU (1) | AU2004212887A1 (de) |
BR (1) | BRPI0407180A (de) |
CA (1) | CA2512883A1 (de) |
DE (1) | DE602004010889T2 (de) |
ES (1) | ES2297382T3 (de) |
MX (1) | MXPA05008581A (de) |
WO (1) | WO2004073606A2 (de) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102336689A (zh) * | 2011-08-29 | 2012-02-01 | 天津市筠凯化工科技有限公司 | 4-氯-3-(三氟甲基)苯磺酰氯的制备及其精制方法 |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7517884B2 (en) | 1998-03-30 | 2009-04-14 | Kalypsys Inc. | Sulfonyl-substituted bicyclic compounds as modulators of PPAR |
BRPI0416238A (pt) * | 2003-11-05 | 2007-01-02 | Hoffmann La Roche | compostos, processo para a sua preparação, composição farmacêutica que compreende os mesmos, uso dos compostos e métodos para o tratamento e/ou a prevenção de doenças que são moduladas por ppar(delta) e/ou agonistas ppar(alfa) |
EP1745014B1 (de) | 2004-05-05 | 2011-07-06 | High Point Pharmaceuticals, LLC | Neue verbindungen, deren herstellung und verwendung |
JP2007536343A (ja) | 2004-05-05 | 2007-12-13 | ノボ ノルディスク アクティーゼルスカブ | Pparアゴニストとしてのフェノキシ酢酸誘導体 |
ES2682282T3 (es) | 2004-10-29 | 2018-09-19 | Kalypsys, Inc. | Compuestos bicíclicos sustituidos con sulfonilo como moduladores de PPAR |
WO2007005455A2 (en) * | 2005-06-30 | 2007-01-11 | Bayer Cropscience Ag | Improved process for preparing (disubstitutedpropenyl) phenylalkyl substituted heterocycles |
ATE529404T1 (de) | 2005-06-30 | 2011-11-15 | High Point Pharmaceuticals Llc | Phenoxyessigsäuren als ppar-delta-aktivatoren |
US7915316B2 (en) * | 2005-08-22 | 2011-03-29 | Allergan, Inc | Sulfonamides |
CN101273013B (zh) * | 2005-09-27 | 2013-06-12 | 盐野义制药株式会社 | 具有pgd2受体拮抗活性的磺酰胺衍生物 |
JP5114202B2 (ja) * | 2005-09-27 | 2013-01-09 | 塩野義製薬株式会社 | Pgd2受容体アンタゴニスト活性を有するスルホンアミド誘導体 |
NZ566831A (en) | 2005-10-25 | 2011-09-30 | Kalypsys Inc | Salts of modulators of PPAR and methods of treating metabolic disorders |
EA015717B1 (ru) | 2005-12-22 | 2011-10-31 | ХАЙ ПОЙНТ ФАРМАСЬЮТИКАЛЗ, ЭлЭлСи | Феноксиуксусные кислоты в качестве активаторов ppar дельта |
EP1999098A2 (de) | 2006-03-09 | 2008-12-10 | High Point Pharmaceuticals, LLC | Verbindungen, die die ppar-aktivität modulieren, ihre herstellung und ihre verwendung |
US7981318B2 (en) * | 2006-11-06 | 2011-07-19 | Sagami Chemical Research Center | Reaction reagent for trifluoromethylation |
US20080176861A1 (en) | 2007-01-23 | 2008-07-24 | Kalypsys, Inc. | Sulfonyl-substituted bicyclic compounds as ppar modulators for the treatment of non-alcoholic steatohepatitis |
KR101152659B1 (ko) * | 2009-10-09 | 2012-06-15 | 한국과학기술연구원 | 세로토닌 수용체 길항 작용과 세로토닌 트랜스포터 억제 작용을 동시에 가지는 설폰아마이드 화합물 |
US20130197043A1 (en) | 2010-08-31 | 2013-08-01 | Snu R&Db Foundation | Use of the fetal reprogramming of a ppar agonist |
JP5767458B2 (ja) * | 2010-11-09 | 2015-08-19 | スガイ化学工業株式会社 | ポリオキシエチレン付加カリックスアレーン誘導体の製造方法 |
US9187411B2 (en) | 2012-01-10 | 2015-11-17 | Eli Lilly And Company | Leukotriene B4 antagonist compound |
US9487493B2 (en) | 2013-09-09 | 2016-11-08 | Vtv Therapeutics Llc | Use of a PPAR-delta agonist for treating muscle atrophy |
WO2016057322A1 (en) | 2014-10-08 | 2016-04-14 | Salk Institute For Biological Studies | Ppar agonists and methods of use thereof |
US10188627B2 (en) | 2014-10-08 | 2019-01-29 | Mitobridge, Inc. | PPAR agonists, compounds, pharmaceutical compositions, and methods of use thereof |
US10103402B2 (en) * | 2015-12-01 | 2018-10-16 | University Of Kentucky Research Foundation | Liquid phenothiazine catholytes for non-aqueous redox flow batteries |
WO2023147309A1 (en) | 2022-01-25 | 2023-08-03 | Reneo Pharmaceuticals, Inc. | Use of ppar-delta agonists in the treatment of disease |
Family Cites Families (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5084466A (en) * | 1989-01-31 | 1992-01-28 | Hoffmann-La Roche Inc. | Novel carboxamide pyridine compounds which have useful pharmaceutical utility |
US5089514A (en) * | 1990-06-14 | 1992-02-18 | Pfizer Inc. | 3-coxazolyl [phenyl, chromanyl or benzofuranyl]-2-hydroxypropionic acid derivatives and analogs as hypoglycemic agents |
JPH05125038A (ja) * | 1991-03-07 | 1993-05-21 | Tanabe Seiyaku Co Ltd | フエノキシアルカン酸誘導体及びその製法 |
JPH05194370A (ja) * | 1992-01-22 | 1993-08-03 | Taisho Pharmaceut Co Ltd | スルホンアミド誘導体 |
US5232945A (en) * | 1992-07-20 | 1993-08-03 | Pfizer Inc. | 3-aryl-2-hydroxypropionic acid derivatives and analogs as antihypertensives |
JPH0672867A (ja) * | 1992-08-27 | 1994-03-15 | Tanabe Seiyaku Co Ltd | 抗脂血剤 |
US6062509A (en) | 1994-12-23 | 2000-05-16 | Hexcel Corporation | Retrofit centerline luggage bin assemblies compatible with existing aircraft bin supports |
US5902726A (en) * | 1994-12-23 | 1999-05-11 | Glaxo Wellcome Inc. | Activators of the nuclear orphan receptor peroxisome proliferator-activated receptor gamma |
CA2212829A1 (en) * | 1995-02-21 | 1996-08-29 | Jiro Takeo | Glutamic acid receptor agonist |
WO1997028115A1 (en) | 1996-02-02 | 1997-08-07 | Merck & Co., Inc. | Antidiabetic agents |
GB9604242D0 (en) | 1996-02-28 | 1996-05-01 | Glaxo Wellcome Inc | Chemical compounds |
ATE413386T1 (de) * | 1998-01-29 | 2008-11-15 | Amgen Inc | Ppar-gamma modulatoren |
EP1067109B1 (de) * | 1998-03-10 | 2009-12-09 | Ono Pharmaceutical Co., Ltd. | Carbonsäurederivate und medikamente die diese als aktiven wirkstoff enthalten |
GB9822473D0 (en) * | 1998-10-16 | 1998-12-09 | Glaxo Group Ltd | Chemical compounds |
US6248781B1 (en) * | 1998-10-21 | 2001-06-19 | Novo Nordisk A/S | Compounds useful in the treatment of conditions mediated by peroxisome proliferator-activated receptors (PPAR) |
CA2369871A1 (en) * | 1999-04-06 | 2000-10-12 | Takashi Fujita | .alpha.-substituted carboxylic acid derivatives |
JP4598278B2 (ja) * | 1999-04-28 | 2010-12-15 | サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | Ppar受容体リガンドとしてのジアリール酸誘導体 |
HUP0202384A3 (en) | 1999-06-25 | 2003-03-28 | Inst For Pharm Discovery Inc | Substituted phenoxyacetic acids |
CA2382966A1 (en) | 1999-08-27 | 2001-03-08 | Eli Lilly And Company | Biaryl-oxa(thia)zole derivatives and their use as ppars modulators |
TWI262185B (en) | 1999-10-01 | 2006-09-21 | Eisai Co Ltd | Carboxylic acid derivatives having anti-hyperglycemia and anti-hyperlipemia action, and pharmaceutical composition containing the derivatives |
WO2001025226A1 (en) * | 1999-10-05 | 2001-04-12 | Bethesda Pharmaceuticals, Inc. | Dithiolane derivatives |
PE20011010A1 (es) * | 1999-12-02 | 2001-10-18 | Glaxo Group Ltd | Oxazoles y tiazoles sustituidos como agonista del receptor activado por el proliferador de peroxisomas humano |
JP4316787B2 (ja) | 2000-01-11 | 2009-08-19 | 壽製薬株式会社 | エーテル又はアミド誘導体、その製法並びにそれを含有する糖尿病治療剤、 |
ES2288982T3 (es) | 2000-08-23 | 2008-02-01 | Eli Lilly And Company | Derivados de acido oxazolil-ariloxiacetico y su uso como agonistas ppar. |
JP2004506722A (ja) | 2000-08-23 | 2004-03-04 | イーライ・リリー・アンド・カンパニー | ペルオキシソーム増殖因子活性化受容体の調節方法 |
US7071220B2 (en) * | 2000-09-18 | 2006-07-04 | Toa Eiyo Ltd. | N-substituted benzothiophenesulfonamide derivatives |
AU2002240235B2 (en) * | 2001-01-30 | 2006-07-06 | Merck & Co., Inc. | Acyl sulfamides for treatment of obesity, diabetes and lipid disorders |
WO2002064130A1 (en) * | 2001-02-15 | 2002-08-22 | Pfizer Products Inc. | Proliferative activator receptor (ppar) compounds |
EE200400001A (et) | 2001-06-07 | 2004-02-16 | Eli Lilly And Company | alfa-metoksütsinnamaadid, nende valmistamine ja kasutamine peroksisoomi proliferaator-aktiveeritud retseptorite moduleerimiseks ning neid sisaldavad ravimkompositsioonid |
ATE375350T1 (de) | 2002-02-21 | 2007-10-15 | Lilly Co Eli | Modulatoren von peroxisome proliferator- aktivierten rezeptoren |
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2004
- 2004-02-10 DE DE602004010889T patent/DE602004010889T2/de not_active Expired - Fee Related
- 2004-02-10 WO PCT/US2004/002015 patent/WO2004073606A2/en active IP Right Grant
- 2004-02-10 CN CNA2004800042507A patent/CN1751037A/zh active Pending
- 2004-02-10 MX MXPA05008581A patent/MXPA05008581A/es active IP Right Grant
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- 2004-02-10 BR BR0407180-8A patent/BRPI0407180A/pt not_active Application Discontinuation
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- 2004-02-10 EP EP04709806A patent/EP1597248B1/de not_active Expired - Lifetime
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Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102336689A (zh) * | 2011-08-29 | 2012-02-01 | 天津市筠凯化工科技有限公司 | 4-氯-3-(三氟甲基)苯磺酰氯的制备及其精制方法 |
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WO2004073606A3 (en) | 2005-03-31 |
MXPA05008581A (es) | 2005-11-04 |
BRPI0407180A (pt) | 2006-02-07 |
EP1597248B1 (de) | 2007-12-26 |
EP1597248A2 (de) | 2005-11-23 |
WO2004073606A2 (en) | 2004-09-02 |
JP2006520755A (ja) | 2006-09-14 |
DE602004010889T2 (de) | 2008-12-11 |
CA2512883A1 (en) | 2004-09-02 |
US7655641B2 (en) | 2010-02-02 |
ATE382043T1 (de) | 2008-01-15 |
ES2297382T3 (es) | 2008-05-01 |
AU2004212887A1 (en) | 2004-09-02 |
DE602004010889D1 (de) | 2008-02-07 |
US20060217433A1 (en) | 2006-09-28 |
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